Detailed information for compound 1557452

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 340.33 | Formula: C18H16N2O5
  • H donors: 0 H acceptors: 3 LogP: 1.41 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1[n+]([O-])c2ccc(cc2[n+](c1c1ccccc1)[O-])OC
  • InChi: 1S/C18H16N2O5/c1-3-25-18(21)17-16(12-7-5-4-6-8-12)20(23)15-11-13(24-2)9-10-14(15)19(17)22/h4-11H,3H2,1-2H3
  • InChiKey: FVXZBMGXLWMDST-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0036 0.0571 0.0763
Schistosoma mansoni glutamate receptor kainate 0.0131 0.2651 0.2631
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.2794 0.373
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0111 0.2194 0.43
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0333 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.1946 0.1946
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0111 0.2194 0.6259
Brugia malayi Guanylyl cyclase protein 23 0.0025 0.0323 0.032
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0353 0.0361
Leishmania major cytochrome p450-like protein 0.0111 0.2194 0.6259
Loa Loa (eye worm) beta-lactamase 0.0036 0.0571 0.0763
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0111 0.2194 0.43
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0192 0.0192
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.1546 0.1546
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0111 0.2194 0.43
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0571 0.0546
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.1946 0.1946
Loa Loa (eye worm) hypothetical protein 0.0025 0.0323 0.0431
Mycobacterium ulcerans lipase LipD 0.0036 0.0571 0.1185
Schistosoma mansoni hypothetical protein 0.0081 0.1546 0.1523
Brugia malayi Receptor family ligand binding region containing protein 0.0025 0.0323 0.032
Loa Loa (eye worm) hypothetical protein 0.0036 0.0571 0.0763
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0333 0.0441
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0333 0.0441
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0571 0.0546
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0056 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1361 0.1338
Loa Loa (eye worm) RNA binding protein 0.0072 0.1361 0.1817
Echinococcus multilocularis glutamate receptor 2 0.0353 0.749 0.749
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0111 0.2194 0.6259
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0156 0.3196 0.3196
Loa Loa (eye worm) glutamate receptor 1 0.0353 0.749 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0333 0.3721
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0025 0.0323 0.0323
Treponema pallidum bacterioferrin (TpF1) 0.0028 0.0393 1
Trichomonas vaginalis ferritin, putative 0.0028 0.0393 0.5297
Schistosoma mansoni cytochrome P450 0.0111 0.2194 0.2173
Brugia malayi CXXC zinc finger family protein 0.0033 0.0496 0.0553
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0165 0.3391 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0111 0.2194 0.6259
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0111 0.2194 0.43
Loa Loa (eye worm) hypothetical protein 0.0025 0.0323 0.0431
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.0323 0.0431
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0192 0.5
Loa Loa (eye worm) cytochrome P450 0.0111 0.2194 0.293
Brugia malayi Cytochrome P450 family protein 0.0165 0.3391 0.4464
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.1546 0.1546
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0571 0.0814
Echinococcus multilocularis glutamate receptor 2 0.0329 0.6972 0.6972
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0111 0.2194 0.43
Echinococcus granulosus metabotropic glutamate receptor 2 0.0025 0.0323 0.0323
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0111 0.2194 0.6259
Echinococcus granulosus glutamate receptor 4 0.0221 0.4617 0.4617
Schistosoma mansoni tyrosine kinase 0.0025 0.0323 0.0297
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0571 0.0656
Schistosoma mansoni apoferritin-2 0.0028 0.0393 0.0367
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0025 0.0323 0.0323
Brugia malayi RNA binding protein 0.0072 0.1361 0.1722
Loa Loa (eye worm) hypothetical protein 0.0026 0.0343 0.0457
Loa Loa (eye worm) hypothetical protein 0.0221 0.4617 0.6164
Schistosoma mansoni ferritin 0.0028 0.0393 0.0367
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0111 0.2194 0.43
