Detailed information for compound 155814

Basic information

Technical information
  • TDR Targets ID: 155814
  • Name: 6-nitro-N-[3-(trifluoromethyl)phenyl]quinazol in-4-amine
  • MW: 334.253 | Formula: C15H9F3N4O2
  • H donors: 1 H acceptors: 4 LogP: 4.13 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc2c(c1)c(ncn2)Nc1cccc(c1)C(F)(F)F
  • InChi: 1S/C15H9F3N4O2/c16-15(17,18)9-2-1-3-10(6-9)21-14-12-7-11(22(23)24)4-5-13(12)19-8-20-14/h1-8H,(H,19,20,21)
  • InChiKey: FKOOZPWZRRDRTK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-nitro-N-[3-(trifluoromethyl)phenyl]-4-quinazolinamine
  • (6-nitroquinazolin-4-yl)-[3-(trifluoromethyl)phenyl]amine
  • ZINC04054378
  • ST5452455
  • PD153035 Analog 14

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus hexokinase 0.0077 0.0719 0.0723
Echinococcus granulosus CREB binding protein 0.0092 0.0896 0.0907
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0212 0.2362 0.2425
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0058 0.0475 0.047
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.015 0.0129
Loa Loa (eye worm) transcription factor SMAD2 0.0225 0.2521 0.2521
Mycobacterium tuberculosis Probable reductase 0.0098 0.0971 0.7226
Plasmodium vivax glutathione reductase, putative 0.0043 0.0297 0.0676
Trichomonas vaginalis phosphofructokinase, putative 0.0027 0.0097 0.0103
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0046 0.0335 0.0593
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0212 0.2362 0.4989
Loa Loa (eye worm) hypothetical protein 0.0038 0.0241 0.0241
Loa Loa (eye worm) 6-phosphofructokinase 0.0099 0.098 0.098
Trypanosoma cruzi phosphomannose isomerase, putative 0.0235 0.2649 0.5611
Toxoplasma gondii phosphomannomutase 0.0078 0.0726 0.1907
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0969 0.0969
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0308 0.3545 0.3545
Echinococcus multilocularis bromodomain containing protein 8 0.0024 0.0061 0.004
Schistosoma mansoni bromodomain containing protein 0.0025 0.0082 0.0082
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0389 0.2734
Echinococcus granulosus 6 phosphofructokinase 0.0099 0.098 0.0994
Schistosoma mansoni hypothetical protein 0.0024 0.0061 0.0061
Onchocerca volvulus Hexokinase homolog 0.0049 0.0365 0.1068
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0235 0.2649 0.2623
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0065 0.0044
Echinococcus multilocularis PHD finger protein rhinoceros 0.0027 0.0095 0.0074
Entamoeba histolytica phosphomannomutase, putative 0.0078 0.0726 0.1969
Echinococcus granulosus protein kinase C binding protein 1 0.0024 0.0061 0.0041
Onchocerca volvulus 0.0077 0.0719 0.2209
Schistosoma mansoni tyrosine kinase 0.0097 0.0955 0.0955
Plasmodium falciparum phosphomannomutase, putative 0.0078 0.0726 0.1907
Echinococcus granulosus histone acetyltransferase KAT2B 0.0809 0.9673 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.015 0.015
Schistosoma mansoni tyrosine kinase 0.018 0.1976 0.1976
Schistosoma mansoni tyrosine kinase 0.0096 0.0943 0.0943
Schistosoma mansoni zinc finger protein 0.0039 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0061
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0058 0.0479 0.3434
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.007 0.0629 0.1231
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0525 0.0525
Trichomonas vaginalis phosphofructokinase, putative 0.0027 0.0097 0.0103
Trichomonas vaginalis phosphofructokinase, putative 0.0027 0.0097 0.0103
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.015 0.0133
Entamoeba histolytica bromodomain-containing protein 0.0024 0.0061 0.0077
Schistosoma mansoni tyrosine kinase 0.0058 0.0475 0.0475
Echinococcus granulosus jumonji domain containing protein 0.0037 0.0222 0.0208
Echinococcus multilocularis 6 phosphofructokinase 0.0099 0.098 0.0961
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0027 0.0097 0.0103
Brugia malayi Probable ClpP-like protease 0.0077 0.0714 0.0682
Loa Loa (eye worm) hypothetical protein 0.0054 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0031 0.015 0.015
Mycobacterium ulcerans hypothetical protein 0.0046 0.0335 0.115
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.022 0.2461 0.6887
