Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.2644 | 0.4923 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0135 | 0.2644 | 0.2644 |
Echinococcus granulosus | tar DNA binding protein | 0.0135 | 0.2644 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.2644 | 0.4923 |
Loa Loa (eye worm) | RNA binding protein | 0.0135 | 0.2644 | 0.2644 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.2644 | 0.4923 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0272 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0135 | 0.2644 | 0.2644 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.2644 | 0.4923 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0272 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0135 | 0.2644 | 0.2644 |
Brugia malayi | TAR-binding protein | 0.0135 | 0.2644 | 0.2644 |
Brugia malayi | RNA binding protein | 0.0135 | 0.2644 | 0.2644 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0135 | 0.2644 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.2644 | 0.4923 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0186 | 0.5371 | 0.5371 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.5371 | 0.5371 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.5371 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | <= 0.0063 ug ml-1 | In vitro antibacterial activity against Escherichia coli ML4707 | ChEMBL. | No reference |
MIC (functional) | <= 0.0063 ug ml-1 | In vitro antibacterial activity against Escherichia coli ML4707 | ChEMBL. | No reference |
MIC (functional) | = 0.039 ug ml-1 | In vitro antibacterial activity against Pseudomonas aeruginosa IFO12689 | ChEMBL. | No reference |
MIC (functional) | = 0.39 ug ml-1 | In vitro antibacterial activity against Pseudomonas aeruginosa E-2 | ChEMBL. | No reference |
MIC (functional) | = 6.25 ug ml-1 | In vitro antibacterial activity against Staphylococcus aureus Smith | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.