Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Nischarin | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | hypothetical protein | Get druggable targets OG5_133208 | All targets in OG5_133208 |
Echinococcus granulosus | nischarin | Get druggable targets OG5_133208 | All targets in OG5_133208 |
Onchocerca volvulus | Nischarin homolog | Get druggable targets OG5_133208 | All targets in OG5_133208 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133208 | All targets in OG5_133208 |
Echinococcus multilocularis | nischarin | Get druggable targets OG5_133208 | All targets in OG5_133208 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.108 | 0.108 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0579 | 0.0579 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0136 | 0.3514 | 1 |
Echinococcus granulosus | nischarin | 0.017 | 0.4526 | 0.4526 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0579 | 0.0579 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.108 | 0.108 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0355 | 1 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0579 | 0.0579 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0355 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.108 | 0.108 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0136 | 0.3514 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.4413 | 0.4413 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0355 | 1 | 1 |
Echinococcus multilocularis | nischarin | 0.017 | 0.4526 | 0.4526 |
Brugia malayi | Dihydrofolate reductase | 0.0355 | 1 | 1 |
Onchocerca volvulus | Nischarin homolog | 0.0166 | 0.4407 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0355 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0136 | 0.3514 | 1 |
Brugia malayi | hypothetical protein | 0.0166 | 0.4413 | 0.4413 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0136 | 0.3514 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.108 | 0.108 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0355 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0355 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0355 | 1 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0136 | 0.3514 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0136 | 0.3514 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0355 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 21200 nM | Displacement of [3H]clonidine from imidazoline I1 receptor in Sprague-Dawley rat kidney membrane after 45 mins by liquid scintillation counting | ChEMBL. | 21129985 |
Ki (binding) | = 10200 nM | Displacement of [3H]2BFI from imidazoline I1 receptor in Sprague-Dawley rat brain membrane after 45 mins by liquid scintillation counting | ChEMBL. | 21129985 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.