Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.0479 | 0.0328 | 1 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0303 | 0.0102 | 0.0055 |
Mycobacterium tuberculosis | Hypothetical protein | 0.3693 | 0.4452 | 0.4544 |
Giardia lamblia | CDC8 | 0.0303 | 0.0102 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.8017 | 1 | 1 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0303 | 0.0102 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyX (ts) (TSase) | 0.4822 | 0.5901 | 0.6059 |
Brugia malayi | dihydrofolate reductase family protein | 0.0479 | 0.0328 | 0.0236 |
Echinococcus granulosus | dihydrofolate reductase | 0.0479 | 0.0328 | 0.0236 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.038 | 0.0201 | 0.0154 |
Echinococcus multilocularis | thymidylate synthase | 0.7762 | 0.9673 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0479 | 0.0328 | 0.0236 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.7762 | 0.9673 | 1 |
Leishmania major | thymidylate kinase-like protein | 0.0303 | 0.0102 | 0.0055 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0303 | 0.0102 | 0.0055 |
Mycobacterium ulcerans | thymidylate synthase | 0.7762 | 0.9673 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0479 | 0.0328 | 0.0236 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.038 | 0.0201 | 0.0154 |
Trypanosoma brucei | thymidine kinase | 0.026 | 0.0048 | 0.0048 |
Brugia malayi | Dihydrofolate reductase | 0.0479 | 0.0328 | 0.0236 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0479 | 0.0328 | 0.0236 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.8017 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.7762 | 0.9673 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0479 | 0.0328 | 0.0236 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0479 | 0.0328 | 0.0236 |
Brugia malayi | hypothetical protein | 0.3693 | 0.4452 | 0.4544 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7762 | 0.9673 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.8017 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.8017 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.3693 | 0.4452 | 0.4425 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.7762 | 0.9673 | 1 |
Trypanosoma brucei | deoxyuridine triphosphatase, putative | 0.038 | 0.0201 | 0.0201 |
Schistosoma mansoni | dihydrofolate reductase | 0.0479 | 0.0328 | 0.0339 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.8017 | 1 | 1 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0303 | 0.0102 | 0.0102 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0303 | 0.0102 | 1 |
Leishmania major | deoxyuridine triphosphatase, putative,dUTP diphosphatase | 0.038 | 0.0201 | 0.0154 |
Mycobacterium ulcerans | FAD-dependent thymidylate synthase | 0.4822 | 0.5901 | 0.6059 |
Echinococcus granulosus | thymidylate synthase | 0.7762 | 0.9673 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.7762 | 0.9673 | 1 |
Schistosoma mansoni | thymidylate kinase | 0.0303 | 0.0102 | 0.0106 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0303 | 0.0102 | 0.0102 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0303 | 0.0102 | 0.0124 |
Trichomonas vaginalis | conserved hypothetical protein | 0.3693 | 0.4452 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYX (TS) (TSase) | 0.4822 | 0.5901 | 0.6059 |
Schistosoma mansoni | thymidylate kinase | 0.0303 | 0.0102 | 0.0106 |
Onchocerca volvulus | 0.7762 | 0.9673 | 1 | |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0303 | 0.0102 | 0.0124 |
Schistosoma mansoni | hypothetical protein | 0.0303 | 0.0102 | 0.0106 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0303 | 0.0102 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.3 uM | Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth after 48 hrs by ZF-Coulter Counting | ChEMBL. | 21146985 |
IC50 (functional) | = 2.3 uM | Antiproliferative activity against mouse L1210 cells assessed as inhibition of cell growth after 48 hrs by ZF-Coulter Counting | ChEMBL. | 21146985 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 21146985 | |
Homo sapiens | ChEMBL23 | 21146985 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.