Detailed information for compound 1558240

Basic information

Technical information
  • TDR Targets ID: 1558240
  • Name: [2-(cyclohexyl-ethylamino)-2-oxoethyl] 4-oxo- 4-thiophen-2-ylbutanoate
  • MW: 351.46 | Formula: C18H25NO4S
  • H donors: 0 H acceptors: 3 LogP: 3.08 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)COC(=O)CCC(=O)c1cccs1)C1CCCCC1
  • InChi: 1S/C18H25NO4S/c1-2-19(14-7-4-3-5-8-14)17(21)13-23-18(22)11-10-15(20)16-9-6-12-24-16/h6,9,12,14H,2-5,7-8,10-11,13H2,1H3
  • InChiKey: DBATZTDAOLZKFB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(cyclohexyl-ethyl-amino)-2-oxo-ethyl] 4-oxo-4-(2-thienyl)butanoate
  • 4-oxo-4-(2-thienyl)butanoic acid [2-(cyclohexyl-ethylamino)-2-oxoethyl] ester
  • 4-keto-4-(2-thienyl)butyric acid [2-(cyclohexyl-ethyl-amino)-2-keto-ethyl] ester
  • [2-(cyclohexyl-ethyl-amino)-2-oxo-ethyl] 4-oxo-4-thiophen-2-yl-butanoate
  • T0510-6156