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0025 0.0323 0.0431
Loa Loa (eye worm) hypothetical protein 0.0256 0.5366 0.7164
Schistosoma mansoni apoferritin-2 0.0028 0.0393 0.0367
Schistosoma mansoni hypothetical protein 0.0081 0.1546 0.1523
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0571 0.099
Mycobacterium ulcerans beta-lactamase 0.0036 0.0571 0.1185
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0111 0.2194 0.43
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0156 0.3196 0.3196
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0111 0.2194 0.6259
Mycobacterium leprae Probable lipase LipE 0.0036 0.0571 0.099
Schistosoma mansoni hypothetical protein 0.0468 1 1
Echinococcus multilocularis cpg binding protein 0.0035 0.0537 0.0537
Schistosoma mansoni glutamate receptor AMPA 0.0131 0.2651 0.2631
Loa Loa (eye worm) cytochrome P450 family protein 0.0165 0.3391 0.4527
Mycobacterium ulcerans bacterioferritin BfrB 0.0028 0.0393 0.0628
Brugia malayi Metabotropic glutamate receptor precursor. 0.0025 0.0323 0.032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.1946 0.1924
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0111 0.2194 0.6259
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0027 0.0027
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0111 0.2194 0.6259
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0028 0.0393 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0156 0.3196 0.3196
Schistosoma mansoni tyrosine kinase 0.0025 0.0323 0.0297
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0333 0.0441
Loa Loa (eye worm) cytochrome P450 family protein 0.0165 0.3391 0.4527
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0571 0.0814
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1361 0.1338
Schistosoma mansoni ap endonuclease 0.0019 0.0192 0.0166
Onchocerca volvulus 0.0033 0.0496 0.695
Schistosoma mansoni glutamate receptor NMDA 0.0131 0.2651 0.2631
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0571 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.1546 0.2064
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0028 0.0393 0.0431
Brugia malayi Latrophilin receptor protein 2 0.0081 0.1546 0.1972
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.1361 0.1817
Brugia malayi Cytochrome P450 family protein 0.0111 0.2194 0.2847
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0571 0.0571
Schistosoma mansoni ferritin light chain 0.0028 0.0393 0.0367
Echinococcus granulosus metabotropic glutamate receptor 5 0.0025 0.0323 0.0323
Brugia malayi metabotropic glutamate receptor type 2 0.0025 0.0323 0.032
Loa Loa (eye worm) glutamate receptor 0.0025 0.0323 0.0431
Echinococcus multilocularis expressed protein 0.0028 0.0393 0.0393
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0111 0.2194 0.43
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0111 0.2194 0.6259
Entamoeba histolytica hypothetical protein 0.0025 0.0323 1
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0111 0.2194 0.6259
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0111 0.2194 0.6259
Echinococcus granulosus ferritin 0.0028 0.0393 0.0393
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.0323 0.0431
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.1361 0.1722
Schistosoma mansoni glutamate receptor kainate 0.0131 0.2651 0.2631
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0111 0.2194 0.43
Schistosoma mansoni metabotropic glutamate receptor 0.0025 0.0323 0.0297
Echinococcus multilocularis nmda type glutamate receptor 0.0049 0.0841 0.0841
Echinococcus granulosus glutamate receptor subunit protein glur 0.027 0.568 0.568
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0025 0.0323 0.0431
Trypanosoma brucei cytochrome P450, putative 0.0165 0.3391 1
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1361 0.1338
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.1946 0.1946
Schistosoma mansoni glutamate receptor kainate 0.0131 0.2651 0.2631
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0025 0.0323 0.0323
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0571 0.0571
Leishmania major extracellular receptor, putative 0.0025 0.0323 0.0408
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0571 1
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0571 0.0814
Loa Loa (eye worm) cytochrome P450 family protein 0.0349 0.7406 0.9887
