Detailed information for compound 155948

Basic information

Technical information
  • TDR Targets ID: 155948
  • Name: 1-[8-(2-hydroxyethoxy)-4-(2-methylanilino)qui nolin-3-yl]propan-1-one
  • MW: 350.411 | Formula: C21H22N2O3
  • H donors: 2 H acceptors: 3 LogP: 4.09 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCOc1cccc2c1ncc(c2Nc1ccccc1C)C(=O)CC
  • InChi: 1S/C21H22N2O3/c1-3-18(25)16-13-22-21-15(8-6-10-19(21)26-12-11-24)20(16)23-17-9-5-4-7-14(17)2/h4-10,13,24H,3,11-12H2,1-2H3,(H,22,23)
  • InChiKey: RTWAELYJYRTBLQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[8-(2-hydroxyethoxy)-4-(2-methylanilino)-3-quinolyl]propan-1-one
  • 1-[8-(2-hydroxyethoxy)-4-(2-methylanilino)-3-quinolyl]-1-propanone
  • 1-[8-(2-hydroxyethoxy)-4-[(2-methylphenyl)amino]quinolin-3-yl]propan-1-one
  • 1-[8-(2-hydroxyethoxy)-4-(o-toluidino)-3-quinolyl]propan-1-one
  • 1-[8-(2-hydroxyethoxy)-4-[(2-methylphenyl)amino]-3-quinolyl]propan-1-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Potassium-transporting ATPase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Potassium-transporting ATPase   290 aa 306 aa 26.1 %
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Potassium-transporting ATPase   290 aa 254 aa 23.6 %
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta, putative Potassium-transporting ATPase   290 aa 256 aa 25.4 %
Echinococcus multilocularis nervana 2 Potassium-transporting ATPase   290 aa 265 aa 22.3 %
Loa Loa (eye worm) hypothetical protein Potassium-transporting ATPase   290 aa 301 aa 25.9 %
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 266 aa 25.6 %
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 267 aa 27.3 %
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Potassium-transporting ATPase   290 aa 267 aa 21.3 %
Echinococcus multilocularis nervana 2 Potassium-transporting ATPase   290 aa 280 aa 29.6 %
Drosophila melanogaster nervana 1 Potassium-transporting ATPase   290 aa 305 aa 23.9 %
Schistosoma japonicum ko:K01540 Na+/K+-exchanging ATPase beta subunit [EC3.6.3.9B], putative Potassium-transporting ATPase   290 aa 258 aa 23.6 %
Onchocerca volvulus Glutamate carboxypeptidase 2 homolog Potassium-transporting ATPase   290 aa 301 aa 25.9 %
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Potassium-transporting ATPase   290 aa 258 aa 24.4 %
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 267 aa 27.3 %
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 266 aa 24.1 %
Echinococcus granulosus nervana 2 Potassium-transporting ATPase   290 aa 280 aa 29.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi protein kinase C II. 0.0063 0.0455 0.0582
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0041 0.0193 0.0246
Plasmodium falciparum cGMP-dependent protein kinase 0.0061 0.0424 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.085 0.2571
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0511 0.0654
Treponema pallidum catabolite gene activator 0.006 0.0412 0.5
Echinococcus granulosus g protein coupled receptor 0.0113 0.1033 0.1321
Echinococcus multilocularis transient receptor potential cation channel 0.0041 0.0193 0.0246
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0041 0.0193 0.0193
Schistosoma mansoni hypothetical protein 0.0113 0.1033 0.1033
Brugia malayi Nuclear hormone receptor family member nhr-19 0.031 0.3305 0.4226
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Onchocerca volvulus 0.006 0.0412 0.1247
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0193 0.0193
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.07 0.7821 1
Schistosoma mansoni nuclear hormone receptor 0.0146 0.1412 0.1412
Brugia malayi nuclear receptor NHR-88 0.031 0.3305 0.4226
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.006 0.0412 0.0527
Onchocerca volvulus 0.0146 0.1412 0.4272
Echinococcus granulosus cyclic nucleotide gated cation channel 0.01 0.0883 0.1129
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Echinococcus granulosus carboxylesterase 5A 0.0068 0.0511 0.0654
Trichomonas vaginalis adenylate cyclase, putative 0.0041 0.0202 0.0212
Brugia malayi hypothetical protein 0.0113 0.1033 0.1321
Schistosoma mansoni voltage-gated potassium channel 0.0142 0.1364 0.1364
