Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0656 | 0.0656 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0656 | 0.1322 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.3291 | 0.6631 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0054 | 0.3291 | 0.3291 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2265 | 0.2265 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.3291 | 0.6631 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.3291 | 0.6631 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4963 | 0.4963 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.2265 | 0.4565 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.3291 | 0.6631 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0656 | 0.1322 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.3652 | 0.3652 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.2265 | 0.2265 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.3291 | 0.6631 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0656 | 0.0656 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3652 | 0.3652 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0656 | 0.1322 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.3291 | 0.6631 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4963 | 0.4963 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0656 | 0.1322 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4963 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0656 | 0.0656 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0656 | 0.1322 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0656 | 0.0656 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4963 | 0.4963 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.3652 | 0.3652 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0656 | 0.1322 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0054 | 0.3291 | 0.3291 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0656 | 0.1322 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0656 | 0.1322 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4963 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4963 | 0.4963 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.3652 | 0.3652 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4963 | 0.4963 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.3291 | 0.6631 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4963 | 0.4963 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0656 | 0.1322 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0656 | 0.1322 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.