Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | para nitrobenzyl esterase | 0.0014 | 0.0367 | 0.0367 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0014 | 0.0367 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0014 | 0.0367 | 0.0367 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0014 | 0.0367 | 0.0367 |
Onchocerca volvulus | 0.0014 | 0.0367 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0014 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0367 | 0.0367 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0014 | 0.0367 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0367 | 0.0367 |
Brugia malayi | Carboxylesterase family protein | 0.0014 | 0.0367 | 0.0367 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0014 | 0.0367 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.0367 | 1 | |
Echinococcus multilocularis | neuroligin | 0.0014 | 0.0367 | 0.0367 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0367 | 0.0367 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0014 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0367 | 0.0367 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0014 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0367 | 0.0367 |
Brugia malayi | Carboxylesterase family protein | 0.0014 | 0.0367 | 0.0367 |
Onchocerca volvulus | 0.0014 | 0.0367 | 1 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0014 | 0.0367 | 0.0367 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0014 | 0.0367 | 0.0367 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0014 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0367 | 0.0367 |
Echinococcus granulosus | neuroligin | 0.0014 | 0.0367 | 0.0367 |
Brugia malayi | Carboxylesterase family protein | 0.0014 | 0.0367 | 0.0367 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0014 | 0.0367 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.0367 | 1 | |
Schistosoma mansoni | acetylcholinesterase | 0.0014 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0014 | 0.0367 | 0.0367 |
Brugia malayi | Carboxylesterase family protein | 0.0014 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0014 | 0.0367 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.0367 | 1 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0014 | 0.0367 | 0.0367 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0014 | 0.0367 | 0.0367 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0014 | 0.0367 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0367 | 0.0367 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0014 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0014 | 0.0367 | 0.0367 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.