Detailed information for compound 155867

Basic information

Technical information
  • TDR Targets ID: 155867
  • Name: tert-butyl N-[(3S)-5-oxo-4,4-dipropyloxolan-3 -yl]carbamate
  • MW: 285.379 | Formula: C15H27NO4
  • H donors: 1 H acceptors: 2 LogP: 3.32 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC1(CCC)[C@@H](COC1=O)NC(=O)OC(C)(C)C
  • InChi: 1S/C15H27NO4/c1-6-8-15(9-7-2)11(10-19-12(15)17)16-13(18)20-14(3,4)5/h11H,6-10H2,1-5H3,(H,16,18)/t11-/m1/s1
  • InChiKey: GDMLNNOXEKHCQM-LLVKDONJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • tert-butyl N-[(3S)-5-oxo-4,4-dipropyl-tetrahydrofuran-3-yl]carbamate
  • N-[(3S)-5-oxo-4,4-dipropyl-3-tetrahydrofuranyl]carbamic acid tert-butyl ester
  • tert-butyl N-[(3S)-5-oxo-4,4-dipropyl-oxolan-3-yl]carbamate
  • N-[(3S)-5-keto-4,4-dipropyl-tetrahydrofuran-3-yl]carbamic acid tert-butyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pre-SET motif family protein 0.003 0.0195 0.0189
Echinococcus granulosus transcription factor btf3 0.0034 0.0238 0.0238
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0238 0.0679
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0275 0.0269
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0098 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0098 0.0098
Schistosoma mansoni nuclear hormone receptor 0.002 0.0098 0.0091
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0067 0.0061
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0108 0.0101
Echinococcus granulosus voltage dependent calcium channel 0.0094 0.0821 0.0821
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0043 0.0327 0.0327
Echinococcus multilocularis voltage dependent calcium channel 0.0094 0.0821 0.0821
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0195 0.052
Echinococcus multilocularis voltage dependent calcium channel 0.0094 0.0821 0.0821
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0098 0.0091
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.006 0.049 0.0484
Echinococcus granulosus cpg binding protein 0.0031 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.025 0.2347 0.2347
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0055 0.0055
Schistosoma mansoni glutaminase 0.0267 0.251 0.2505
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0055 0.0018
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0183 0.0473
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.038 0.0374
Trypanosoma brucei hypothetical protein, conserved 0.0291 0.2744 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0238 0.042
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0238 0.0996
Schistosoma mansoni zinc finger protein 0.0021 0.0107 0.01
Onchocerca volvulus 0.0028 0.0179 0.0082
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0055 0.0025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0098 0.0098
Schistosoma mansoni hypothetical protein 0.0028 0.0183 0.0176
Loa Loa (eye worm) X11 protein 0.0067 0.056 0.056
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0195 0.0195
Brugia malayi Pre-SET motif family protein 0.0204 0.1894 0.1889
Schistosoma mansoni cpg binding protein 0.0028 0.0179 0.0172
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0291 0.2744 0.5
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0098 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0098 0.0091
Schistosoma mansoni bromodomain containing protein 0.0063 0.0524 0.0517
Mycobacterium tuberculosis Conserved protein 0.0024 0.0138 0.0308
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0055 0.0055
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0094 0.0821 0.0821
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0098
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0135 0.0135
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0098 0.0098
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0098 0.0098
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.1033 1 1
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0057 0.0462 0.2186
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0135 0.0129
Echinococcus granulosus peregrin 0.0031 0.0205 0.0205
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1043 0.1043
Schistosoma mansoni hypothetical protein 0.0015 0.0055 0.0049
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0183 0.0473
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0098 0.0091
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0067 0.0061
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0055 0.0055
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0238 0.042
Schistosoma mansoni cpg binding protein 0.0031 0.0212 0.0206
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0358 0.0358
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0094 0.0821 0.0815
Schistosoma mansoni voltage-gated cation channel 0.0094 0.0821 0.0815
Echinococcus multilocularis peregrin 0.0031 0.0205 0.0205
Loa Loa (eye worm) calcium channel 0.0094 0.0821 0.0821
Loa Loa (eye worm) glutaminase 0.0267 0.251 0.251
Echinococcus multilocularis amyloid beta A4 protein 0.0067 0.056 0.056
Onchocerca volvulus 0.003 0.0195 0.0099
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0291 0.2744 1
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0291 0.2744 0.5
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0055 0.0158
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0292 0.0292
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0241 0.0241
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0815 0.0815
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0098 0.0091
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0275 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0098 0.0091
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0275 0.0275
Schistosoma mansoni hypothetical protein 0.0033 0.023 0.0223
Onchocerca volvulus 0.1033 1 1
Brugia malayi Bromodomain containing protein 0.0031 0.0205 0.0199
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0055 0.0049
Trichomonas vaginalis glutaminase, putative 0.0267 0.251 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0098 0.0091
Loa Loa (eye worm) hypothetical protein 0.1033 1 1
Brugia malayi beta-NAC-like protein 0.0034 0.0238 0.0232
Echinococcus granulosus jumonji domain containing protein 0.004 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0037 0.0271 0.0271
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0098 0.0098
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0183 0.0183
Schistosoma mansoni thyroid hormone receptor 0.002 0.0098 0.0091