Onchocerca volvulus 0.0029 0.0058 0.0175
Echinococcus granulosus rhodopsin orphan GPCR 0.0113 0.1033 0.1321
Brugia malayi Nuclear hormone receptor family member nhr-25 0.031 0.3305 0.4226
Onchocerca volvulus 0.0041 0.0193 0.0583
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0041 0.0202 0.0212
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.006 0.0412 0.0412
Echinococcus granulosus fatty acid amide hydrolase 1 0.0102 0.0899 0.1149
Echinococcus granulosus sodium leak channel non selective protein 0.0041 0.0193 0.0246
Echinococcus multilocularis protein patched 0.0288 0.3056 0.3908
Loa Loa (eye worm) voltage-gated potassium channel 0.0041 0.0193 0.0246
Brugia malayi hypothetical protein 0.0113 0.1033 0.1321
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0113 0.1033 0.1321
Brugia malayi Nuclear hormone receptor E75 0.0146 0.1412 0.1806
Echinococcus granulosus alpha 1A adrenergic receptor 0.0113 0.1033 0.1321
Loa Loa (eye worm) hypothetical protein 0.0146 0.1412 0.1806
Trypanosoma brucei protein kinase A regulatory subunit 0.006 0.0412 0.0381
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0246
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0246
Brugia malayi ecdysone receptor 0.0146 0.1412 0.1806
Brugia malayi Protein kinase domain containing protein 0.0034 0.0119 0.0152
Schistosoma mansoni hypothetical protein 0.006 0.0412 0.0412
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0041 0.0202 0.0212
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0041 0.0193 0.0246
Echinococcus multilocularis ecdysone induced protein 78C 0.031 0.3305 0.4226
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0041 0.0202 0.0212
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0012 0.0012
Brugia malayi tailless protein 0.0146 0.1412 0.1806
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0328 0.3521 0.7588
Schistosoma mansoni amine GPCR 0.0113 0.1033 0.1033
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0295 0.3139 0.3139
Echinococcus multilocularis rhodopsin orphan GPCR 0.0113 0.1033 0.1321
Brugia malayi Carboxylesterase family protein 0.0068 0.0511 0.0654
Loa Loa (eye worm) hypothetical protein 0.0164 0.1615 0.2065
Onchocerca volvulus 0.006 0.0412 0.1247
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0113 0.1033 0.1321
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.085 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0142 0.1364 0.1744
Loa Loa (eye worm) hypothetical protein 0.0068 0.0511 0.0654
Echinococcus multilocularis calcium activated potassium channel 0.0042 0.0205 0.0262
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.031 0.3305 0.4226
Brugia malayi Nuclear hormone receptor-like 1 0.031 0.3305 0.4226
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.1142 0.146
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.006 0.0412 0.0679
Brugia malayi hypothetical protein 0.0113 0.1033 0.1321
Loa Loa (eye worm) hypothetical protein 0.0295 0.3139 0.4014
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0288 0.3056 0.3908
Echinococcus granulosus hypothetical protein 0.0041 0.0193 0.0246
Brugia malayi MH2 domain containing protein 0.0123 0.1142 0.146
Trichomonas vaginalis adenylate cyclase type vIII, putative 0.0041 0.0202 0.0212
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0041 0.0193 0.0246
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0193 0.0193
Echinococcus granulosus 7TM GPCR rhodopsin 0.0113 0.1033 0.1321
Mycobacterium leprae Conserved hypothetical protein 0.006 0.0412 1
Echinococcus granulosus RNA directed DNA polymerase 0.0157 0.1537 0.1965
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0041 0.0193 0.0246
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0193 0.0193
Echinococcus multilocularis potassium voltage gated channel protein 0.0041 0.0193 0.0246
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0424 0.0424
Leishmania major protein kinase, putative 0.0061 0.0424 0.0304
Giardia lamblia Kinase, PLK 0.0097 0.085 0.2055
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0113 0.1033 0.1321
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Trichomonas vaginalis hypothetical protein 0.0041 0.0202 0.0212