Brugia malayi Bromodomain containing protein 0.0024 0.0061 0.0027
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0248 0.2808 0.7883
Leishmania major hypothetical protein, conserved 0.0024 0.0061 0.0058
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0132 0.1381 0.1381
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0099 0.098 0.7297
Loa Loa (eye worm) PHD-finger family protein 0.0027 0.0095 0.0095
Loa Loa (eye worm) MH2 domain-containing protein 0.0225 0.2521 0.2521
Leishmania major phosphomannose isomerase 0.0235 0.2649 0.5637
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0099 0.098 0.3905
Trichomonas vaginalis CAMK family protein kinase 0.0178 0.1947 0.5412
Brugia malayi PHD-finger family protein 0.0044 0.0312 0.0279
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.1947 0.1947
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0034
Entamoeba histolytica hexokinase 1 0.0077 0.0719 0.195
Onchocerca volvulus 0.0077 0.0719 0.2209
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0027 0.0097 0.0103
Loa Loa (eye worm) phosphomannomutase 2 0.0078 0.0726 0.0726
Loa Loa (eye worm) CBP-B 0.0071 0.0637 0.0637
Echinococcus granulosus Niemann Pick C1 protein 0.009 0.0866 0.0875
Entamoeba histolytica phosphomannose isomerase, putative 0.0235 0.2649 0.7446
Trichomonas vaginalis phosphofructokinase, putative 0.0099 0.098 0.2638
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0297 0.0276
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0121 0.1248 0.9359
Echinococcus granulosus GPCR family 2 0.0031 0.015 0.0133
Loa Loa (eye worm) BRM protein 0.0024 0.0061 0.0061
Schistosoma mansoni bromodomain containing protein 0.0024 0.0061 0.0061
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0121 0.1248 0.4641
Trichomonas vaginalis CAMK family protein kinase 0.0178 0.1947 0.5412
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0061
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0714 0.2728
Brugia malayi Bromodomain containing protein 0.0024 0.0061 0.0027
Brugia malayi glutathione reductase 0.0043 0.0297 0.0263
Trypanosoma cruzi hexokinase, putative 0.0077 0.0719 0.1427
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0027 0.0095 0.0095
Brugia malayi bromodomain containing protein 0.0024 0.0061 0.0027
Echinococcus granulosus CREB binding protein 0.0065 0.0571 0.0569
Brugia malayi Bromodomain containing protein 0.0024 0.0061 0.0027
Loa Loa (eye worm) hypothetical protein 0.0064 0.0558 0.0558
Trichomonas vaginalis bromodomain-containing protein, putative 0.0248 0.2808 0.7883
Entamoeba histolytica acetyltransferase, GNAT family 0.0224 0.2517 0.7071
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0235 0.2649 0.2649
Trichomonas vaginalis phosphofructokinase, putative 0.0099 0.098 0.2638
Echinococcus multilocularis bromodomain containing 2 0.0024 0.0061 0.004
Entamoeba histolytica phosphofructokinase, putative 0.0099 0.098 0.2695
Loa Loa (eye worm) hypothetical protein 0.009 0.0866 0.0866
Brugia malayi N-terminal motif family protein 0.02 0.2222 0.2196
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0248 0.2808 0.7883
Entamoeba histolytica phosphofructokinase, putative 0.0099 0.098 0.2695
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0091 0.0883 0.0883
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0525 0.0525
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0098 0.0969 0.0969
Toxoplasma gondii PHD-finger domain-containing protein 0.0027 0.0095 0.0097
Plasmodium vivax phosphomannomutase, putative 0.0078 0.0726 0.1907
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0061
Brugia malayi 6-phosphofructokinase 0.0099 0.098 0.0949
Leishmania major hypothetical protein, conserved 0.0024 0.0061 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.0178 0.1947 0.5412
Leishmania major macrophage migration inhibitory factor-like protein 0.0308 0.3545 0.757
Leishmania major hypothetical protein, conserved 0.0132 0.1382 0.2905
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0061
Brugia malayi hexokinase 0.0077 0.0719 0.0687
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0212 0.2362 0.2362
Echinococcus granulosus phosphomannomutase 0.0078 0.0726 0.073
Toxoplasma gondii 6-phosphofructokinase 0.0027 0.0097 0.0103
Echinococcus multilocularis zinc finger protein 0.0039 0.0253 0.0232