Plasmodium falciparum phd finger protein, putative 0.0028 0.0183 0.0624
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0098
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0098 0.0091
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0098 0.0098
Brugia malayi nuclear hormone receptor 0.002 0.0098 0.0091
Giardia lamblia PHD finger protein 15 0.0028 0.0183 0.5
Mycobacterium ulcerans glutaminase 0.0267 0.251 0.9103
Entamoeba histolytica hypothetical protein 0.0291 0.2744 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0098 0.0091
Brugia malayi ecdysteroid receptor 0.002 0.0098 0.0091
Schistosoma mansoni cpg binding protein 0.0031 0.0212 0.0206
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0138 0.0466
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0238 0.0238
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0496 0.049
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0098 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0098 0.0091
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0291 0.2744 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0291 0.2744 0.5
Echinococcus granulosus voltage dependent calcium channel 0.002 0.0097 0.0097
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0055 0.0025
Schistosoma mansoni coup transcription factor 0.002 0.0098 0.0091
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0098 0.0091
Brugia malayi Bromodomain containing protein 0.0075 0.0635 0.0629
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0138 0.0466
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0029
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0183 0.0183
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0238 0.0826
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0238 0.0696
Toxoplasma gondii hypothetical protein 0.0017 0.0073 0.0067
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0138 0.0138
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0098 0.0091
Schistosoma mansoni hypothetical protein 0.0015 0.0051 0.0044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0098 0.0091
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0007 0.0007
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0055 0.0055
Brugia malayi jmjC domain containing protein 0.0038 0.0275 0.0269
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.1932 1
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0138 0.0138
Leishmania major basic transcription factor 3a, putative 0.0034 0.0238 0.0696
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0098 0.0091
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0098 0.0098
Echinococcus granulosus L aminoadipate semialdehyde 0.1033 1 1
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0102 0.0102
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0094 0.0821 0.0815
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0055 0.0055
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0098 0.0091
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0098 0.0098
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0358 0.0351
Brugia malayi CXXC zinc finger family protein 0.0028 0.0179 0.0172
Echinococcus multilocularis sodium channel protein 0.004 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0094 0.0821 0.0821
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0098 0.0098
Echinococcus multilocularis cpg binding protein 0.0031 0.0212 0.0212
Brugia malayi MH2 domain containing protein 0.0116 0.1043 0.1037
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0055 0.0055
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0179 0.0179
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0098 0.0098
Echinococcus granulosus GPCR family 2 0.0015 0.0055 0.0055
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0884 0.8548 0.8548
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0138 0.0308
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0055 0.0018
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0055 0.0055
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0007 0.0007
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0067 0.0067
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0291 0.2744 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0293 0.0293
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0098 0.0091
Trichomonas vaginalis set domain proteins, putative 0.0232 0.2169 0.8559
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0098
Echinococcus granulosus amyloid beta A4 protein 0.0067 0.056 0.056
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0238 0.0826
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0055 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0098 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0358 0.0351
Loa Loa (eye worm) hypothetical protein 0.0094 0.0821 0.0821
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0055
Brugia malayi steroid hormone receptor 0.002 0.0098 0.0091
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0073 0.0073
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0098 0.0091
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0291 0.2744 1
Trypanosoma brucei hypothetical protein, conserved 0.0207 0.1932 0.6987
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0098 0.0098
Brugia malayi jmjC domain containing protein 0.0093 0.0815 0.0809
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0247 0.0247
Echinococcus multilocularis zinc finger protein 0.0021 0.0107 0.0107
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0028 0.0028
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0094 0.0821 0.0821
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0055 0.0049
Loa Loa (eye worm) hypothetical protein 0.0017 0.0073 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0098 0.0091
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0291 0.2744 1
Onchocerca volvulus Alhambra homolog 0.0028 0.0183 0.0086
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0057 0.0462 0.1527
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0479 0.0479
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.1932 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0098
Loa Loa (eye worm) glutaminase 2 0.0267 0.251 0.251
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0489 0.0489
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0098 0.0091
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0098
Schistosoma mansoni hypothetical protein 0.0015 0.0055 0.0049
Schistosoma mansoni transcription factor btf3 0.0034 0.0238 0.0232
