Detailed information for compound 1558858

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 367.481 | Formula: C23H29NO3
  • H donors: 1 H acceptors: 0 LogP: 3.78 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC1Cc2ccccc2[C@@]2(O1)CC[C@H](CC2)NCc1ccc(cc1)OC
  • InChi: 1S/C23H29NO3/c1-25-20-9-7-17(8-10-20)16-24-19-11-13-23(14-12-19)21-6-4-3-5-18(21)15-22(26-2)27-23/h3-10,19,22,24H,11-16H2,1-2H3/t19-,22?,23-
  • InChiKey: DNIJYSZGAWKCFH-HUJQNASWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Sigma-1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma cruzi C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania major C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania donovani C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei gambiense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania mexicana C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania infantum C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania braziliensis C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Brugia malayi ERG2 and Sigma1 receptor like protein Get druggable targets OG5_131051 All targets in OG5_131051
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0042 0.0151 0.0267
Brugia malayi secreted modular calcium-binding protein 1 0.0088 0.0413 0.0733
Entamoeba histolytica P-glycoprotein 5, putative 0.0024 0.0054 0.0094
Leishmania major cysteine peptidase A (CPA) 0.0036 0.0117 0.0221
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0038 0.0042
Brugia malayi Cathepsin L-like precursor 0.0036 0.0117 0.0206
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0054 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0667 0.368 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0145 0.0144
Trypanosoma cruzi cruzipain precursor, putative 0.0135 0.068 0.1295
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0155 0.0788 0.0895
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0145 0.0144
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0032 0.0086
Trypanosoma brucei metacaspase MCA3 0.002 0.0032 0.0059
Plasmodium vivax basic transcription factor 3b, putative 0.004 0.0144 0.1248
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0054 0.0146
Schistosoma mansoni hypothetical protein 0.0112 0.0548 0.0621
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0024 0.0026
Brugia malayi TAR-binding protein 0.0073 0.0329 0.0585
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0065
Leishmania major cathepsin L-like protease 0.0135 0.068 0.1295
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0036 0.0118 0.0223
Trichomonas vaginalis taga, putative 0.0024 0.0054 0.0146
Onchocerca volvulus 0.0036 0.0117 0.019
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0054 0.006
Leishmania major basic transcription factor 3a, putative 0.004 0.0144 0.0273
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0117 0.0317
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0071 0.0124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.000000000022264 0.000000000060502
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0116 0.0572 0.1089
Treponema pallidum fructose-bisphosphate aldolase 0.0667 0.368 1
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0151 0.0411
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0145 0.0257
Brugia malayi Pre-SET motif family protein 0.0036 0.0119 0.021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0145 0.0164
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0145 0.0164
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0032 0.0086
Plasmodium falciparum GMP synthase [glutamine-hydrolyzing] 0.0038 0.013 0.0431
Leishmania major p-glycoprotein 0.0024 0.0054 0.0101
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0117 0.0116
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0054 0.0146
Onchocerca volvulus 0.0027 0.0071 0.0109
Brugia malayi Cell death protein 3 precursor 0.0068 0.03 0.0533
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0299 0.1601 0.2848
Loa Loa (eye worm) hypothetical protein 0.0088 0.0413 0.0733
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0145 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0032 0.0086
Echinococcus granulosus death domain containing protein 0.0017 0.001 0.001
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0054 0.0146
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0129 0.0644 0.0643
Echinococcus multilocularis lysine specific demethylase 6a 0.0036 0.0118 0.0117
Loa Loa (eye worm) hypothetical protein 0.0065 0.0281 0.0498
Schistosoma mansoni coup transcription factor 0.0041 0.0145 0.0164
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0065
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0024 0.0054 0.0471
Schistosoma mansoni rab6-interacting 0.0065 0.0281 0.0318
Loa Loa (eye worm) hypothetical protein 0.0038 0.013 0.023
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0019 0.0021
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0584 0.0663
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0145 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0145 0.0257
Loa Loa (eye worm) hypothetical protein 0.0041 0.0145 0.0257
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.0054 0.0053
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0019 0.0021
Brugia malayi Death domain containing protein 0.0017 0.001 0.0016
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.068 0.1295
Trichomonas vaginalis glucosylceramidase, putative 0.0299 0.1601 0.4351
Trypanosoma cruzi MFS transporter, putative 0.0129 0.0644 0.1226
Brugia malayi Cathepsin L-like cysteine proteinase 0.0024 0.005 0.0088
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0151 0.0551
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0024 0.0041
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0584 0.0663
Brugia malayi sodium-independent organic anion transporter family protein 0.0129 0.0644 0.1144
Schistosoma mansoni organic anion transporter 0.0129 0.0644 0.073
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0329 0.0585
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.068 0.1295
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.068 0.1295
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0118 0.0209
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0081 0.0152
Schistosoma mansoni inositol monophosphatase 0.0043 0.0157 0.0177
Schistosoma mansoni rab6-interacting 0.0065 0.0281 0.0318
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0667 0.368 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0054 0.0146
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0019 0.0035
Toxoplasma gondii hypothetical protein 0.0152 0.0776 0.6903
Mycobacterium tuberculosis Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) 0.0095 0.0452 0.1657
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0475 0.2597 0.9534
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0475 0.2597 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.068 0.1295
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0329 0.0373
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0157 0.0177
Schistosoma mansoni hypothetical protein 0.0048 0.0185 0.0209
Brugia malayi Pre-SET motif family protein 0.0242 0.1282 0.228
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0054 0.0146
Onchocerca volvulus 0.0129 0.0644 0.113
Echinococcus multilocularis expressed protein 0.0088 0.0413 0.0412
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0024 0.0041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0041
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0065
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.005 0.0084
Plasmodium falciparum LCCL domain-containing protein 0.0065 0.0281 0.1014
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.1081 0.2938