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii thioredoxin reductase 0.0051 0.0429 0.8795
Brugia malayi Thioredoxin reductase 0.0051 0.0429 0.0535
Brugia malayi hypothetical protein 0.0055 0.0488 0.0609
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0488 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0137 1
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0137 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0103 0.2116
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0222 0.0222
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0137 0.2806
Brugia malayi Calcitonin receptor-like protein seb-1 0.0162 0.1869 0.2332
Brugia malayi MH2 domain containing protein 0.0044 0.0334 0.0417
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.1436 1
Leishmania major importin beta-1 subunit, putative 0.0028 0.0137 0.2806
Brugia malayi latrophilin 2 splice variant baaae 0.0111 0.1205 0.1505
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0024 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0269 0.3236 0.3236
Loa Loa (eye worm) transcription factor SMAD2 0.0639 0.8012 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.1269 0.8837
Echinococcus granulosus tar DNA binding protein 0.0269 0.3236 0.3236
Brugia malayi glutathione reductase 0.0051 0.0429 0.0535
Loa Loa (eye worm) hypothetical protein 0.0055 0.0488 0.0601
Echinococcus multilocularis smad 0.0044 0.0334 0.0334
Echinococcus granulosus Smad4 0.0044 0.0334 0.0334
Entamoeba histolytica hypothetical protein 0.0028 0.0137 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0639 0.8012 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0006 0.0006
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0436 0.0537
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0006 0.0044
Schistosoma mansoni hypothetical protein 0.0051 0.0436 0.0436
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0006 0.0129
Schistosoma mansoni smad 0.0019 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0111 0.1205 0.1498
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0006 0.0006
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0 0.5
Treponema pallidum NADH oxidase 0.0018 0 0.5
Echinococcus multilocularis tar DNA binding protein 0.0269 0.3236 0.3236
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.0024 0.0024
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0006 0.0129
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0006 0.0129
Brugia malayi MH1 domain containing protein 0.0024 0.0083 0.0104
Brugia malayi TAR-binding protein 0.0269 0.3236 0.4039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0485 0.0485
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0485 0.0485
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0103 1
Echinococcus multilocularis snurportin 1 0.0372 0.4567 0.4567
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0436 0.0544
Schistosoma mansoni hypothetical protein 0.0051 0.0436 0.0436
Loa Loa (eye worm) hypothetical protein 0.0165 0.1903 0.2369
Brugia malayi hypothetical protein 0.0165 0.1903 0.2375
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0.0024 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0269 0.3236 0.3236
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0162 0.1869 0.2326
Loa Loa (eye worm) glutathione reductase 0.0051 0.0429 0.0528
Loa Loa (eye worm) Smad1 0.0044 0.0334 0.0409
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0024 0.0022
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0083 0.0096
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.0024 0.0024
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.1436 1
Echinococcus granulosus smad 0.0044 0.0334 0.0334
Schistosoma mansoni smad1 5 8 and 0.0044 0.0334 0.0334
Schistosoma mansoni smad1 5 8 and 0.0044 0.0334 0.0334
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0006 0.0008
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.1269 0.8837
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0 0.5
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0103 0.0129
Brugia malayi MH2 domain containing protein 0.0019 0.0024 0.0029
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.1436 1
Schistosoma mansoni smad1 5 8 and 0.0044 0.0334 0.0334
Plasmodium falciparum importin beta, putative 0.0035 0.0222 0.4548
Schistosoma mansoni tar DNA-binding protein 0.0269 0.3236 0.3236
Echinococcus granulosus importin subunit beta 1 0.0035 0.0222 0.0222
Plasmodium vivax importin-beta 2, putative 0.0035 0.0222 0.4548
Echinococcus multilocularis microtubule associated protein 2 0.0793 1 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.1269 0.8837
Loa Loa (eye worm) TAR-binding protein 0.0269 0.3236 0.4034
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0103 0.2116
Schistosoma mansoni importin beta-1 0.0035 0.0222 0.0222
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0006 0.0006
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0488 1
Brugia malayi MH2 domain containing protein 0.0044 0.0334 0.0417
Brugia malayi MH1 domain containing protein 0.0044 0.0334 0.0417
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0103 0.2116
Brugia malayi hypothetical protein 0.0036 0.0234 0.0292
Brugia malayi isocitrate dehydrogenase 0.0018 0.0006 0.0008
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.1269 0.8837
Plasmodium falciparum glutathione reductase 0.0051 0.0429 0.8795
Loa Loa (eye worm) hypothetical protein 0.0051 0.0436 0.0537
Loa Loa (eye worm) hypothetical protein 0.0162 0.1869 0.2326
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0006 0.0129
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0 0.5
Echinococcus multilocularis mothers against decapentaplegic 5 0.0044 0.0334 0.0334
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0103 0.0121
Schistosoma mansoni ran 0.0026 0.0103 0.0103
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0103 0.0103
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0429 0.0429
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0488 1
Schistosoma mansoni hypothetical protein 0.0051 0.0436 0.0436
Schistosoma mansoni Smad4 0.0044 0.0334 0.0334
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0093 0.0093
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0222 0.4548
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0006 0.0006
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0488 1
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.0024 0.0024
Brugia malayi Importin beta-1 subunit 0.0035 0.0222 0.0277
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0485 0.0485
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0 0.5
Onchocerca volvulus 0.0165 0.1903 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0162 0.1869 0.2332
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0436 0.0436
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0485 0.0485
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.1269 0.8837
Echinococcus granulosus snurportin 1 0.0372 0.4567 0.4567
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0429 0.0528
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0006 0.0006
Schistosoma mansoni smad 0.0044 0.0334 0.0334
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0436 0.0544
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0222 0.4548
Brugia malayi RNA binding protein 0.0269 0.3236 0.4039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0022
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0103 0.2116
Schistosoma mansoni tar DNA-binding protein 0.0269 0.3236 0.3236
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0488 1
Schistosoma mansoni microtubule-associated protein tau 0.0793 1 1
Schistosoma mansoni Smad4 0.0019 0.0024 0.0024
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0093 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0485 0.0485
Trypanosoma brucei trypanothione reductase 0.0051 0.0429 0.8795
Leishmania major hypothetical protein, conserved 0.0055 0.0488 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4567 0.5698
Brugia malayi RNA recognition motif domain containing protein 0.0269 0.3236 0.4039
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0006 0.0129
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0269 0.3236 0.4034
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0429 0.8795
Plasmodium falciparum thioredoxin reductase 0.0051 0.0429 0.8795
Leishmania major GTP-binding protein, putative 0.0026 0.0103 0.2116
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0006 0.0129
Schistosoma mansoni hypothetical protein 0.0025 0.0093 0.0093
Echinococcus multilocularis GPCR, family 2 0.0051 0.0436 0.0436
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0485 0.0485
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0103 0.2116
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0006 0.0129
Loa Loa (eye worm) RNA binding protein 0.0269 0.3236 0.4034
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0044 0.0334 0.0334
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0044 0.0334 0.0334
Schistosoma mansoni Smad4 0.0019 0.0024 0.0024
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0006 0.0006
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0429 0.2985
Schistosoma mansoni hypothetical protein 0.0051 0.0436 0.0436
Loa Loa (eye worm) MH2 domain-containing protein 0.0044 0.0334 0.0409
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0222 0.4548
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0006 0.0129
Brugia malayi Smad1 0.0044 0.0334 0.0417
Echinococcus granulosus GPCR family 2 0.0051 0.0436 0.0436
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0103 0.0103
Trichomonas vaginalis ran, putative 0.0026 0.0103 0.7541
Leishmania major trypanothione reductase 0.0051 0.0429 0.8795
Loa Loa (eye worm) MH1 domain-containing protein 0.0044 0.0334 0.0409
Loa Loa (eye worm) nuclear factor I 0.0024 0.0083 0.0096
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0006 0.0006
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0488 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0485 0.0598
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0436 0.0436
Schistosoma mansoni hypothetical protein 0.0111 0.1205 0.1205
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0137 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0103 0.2116
Mycobacterium tuberculosis Probable reductase 0.0116 0.1269 0.8837
Echinococcus granulosus TGF beta signal transducer SmadC 0.0044 0.0334 0.0334
Plasmodium vivax glutathione reductase, putative 0.0051 0.0429 0.8795
Brugia malayi MH2 domain containing protein 0.0639 0.8012 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0485 0.0485
Schistosoma mansoni tar DNA-binding protein 0.0269 0.3236 0.3236
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0485 0.0606
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0436 0.0436
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0436 0.0436
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0429 0.8795
Brugia malayi MH1 domain containing protein 0.0044 0.0334 0.0417
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0429 0.0429
Brugia malayi RNA, U transporter 1 0.0099 0.105 0.131
Echinococcus multilocularis Smad4 0.0044 0.0334 0.0334
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0006 0.0129
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0 0.5
Schistosoma mansoni ran 0.0026 0.0103 0.0103
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.1436 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0269
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.0024 0.0024
Brugia malayi MH1 domain containing protein 0.0024 0.0083 0.0104
Schistosoma mansoni hypothetical protein 0.0372 0.4567 0.4567
Echinococcus granulosus mothers against decapentaplegic 5 0.0044 0.0334 0.0334
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0488 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.2643 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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