Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphatase, orphan 1 | Starlite/ChEMBL | No references |
Homo sapiens | mannose phosphate isomerase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | Putative Phosphatase/Protein of unknown function DUF89, putative | phosphatase, orphan 1 | 292 aa | 281 aa | 28.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | phosphomannose isomerase type I protein | 0.0117 | 1 | 0.5 |
Entamoeba histolytica | phosphomannose isomerase, putative | 0.0117 | 1 | 0.5 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.0117 | 1 | 0.5 |
Leishmania major | phosphomannose isomerase | 0.0117 | 1 | 1 |
Mycobacterium ulcerans | mannose-6-phosphate isomerase ManA | 0.0117 | 1 | 0.5 |
Brugia malayi | mannose-6-phosphate isomerase, class I family protein | 0.0117 | 1 | 0.5 |
Echinococcus granulosus | mannose 6 phosphate isomerase | 0.0117 | 1 | 0.5 |
Trichomonas vaginalis | mannose-6-phosphate isomerase, putative | 0.0117 | 1 | 0.5 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.0117 | 1 | 1 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.0117 | 1 | 0.5 |
Plasmodium vivax | mannose-6-phosphate isomerase, putative | 0.0117 | 1 | 0.5 |
Plasmodium falciparum | mannose-6-phosphate isomerase, putative | 0.0117 | 1 | 0.5 |
Echinococcus multilocularis | mannose 6 phosphate isomerase | 0.0117 | 1 | 0.5 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.0117 | 1 | 1 |
Trypanosoma brucei | phosphomannose isomerase | 0.0117 | 1 | 1 |
Schistosoma mansoni | mannose-6-phosphate isomerase | 0.0117 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.534 uM | PUBCHEM_BIOASSAY: SAR assay for compounds that inhibit PHOSPHO1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1545, AID1565, AID1574] | ChEMBL. | No reference |
IC50 (binding) | = 14.4 uM | PUBCHEM_BIOASSAY: Confirmation of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1209, AID1220, AID1545, AID1553, AID1574, AID1620] | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | PUBCHEM_BIOASSAY: Counter screen SAR assay for PMM2 inhibitors via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1545, AID1574] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.