Schistosoma mansoni jumonji/arid domain-containing protein 0.0138 0.0695 0.0788
Echinococcus multilocularis cpg binding protein 0.0069 0.0307 0.0306
Loa Loa (eye worm) hypothetical protein 0.0041 0.0145 0.0257
Echinococcus granulosus cysteine protease 0.0018 0.0019 0.0021
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0145 0.0144
Echinococcus granulosus lysine specific demethylase 6a 0.0036 0.0118 0.0133
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0151 0.0551
Brugia malayi tailless protein 0.0019 0.0024 0.0041
Brugia malayi hypothetical protein 0.0065 0.0281 0.0498
Schistosoma mansoni protein phosphatase 2C 0.0036 0.0118 0.0133
Echinococcus multilocularis lipoxygenase domain containing protein 0.0065 0.0281 0.028
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0054 0.0146
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0017 0.0011 0.0011
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0116 0.0572 0.1089
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0464 0.0463
Trypanosoma brucei Metacaspase-4 0.002 0.0032 0.0059
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0134 0.0674 0.0673
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0151 0.0551
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0054 0.0146
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0041
Trichomonas vaginalis nh(3)-dependent NAD(+) synthetase, putative 0.0095 0.0452 0.1228
Onchocerca volvulus 0.0019 0.0024 0.0025
Loa Loa (eye worm) hypothetical protein 0.0041 0.0145 0.0257
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.0054 0.0053
Giardia lamblia Fructose-bisphosphate aldolase 0.0667 0.368 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0036 0.0118 0.0133
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0119 0.0134
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0572 0.1555
Echinococcus granulosus apoptotic protease activating factor 1 0.0048 0.0185 0.0209
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.1022 0.2776
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0071 0.0257
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0132 0.0481
Loa Loa (eye worm) hypothetical protein 0.0041 0.0145 0.0257
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0024 0.0041
Entamoeba histolytica transcription factor BTF3, putative 0.004 0.0144 0.0341
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0145 0.0257
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0055
Loa Loa (eye worm) agrin synaptic family protein 0.0088 0.0413 0.0733
Entamoeba histolytica P-glycoprotein-2 0.0024 0.0054 0.0094
Loa Loa (eye worm) hypothetical protein 0.0042 0.0151 0.0267
Echinococcus multilocularis lysine specific demethylase 5A 0.0134 0.0674 0.0673
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0447 0.2439 0.4648
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0088 0.0413 0.0733
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.0475 0.2597 0.6645
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.002 0.0032 0.0035
Echinococcus granulosus follistatin 0.0088 0.0413 0.0468
Trichomonas vaginalis esterase, putative 0.0042 0.0151 0.0411
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0129 0.0644 0.073
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0145 0.0144
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0071 0.0257
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0071 0.0257
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0054 0.006
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0145 0.0144
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0145 0.0164
Loa Loa (eye worm) hypothetical protein 0.0129 0.0644 0.1144
Brugia malayi sodium-independent organic anion transporter family protein 0.0129 0.0644 0.1144
Trichomonas vaginalis abcb9, putative 0.0024 0.0054 0.0146
Brugia malayi Cytochrome P450 family protein 0.0034 0.0106 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0144 0.0392
Loa Loa (eye worm) DR-78 0.0019 0.0024 0.0041
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0133 0.0666 0.1267
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0117 0.0131
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.000000000022264 0.000000000060502
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0071 0.0257
Schistosoma mansoni nuclear receptor 0.0019 0.0024 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0117 0.0317
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0151 0.0411
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.0054 0.0146
Mycobacterium tuberculosis Conserved hypothetical protein 0.0498 0.2724 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0145 0.0164
Schistosoma mansoni multidrug resistance protein 0.0024 0.0054 0.006
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0019 0.0033
Brugia malayi Muscleblind-like protein 0.0341 0.184 0.3273
Loa Loa (eye worm) RNA binding protein 0.0073 0.0329 0.0585
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0054 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0117 0.0317
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0117 0.0317
Loa Loa (eye worm) hypothetical protein 0.0042 0.0151 0.0267
Echinococcus multilocularis microtubule associated protein 2 0.1576 0.8803 0.8803
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0119 0.0134
Echinococcus granulosus GMP synthase glutamine hydrolyzing 0.0038 0.013 0.0147
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.000000000022264 0.000000000060502
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0145 0.0257
Loa Loa (eye worm) glutaminase 2 0.0316 0.17 0.3023
Loa Loa (eye worm) hypothetical protein 0.1011 0.562 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0088
Brugia malayi nuclear receptor RXR 0.0019 0.0024 0.0041
Onchocerca volvulus 0.0024 0.005 0.0072
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0088 0.0413 0.3671
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0052 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0144 0.0392
Mycobacterium ulcerans hypothetical protein 0.0042 0.0151 0.0551
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0024 0.0054 0.0101
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0151 0.0551
Schistosoma mansoni jumonji domain containing protein 0.0036 0.0118 0.0133
Echinococcus granulosus muscleblind protein 0.0341 0.184 0.2089
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0036 0.0119 0.021
Schistosoma mansoni inositol monophosphatase 0.0043 0.0157 0.0177
Onchocerca volvulus 0.0019 0.0024 0.0025
Brugia malayi nuclear receptor NHR-88 0.0019 0.0024 0.0041
Onchocerca volvulus Cathepsin F homolog 0.0036 0.0117 0.019
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0117 0.0116
Echinococcus granulosus Solute carrier organic anion transporter family 0.0129 0.0644 0.073
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0071 0.0269
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0012 0.0013
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0329 0.0585
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0151 0.015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0041
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0151 0.1309
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0129 0.0644 0.0643
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0119 0.0118
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0015 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0117 0.0317
Onchocerca volvulus 0.0036 0.0117 0.019
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0151 0.0578
Echinococcus multilocularis follistatin 0.0088 0.0413 0.0412
Schistosoma mansoni caspase-7 (C14 family) 0.002 0.0032 0.0035
Brugia malayi conserved hypotetical protein 0.0019 0.0024 0.0041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0041
