Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | heterochromatin protein 1 | 0.007 | 0.1948 | 0.1948 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0924 | 0.1148 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0248 | 0.0248 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0248 | 0.0248 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0248 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.1874 | 0.1874 |
Echinococcus granulosus | chromobox protein 1 | 0.007 | 0.1948 | 0.1948 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.0681 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.007 | 0.1948 | 0.242 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.1874 | 0.1874 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0591 | 0.0591 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0022 | 0.0334 | 0.4908 |
Schistosoma mansoni | ran | 0.0022 | 0.0334 | 0.0334 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.0681 | 0.0681 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0024 | 0.0407 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0248 | 0.0307 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0022 | 0.0334 | 0.0334 |
Schistosoma mansoni | chromobox protein | 0.007 | 0.1948 | 0.1948 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.7594 | 0.7594 |
Onchocerca volvulus | 0.0254 | 0.8052 | 1 | |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.024 | 0.7594 | 0.7594 |
Brugia malayi | hypothetical protein | 0.024 | 0.7594 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0407 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0591 | 0.8675 |
Brugia malayi | Pre-SET motif family protein | 0.0032 | 0.0681 | 0.0897 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0031 | 0.0642 | 0.0642 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0022 | 0.0334 | 0.0334 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.0924 | 0.1148 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0223 | 0.7028 | 0.7028 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0591 | 0.0591 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0248 | 0.0248 |
Brugia malayi | Heterochromatin protein 1 | 0.007 | 0.1948 | 0.2565 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.1024 | 0.1271 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.1874 | 0.1874 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0591 | 0.0591 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0032 | 0.0681 | 0.0681 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0681 | 0.0681 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1148 | 0.1148 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0924 | 0.0924 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.1874 | 0.1874 |
Echinococcus multilocularis | chromobox protein 1 | 0.007 | 0.1948 | 0.1948 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.1245 | 0.164 |
Trichomonas vaginalis | importin beta-1, putative | 0.0024 | 0.0407 | 0.0506 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0642 | 0.0642 |
Onchocerca volvulus | 0.0011 | 0.000000044513 | 0.000000055286 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.446 | 0.446 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.1148 | 0.1148 |
Trichomonas vaginalis | set domain proteins, putative | 0.0254 | 0.8052 | 1 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.1874 | 0.2468 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0248 | 0.0326 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1148 | 0.1148 |
Onchocerca volvulus | 0.0043 | 0.1063 | 0.132 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.1874 | 0.2468 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1148 | 0.1148 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0135 | 0.4101 | 0.4101 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0248 | 0.3632 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0032 | 0.0681 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0146 | 0.446 | 0.446 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0248 | 0.6078 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0248 | 0.0307 |
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.446 | 0.446 |
Echinococcus multilocularis | snurportin 1 | 0.0312 | 1 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.007 | 0.1948 | 0.1948 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0591 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0223 | 0.7028 | 0.9255 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.1874 | 0.1874 |
Brugia malayi | chromobox protein homolog 3 | 0.0039 | 0.0924 | 0.1217 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0591 | 0.0591 |
Brugia malayi | RNA, U transporter 1 | 0.0083 | 0.2384 | 0.314 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0681 | 0.0681 |
Schistosoma mansoni | hypothetical protein | 0.0135 | 0.4101 | 0.4101 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0681 | 0.0681 |
Schistosoma mansoni | hypothetical protein | 0.0312 | 1 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0591 | 1 |
Echinococcus granulosus | Chromobox protein 3 | 0.0011 | 0.000000044513 | 0.000000044513 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0681 | 0.0681 |
Brugia malayi | RNA binding protein | 0.0068 | 0.1874 | 0.2468 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1148 | 0.1148 |
Trichomonas vaginalis | ran, putative | 0.0022 | 0.0334 | 0.0415 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0334 | 0.044 |
Leishmania major | GTP-binding protein, putative | 0.0022 | 0.0334 | 0.5441 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0407 | 0.0506 |
Entamoeba histolytica | Ran family GTPase | 0.0022 | 0.0334 | 0.8212 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0543 | 0.0675 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0407 | 0.0506 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0248 | 0.4187 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.1874 | 0.1874 |
Brugia malayi | SET domain containing protein | 0.0013 | 0.0039 | 0.0051 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.024 | 0.7594 | 0.7594 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0248 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0043 | 0.1063 | 0.1063 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.1874 | 0.1874 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0248 | 0.0248 |
Leishmania major | importin beta-1 subunit, putative | 0.0024 | 0.0407 | 1 |
Schistosoma mansoni | ran | 0.0022 | 0.0334 | 0.0334 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0334 | 0.2529 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0591 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1148 | 0.1148 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1148 | 0.1148 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.1874 | 0.1874 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.1148 | 0.1512 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.1024 | 0.1271 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0334 | 0.5657 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0248 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.007 | 0.1948 | 0.1948 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0135 | 0.4101 | 0.4101 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.1024 | 0.1271 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0248 | 0.0248 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0543 | 0.0675 |
Echinococcus multilocularis | Chromobox protein 3 | 0.0011 | 0.000000044513 | 0.000000044513 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1148 | 0.1148 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.1874 | 0.1874 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.1874 | 0.1874 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0248 | 0.3632 |
Trichomonas vaginalis | chromobox protein, putative | 0.007 | 0.1948 | 0.242 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0591 | 0.0779 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0032 | 0.0681 | 0.0681 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0334 | 1 |
Onchocerca volvulus | 0.0049 | 0.1245 | 0.1547 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0924 | 0.1148 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0248 | 0.5 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0022 | 0.0334 | 0.4908 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0334 | 0.5441 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0312 | 1 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0591 | 0.8675 |
Echinococcus granulosus | chromobox protein 1 | 0.007 | 0.1948 | 0.1948 |
Onchocerca volvulus | 0.0031 | 0.0642 | 0.0798 | |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0334 | 0.5441 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0334 | 0.0334 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.1245 | 0.1245 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.1245 | 0.1245 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.