Trichomonas vaginalis conserved hypothetical protein 0.0308 0.3545 1
Brugia malayi Bm-MIF-1, identical 0.0308 0.3545 0.3523
Mycobacterium tuberculosis Conserved protein 0.0046 0.0335 0.2318
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0033 0.017 0.0149
Brugia malayi TAR-binding protein 0.0062 0.0525 0.0492
Brugia malayi Hexokinase family protein 0.0077 0.0719 0.0687
Echinococcus granulosus hexokinase 0.0077 0.0719 0.0723
Echinococcus multilocularis Bromodomain containing protein 0.0024 0.0061 0.004
Loa Loa (eye worm) hypothetical protein 0.0025 0.0072 0.0072
Schistosoma mansoni 6-phosphofructokinase 0.0099 0.098 0.098
Trypanosoma brucei phosphomannomutase 0.0078 0.0726 0.1441
Schistosoma mansoni tyrosine kinase 0.0096 0.0943 0.0943
Brugia malayi Bromodomain containing protein 0.0024 0.0061 0.0027
Echinococcus granulosus bromodomain containing 2 0.0024 0.0061 0.0041
Mycobacterium tuberculosis Probable oxidoreductase 0.0109 0.1105 0.8259
Echinococcus granulosus PHD finger protein rhinoceros 0.0027 0.0095 0.0076
Echinococcus multilocularis jumonji domain containing protein 0.0037 0.0222 0.0201
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0109 0.1105 0.8259
Leishmania major hypothetical protein, conserved,predicted bromodomain protein 0.0024 0.0061 0.0058
Onchocerca volvulus 0.0024 0.0061 0.0087
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0127 0.1331 1
Toxoplasma gondii thioredoxin reductase 0.0043 0.0297 0.0676
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0095 0.0098
Brugia malayi PHD-finger family protein 0.0027 0.0095 0.0061
Echinococcus multilocularis hexokinase 0.0077 0.0719 0.0699
Toxoplasma gondii phosphofructokinase PFKII 0.0027 0.0097 0.0103
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.022 0.2461 0.6887
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0092 0.0896 0.0896
Echinococcus multilocularis citrate lyase subunit beta protein 0.0046 0.0335 0.0314
Echinococcus multilocularis 0.0056 0.0453 0.0433
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0098 0.0971 0.7226
Loa Loa (eye worm) hexokinase type II 0.0077 0.0719 0.0719
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0427 0.1051
Schistosoma mansoni hypothetical protein 0.0031 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0067 0.059 0.059
Brugia malayi hexokinase type II 0.0025 0.0072 0.0038
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0178 0.1947 0.1995
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0027 0.0097 0.0104
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0235 0.2649 0.2623
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0097 0.0955 0.0968
Brugia malayi Bromodomain containing protein 0.0024 0.0061 0.0027
Echinococcus multilocularis sterol regulatory element binding protein 0.0038 0.0241 0.022
Plasmodium falciparum phd finger protein, putative 0.0027 0.0095 0.0097
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0699 0.068
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0046 0.0335 0.0593
Schistosoma mansoni tyrosine kinase 0.0097 0.0955 0.0955
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Trichomonas vaginalis phosphomannomutase, putative 0.0078 0.0726 0.1907
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0525 0.0492
Schistosoma mansoni mannose-6-phosphate isomerase 0.0235 0.2649 0.2649
Brugia malayi Protein kinase domain containing protein 0.0058 0.0475 0.0442
Entamoeba histolytica bromodomain-containing protein 0.0024 0.0061 0.0077
Schistosoma mansoni polybromo-1 0.0024 0.0061 0.0061
Loa Loa (eye worm) hexokinase 0.0077 0.0719 0.0719
Echinococcus multilocularis protein dispatched 1 0.0044 0.0307 0.0286
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0297 0.0285
Onchocerca volvulus 0.0049 0.0365 0.1068
Trypanosoma brucei hexokinase 0.0077 0.0719 0.1427
Trichomonas vaginalis CAMK family protein kinase 0.0178 0.1947 0.5412
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0109 0.1105 0.8259
Leishmania major DNA-binding protein, putative,predicted bromodomain protein 0.0024 0.0061 0.0058
Schistosoma mansoni kinase 0.009 0.0876 0.0876
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0714 0.2722
Brugia malayi Bromodomain containing protein 0.0024 0.0061 0.0027
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0737 0.8797 0.8795