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0133 0.0666 0.1267
Loa Loa (eye worm) hypothetical protein 0.0027 0.0071 0.0124
Echinococcus multilocularis caspase 8 0.002 0.0032 0.0031
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0081 0.0152
Brugia malayi jmjC domain containing protein 0.0036 0.0118 0.0209
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0054 0.0146
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0119 0.0134
Toxoplasma gondii histone lysine methyltransferase SET1 0.0125 0.0624 0.5551
Echinococcus granulosus cathepsin L 0.0018 0.0019 0.0021
Echinococcus multilocularis apoptotic protease activating factor 1 0.0048 0.0185 0.0184
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0326 0.1755 0.6441
Loa Loa (eye worm) cysteine protease 0.0036 0.0117 0.0206
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.004 0.0139 0.0138
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0145 0.0144
Mycobacterium ulcerans GMP synthase 0.0038 0.013 0.0476
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0117 0.0317
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0151 0.0551
Schistosoma mansoni netrin receptor unc5 0.0017 0.001 0.001
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0667 0.368 1
Brugia malayi hypothetical protein 0.0019 0.0024 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0144 0.0392
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.068 0.1295
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.002 0.0032 0.0035
Entamoeba histolytica P-glycoprotein-2 0.0024 0.0054 0.0094
Entamoeba histolytica P-glyco protein 6, putative 0.0024 0.0054 0.0094
Mycobacterium leprae PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]) 0.0095 0.0452 0.1738
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0055
Brugia malayi Cathepsin L-like precursor 0.0036 0.0117 0.0206
Echinococcus multilocularis muscleblind protein 0.0341 0.184 0.1839
Mycobacterium ulcerans NAD synthetase 0.0095 0.0452 0.1657
Brugia malayi jmjC domain containing protein 0.0138 0.0695 0.1235
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0024 0.0023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0145 0.0164
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0117 0.0317
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0079 0.0362 0.041
Loa Loa (eye worm) hypothetical protein 0.0129 0.0644 0.1144
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0119 0.0134
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0054 0.006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0094
Loa Loa (eye worm) doublecortin family protein 0.0065 0.0281 0.0498
Brugia malayi Cathepsin L-like precursor 0.0024 0.005 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0117 0.0317
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0117 0.0266
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0117 0.0317
Brugia malayi jmjC domain containing protein 0.0134 0.0674 0.1197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.068 0.1295
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0145 0.0241
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0019 0.0033
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0151 0.0171
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0151 0.0411
Entamoeba histolytica NAD synthetase, putative 0.0095 0.0452 0.1182
Trypanosoma cruzi metacaspase 5, putative 0.002 0.0032 0.0059
Brugia malayi Doublecortin family protein 0.0065 0.0281 0.0498
Loa Loa (eye worm) hypothetical protein 0.0036 0.0118 0.0209
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0038 0.0037
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0081 0.071
Brugia malayi hypothetical protein 0.0019 0.0022 0.0038
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0157 0.0376
Trypanosoma brucei metacaspase MCA2 0.002 0.0032 0.0059
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0025 0.009
Plasmodium vivax multidomain scavenger receptor, putative 0.0065 0.0281 0.2469
Echinococcus granulosus caspase 2 0.0068 0.03 0.034
Schistosoma mansoni multidrug resistance protein 0.0024 0.0054 0.006
Leishmania major cytochrome p450-like protein 0.0034 0.0106 0.02
Onchocerca volvulus Glucosylceramidase homolog 0.0196 0.1022 0.1803
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0041
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0095 0.0452 0.0513
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0151 0.0551
Trichomonas vaginalis glutaminase, putative 0.0316 0.17 0.4619
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0054 0.006
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0054 0.0146
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0106 0.0187
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0054 0.0146
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.0286 0.0507
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0071 0.014
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0117 0.019
Leishmania major cathepsin L-like protease 0.0036 0.0117 0.0221
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0329 0.0329
Echinococcus granulosus JmjC domain containing protein 4 0.0036 0.0118 0.0133
Leishmania major cathepsin L-like protease 0.0036 0.0117 0.0221
Echinococcus granulosus tar DNA binding protein 0.0073 0.0329 0.0373
Echinococcus multilocularis cysteine protease 0.0036 0.0117 0.0116
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0024 0.0026
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0024 0.0052 0.0058
Echinococcus granulosus Ankyrin 0.0017 0.0011 0.0011
Brugia malayi glutaminase DH11.1 0.0316 0.17 0.3023
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0085 0.0397 0.0396
Schistosoma mansoni zinc finger protein 0.0019 0.0024 0.0026
Leishmania major cathepsin L-like protease 0.0135 0.068 0.1295
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0037 0.0041
Echinococcus granulosus transcription factor btf3 0.004 0.0144 0.0163
Entamoeba histolytica cysteine protease, putative 0.0036 0.0117 0.0266
Brugia malayi GMP synthase 0.0038 0.013 0.023
Echinococcus granulosus microtubule associated protein 2 0.1576 0.8803 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.0644 0.1144
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0572 0.1555
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.2424 0.4313
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0117 0.0131
Trypanosoma cruzi metacaspase, putative 0.002 0.0032 0.0059
Entamoeba histolytica hypothetical protein 0.0042 0.0151 0.0359
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0464 0.0824
Echinococcus multilocularis Polycystic kidney disease protein 0.0065 0.0281 0.028
Loa Loa (eye worm) hypothetical protein 0.0036 0.0117 0.0206
Trypanosoma brucei metacaspase 0.002 0.0032 0.0059
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0037 0.0065
Brugia malayi Protein kinase domain containing protein 0.0018 0.0016 0.0027
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0584 0.0663
Loa Loa (eye worm) hypothetical protein 0.0117 0.0575 0.1021
Plasmodium vivax vivapain-2 0.0036 0.0117 0.1001
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.002 0.0032 0.0031
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.0475 0.2597 1
Brugia malayi jmjC domain containing protein 0.0036 0.0118 0.0209
Trypanosoma cruzi metacaspase 5, putative 0.002 0.0032 0.0059
Brugia malayi Inositol-1 0.0043 0.0157 0.0278
Loa Loa (eye worm) hypothetical protein 0.0079 0.0362 0.0642
Onchocerca volvulus 0.0129 0.0644 0.113
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0145 0.0164
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0081 0.0237
Onchocerca volvulus Putative organic anion transporter 0.0129 0.0644 0.113
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0036 0.0117 0.0206
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0036 0.0117 0.0377
