Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0492 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0492 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0492 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0492 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0492 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0492 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0492 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0492 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0492 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0492 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0492 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0492 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 25 ug ml-1 | Antimicrobial activity against Cryptococcus neoformans ATCC 3235 after 72 to 96 hrs by two fold serial dilution method | ChEMBL. | 21397368 |
MIC (functional) | = 100 ug ml-1 | Antimicrobial activity against Escherichia coli ATCC 26032 after 24 hrs by two fold serial dilution method | ChEMBL. | 21397368 |
MIC (functional) | = 100 ug ml-1 | Antimicrobial activity against Candida albicans ATCC 3430 by two fold serial dilution method | ChEMBL. | 21397368 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.