Detailed information for compound 1556449

Basic information

Technical information
  • TDR Targets ID: 1556449
  • Name: 2-(3,4-dimethylphenyl)-N-(1-phenylethyl)quino line-4-carboxamide
  • MW: 380.482 | Formula: C26H24N2O
  • H donors: 1 H acceptors: 2 LogP: 5.75 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc(nc2c1cccc2)c1ccc(c(c1)C)C)NC(c1ccccc1)C
  • InChi: 1S/C26H24N2O/c1-17-13-14-21(15-18(17)2)25-16-23(22-11-7-8-12-24(22)28-25)26(29)27-19(3)20-9-5-4-6-10-20/h4-16,19H,1-3H3,(H,27,29)
  • InChiKey: JXZPQQWKXCPYDQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3,4-dimethylphenyl)-N-(1-phenylethyl)-4-quinolinecarboxamide
  • 2-(3,4-dimethylphenyl)-N-(1-phenylethyl)cinchoninamide
  • K786-0608
  • NCGC00139774-01
  • Oprea1_687554
  • AK-968/11987184
  • Oprea1_469600

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0515 0.1368
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0497 0.135
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0271 0.0271
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0497 0.135
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0097 0.0097
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0203 0.0203
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0497 0.135
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0036 0.0893 0.1004
Loa Loa (eye worm) hypothetical protein 0.0145 0.4197 0.4718
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0097 0.0109
Loa Loa (eye worm) hypothetical protein 0.0024 0.0515 0.0579
Loa Loa (eye worm) hypothetical protein 0.0024 0.0515 0.0579
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0097 0.0097
Echinococcus multilocularis muscleblind protein 1 0.0145 0.4197 0.4197
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0128 0.3682 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0301 0.0439
Schistosoma mansoni hypothetical protein 0.0016 0.0271 0.0271
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0018 0.0322 0.0875
Echinococcus multilocularis 0.0018 0.0322 0.0322
Trypanosoma cruzi DNA damage repair protein, putative 0.0007 0.0007 0.0018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0893 0.0893
Trichomonas vaginalis esterase, putative 0.0036 0.0893 0.2426
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0128 0.3682 0.4139
Trichomonas vaginalis fk506-binding protein, putative 0.0018 0.0322 0.0875
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.1044 0.1044
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0097 0.0097
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0111 0.3166 0.3559
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.2543 0.2859
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0497 0.135
Schistosoma mansoni hypothetical protein 0.0034 0.0834 0.0834
Brugia malayi beta-lactamase family protein 0.0036 0.0893 0.1004
Trypanosoma brucei unspecified product 0.0016 0.0276 0.0751
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0036 0.0893 0.1004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0036 0.0893 0.1004
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0018 0.0322 0.0362
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0515 0.1399
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0097 0.0097
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0018 0.0322 0.0362
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0893 0.1302
Onchocerca volvulus 0.0036 0.0893 0.1004
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0018 0.0322 0.0362
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0893 0.1302
Plasmodium vivax DNA repair protein REV1, putative 0.0007 0.0007 0.0018
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0097 0.0109
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0097 0.0109
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0893 1
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0018 0.0322 0.5
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0007 0.0018
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.4065 0.4065
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0128 0.3682 1
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0007 0.0007 0.0064
Loa Loa (eye worm) hypothetical protein 0.005 0.1319 0.1483
Leishmania major DNA polymerase kappa, putative 0.0023 0.0497 0.135
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0515 0.1368
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0497 0.135
Brugia malayi beta-lactamase family protein 0.0036 0.0893 0.1004
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0497 0.135
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0331 1
Schistosoma mansoni hypothetical protein 0.0335 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.2543 0.2543
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0097 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0007 0.0018
Brugia malayi ecdysteroid receptor 0.001 0.0097 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0097 0.0109
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0128 0.3682 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.1044 0.2837
Schistosoma mansoni thyroid hormone receptor 0.001 0.0097 0.0097
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0497 0.0559
Brugia malayi Muscleblind-like protein 0.0145 0.4197 0.4718
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0715 0.1942
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.013 0.3766 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0893 0.2426
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0036 0.0893 0.1004
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0018 0.0322 0.0858
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0097 0.0109
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0515 0.0579
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0018 0.0322 0.0855
Echinococcus multilocularis GPCR, family 2 0.0016 0.0271 0.0271
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0097 0.0097
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0331 0.0898
Loa Loa (eye worm) hypothetical protein 0.001 0.0097 0.0109
Loa Loa (eye worm) hypothetical protein 0.0018 0.0331 0.0372
Schistosoma mansoni immunophilin 0.013 0.3766 0.3766
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0097 0.0097
Trypanosoma cruzi DNA polymerase eta, putative 0.0007 0.0007 0.0018