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0024 0.0026
Trypanosoma cruzi major cysteine proteinase, putative 0.0106 0.0517 0.0983
Loa Loa (eye worm) hypothetical protein 0.0027 0.0071 0.0124
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0326 0.1755 0.6441
Onchocerca volvulus 0.0042 0.0151 0.0252
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0116 0.0572 0.1089
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0667 0.368 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0145 0.0257
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0024 0.0025
Loa Loa (eye worm) hypothetical protein 0.0042 0.0151 0.0267
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0118 0.0209
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.1022 0.2776
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.002 0.0032 0.0273
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0132 0.0505
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0145 0.0164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0117 0.0317
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.001 0.0016
Mycobacterium ulcerans glutaminase 0.0316 0.17 0.6239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0145 0.0257
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0019 0.0035
Echinococcus multilocularis Ankyrin 0.0017 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0145 0.0257
Brugia malayi hypothetical protein 0.0019 0.0024 0.0041
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0071 0.0133
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0024 0.0041
Toxoplasma gondii protease inhibitor PI2 0.0088 0.0413 0.3671
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0145 0.0241
Brugia malayi Uncoordinated protein 44 0.0017 0.001 0.0016
Mycobacterium ulcerans lipase LipD 0.0042 0.0151 0.0551
Plasmodium falciparum JmjC domain-containing protein, putative 0.0036 0.0118 0.0383
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0041
Onchocerca volvulus 0.0036 0.0117 0.019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0151 0.0171
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0047 0.0128
Plasmodium vivax vivapain-1 0.0018 0.0019 0.0133
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0057 0.0238 0.0269
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.1022 0.2776
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.0117 0.0221
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.0675 0.1199
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.002 0.0032 0.0273
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0054 0.0471
Schistosoma mansoni polycystin 1-related 0.0065 0.0281 0.0318
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0124 0.0614 0.1168
Loa Loa (eye worm) hypothetical protein 0.0041 0.0145 0.0257
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0133 0.0667 0.0667
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.001 0.0009
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0037 0.0041
Onchocerca volvulus 0.0129 0.0644 0.113
Brugia malayi hypothetical protein 0.0129 0.0644 0.1144
Onchocerca volvulus 0.0048 0.0185 0.0312
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0104 0.0117
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.1081 0.2938
Loa Loa (eye worm) inositol-1 0.0043 0.0157 0.0278
Brugia malayi hypothetical protein 0.1011 0.562 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0117 0.0317
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0047 0.0128
Onchocerca volvulus 0.0065 0.0281 0.0483
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0145 0.0164
Trypanosoma brucei GMP synthase [glutamine-hydrolysing] 0.0038 0.013 0.0247
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0329 0.0373
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0032 0.0086
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0079 0.0362 0.041
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0032 0.0086
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0081 0.0152
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.0015 0.0014
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.2424 0.462
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0464 0.0463
Loa Loa (eye worm) hypothetical protein 0.0445 0.2424 0.4313
Plasmodium falciparum metacaspase-like protein 0.002 0.0032 0.0047
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0151 0.0551
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.1022 0.2776
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0266 0.1417 0.52
Trypanosoma brucei NAD+ synthase, putative 0.0095 0.0452 0.086
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0024 0.0026
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0088 0.0413 0.3671
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0024 0.0026
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0071 0.0269
Brugia malayi Cytochrome P450 family protein 0.0056 0.0229 0.0407
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0145 0.0144
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.0475 0.2597 0.9534
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0071 0.0124
Brugia malayi jmjC domain containing protein 0.0036 0.0118 0.0209
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0054 0.0146
Echinococcus granulosus lipoxygenase domain containing protein 0.0065 0.0281 0.0318
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0041
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.083 0.158
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0145 0.0257
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0145 0.0164
Echinococcus multilocularis caspase 2 0.0068 0.03 0.03
Leishmania major cathepsin L-like protease 0.0036 0.0117 0.0221
Brugia malayi Cathepsin L-like precursor 0.0036 0.0117 0.0206
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0071 0.0257
Leishmania major mitochondrial DNA polymerase beta 0.0945 0.5246 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0145 0.0164
Schistosoma mansoni jumonji domain containing protein 0.0134 0.0674 0.0764
Brugia malayi prostaglandin transporter 0.0129 0.0644 0.1144
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0329 0.0373
Onchocerca volvulus 0.0088 0.0413 0.0718
Brugia malayi hypothetical protein 0.0048 0.0185 0.0328
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0032 0.0086
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0572 0.1555
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0036 0.0063
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0157 0.0298
Mycobacterium tuberculosis Conserved protein 0.0042 0.0151 0.0551
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0667 0.368 1
Echinococcus multilocularis transcription factor btf3 0.004 0.0144 0.0143
Plasmodium vivax glutamine-dependent NAD(+) synthetase, putative 0.0095 0.0452 0.3999
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0032 0.0113
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.0054 0.0146
Trichomonas vaginalis abcb9, putative 0.0024 0.0054 0.0146
Trypanosoma cruzi NAD+ synthase, putative 0.0095 0.0452 0.086
Echinococcus granulosus Polycystic kidney disease protein 0.0065 0.0281 0.0318
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0118 0.0584 0.0584
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0118 0.0209
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0071 0.0124
Trypanosoma brucei transcription factor BTF3, putative 0.004 0.0144 0.0273
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0116 0.0572 0.1089
Brugia malayi MH2 domain containing protein 0.0134 0.0675 0.1199
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0151 0.0171
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0019 0.0035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0024 0.0026
