Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | flap structure-specific endonuclease 1 | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | exonuclease, putative | flap structure-specific endonuclease 1 | 380 aa | 322 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | unspecified product | 0.0016 | 0.1887 | 0.1887 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.6568 | 0.6568 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.3432 | 0.3432 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.3432 | 0.3432 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.3432 | 0.3432 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0031 | 0.517 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.3432 | 0.5 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0031 | 0.517 | 0.7872 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.6568 | 1 |
Echinococcus granulosus | flap endonuclease 1 | 0.0031 | 0.517 | 0.2647 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.3432 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.3432 | 0.3432 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.3432 | 0.3432 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0031 | 0.517 | 0.2647 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.3432 | 0.3432 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.3432 | 0.3432 |
Trypanosoma brucei | unspecified product | 0.0016 | 0.1887 | 0.1887 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.3432 | 0.3432 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.3432 | 0.3432 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0031 | 0.517 | 0.517 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.1887 | 0.1887 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0031 | 0.517 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.6568 | 0.6568 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.3432 | 0.3432 |
Entamoeba histolytica | Flap nuclease, putative | 0.0031 | 0.517 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.3432 | 0.3432 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0031 | 0.517 | 0.517 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.3432 | 0.3432 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.3432 | 0.3432 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.3432 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0.3432 | 0.3432 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.3432 | 0.3432 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0031 | 0.517 | 0.517 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.3432 | 0.3432 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 1 | 1 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0031 | 0.517 | 1 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0031 | 0.517 | 0.517 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.3432 | 0.3432 |
Schistosoma mansoni | flap endonuclease-1 | 0.0028 | 0.4525 | 0.4525 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.3432 | 0.3432 |
Brugia malayi | Flap endonuclease-1 | 0.0031 | 0.517 | 0.517 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0.3432 | 0.3432 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.3432 | 0.3432 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.3432 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.3432 | 0.6637 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.3432 | 0.3432 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.3432 | 0.3432 |
Plasmodium falciparum | flap endonuclease 1 | 0.0031 | 0.517 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.3432 | 0.3432 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.1887 | 0.1887 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.1887 | 0.1887 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.3432 | 0.3432 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 38.6 uM | Inhibition of human poly(A)-selective ribonuclease Caf1 by fluorescence-based assay | ChEMBL. | 26299350 |
Potency (functional) | 0.5012 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 21.3313 uM | PubChem BioAssay. qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.