Onchocerca volvulus 0.0018 0.0322 0.0362
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2543 0.2543
Leishmania major hypothetical protein, conserved 0.003 0.0715 0.1942
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0007 0.0064
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0018 0.0322 0.0875
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0715 0.1942
Schistosoma mansoni DNA polymerase eta 0.0023 0.0497 0.0497
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0893 0.2426
Onchocerca volvulus 0.0024 0.0515 0.0579
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0097 0.0109
Loa Loa (eye worm) hypothetical protein 0.001 0.0097 0.0109
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0007
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0018 0.0322 0.0875
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0097 0.0109
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0097 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0097 0.0109
Mycobacterium tuberculosis Conserved protein 0.0036 0.0893 0.1302
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0018 0.0322 0.0362
Schistosoma mansoni hypothetical protein 0.0016 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.001 0.0097 0.0109
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0097 0.0097
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.1044 0.2837
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0893 0.2426
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0018 0.0322 0.0469
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0097 0.0109
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0097 0.0097
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0128 0.3682 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0893 0.0893
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.001 0.0097 0.0109
Mycobacterium ulcerans hypothetical protein 0.0007 0.0007 0.0018
Mycobacterium ulcerans hypothetical protein 0.0036 0.0893 0.2426
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0128 0.3682 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0331 0.0372
Loa Loa (eye worm) beta-lactamase 0.0036 0.0893 0.1004
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0097 0.0097
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0301 0.0439
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0322 0.0875
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0097 0.0109
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0515 0.5766
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0497 0.135
Trichomonas vaginalis immunophilin, putative 0.0128 0.3682 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0128 0.3702 0.4162
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0097 0.0109
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0497 0.135
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0497 0.135
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0497 0.0497
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0018 0.0322 0.0362
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0331 0.0482
Schistosoma mansoni coup transcription factor 0.001 0.0097 0.0097
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0018 0.0322 0.0858
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0018 0.0322 0.0875
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0097 0.0109
Mycobacterium ulcerans beta-lactamase 0.0036 0.0893 0.2426
Trichomonas vaginalis fk506-binding protein, putative 0.0018 0.0322 0.0875
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.2543 0.2859
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0097 0.0109
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0515 0.5766
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0097 0.0109
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0893 0.1302
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0018 0.0322 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.001 0.0097 0.0109
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0128 0.3682 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0497 0.0559
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0515 0.1399
Brugia malayi nuclear hormone receptor 0.001 0.0097 0.0109
Schistosoma mansoni hypothetical protein 0.0018 0.0322 0.0322
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.1044 0.2837
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0893 0.1302
Loa Loa (eye worm) hypothetical protein 0.001 0.0097 0.0109
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.2543 0.2543
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0276 0.0751
Loa Loa (eye worm) acetyltransferase 0.014 0.4065 0.4571
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0497 0.135
Loa Loa (eye worm) hypothetical protein 0.0016 0.0271 0.0305
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0128 0.3682 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0515 0.0751
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0715 0.1942
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2543 0.2543
Echinococcus granulosus FK506 binding protein 2 0.0018 0.0322 0.0322
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0097 0.0109
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0097 0.0109
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0018 0.0331 0.0372
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.3945 0.3945
Brugia malayi hypothetical protein 0.0298 0.8894 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0515 0.1399
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0497 0.0559
Echinococcus multilocularis muscleblind protein 0.0145 0.4197 0.4197
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0128 0.3682 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0497 0.135
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0018 0.0322 0.0322
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0276 0.0751
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0097 0.0097
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0113 0.323 0.323
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0097 0.0097
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0097 0.0097
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0834 0.0938
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0128 0.3682 0.4139