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0017 0.0011 0.0011
Leishmania major metacaspase, putative 0.002 0.0032 0.0059
Trypanosoma cruzi metacaspase, putative 0.002 0.0032 0.0059
Schistosoma mansoni glutaminase 0.0316 0.17 0.193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0464 0.0526
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.002 0.0032 0.0273
Loa Loa (eye worm) hypothetical protein 0.0036 0.0118 0.0209
Schistosoma mansoni nuclear receptor 0.0019 0.0024 0.0026
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0151 0.0267
Loa Loa (eye worm) hypothetical protein 0.0041 0.0145 0.0257
Schistosoma mansoni hypothetical protein 0.0017 0.001 0.001
Entamoeba histolytica hypothetical protein 0.0042 0.0151 0.0359
Schistosoma mansoni hypothetical protein 0.0056 0.0231 0.0261
Onchocerca volvulus 0.0036 0.0119 0.0194
Loa Loa (eye worm) hypothetical protein 0.0088 0.0413 0.0733
Echinococcus multilocularis pol protein 0.1788 1 1
Schistosoma mansoni lipoxygenase 0.0137 0.069 0.0783
Echinococcus granulosus mitogen activated protein kinase 3 0.0116 0.0572 0.0649
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0088 0.0413 0.3671
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.001 0.001
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0024 0.0054 0.0086
Echinococcus multilocularis lipoxygenase domain containing protein 0.0065 0.0281 0.028
Echinococcus multilocularis JmjC domain containing protein 4 0.0036 0.0118 0.0117
Schistosoma mansoni caspase-7 (C14 family) 0.0068 0.03 0.034
Brugia malayi ABC transporter family protein 0.0024 0.0054 0.0094
Brugia malayi hypothetical protein 0.0065 0.0281 0.0498
Onchocerca volvulus 0.0024 0.0054 0.0078
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0584 0.0663
Loa Loa (eye worm) hypothetical protein 0.0068 0.03 0.0533
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.005 0.0056
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0088 0.0413 0.3671
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0134 0.0674 0.0764
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0016
Schistosoma mansoni agrin 0.0088 0.0413 0.0468
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0041
Plasmodium vivax hypothetical protein, conserved 0.002 0.0032 0.0241
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0036 0.0118 0.1044
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0157 0.0574
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0032 0.0086
Mycobacterium ulcerans hypothetical protein 0.0498 0.2724 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0145 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0145 0.0257
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0032 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.068 0.1295
Brugia malayi multidrug resistance protein 3 0.0024 0.0054 0.0094
Schistosoma mansoni retinoic acid receptor RXR 0.0155 0.0788 0.0895
Brugia malayi Cathepsin L-like precursor 0.0036 0.0117 0.0206
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0106 0.0187
Schistosoma mansoni cpg binding protein 0.0066 0.0286 0.0324
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0081 0.0679
Leishmania major cathepsin L-like protease 0.0135 0.068 0.1295
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0151 0.0551
Loa Loa (eye worm) hypothetical protein 0.0274 0.1459 0.2595
Brugia malayi beta-lactamase family protein 0.0042 0.0151 0.0267
Echinococcus granulosus phd:f box containing protein 0.0036 0.0118 0.0133
Schistosoma mansoni mixed-lineage leukemia protein mll 0.014 0.0708 0.0803
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0145 0.0164
Trichomonas vaginalis abcb9, putative 0.0024 0.0054 0.0146
Schistosoma mansoni jumonji/arid domain-containing protein 0.0138 0.0695 0.0788
Leishmania major hypothetical protein, conserved 0.0029 0.0081 0.0152
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0036 0.0117 0.0377
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.0475 0.2597 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0145 0.0144
Schistosoma mansoni organic anion transporter 0.0129 0.0644 0.073
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0464 0.0526
Brugia malayi ecdysone receptor 0.0019 0.0024 0.0041
Echinococcus granulosus nuclear factor of activated T cells 5 0.0085 0.0397 0.045
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0145 0.0164
Entamoeba histolytica hypothetical protein 0.004 0.0144 0.0341
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0667 0.368 1
Brugia malayi hypothetical protein 0.0042 0.0151 0.0267
Echinococcus granulosus agrin 0.0088 0.0413 0.0468
Echinococcus multilocularis Protein lozenge 0.0127 0.0632 0.0631
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.1022 0.2776
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0117 0.0266
Entamoeba histolytica hypothetical protein 0.0042 0.0151 0.0359
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0144 0.0273
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0231 0.0409
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0129 0.0644 0.1144
Echinococcus multilocularis pol protein 0.1788 1 1
Toxoplasma gondii NAC domain-containing protein 0.004 0.0144 0.1277
Echinococcus granulosus bloom syndrome protein 0.0023 0.0047 0.0052
Loa Loa (eye worm) hypothetical protein 0.0129 0.0644 0.1144
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0144 0.0273
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.001 0.001
Echinococcus granulosus netrin receptor unc 5 0.0017 0.001 0.001
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0151 0.0411
Schistosoma mansoni lozenge 0.0127 0.0632 0.0717
Schistosoma mansoni cpg binding protein 0.0069 0.0307 0.0348
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0117 0.0317
Trichomonas vaginalis glucosylceramidase, putative 0.0299 0.1601 0.4351
Brugia malayi Melibiase family protein 0.0079 0.0362 0.0642
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0242 0.1282 0.228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0019 0.0053
Loa Loa (eye worm) hypothetical protein 0.0227 0.1198 0.213
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0032 0.0086
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.0015 0.0016
Echinococcus granulosus cathepsin l1 0.0024 0.005 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.068 0.1295
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0055
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0032 0.0086
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0464 0.0526
Brugia malayi steroid hormone receptor 0.0041 0.0145 0.0257
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0117 0.019
Schistosoma mansoni phosphatidylserine receptor 0.0036 0.0118 0.0133
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0024 0.0026
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0106 0.02
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0145 0.0257
Loa Loa (eye worm) hypothetical protein 0.0129 0.0644 0.1144
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0054 0.0146
Brugia malayi Cathepsin L-like precursor 0.0024 0.005 0.0088
Echinococcus granulosus cathepsin l cysteine peptidase 0.0036 0.0117 0.0131
Echinococcus multilocularis cathepsin L 0.0018 0.0019 0.0019
Loa Loa (eye worm) multidrug resistance protein 3 0.0024 0.0054 0.0094
Schistosoma mansoni hypothetical protein 0.0196 0.1022 0.116
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0024 0.0054 0.0194
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0145 0.0257
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0118 0.0584 0.0584
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0945 0.5246 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0054 0.0146
Loa Loa (eye worm) hypothetical protein 0.0341 0.184 0.3273
Schistosoma mansoni microtubule-associated protein tau 0.1576 0.8803 1