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0087 0.0833 0.0841
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0127 0.1331 1
Leishmania major trypanothione reductase 0.0043 0.0297 0.0566
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.022 0.2461 0.6887
Loa Loa (eye worm) hypothetical protein 0.0025 0.0082 0.0082
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0389 0.0381
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0297 0.0676
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0212 0.2362 1
Entamoeba histolytica bromodomain-containing protein 0.0024 0.0061 0.0077
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0099 0.098 0.7297
Giardia lamblia Macrophage migration inhibitory factor 0.0308 0.3545 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0027 0.0095 0.0097
Trypanosoma cruzi hypothetical protein, conserved 0.04 0.4672 1
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0297 0.0511
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0525 0.0525
Trichomonas vaginalis CAMK family protein kinase 0.0178 0.1947 0.5412
Onchocerca volvulus Brd8 homolog 0.0024 0.0061 0.0087
Brugia malayi serine/threonine-protein kinase plk-2 0.0178 0.1947 0.1919
Treponema pallidum hexokinase (hxk) 0.0077 0.0719 0.2752
Loa Loa (eye worm) acetyltransferase 0.0835 1 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0099 0.098 0.1993
Schistosoma mansoni hypothetical protein 0.0027 0.0095 0.0095
Loa Loa (eye worm) phosphofructokinase 0.0099 0.098 0.098
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.015 0.0129
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0848 0.2258
Schistosoma mansoni transcription initiation factor tfiid 0.0024 0.0061 0.0061
Entamoeba histolytica serine/threonine protein kinase, putative 0.0178 0.1947 0.5447
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0138 0.1463 0.4023
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0714 0.0714
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0098 0.0971 0.7226
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0714 0.2599
Echinococcus multilocularis hexokinase 0.0077 0.0719 0.0699
Leishmania major ATP-dependent phosphofructokinase 0.0099 0.098 0.204
Mycobacterium ulcerans lipoprotein LpqF 0.0058 0.0479 0.1703
Brugia malayi hypothetical protein 0.0275 0.3135 0.3111
Schistosoma mansoni bromodomain containing 0.0024 0.0061 0.0061
Brugia malayi jmjC domain containing protein 0.0087 0.0833 0.0802
Echinococcus granulosus Bromodomain containing protein 0.0024 0.0061 0.0041
Onchocerca volvulus Bromodomain adjacent to zinc finger domain protein 1A homolog 0.0024 0.0061 0.0087
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0037 0.0224 0.0224
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0835 1 1
Entamoeba histolytica bromodomain-containing protein 0.0024 0.0061 0.0077
Echinococcus multilocularis Niemann Pick C1 protein 0.0128 0.1337 0.1318
Onchocerca volvulus Serine\/threonine kinase homolog 0.0178 0.1947 0.6169
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0024 0.0061 0.0061
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0248 0.2808 0.7883
Loa Loa (eye worm) hypothetical protein 0.0025 0.0072 0.0072
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0714 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0184 0.0184
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0308 0.3545 1
Echinococcus granulosus hexokinase 0.0077 0.0719 0.0723
Plasmodium vivax hexokinase, putative 0.0077 0.0719 0.1888
Echinococcus multilocularis hexokinase 0.0077 0.0719 0.0699
Schistosoma mansoni hypothetical protein 0.0031 0.015 0.015
Brugia malayi ATPase, AAA family protein 0.0024 0.0061 0.0027
Mycobacterium tuberculosis Probable dehydrogenase 0.0098 0.0971 0.7226
Schistosoma mansoni hypothetical protein 0.0031 0.015 0.015
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0389 0.2734
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0027 0.0097 0.0103
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0235 0.2649 0.2649
Echinococcus granulosus insulin receptor 0.0058 0.0475 0.047
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0699 0.0703
Echinococcus granulosus PH interacting protein 0.0024 0.0061 0.0041
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0095 0.0098
Leishmania major hexokinase, putative 0.0077 0.0719 0.1476
