Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | intermediate filament protein | 0.0027 | 0.1328 | 0.1328 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0108 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.6667 | 0.6667 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.6667 | 0.6667 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0108 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6667 | 0.6156 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6667 | 0.6156 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.1328 | 0.1328 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0029 | 0.1583 | 0.5 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0108 | 1 | 1 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0029 | 0.1583 | 0.5 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0029 | 0.1583 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6667 | 0.6156 |
Brugia malayi | RNA binding protein | 0.0076 | 0.6667 | 0.6667 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0029 | 0.1583 | 0.5 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0108 | 1 | 0.5 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0108 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0.1328 | 0.5 | |
Leishmania major | ATP-dependent phosphofructokinase | 0.0108 | 1 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.6667 | 0.6667 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.6667 | 0.6156 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0108 | 1 | 0.5 |
Brugia malayi | 6-phosphofructokinase | 0.0108 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1328 | 0.1328 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0108 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6667 | 0.6156 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0108 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.1328 | 0.1328 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0029 | 0.1583 | 0.5 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0029 | 0.1583 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.6667 | 0.6667 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1276 | 0.1276 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0108 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.6667 | 0.6156 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0108 | 1 | 1 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0108 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6667 | 0.6156 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0108 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.6667 | 0.6667 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0108 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0108 | 1 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.1328 | 0.5 | |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0029 | 0.1583 | 0.5 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0108 | 1 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0108 | 1 | 1 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0108 | 1 | 1 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0029 | 0.1583 | 0.5 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0108 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0108 | 1 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0108 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.1328 | 0.1328 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0029 | 0.1583 | 0.5 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0029 | 0.1583 | 0.5 |
Loa Loa (eye worm) | phosphofructokinase | 0.0108 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.