Echinococcus multilocularis survival motor neuron protein 1 0.0274 0.1459 0.1458
Brugia malayi nuclear receptor RXR 0.0021 0.0037 0.0065
Giardia lamblia Kinase, CMGC MAPK 0.0116 0.0572 0.0373
Entamoeba histolytica P-glycoprotein-2, putative 0.0024 0.0054 0.0094
Loa Loa (eye worm) RecQ helicase 0.0023 0.0047 0.0082
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0145 0.0164
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0667 0.368 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.004 0.0139 0.0157
Onchocerca volvulus 0.0129 0.0644 0.113
Echinococcus granulosus caspase 0.002 0.0032 0.0035
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0032 0.0242
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0945 0.5246 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0145 0.0257
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0071 0.0133
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0019 0.0035
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0054 0.0146
Toxoplasma gondii transporter, major facilitator family protein 0.0129 0.0644 0.5727
Echinococcus granulosus survival motor neuron protein 1 0.0274 0.1459 0.1656
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0214 0.1123 1
Onchocerca volvulus Putative organic anion transporter 0.0129 0.0644 0.113
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0116 0.0572 0.1017
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0024 0.0025
Plasmodium vivax vivapain-2 0.0036 0.0117 0.1001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.000000000022264 0.000000000060502
Toxoplasma gondii bifunctional GMP synthase/glutamine amidotransferase protein 0.0038 0.013 0.1154
Onchocerca volvulus 0.0041 0.0145 0.0241
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0464 0.0526
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.005 0.0137
Echinococcus granulosus geminin 0.0196 0.1022 0.116
Onchocerca volvulus 0.0066 0.0286 0.0492
Schistosoma mansoni transcription factor btf3 0.004 0.0144 0.0163
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0329 0.0585
Plasmodium vivax unspecified product 0.0018 0.0019 0.0133
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0024 0.0041
Plasmodium vivax GMP synthetase, putative 0.0038 0.013 0.1124
Schistosoma mansoni survival motor neuron protein 0.0056 0.0231 0.0261
Trichomonas vaginalis glucosylceramidase, putative 0.0299 0.1601 0.4351
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0254 0.1347 0.1346
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0024 0.0023
Toxoplasma gondii ABC1 family protein 0.0042 0.0151 0.1338
Loa Loa (eye worm) fibroinase 0.0036 0.0117 0.0206
Mycobacterium ulcerans hypothetical protein 0.0027 0.0071 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0145 0.0257
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0088 0.0413 0.0733
Brugia malayi Cathepsin L-like precursor 0.0036 0.0117 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0117 0.0317
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0037 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0117 0.0317
Loa Loa (eye worm) hypothetical protein 0.0036 0.0118 0.0209
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.068 0.1295
Mycobacterium leprae Probable lipase LipE 0.0042 0.0151 0.0578
Onchocerca volvulus 0.0056 0.0231 0.0394
Echinococcus multilocularis RUN 0.0065 0.0281 0.028
Mycobacterium ulcerans beta-lactamase 0.0042 0.0151 0.0551
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0145 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0145 0.0257
Toxoplasma gondii glutamine-dependent NAD(+) synthetase protein, putative 0.0095 0.0452 0.4019
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0036 0.0118 0.1044
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0214 0.1123 0.4123
Echinococcus granulosus lipoxygenase domain containing protein 0.0065 0.0281 0.0318
Trypanosoma brucei RNA helicase, putative 0.0112 0.0548 0.1043
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0015 0.0016
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0041
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0055
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0088 0.0413 0.0733
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0214 0.1123 1
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0054 0.0146
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0151 0.017
Brugia malayi hypothetical protein 0.0021 0.0037 0.0065
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.2424 0.462
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0299 0.1601 0.2848
Schistosoma mansoni hypothetical protein 0.0196 0.1022 0.116
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0024 0.0041
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0088 0.0413 0.0733
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0116 0.0572 0.5091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0119 0.0134
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0031 0.0045
Brugia malayi beta-lactamase 0.0042 0.0151 0.0267
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0117 0.0317
Brugia malayi hypothetical protein 0.0274 0.1459 0.2595
Leishmania major cathepsin L-like protease 0.0036 0.0117 0.0221
Toxoplasma gondii melibiase subfamily protein 0.0118 0.0584 0.5198
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0157 0.0156
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0032 0.0086
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0214 0.1123 0.4324
Brugia malayi Cathepsin L-like precursor 0.0036 0.0117 0.0206
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0117 0.0116
Brugia malayi sodium-independent organic anion transporter family protein 0.0129 0.0644 0.1144
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0025 0.009
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.000000000022264 0.000000000060502
Toxoplasma gondii Alpha-galactosidase 0.0017 0.0011 0.0088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0464 0.0526
Leishmania major cathepsin L-like protease 0.0036 0.0117 0.0221
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0019 0.0035
Echinococcus granulosus mitogen activated protein kinase 0.0116 0.0572 0.0649
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0145 0.0144
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0019 0.0021
Brugia malayi SPARC precursor 0.0088 0.0413 0.0733
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.2424 0.462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.068 0.1295
Brugia malayi hypothetical protein 0.0021 0.0037 0.0065
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.001 0.0009
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0054 0.0053
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0157 0.0298
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0032 0.0113
Loa Loa (eye worm) hypothetical protein 0.0027 0.0071 0.0124
Plasmodium vivax multidrug resistance protein 1, putative 0.0024 0.0054 0.0439
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0024 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0667 0.368 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0116 0.0572 0.1089
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0032 0.0086
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0017 0.0012 0.0033
Loa Loa (eye worm) beta-lactamase 0.0042 0.0151 0.0267
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0214 0.1123 0.4256
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0019 0.0053
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.000000000022264 0.000000000060502
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0329 0.0373
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0145 0.0257
Brugia malayi beta-NAC-like protein 0.004 0.0144 0.0255
Onchocerca volvulus 0.0042 0.0151 0.0252