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.022 0.2461 0.6887
Trypanosoma brucei Putative Phosphatase/Protein of unknown function DUF89, putative 0.0132 0.1382 0.2864
Brugia malayi Bromodomain containing protein 0.009 0.087 0.0838
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0027 0.0097 0.0104
Loa Loa (eye worm) jmjC domain-containing protein 0.0055 0.044 0.044
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.02 0.2222 0.7057
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0235 0.2649 0.7426
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0848 0.2258
Onchocerca volvulus 0.0275 0.3135 1
Echinococcus granulosus Protein patched homolog 1 0.0038 0.0241 0.0227
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0095 0.0097
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0046 0.0335 0.115
Schistosoma mansoni hypothetical protein 0.0024 0.0061 0.0061
Echinococcus granulosus sterol regulatory element binding protein 0.0038 0.0241 0.0227
Loa Loa (eye worm) hypothetical protein 0.02 0.2222 0.2222
Schistosoma mansoni phosphomannomutase 0.0078 0.0726 0.0726
Brugia malayi phosphomannomutase 2 0.0078 0.0726 0.0694
Loa Loa (eye worm) hypothetical protein 0.0033 0.0169 0.0169
Leishmania major hypothetical protein, conserved 0.04 0.4672 1
Loa Loa (eye worm) glutathione reductase 0.0043 0.0297 0.0297
Echinococcus multilocularis epidermal growth factor receptor 0.0097 0.0955 0.0936
Schistosoma mansoni helicase 0.0024 0.0061 0.0061
Echinococcus granulosus bromodomain containing protein 8 0.0024 0.0061 0.0041
Loa Loa (eye worm) TK/EGFR protein kinase 0.018 0.1976 0.1976
Brugia malayi BRM protein 0.0024 0.0061 0.0027
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0035 0.0197 0.0197
Leishmania major macrophage migration inhibitory factor-like protein 0.0308 0.3545 0.757
Echinococcus multilocularis PH interacting protein 0.0024 0.0061 0.004
Loa Loa (eye worm) hypothetical protein 0.0047 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.006 0.051 0.051
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0714 0.1873
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0024 0.0061 0.004
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0109 0.1105 0.8259
Echinococcus multilocularis GPCR, family 2 0.0031 0.015 0.0129
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0525 0.0525
Giardia lamblia Histone acetyltransferase GCN5 0.0224 0.2517 0.7048
Brugia malayi polybromodomain protein 0.0024 0.0061 0.0027
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0969 0.0938
Echinococcus granulosus expressed conserved protein 0.0084 0.08 0.0807
Echinococcus granulosus polybromo 1 0.0024 0.0061 0.0041
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0138 0.1463 0.5464
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0212 0.2362 0.4989
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0027 0.0097 0.0103
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0132 0.1382 0.2864
Echinococcus granulosus tar DNA binding protein 0.0062 0.0525 0.0522
Trichomonas vaginalis phosphofructokinase, putative 0.0027 0.0097 0.0103
Onchocerca volvulus Putative phosphomannomutase 0.0078 0.0726 0.223
Schistosoma mansoni tyrosine kinase 0.0058 0.0475 0.0475
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0427 0.1051
Giardia lamblia Kinase, PLK 0.0178 0.1947 0.5412
Schistosoma mansoni hypothetical protein 0.0024 0.0061 0.0061
Echinococcus granulosus histone acetyltransferase KAT2B 0.0248 0.2808 0.2887
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0178 0.1947 0.193
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0212 0.2362 0.8903
Echinococcus granulosus epidermal growth factor receptor 0.0097 0.0955 0.0968
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0525 0.0505
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0184 0.0169
Schistosoma mansoni hexokinase 0.0077 0.0719 0.0719
Brugia malayi jmjC domain containing protein 0.0034 0.0184 0.0151
Brugia malayi phosphofructokinase 0.0099 0.098 0.0949
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0714 0.0717
Echinococcus granulosus citrate lyase subunit beta protein 0.0046 0.0335 0.0325
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0099 0.098 0.1993
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0235 0.2649 0.7426