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0055 0.0049
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0094 0.0821 0.0821
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0183 0.0183
Mycobacterium leprae conserved hypothetical protein 0.0291 0.2744 0.5
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.004 0.0293 0.0293
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0028 0.0028
Brugia malayi photoreceptor-specific nuclear receptor 0.025 0.2347 0.2342
Brugia malayi hypothetical protein 0.0064 0.0534 0.0528
Loa Loa (eye worm) hypothetical protein 0.0049 0.0381 0.0381
Schistosoma mansoni hypothetical protein 0.0015 0.0055 0.0049
Brugia malayi PHD-finger family protein 0.0026 0.0158 0.0151
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0098 0.0098
Plasmodium vivax SET domain protein, putative 0.003 0.0195 0.067
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0098 0.0091
Brugia malayi Bromodomain containing protein 0.0037 0.027 0.0263
Schistosoma mansoni amyloid beta A4 protein related 0.0067 0.056 0.0553
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0247 0.0247
Echinococcus multilocularis GPCR, family 2 0.0015 0.0055 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0098 0.0098
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0055 0.0049
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0046 0.0358 0.0358
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0098 0.0091
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0098 0.0091
Brugia malayi PHD-finger family protein 0.0013 0.0029 0.0023
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0055 0.0055
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1043 0.1043
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0291 0.2744 1
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0183 0.0624
Loa Loa (eye worm) hypothetical protein 0.0017 0.0073 0.0073
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0098 0.0098
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0195 0.0189
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0098 0.0098
Schistosoma mansoni zinc finger protein 0.0015 0.0051 0.0044
Echinococcus multilocularis L aminoadipate semialdehyde 0.1033 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.023 0.0223
Loa Loa (eye worm) voltage-dependent calcium channel 0.002 0.0097 0.0097
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0055 0.0055
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0094 0.0821 0.0821
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0183 0.0176
Toxoplasma gondii transporter, cation channel family protein 0.002 0.0097 0.0153
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0179 0.0179
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0358 0.0358
Brugia malayi isocitrate dehydrogenase 0.0015 0.0055 0.0049
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0074 0.0068
Loa Loa (eye worm) hypothetical protein 0.0069 0.0579 0.0579
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0098 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0098 0.0098
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0138 0.0326
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0098 0.0098
Echinococcus multilocularis transcription factor btf3 0.0034 0.0238 0.0238
Brugia malayi glutaminase DH11.1 0.0267 0.251 0.2505
Echinococcus granulosus FTZ F1 alpha 0.002 0.0098 0.0098
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0815 0.0815
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0098 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Onchocerca volvulus 0.0232 0.2169 0.2091
Brugia malayi nuclear receptor NHR-88 0.002 0.0098 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0238 0.042
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0094 0.0821 0.0815
Loa Loa (eye worm) hypothetical protein 0.0028 0.0183 0.0183
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0064 0.0534 0.0534
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0094 0.0821 0.0821
Leishmania major hypothetical protein, conserved 0.0207 0.1932 0.6987
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0275 0.0269
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0489 0.0489
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0055 0.0018
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0055 0.0158
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0007 0.0007
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0098 0.0098
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0456 0.1492
Schistosoma mansoni hypothetical protein 0.002 0.0102 0.0095
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0291 0.2744 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0195 0.0189
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.038 0.0374
Schistosoma mansoni hypothetical protein 0.0015 0.0055 0.0049
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.038 0.038
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1894 0.1894
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0628 0.0622
Brugia malayi PHD-finger family protein 0.0028 0.0183 0.0176
Loa Loa (eye worm) hypothetical protein 0.0049 0.038 0.038
Echinococcus granulosus zinc finger protein 0.0021 0.0107 0.0107
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0098 0.0091
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Schistosoma mansoni thyroid hormone receptor 0.002 0.0098 0.0091
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0055 0.0055
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0033 0.023 0.023
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0098 0.0098
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0238 0.0996
Leishmania major phosphopantetheinyl transferase-like protein 0.0291 0.2744 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0094 0.0821 0.0821

Activities

Activity type Activity value Assay description Source Reference
BA (binding) = 46 Gamma-aminobutyric-acid A receptor modulating activity (expressed as biological activity). ChEMBL. 14684308
cLogP = 4.03 Octanol-water partition coefficient of the compound was determined ChEMBL. 14684308
Stimulation (functional) = 46 % Percent stimulation of GABA-induced currents in Xenopus Oocytes expressing rat GABA-A receptor alpha1-beta2-gamma2 subunits at 200 uM ChEMBL. 12061884
Stimulation (functional) = 46 % Percent stimulation of GABA-induced currents in Xenopus Oocytes expressing rat GABA-A receptor alpha1-beta2-gamma2 subunits at 200 uM ChEMBL. 12061884

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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