Brugia malayi jmjC domain containing protein 0.0036 0.0118 0.0209
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0119 0.1052
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.0675 0.1199
Echinococcus multilocularis geminin 0.0196 0.1022 0.1021
Echinococcus multilocularis dnaJ subfamily B 0.0934 0.5184 0.5183
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0145 0.0164
Trypanosoma brucei protein kinase, putative 0.0116 0.0572 0.1089
Trypanosoma brucei cytochrome P450, putative 0.0034 0.0106 0.02
Loa Loa (eye worm) hypothetical protein 0.0129 0.0644 0.1144
Schistosoma mansoni cpg binding protein 0.0069 0.0307 0.0348
Echinococcus multilocularis muscleblind protein 1 0.0341 0.184 0.1839
Onchocerca volvulus Putative organic anion transporter 0.0129 0.0644 0.113
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0037 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0117 0.0317
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0036 0.0118 0.0223
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0079 0.0362 0.0983
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0145 0.0257
Loa Loa (eye worm) hypothetical protein 0.1011 0.562 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0281 0.0498
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.0475 0.2597 1
Loa Loa (eye worm) ICD-1 protein 0.004 0.0144 0.0255
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0157 0.1392
Loa Loa (eye worm) hypothetical protein 0.0042 0.0151 0.0267
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.068 0.1295
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0024 0.0041
Onchocerca volvulus 0.0036 0.0117 0.019
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0088
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0151 0.0286
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0048 0.0185 0.0328
Onchocerca volvulus 0.0065 0.0281 0.0483
Loa Loa (eye worm) histone methyltransferase 0.0022 0.0038 0.0066
Plasmodium vivax SET domain protein, putative 0.0036 0.0119 0.1022
Brugia malayi nuclear receptor NHR-88 0.0041 0.0145 0.0257
Plasmodium falciparum basic transcription factor 3b, putative 0.004 0.0144 0.0484
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0047 0.0082
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0024 0.0041
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0447 0.2439 0.4648
Loa Loa (eye worm) runx1 0.0127 0.0632 0.1123
Plasmodium falciparum glutamine-dependent NAD(+) synthetase, putative 0.0095 0.0452 0.1678
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0024 0.0023
Plasmodium vivax JmjC domain containing protein 0.0036 0.0118 0.1015
Brugia malayi cathepsin L-like precursor 0.0024 0.005 0.0088
Brugia malayi ecdysteroid receptor 0.0041 0.0145 0.0257
Schistosoma mansoni follistatin 0.0088 0.0413 0.0468
Mycobacterium tuberculosis Conserved protein 0.0042 0.0151 0.0551
Loa Loa (eye worm) glutaminase 0.0316 0.17 0.3023
Onchocerca volvulus 0.0036 0.0117 0.019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0019 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0041
Onchocerca volvulus 0.0036 0.0117 0.019
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.0572 0.0649
Echinococcus granulosus caspase 8 0.002 0.0032 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0071 0.0257
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0036 0.0118 0.0223
Echinococcus granulosus lysine specific demethylase 5A 0.0138 0.0695 0.0788
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0054 0.0146
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0133 0.0666 0.1267
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0572 0.1555
Mycobacterium tuberculosis Conserved protein 0.0042 0.0151 0.0551
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0024 0.0054 0.0094
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0145 0.0164
Schistosoma mansoni loxhd1 0.0065 0.0281 0.0318
Plasmodium vivax vivapain-3 0.0018 0.0019 0.0133
Trichomonas vaginalis set domain proteins, putative 0.0275 0.147 0.3994
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0117 0.0317
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0214 0.1123 0.4123
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0157 0.0298
Echinococcus multilocularis GMP synthase (glutamine hydrolyzing) 0.0038 0.013 0.013
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0024 0.0026
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.1022 0.2776
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.0117 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0145 0.0257
Schistosoma mansoni GMP synthetase 0.0038 0.013 0.0147
Plasmodium falciparum metacaspase 1 0.002 0.0032 0.0047
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0071 0.014
Trichomonas vaginalis glucosylceramidase, putative 0.0299 0.1601 0.4351
Brugia malayi hypothetical protein 0.0129 0.0644 0.1144
Echinococcus multilocularis agrin 0.0088 0.0413 0.0412
Toxoplasma gondii cathepsin CPL 0.0036 0.0117 0.1031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0036
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0019 0.0021
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0447 0.2439 0.4648
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0024 0.0026
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0151 0.015
Leishmania major hypothetical protein, conserved 0.0036 0.0118 0.0223
Echinococcus granulosus dnaJ subfamily B 0.0934 0.5184 0.5888
Plasmodium falciparum multidrug resistance protein 1 0.0024 0.0054 0.0133
Loa Loa (eye worm) hypothetical protein 0.0129 0.0644 0.1144
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0019 0.0021
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0106 0.02
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0019 0.0035
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0054 0.0146
Brugia malayi Cytochrome P450 family protein 0.0034 0.0106 0.0187
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0133 0.0666 0.1267
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0145 0.0164
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.000000000022264 0.000000000060502
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0116 0.0572 0.1089
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0117 0.0206
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0667 0.368 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0945 0.5246 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0025 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0145 0.0257
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0157 0.0298
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0117 0.0317
Loa Loa (eye worm) ctsf protein 0.0036 0.0117 0.0206
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0151 0.0551
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0088 0.0413 0.0733
Brugia malayi nuclear hormone receptor 0.0019 0.0024 0.0041
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0088 0.0413 0.0733
Onchocerca volvulus 0.0036 0.0117 0.019
Schistosoma mansoni hypothetical protein 0.0065 0.0281 0.0318
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0054 0.0146
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.0091
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0157 0.0427
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0054 0.0146
Plasmodium falciparum enoyl-acyl carrier reductase 0.0214 0.1123 0.4283
Loa Loa (eye worm) hypothetical protein 0.0088 0.0413 0.0733
Loa Loa (eye worm) CYP4Cod1 0.0034 0.0106 0.0187
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0151 0.017
Echinococcus granulosus cathepsin L cysteine proteinase 0.0036 0.0117 0.0131
Trypanosoma cruzi metacaspase, putative 0.002 0.0032 0.0059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0041
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.002 0.0032 0.0055