Mycobacterium ulcerans 6-phosphofructokinase 0.0099 0.098 0.3619
Trypanosoma brucei polo-like protein kinase 0.0178 0.1947 0.409
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0427 0.0794
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0235 0.2649 0.2633
Trichomonas vaginalis phosphofructokinase, putative 0.0027 0.0097 0.0103
Schistosoma mansoni tyrosine kinase 0.0096 0.0943 0.0943
Echinococcus multilocularis protein patched 0.0038 0.0241 0.022
Onchocerca volvulus Alhambra homolog 0.0027 0.0095 0.0196
Schistosoma mansoni hypothetical protein 0.0067 0.059 0.059
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0525 0.0525
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0427 0.1051
Echinococcus multilocularis CREB binding protein 0.007 0.0629 0.0609
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0098 0.0971 0.7226
Loa Loa (eye worm) RNA binding protein 0.0062 0.0525 0.0525
Schistosoma mansoni patched 1 0.0038 0.0241 0.0241
Echinococcus granulosus hexokinase type 2 0.0077 0.0719 0.0723
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0525 0.0525
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0024 0.0061 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.04 0.4672 1
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0212 0.2362 0.5018
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0132 0.1382 0.2864
Entamoeba histolytica bromodomain-containing protein 0.0024 0.0061 0.0077
Onchocerca volvulus 0.0024 0.0061 0.0087
Trypanosoma brucei hypothetical protein, conserved 0.04 0.4672 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0178 0.1947 0.1947
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0714 0.1873
Trypanosoma brucei phosphomannose isomerase 0.0235 0.2649 0.5611
Mycobacterium ulcerans hypothetical protein 0.0046 0.0335 0.115
Loa Loa (eye worm) hexokinase 0.0077 0.0719 0.0719
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0027 0.0097 0.0103
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0308 0.3545 1
Entamoeba histolytica hypothetical protein 0.0024 0.0061 0.0077
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0235 0.2649 1
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0058 0.0479 0.3434
Schistosoma mansoni hypothetical protein 0.0031 0.015 0.015
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.0297 0.2024
Trypanosoma cruzi polo-like protein kinase, putative 0.0178 0.1947 0.409
Brugia malayi Niemann-Pick C1 protein precursor 0.009 0.0866 0.0835
Schistosoma mansoni hypothetical protein 0.0037 0.0224 0.0224
Echinococcus multilocularis insulin receptor 0.0058 0.0475 0.0455
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0087 0.0833 0.0814
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.022 0.2461 0.6887
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0068 0.0604 0.1177
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0389 0.0368
Onchocerca volvulus 0.0077 0.0719 0.2209
Brugia malayi Bromodomain containing protein 0.005 0.0386 0.0353
Trypanosoma brucei beta lactamase 0.0058 0.0479 0.0907
Loa Loa (eye worm) hypothetical protein 0.0045 0.0327 0.0327
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.059 0.0558
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0061 0.0061
Brugia malayi glucose-6-phosphate dehydrogenase 0.0212 0.2362 0.2336
Echinococcus multilocularis Bromodomain containing protein 0.0024 0.0061 0.004
Brugia malayi MH2 domain containing protein 0.0225 0.2521 0.2495
Trypanosoma cruzi phosphomannose isomerase, putative 0.0235 0.2649 0.5611
Brugia malayi hypothetical protein 0.0035 0.0195 0.0161
Trypanosoma cruzi polo-like protein kinase, putative 0.0178 0.1947 0.409
Schistosoma mansoni hypothetical protein 0.0037 0.0224 0.0224
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0212 0.2362 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0027 0.0097 0.0179
Trichomonas vaginalis CAMK family protein kinase 0.0178 0.1947 0.5412
Brugia malayi Bromodomain containing protein 0.0024 0.0061 0.0027
Brugia malayi Furin-like cysteine rich region family protein 0.018 0.1976 0.1948
Loa Loa (eye worm) hypothetical protein 0.0059 0.0488 0.0488
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.0231 0.0231
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0427 0.0794
Trypanosoma brucei hexokinase 0.0077 0.0719 0.1427