Trypanosoma cruzi cytochrome P450, putative 0.0165 0.3391 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.1138 0.4722
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0256 0.5366 0.7164
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0378 0.8035 0.8035
Echinococcus multilocularis geminin 0.0173 0.3549 0.3549
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0571 0.1185
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0571 0.1185
Onchocerca volvulus 0.0026 0.0353 0.1213
Echinococcus granulosus nmda type glutamate receptor 0.0025 0.0323 0.0323
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0049 0.0841 0.0841
Schistosoma mansoni intermediate filament proteins 0.0026 0.0353 0.0327
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.2794 0.373
Brugia malayi beta-lactamase family protein 0.0036 0.0571 0.0656
Echinococcus granulosus intermediate filament protein 0.0026 0.0353 0.0353
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0111 0.2194 0.6259
Brugia malayi hypothetical protein 0.0025 0.0323 0.032
Echinococcus granulosus tar DNA binding protein 0.0072 0.1361 0.1361
Brugia malayi hypothetical protein 0.0016 0.0137 0.0068
Toxoplasma gondii cytochrome p450 superfamily protein 0.0111 0.2194 1
Schistosoma mansoni ferritin 0.0028 0.0393 0.0367
Loa Loa (eye worm) hypothetical protein 0.0221 0.4617 0.6164
Mycobacterium tuberculosis Conserved protein 0.0036 0.0571 0.0814
Schistosoma mansoni lamin 0.0026 0.0353 0.0327
Mycobacterium tuberculosis Conserved protein 0.0036 0.0571 0.0814
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0111 0.2194 0.6259
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0111 0.2194 0.6259
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.006
Echinococcus multilocularis tar DNA binding protein 0.0072 0.1361 0.1361
Schistosoma mansoni cpg binding protein 0.0035 0.0537 0.0511
Trypanosoma cruzi cytochrome P450, putative 0.0165 0.3391 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0323 0.0431
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0111 0.2194 0.43
Echinococcus multilocularis GPCR, family 2 0.0081 0.1546 0.1546
Brugia malayi Cytochrome P450 family protein 0.0165 0.3391 0.4464
Echinococcus granulosus lamin 0.0026 0.0353 0.0353
Mycobacterium tuberculosis Conserved protein 0.0036 0.0571 0.0814
Loa Loa (eye worm) glutamate receptor 2 0.0131 0.2651 0.354
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0192 0.0192
Echinococcus multilocularis musashi 0.0026 0.0353 0.0353
Loa Loa (eye worm) hypothetical protein 0.0025 0.0333 0.0445
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0049 0.0841 0.0841
Echinococcus multilocularis 0.0111 0.2194 0.2194
Schistosoma mansoni hypothetical protein 0.0081 0.1546 0.1523
Brugia malayi beta-lactamase family protein 0.0036 0.0571 0.0656
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0353 0.0472
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0192 0.0257
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0156 0.3196 0.3196
Brugia malayi hypothetical protein 0.0025 0.0333 0.0334
Loa Loa (eye worm) hypothetical protein 0.0175 0.3598 0.4804
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.1946 0.2512
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0086 0.0115
Leishmania major hypothetical protein, conserved 0.0025 0.0333 0.0441
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0111 0.2194 0.6259
Mycobacterium ulcerans bacterioferritin BfrA 0.0028 0.0393 0.0628
Echinococcus granulosus glutamate receptor 2 0.0378 0.8035 0.8035
Loa Loa (eye worm) hypothetical protein 0.0036 0.0571 0.0763
Schistosoma mansoni hypothetical protein 0.0111 0.2194 0.2173
Leishmania major cytochrome p450-like protein 0.0165 0.3391 1
Schistosoma mansoni lamin 0.0026 0.0353 0.0327
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0111 0.2194 0.43
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0111 0.2194 0.6259
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0353 0.0472
Brugia malayi Glutamate receptor 2 precursor 0.0353 0.749 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0111 0.2194 0.6259
Loa Loa (eye worm) hypothetical protein 0.0036 0.0571 0.0763
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0571 1
Schistosoma mansoni ATP-binding cassette transporter 0.0131 0.2651 0.2631
Loa Loa (eye worm) TAR-binding protein 0.0072 0.1361 0.1817
Echinococcus multilocularis lamin dm0 0.0026 0.0353 0.0353
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0111 0.2194 0.6259