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0071 0.0257
Trypanosoma cruzi NAD+ synthase, putative 0.0095 0.0452 0.086
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0229 0.0407
Onchocerca volvulus 0.0129 0.0644 0.113
Brugia malayi hypothetical protein 0.0029 0.0081 0.0142
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0326 0.1755 0.6756
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0254 0.1347 0.1529
Leishmania major GMP synthase, putative,glutamine amidotransferase, putative 0.0038 0.013 0.0247
Echinococcus granulosus cpg binding protein 0.0069 0.0307 0.0348
Brugia malayi nuclear hormone receptor 0.0041 0.0145 0.0257
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.068 0.1295
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0117 0.0317
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0037 0.0036
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.001 0.0016
Brugia malayi nuclear receptor NHR-67 0.0019 0.0024 0.0041
Loa Loa (eye worm) jmjC domain-containing protein 0.0138 0.0695 0.1235
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0088
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0214 0.1123 0.3961
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0054 0.0146
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0329 0.0373
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0145 0.0257
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0071 0.0133
Brugia malayi MAP kinase sur-1 0.0116 0.0572 0.1017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0117 0.0317
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.1022 0.2776
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.068 0.1295
Schistosoma mansoni phd/f-box containing protein 0.0036 0.0118 0.0133
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0041
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0464 0.0824
Echinococcus granulosus jumonji domain containing 1A 0.0036 0.0118 0.0133
Onchocerca volvulus Cell death protein 3 homolog 0.0068 0.03 0.0518
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0024 0.0026
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0071 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.005 0.0137
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0145 0.0257
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0054 0.0146
Brugia malayi RNA binding protein 0.0073 0.0329 0.0585
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0118 0.0584 0.0663
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0032 0.0086
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.0106 0.0385
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0145 0.0164
Echinococcus multilocularis mitogen activated protein kinase 3 0.0116 0.0572 0.0571
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0054 0.006
Loa Loa (eye worm) hypothetical protein 0.0042 0.0151 0.0267
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.000000000022264 0.000000000060502
Plasmodium falciparum cysteine proteinase falcipain 3 0.0036 0.0117 0.0377
Onchocerca volvulus 0.1011 0.562 1
Trichomonas vaginalis glucosylceramidase, putative 0.0299 0.1601 0.4351
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0151 0.0411
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0117 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0032 0.0086
Echinococcus multilocularis multidrug resistance protein 1 0.0017 0.0012 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0024 0.0023
Entamoeba histolytica P-glycoprotein-5 0.0024 0.0054 0.0094
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0151 0.0286
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0065
Onchocerca volvulus 0.0276 0.147 0.2603
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0018
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0145 0.0164
Brugia malayi CXXC zinc finger family protein 0.0066 0.0286 0.0507
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0117 0.0317
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0004 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0071 0.0257
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0667 0.368 1
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.068 0.1295
Schistosoma mansoni multidrug resistance protein 0.0024 0.0054 0.006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0065
Echinococcus multilocularis mitogen activated protein kinase 0.0116 0.0572 0.0571
Echinococcus multilocularis caspase 0.002 0.0032 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0117 0.0317
Schistosoma mansoni smdr2 0.0024 0.0054 0.006
Entamoeba histolytica hypothetical protein 0.0042 0.0151 0.0359
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0071 0.0257
Schistosoma mansoni hypothetical protein 0.0042 0.0151 0.017
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0037 0.0041
Trypanosoma brucei metacaspase 5, putative 0.002 0.0032 0.0059
Leishmania major NAD synthase, putative 0.0095 0.0452 0.086
Echinococcus granulosus RUN 0.0065 0.0281 0.0318
Plasmodium vivax metacaspase 1, putative 0.002 0.0032 0.0241
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0117 0.0317
Entamoeba histolytica P-glycoprotein-1 0.0024 0.0054 0.0094
Echinococcus multilocularis cysteine protease 0.0036 0.0117 0.0116
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0025 0.009
Echinococcus multilocularis jumonji domain containing 1A 0.0036 0.0118 0.0117
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0054 0.0146
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0151 0.0286
Echinococcus multilocularis phd:f box containing protein 0.0036 0.0118 0.0117
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0157 0.0427
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0054 0.0146
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0032 0.0086
Schistosoma mansoni hypothetical protein 0.0934 0.5184 0.5888
Leishmania major hypothetical protein, conserved 0.0042 0.0151 0.0286
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0032 0.0086
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0015 0.0014
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0081 0.0237
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0157 0.0427
Schistosoma mansoni lipoxygenase 0.0254 0.1347 0.1529
Schistosoma mansoni caspase-3 (C14 family) 0.002 0.0032 0.0035
Trypanosoma cruzi metacaspase, putative 0.002 0.0032 0.0059
Loa Loa (eye worm) hypothetical protein 0.0341 0.184 0.3273
Trichomonas vaginalis glucosylceramidase, putative 0.0299 0.1601 0.4351
Brugia malayi beta-lactamase family protein 0.0042 0.0151 0.0267
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0119 0.0118
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.0142
Echinococcus multilocularis pol protein 0.1788 1 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0116 0.0572 0.1089
Trichomonas vaginalis hypothetical protein 0.0214 0.1123 0.3053
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0024 0.0026
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0145 0.0164
Onchocerca volvulus 0.0042 0.0151 0.0252
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0117 0.0317
Echinococcus granulosus cathepsin l1 0.0036 0.0117 0.0131
Loa Loa (eye worm) hypothetical protein 0.0041 0.0145 0.0257
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0151 0.0267
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0117 0.0317
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0145 0.0241
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0054 0.0146
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0145 0.0257

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 169 nM Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain by scintillation analyzer ChEMBL. 21531141

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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