Echinococcus granulosus epidermal growth factor receptor 0.018 0.1976 0.2025
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0308 0.3545 1
Echinococcus multilocularis phosphomannomutase 0.0078 0.0726 0.0706
Brugia malayi Latrophilin receptor protein 2 0.0031 0.015 0.0116
Plasmodium falciparum thioredoxin reductase 0.0043 0.0297 0.0676
Brugia malayi 6-phosphofructokinase 0.0099 0.098 0.0949
Echinococcus granulosus Bromodomain containing protein 0.0024 0.0061 0.0041
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0046 0.0335 0.115
Plasmodium vivax 6-phosphofructokinase, putative 0.0027 0.0097 0.0103
Plasmodium falciparum hexokinase 0.0077 0.0719 0.1888
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0184 0.0184
Echinococcus multilocularis 0.0024 0.0061 0.004
Schistosoma mansoni bromodomain containing protein 0.0079 0.0739 0.0739
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0095 0.0471
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0427 0.0794
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0235 0.2649 0.7426
Brugia malayi hypothetical protein 0.0054 0.0427 0.0395
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0212 0.2362 0.2362
Echinococcus multilocularis lysine specific demethylase 5A 0.0032 0.0163 0.0142
Trichomonas vaginalis phosphofructokinase, putative 0.0099 0.098 0.2638
Echinococcus multilocularis epidermal growth factor receptor 0.018 0.1976 0.1959
Echinococcus multilocularis Niemann Pick C1 protein 0.009 0.0866 0.0847
Echinococcus multilocularis peregrin 0.005 0.0386 0.0365
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0714 0.2599
Loa Loa (eye worm) 6-phosphofructokinase 0.0099 0.098 0.098
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0108 0.1088 0.3002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.015 0.0116
Schistosoma mansoni hypothetical protein 0.0037 0.0224 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0241 0.0515
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0034
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0308 0.3545 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0061
Plasmodium falciparum histone acetyltransferase GCN5 0.0224 0.2517 0.7048
Trypanosoma cruzi hexokinase, putative 0.0077 0.0719 0.1427
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.015 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0525 0.0525
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0714 0.5241
Echinococcus granulosus zinc finger protein 0.0039 0.0253 0.024
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0389 0.2734
Schistosoma mansoni phd finger protein 0.0024 0.0061 0.0061
Plasmodium falciparum macrophage migration inhibitory factor 0.0308 0.3545 1
Onchocerca volvulus 0.0024 0.0061 0.0087
Plasmodium falciparum glutathione reductase 0.0043 0.0297 0.0676
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0038 0.0241 0.0241
Trichomonas vaginalis phosphofructokinase, putative 0.0027 0.0097 0.0103
Schistosoma mansoni hypothetical protein 0.0024 0.0061 0.0061
Echinococcus granulosus transcription initiation factor TFIID subunit 1 0.0024 0.0061 0.0041
Loa Loa (eye worm) hypothetical protein 0.0053 0.0417 0.0417
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0969 0.0938
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0073 0.0669 0.4898
Schistosoma mansoni 6-phosphofructokinase 0.0099 0.098 0.098
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0714 0.1873
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0046 0.0335 0.2318
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0714 0.2722
Schistosoma mansoni CREB-binding protein 2 0.0092 0.0896 0.0896
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0178 0.1947 0.4124
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0033 0.017 0.0154
Leishmania major hexokinase, putative 0.0077 0.0719 0.1476
Leishmania major phosphomannomutase, putative 0.0078 0.0726 0.1491
Brugia malayi Bromodomain containing protein 0.0056 0.0461 0.0428
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.002 0.0021 0.0021
Leishmania major hypothetical protein, conserved 0.0054 0.0427 0.0848
Echinococcus granulosus mannose 6 phosphate isomerase 0.0235 0.2649 0.2722
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0061
Brugia malayi Hexokinase family protein 0.0024 0.0064 0.003
