Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0911 | 0.0911 |
Echinococcus multilocularis | NADH dehydrogenase (ubiquinone) flavoprotein 1 | 0.0079 | 0.2706 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0.0911 | 0.3365 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0911 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0038 | 0.0911 | 0.0911 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0079 | 0.2706 | 1 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | 0.0079 | 0.2706 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0.0911 | 0.3365 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0.0911 | 0.5 |
Leishmania major | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0079 | 0.2706 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1323 | 0.2297 |
Treponema pallidum | nitrogen fixation protein (rnfC) | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1323 | 0.2297 |
Loa Loa (eye worm) | NADH-ubiquinone oxidoreductase 51 kDa subunit | 0.0079 | 0.2706 | 1 |
Echinococcus granulosus | NADH dehydrogenase ubiquinone flavoprotein 1 | 0.0079 | 0.2706 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1323 | 0.2297 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0079 | 0.2706 | 1 |
Wolbachia endosymbiont of Brugia malayi | NADH dehydrogenase I subunit F | 0.0079 | 0.2706 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.0911 | 0.5 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0079 | 0.2706 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1323 | 0.2297 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0911 | 0.0911 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0038 | 0.0911 | 0.0911 |
Schistosoma mansoni | NADH-ubiquinone oxidoreductase | 0.0079 | 0.2706 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0038 | 0.0911 | 0.0911 |
Brugia malayi | NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor | 0.0079 | 0.2706 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.0911 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1323 | 0.2297 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0911 | 0.0911 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1323 | 0.2297 |
Mycobacterium ulcerans | NADH dehydrogenase I subunit F | 0.0079 | 0.2706 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.0911 | 0.3365 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0038 | 0.0911 | 0.0911 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0079 | 0.2706 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0038 | 0.0911 | 0.0911 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1323 | 0.2297 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0038 | 0.0911 | 0.0911 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0.0911 | 0.3365 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative | 0.0079 | 0.2706 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1323 | 0.2297 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) | 0.0079 | 0.2706 | 0.2706 |
Onchocerca volvulus | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog | 0.0042 | 0.109 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0038 | 0.0911 | 0.0911 |
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0.0911 | 0.3365 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1323 | 0.2297 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.