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0571 1
Schistosoma mansoni glutamate receptor NMDA 0.0156 0.3196 0.3178
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0111 0.2194 0.6259
Loa Loa (eye worm) hypothetical protein 0.0026 0.0353 0.0472
Brugia malayi MH2 domain containing protein 0.0138 0.2794 0.3657
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0571 1
Loa Loa (eye worm) hypothetical protein 0.0221 0.4617 0.6164
Schistosoma mansoni protein kinase 0.0025 0.0323 0.0297
Schistosoma mansoni hypothetical protein 0.0049 0.0841 0.0816
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0333 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0111 0.2194 0.6259
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0049 0.0841 0.0841
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0571 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.1546 0.2064
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0571 0.0814
Leishmania major cytochrome p450-like protein 0.0111 0.2194 0.6259
Echinococcus multilocularis glutamate receptor subunit protein glur 0.027 0.568 0.568
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0028 0.0393 0.0431
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1361 0.1338
Loa Loa (eye worm) hypothetical protein 0.0025 0.0323 0.0431
Echinococcus granulosus nmda type glutamate receptor 0.0049 0.0841 0.0841
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1361 0.1338
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0156 0.3196 0.3196
Trichomonas vaginalis esterase, putative 0.0036 0.0571 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0027 0.0027
Brugia malayi Glutamate receptor 1 precursor 0.0353 0.749 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.4847 1
Schistosoma mansoni glutamate receptor AMPA 0.0131 0.2651 0.2631
Echinococcus multilocularis receptor type guanylyl cyclase 0.0025 0.0323 0.0323
Schistosoma mansoni ap endonuclease 0.0019 0.0192 0.0166
Schistosoma mansoni ferritin light chain 0.0028 0.0393 0.0367
Brugia malayi Calcitonin receptor-like protein seb-1 0.0256 0.5366 0.7131
Mycobacterium leprae Conserved hypothetical protein 0.0111 0.2194 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0571 0.0763
Echinococcus multilocularis dnaJ subfamily B 0.0468 1 1
Echinococcus granulosus lamin dm0 0.0026 0.0353 0.0353
Echinococcus granulosus expressed protein 0.0028 0.0393 0.0393
Loa Loa (eye worm) hypothetical protein 0.0013 0.0056 0.0074
Schistosoma mansoni ferritin 0.0028 0.0393 0.0367
Loa Loa (eye worm) hypothetical protein 0.0025 0.0323 0.0431
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.1546 0.1546
Echinococcus granulosus GPCR family 2 0.0081 0.1546 0.1546
Loa Loa (eye worm) hypothetical protein 0.0025 0.0323 0.0431
Onchocerca volvulus 0.0036 0.0571 1
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0025 0.0323 0.032
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0111 0.2194 0.43
Loa Loa (eye worm) hypothetical protein 0.0025 0.0323 0.0431
Toxoplasma gondii ABC1 family protein 0.0036 0.0571 0.1893
Schistosoma mansoni ferritin 0.0028 0.0393 0.0367
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0256 0.5366 0.7131
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0571 0.1185
Loa Loa (eye worm) hypothetical protein 0.0025 0.0323 0.0431
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.1546 0.1546
Schistosoma mansoni hypothetical protein 0.0173 0.3549 0.3532
Mycobacterium leprae putative cytochrome p450 0.0111 0.2194 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0111 0.2194 0.43
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0111 0.2194 0.6259
Echinococcus granulosus glutamate NMDA receptor subunit 0.0131 0.2651 0.2651
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0025 0.0323 0.0431
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.1546 0.1972
Echinococcus granulosus receptor type guanylyl cyclase 0.0025 0.0323 0.0323
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0049 0.0841 0.0841
Brugia malayi intermediate filament protein 0.0026 0.0353 0.0361
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0111 0.2194 0.43
Brugia malayi beta-lactamase 0.0036 0.0571 0.0656
Schistosoma mansoni hypothetical protein 0.0173 0.3549 0.3532
Brugia malayi cytochrome P450 0.0111 0.2194 0.2847
Echinococcus multilocularis glutamate receptor 4 0.0221 0.4617 0.4617
Echinococcus multilocularis lamin 0.0026 0.0353 0.0353
