Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Escherichia coli | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Escherichia coli | Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0721 | 1 | 0.5 |
Brugia malayi | thymidylate synthase | 0.051 | 0.6254 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0721 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.051 | 0.6254 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.051 | 0.6254 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.051 | 0.6254 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0721 | 1 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.034 | 0.325 | 0.3053 |
Brugia malayi | Dihydrofolate reductase | 0.034 | 0.325 | 0.3053 |
Loa Loa (eye worm) | thymidylate synthase | 0.051 | 0.6254 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.034 | 0.3244 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.034 | 0.325 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.051 | 0.6254 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.034 | 0.325 | 0.5197 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0721 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.034 | 0.3244 | 0.304 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.034 | 0.325 | 0.3053 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0721 | 1 | 0.5 |
Onchocerca volvulus | 0.051 | 0.6254 | 0.5 | |
Echinococcus granulosus | thymidylate synthase | 0.051 | 0.6254 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.034 | 0.325 | 0.4579 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.034 | 0.325 | 0.002 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.051 | 0.6254 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.034 | 0.325 | 0.4579 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.01 uM | Inhibition of Toxoplasma gondii DHFR by spectrophotometry | ChEMBL. | 21550809 |
IC50 (binding) | = 0.034 uM | Inhibition of human TS assessed as oxidation of tetrahydrofolate to dihydrofolate after 2 to 12 mins by spectrophotometry | ChEMBL. | 21550809 |
IC50 (binding) | = 0.05 uM | Inhibition of Escherichia coli TS assessed as oxidation of tetrahydrofolate to dihydrofolate after 2 to 12 mins by spectrophotometry | ChEMBL. | 21550809 |
IC50 (binding) | = 0.1 uM | Inhibition of human DHFR by spectrophotometry | ChEMBL. | 21550809 |
IC50 (binding) | = 0.17 uM | Inhibition of Toxoplasma gondii TS assessed as oxidation of tetrahydrofolate to dihydrofolate after 2 to 12 mins by spectrophotometry | ChEMBL. | 21550809 |
IC50 (binding) | = 0.4 uM | Inhibition of Escherichia coli DHFR by spectrophotometry | ChEMBL. | 21550809 |
Ratio IC50 (binding) | = 50 | Ratio of premetrexed IC50 to compound IC50 for human TS | ChEMBL. | 21550809 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.