Loa Loa (eye worm) hexokinase 0.0049 0.0365 0.0365
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0297 0.0297
Echinococcus multilocularis polybromo 1 0.0024 0.0061 0.004
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.022 0.2461 0.6887
Trichomonas vaginalis phosphofructokinase, putative 0.0099 0.098 0.2638
Brugia malayi Thioredoxin reductase 0.0043 0.0297 0.0263
Echinococcus granulosus peregrin 0.005 0.0386 0.0378
Echinococcus granulosus global transcription activator snf2l2 0.0024 0.0061 0.0041
Echinococcus multilocularis global transcription activator snf2l2 0.0024 0.0061 0.004
Toxoplasma gondii hexokinase 0.0077 0.0719 0.1888
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0058 0.0475 0.0455
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0835 1 1
Entamoeba histolytica phosphofructokinase, putative 0.0099 0.098 0.2695
Entamoeba histolytica bromodomain-containing protein 0.0024 0.0061 0.0077
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0714 0.1873
Brugia malayi Hexokinase family protein 0.0049 0.0365 0.0332
Brugia malayi RNA binding protein 0.0062 0.0525 0.0492
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0065 0.0045
Entamoeba histolytica hexokinase 2 0.0077 0.0719 0.195
Brugia malayi polybromodomain protein 0.0024 0.0061 0.0027
Brugia malayi TAZ zinc finger family protein 0.0092 0.0896 0.0865
Schistosoma mansoni hypothetical protein 0.0024 0.0065 0.0065
Echinococcus multilocularis expressed conserved protein 0.0084 0.08 0.078
Loa Loa (eye worm) hexokinase 0.0024 0.0064 0.0064
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0046 0.0335 0.0648
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0132 0.1381 0.1381
Trypanosoma brucei AAA ATPase, putative 0.0024 0.0061 0.00000067115
Loa Loa (eye worm) hypothetical protein 0.0275 0.3135 0.3135
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0034
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0098 0.0971 0.7226
Echinococcus multilocularis protein kinase C binding protein 1 0.0024 0.0061 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0178 0.1947 0.5412
Loa Loa (eye worm) TK/INSR protein kinase 0.0058 0.0475 0.0475
Schistosoma mansoni jumonji domain containing protein 0.0069 0.0615 0.0615
Plasmodium vivax 6-phosphofructokinase, putative 0.0027 0.0097 0.0103
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0212 0.2362 0.2345
Toxoplasma gondii hypothetical protein 0.0027 0.0095 0.0098
Loa Loa (eye worm) hypothetical protein 0.0077 0.0714 0.0714
Giardia lamblia PHD finger protein 15 0.0027 0.0095 0.0097
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0427 0.1051
Trypanosoma brucei trypanothione reductase 0.0043 0.0297 0.0511
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0248 0.2808 0.7883
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0714 0.0694
Entamoeba histolytica ankyrin repeat protein, putative 0.0024 0.0061 0.0077
Echinococcus granulosus Niemann Pick C1 protein 0.0128 0.1337 0.1363
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0046 0.0335 0.0785
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0098 0.0971 0.7226
Toxoplasma gondii phosphomannose isomerase type I protein 0.0235 0.2649 0.7426
Trypanosoma cruzi phosphomannomutase, putative 0.0078 0.0726 0.1441
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0046 0.0335 0.115
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0027 0.0097 0.0008
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.009 0.0866 0.237
Trypanosoma brucei hexokinase, putative 0.0077 0.0719 0.1427
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.022 0.2461 0.6887
Echinococcus multilocularis hexokinase type 2 0.0077 0.0719 0.0699
Brugia malayi CHE-14 protein 0.0038 0.0241 0.0207

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10000 nM Concentration required to inhibit the phosphorylation of a 14-residue fragment of phospholipase C gamma 1 by Epidermal growth factor receptor from A431 cell vesicles ChEMBL. 8568816
IC50 (binding) > 10000 nM Concentration required to inhibit the phosphorylation of a 14-residue fragment of phospholipase C gamma 1 by Epidermal growth factor receptor from A431 cell vesicles ChEMBL. 8568816

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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