Onchocerca volvulus 0.0036 0.0571 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0571 0.0763
Schistosoma mansoni metabotropic glutamate receptor 0.0025 0.0323 0.0297
Echinococcus granulosus cpg binding protein 0.0035 0.0537 0.0537
Trypanosoma cruzi extracellular receptor, putative 0.0025 0.0323 0.0408
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.1946 0.1924
Echinococcus multilocularis glutamate receptor 2 0.0378 0.8035 0.8035
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0571 0.0814
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0056 0.0056
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0049 0.0841 0.0841
Echinococcus granulosus cytochrome P450 2K1 0.0111 0.2194 0.2194
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0571 0.1185
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0111 0.2194 0.6259
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0571 0.0814
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0049 0.0841 0.0841
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.0323 0.0431
Onchocerca volvulus 0.0036 0.0571 1
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0571 0.0814
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0111 0.2194 0.43
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.1946 0.1946
Schistosoma mansoni hypothetical protein 0.0175 0.3598 0.358
Echinococcus granulosus atrial natriuretic peptide receptor 0.0025 0.0323 0.0323
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0111 0.2194 0.6259
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0333 0.0705
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0111 0.2194 0.43
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0131 0.2651 0.2651
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.1946 0.1924
Echinococcus multilocularis tyrosine kinase 0.0025 0.0323 0.0323
Echinococcus multilocularis nmda type glutamate receptor 0.0025 0.0323 0.0323
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0111 0.2194 0.43
Echinococcus multilocularis ferritin 0.0028 0.0393 0.0393
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0111 0.2194 0.43
Schistosoma mansoni cpg binding protein 0.0035 0.0537 0.0511
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.1946 0.2598
Echinococcus granulosus geminin 0.0173 0.3549 0.3549
Loa Loa (eye worm) CYP4Cod1 0.0165 0.3391 0.4527
Onchocerca volvulus 0.0026 0.0353 0.1213
Echinococcus multilocularis NMDA receptor 0.0049 0.0841 0.0841
Brugia malayi TAR-binding protein 0.0072 0.1361 0.1722
Loa Loa (eye worm) hypothetical protein 0.0025 0.0323 0.0431
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0192 0.0144
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0111 0.2194 0.6259
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0111 0.2194 0.43
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0111 0.2194 0.43
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0571 0.0763
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0156 0.3196 0.3196
Mycobacterium ulcerans hypothetical protein 0.0036 0.0571 0.1185
Schistosoma mansoni hypothetical protein 0.0081 0.1546 0.1523
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0111 0.2194 0.6259
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0378 0.8035 0.8035
Schistosoma mansoni cpg binding protein 0.0033 0.0496 0.047
Echinococcus granulosus tyrosine kinase 0.0025 0.0323 0.0323
Leishmania major hypothetical protein, conserved 0.0036 0.0571 0.1185
Echinococcus granulosus glutamate receptor 2 0.0329 0.6972 0.6972
Brugia malayi Receptor family ligand binding region containing protein 0.0025 0.0323 0.032
Brugia malayi Cytochrome P450 family protein 0.0349 0.7406 0.9886
Brugia malayi latrophilin 2 splice variant baaae 0.0175 0.3598 0.4743
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0111 0.2194 0.6259
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0571 0.1185
Loa Loa (eye worm) hypothetical protein 0.0055 0.0974 0.1301
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.13 0.1277
Echinococcus granulosus glutamate receptor 1 0.0221 0.4617 0.4617
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0496 0.0662

Activities

Activity type Activity value Assay description Source Reference
GI (functional) = 0 % Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as growth inhibition at 25 uM after 5 days relative to control ChEMBL. 21506600

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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