Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | AMP deaminase, putative | 0.0056 | 0.1335 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.0172 | 0.5241 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0328 | 0.246 |
Trypanosoma brucei | AMP deaminase, putative | 0.0056 | 0.1335 | 1 |
Treponema pallidum | adenosine deaminase | 0.0172 | 0.5241 | 0.5 |
Onchocerca volvulus | 0.0249 | 0.7851 | 0.752 | |
Entamoeba histolytica | adenosine deaminase, putative | 0.0172 | 0.5241 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0172 | 0.5241 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.0172 | 0.5241 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3354 | 0.3354 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0056 | 0.1335 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1045 | 0.1995 |
Schistosoma mansoni | adenosine deaminase-related | 0.0172 | 0.5241 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.0056 | 0.1335 | 0.2548 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0328 | 0.0627 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0328 | 0.0627 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1045 | 0.1045 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0172 | 0.5241 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0328 | 0.0627 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0172 | 0.5241 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.0172 | 0.5241 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1045 | 0.1995 |
Leishmania major | hypothetical protein, conserved | 0.0056 | 0.1335 | 0.2548 |
Trypanosoma brucei | AMP deaminase, putative | 0.0056 | 0.1335 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0056 | 0.1335 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.0172 | 0.5241 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0328 | 0.0627 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0172 | 0.5241 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3354 | 0.3354 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0328 | 0.0627 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.0056 | 0.1335 | 0.2548 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0056 | 0.1335 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1045 | 0.1995 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0249 | 0.7851 | 0.7851 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1045 | 0.1995 |
Leishmania major | AMP deaminase, putative | 0.0056 | 0.1335 | 0.2548 |
Brugia malayi | adenosine monophosphate deaminase | 0.0056 | 0.1335 | 0.1335 |
Onchocerca volvulus | 0.0313 | 1 | 1 | |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0056 | 0.1335 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1335 | 0.1335 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0172 | 0.5241 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.3617 | 0.3617 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0328 | 0.246 |
Plasmodium vivax | adenosine deaminase, putative | 0.0172 | 0.5241 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0172 | 0.5241 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1045 | 0.1995 |
Plasmodium vivax | adenosine/AMP deaminase, putative | 0.0056 | 0.1335 | 0.2548 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0056 | 0.1335 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1045 | 0.1045 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0056 | 0.1335 | 1 |
Brugia malayi | Pax transcription factor protein 2 | 0.0249 | 0.7851 | 0.7851 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 0.3617 | 0.3617 |
Schistosoma mansoni | adenosine deaminase | 0.0172 | 0.5241 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0172 | 0.5241 | 0.5 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0328 | 0.0328 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0328 | 0.246 |
Echinococcus multilocularis | AMP deaminase 2 | 0.0056 | 0.1335 | 0.2548 |
Trypanosoma brucei | AMP deaminase, putative | 0.0056 | 0.1335 | 1 |
Echinococcus granulosus | AMP deaminase 2 | 0.0056 | 0.1335 | 0.2548 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0017 | 0.0017 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0172 | 0.5241 | 0.4508 |
Schistosoma mansoni | AMP deaminase | 0.0056 | 0.1335 | 0.2548 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0056 | 0.1335 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3354 | 0.3354 |
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.3617 | 0.3617 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0056 | 0.1335 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1045 | 0.1995 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1045 | 0.1995 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0172 | 0.5241 | 0.5241 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.0056 | 0.1335 | 0.2548 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0172 | 0.5241 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3354 | 0.3354 |
Loa Loa (eye worm) | AMP deaminase | 0.0056 | 0.1335 | 0.1335 |
Toxoplasma gondii | AMP deaminase | 0.0056 | 0.1335 | 0.2548 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0328 | 0.0328 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.5241 | 0.5241 |
Plasmodium falciparum | AMP deaminase, putative | 0.0056 | 0.1335 | 0.2548 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.3 nM | Inhibition of human recombinant IKK2 in human PBMC | ChEMBL. | 21236687 |
IC50 (functional) | = 10 nM | Inhibition of LPS-stimulated TNFalpha release in human PBMC | ChEMBL. | 21236687 |
Inhibition (binding) | = 58 % | Displacement of dofetilide from human ERG transfected in HEK293 cells by fluorescence polarization assay | ChEMBL. | 21236687 |
T1/2 (binding) | > 4 hr | Binding affinity to human IKK2 in PBMC assessed as half life by cell-based assay | ChEMBL. | 21236687 |
T1/2 (binding) | = 6 hr | Binding affinity to human recombinant IKK2 assessed as half life | ChEMBL. | 21236687 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21236687 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.