Trichomonas vaginalis fk506 binding protein, putative 0.0018 0.0322 0.0875
Loa Loa (eye worm) hypothetical protein 0.0298 0.8894 1
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0018 0.0322 0.3083
Brugia malayi polk-prov protein 0.0007 0.0007 0.0007
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0097 0.0097
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0893 0.2426
Mycobacterium tuberculosis Conserved protein 0.0036 0.0893 0.1302
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0018 0.0322 0.3083
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0128 0.3682 1
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0007 0.0018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1319 0.1483
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.0018 0.0322 0.3606
Mycobacterium ulcerans lipase LipD 0.0036 0.0893 0.2426
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0497 0.135
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0322 0.0875
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0515 0.0579
Echinococcus granulosus FTZ F1 alpha 0.001 0.0097 0.0097
Mycobacterium tuberculosis Conserved protein 0.0036 0.0893 0.1302
Toxoplasma gondii ABC1 family protein 0.0036 0.0893 0.8551
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0097 0.0109
Leishmania major hypothetical protein, conserved 0.0036 0.0893 0.2426
Loa Loa (eye worm) FKBP5 protein 0.0128 0.3682 0.4139
Loa Loa (eye worm) hypothetical protein 0.0018 0.0331 0.0372
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0128 0.3682 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0515 0.1399
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0018 0.0322 0.0875
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0007 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0097 0.0109
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1319 0.1483
Giardia lamblia DINP protein human, muc B family 0.0023 0.0497 0.1335
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0497 0.135
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0276 0.0751
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0018 0.0322 0.0855
Trypanosoma cruzi DNA damage repair protein, putative 0.0007 0.0007 0.0018
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0515 0.1368
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0893 0.1004
Leishmania major DNA polymerase eta, putative 0.0023 0.0497 0.135
Brugia malayi beta-lactamase 0.0036 0.0893 0.1004
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0271 0.0305
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0497 0.135
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0018 0.0322 0.0858
Onchocerca volvulus 0.0036 0.0893 0.1004
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.4065 0.4065
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0497 0.135
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0515 0.1399
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0007 0.0018
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0515 0.0751
Trypanosoma brucei chrX additional, unordered contigs 0.0007 0.0007 0.0018
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0018 0.0322 0.0875
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0128 0.3682 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0515 0.1399
Echinococcus granulosus dna polymerase eta 0.0023 0.0497 0.0497
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0271 0.0271
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0097 0.0097
Brugia malayi hypothetical protein 0.002 0.0386 0.0434
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.013 0.3766 0.3766
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.686 1
Leishmania major DNA damage repair protein, putative 0.0007 0.0007 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0301 0.0439
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.2543 0.2543
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0497 0.135
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.094 0.2495
Echinococcus granulosus muscleblind protein 0.0145 0.4197 0.4197
Leishmania major DNA polymerase kappa, putative 0.0007 0.0007 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2543 0.2543
Onchocerca volvulus 0.0018 0.0342 0.0385
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0515 0.0579
Loa Loa (eye worm) hypothetical protein 0.0036 0.0893 0.1004
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0097 0.0097
Schistosoma mansoni fk506 binding protein 0.0018 0.0322 0.0322
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0097 0.0097
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0331 0.0898
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0893 0.2426
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0128 0.3682 0.3682
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.002 0.0406 0.0406
Loa Loa (eye worm) hypothetical protein 0.0018 0.0331 0.0372
Schistosoma mansoni immunophilin 0.0113 0.323 0.323
Schistosoma mansoni nuclear hormone receptor 0.001 0.0097 0.0097
Leishmania major fk506-binding protein 1-like protein 0.0128 0.3682 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0271 0.0305
Brugia malayi steroid hormone receptor 0.001 0.0097 0.0109
Loa Loa (eye worm) hypothetical protein 0.001 0.0097 0.0109
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0497 0.132
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0097 0.0109
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1319 0.1483
Plasmodium falciparum DNA repair protein REV1, putative 0.0007 0.0007 0.0018
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0007 0.0064
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.1044 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0715 0.1942
Echinococcus granulosus dna polymerase kappa 0.0023 0.0497 0.0497
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0097 0.0109
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0893 0.0893
Giardia lamblia Hypothetical protein 0.0018 0.0322 0.0858
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0128 0.3682 1
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0497 0.135
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0893 0.2426
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0497 0.135
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0128 0.3682 1
Leishmania major DNA polymerase eta, putative 0.0007 0.0007 0.0018
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0497 0.135
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0018 0.0322 0.0875
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0097 0.0097
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0018 0.0322 0.0362
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0018 0.0322 0.0875
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.013 0.3766 1
Onchocerca volvulus 0.001 0.0097 0.0109
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0018 0.0322 0.0875
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0018 0.0322 0.0875
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0097 0.0109
Echinococcus multilocularis geminin 0.0335 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0497 0.0559
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0018 0.0322 0.0875
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0893 0.2426
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0024 0.0515 0.0579
Schistosoma mansoni hypothetical protein 0.0014 0.0203 0.0203
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0018 0.0322 0.0875
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0097 0.0097
Onchocerca volvulus 0.0036 0.0893 0.1004
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0497 0.135
Brugia malayi hypothetical protein 0.003 0.0715 0.0804
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0271 0.0271
Trypanosoma brucei unspecified product 0.0016 0.0276 0.0751
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0097 0.0109
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0018 0.0322 0.0875
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0322 0.0875
Brugia malayi nuclear receptor NHR-88 0.001 0.0097 0.0109
Schistosoma mansoni immunophilin 0.013 0.3766 0.3766
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0497 0.0497
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0893 0.2426
Loa Loa (eye worm) hypothetical protein 0.0036 0.0893 0.1004
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0715 0.1942
Trichomonas vaginalis fk506-binding protein, putative 0.0128 0.3682 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0515 0.1399
Mycobacterium ulcerans hypothetical protein 0.0024 0.0515 0.1399
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0018 0.0322 0.3083
Schistosoma mansoni hypothetical protein 0.0016 0.0271 0.0271
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0893 0.1302
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0893 0.0893
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0893 0.2426
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0097 0.0097
Mycobacterium ulcerans hypothetical protein 0.0018 0.0322 0.0875
Onchocerca volvulus 0.0298 0.8894 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.094 0.2552
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0497 0.135
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0515 0.1399
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0113 0.323 0.323
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0497 0.0725
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0097 0.0109
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.4065 0.4571
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0497 0.135
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0097 0.0097
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0515 0.1399
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.094 0.2539
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0497 0.135
Echinococcus multilocularis fk506 binding protein 0.0128 0.3682 0.3682
Loa Loa (eye worm) hypothetical protein 0.0145 0.4197 0.4718
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.013 0.3766 0.3766
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0331 0.0898
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0515 0.1399
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0497 0.0497
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.1044 1
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0007 0.0018
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0497 0.135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0097 0.0109
Schistosoma mansoni hypothetical protein 0.0335 1 1
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0715 0.6844
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0497 0.0497
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0893 0.1302
Echinococcus multilocularis dna polymerase eta 0.0023 0.0497 0.0497
Echinococcus granulosus GPCR family 2 0.0016 0.0271 0.0271
Trypanosoma brucei unspecified product 0.0023 0.0497 0.135
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0497 0.0497
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0497 0.0725
Loa Loa (eye worm) hypothetical protein 0.001 0.0097 0.0109
Leishmania major peptidylprolyl isomerase-like protein 0.0128 0.3682 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0097 0.0109
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0715 0.1942
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0893 0.2426
Schistosoma mansoni hypothetical protein 0.0016 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.003 0.0715 0.0804
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0893 0.1004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.2543 0.2543
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0301 0.0439
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0893 0.2426
Schistosoma mansoni thyroid hormone receptor 0.001 0.0097 0.0097
Mycobacterium leprae Probable lipase LipE 0.0036 0.0893 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0271 0.0305
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0097 0.0109
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0128 0.3682 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0834 0.0938
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0128 0.3682 0.3682
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0893 0.1302
Loa Loa (eye worm) hypothetical protein 0.0018 0.0322 0.0362
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0018 0.0322 0.3083

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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