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0041 0.0193 0.0193
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0424 0.0424
Loa Loa (eye worm) melatonin receptor type 1A 0.0113 0.1033 0.1321
Schistosoma mansoni alpha-1 adrenergic receptor 0.0113 0.1033 0.1033
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0113 0.1033 0.1321
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.006 0.0412 0.0288
Echinococcus granulosus transient receptor potential cation channel 0.0041 0.0193 0.0246
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0026 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0181 0.1815 0.2321
Echinococcus granulosus protein kinase C gamma type 0.0196 0.1992 0.2547
Schistosoma mansoni neuropeptide receptor 0.0113 0.1033 0.1033
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.006 0.0412 0.0527
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0119 0.0119
Brugia malayi C1-like domain containing protein 0.0025 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0295 0.3139 0.4014
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Echinococcus granulosus fmrfamide receptor 0.0113 0.1033 0.1321
Schistosoma mansoni two-pore calcium channel 0.0041 0.0193 0.0193
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.006 0.0412 0.0381
Echinococcus multilocularis neuropeptide FF receptor 2 0.0113 0.1033 0.1321
Trichomonas vaginalis adenylate cyclase, putative 0.0041 0.0202 0.0212
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0026 0.0019 0.0024
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0041 0.0202 0.0212
Onchocerca volvulus 0.0113 0.1033 0.3125
Onchocerca volvulus 0.0113 0.1033 0.3125
Echinococcus multilocularis protein kinase c epsilon type 0.0063 0.0455 0.0582
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0295 0.3139 0.4014
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0463 0.5077 0.6492
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0025 0.0012 0.0016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0113 0.1033 0.1033
Brugia malayi Protein kinase c protein 2 0.0187 0.1885 0.241
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0024
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.006 0.0412 0.0412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0113 0.1033 0.1033
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0043 0.0214 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-3 0.031 0.3305 0.4226
Brugia malayi N-terminal motif family protein 0.006 0.0412 0.0527
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0041 0.0202 0.0212
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0198 0.3957
Echinococcus granulosus cGMP dependent protein kinase 1 0.0061 0.0424 0.0543
Echinococcus granulosus rhodopsin orphan GPCR 0.0113 0.1033 0.1321
Schistosoma mansoni neuropeptide F-like receptor 0.0113 0.1033 0.1033
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0113 0.1033 0.1321
Echinococcus granulosus rhodopsin orphan GPCR 0.0113 0.1033 0.1321
Schistosoma mansoni hypothetical protein 0.0352 0.3797 0.3797
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0102 0.0899 0.1149
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0161 0.1591 0.1591
Echinococcus granulosus neuropeptide receptor A26 0.0113 0.1033 0.1321
Schistosoma mansoni hypothetical protein 0.0113 0.1033 0.1033
Loa Loa (eye worm) TYRA-2 protein 0.0113 0.1033 0.1321
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0146 0.1412 0.1806
Trichomonas vaginalis guanylate cyclase beta 1 subunit, putative 0.0041 0.0202 0.0212
Trichomonas vaginalis adenylate cyclase type, putative 0.0041 0.0202 0.0212
Brugia malayi G protein-coupled receptor 0.0113 0.1033 0.1321
Entamoeba histolytica protein kinase, putative 0.0034 0.0119 0.14
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0511 0.0654
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0146 0.1412 0.4272
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0193 0.0193
Schistosoma mansoni nuclear receptor 0.0146 0.1412 0.1412
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0113 0.1033 0.1033
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0164 0.1615 0.2065
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0041 0.0202 0.0212
Schistosoma mansoni serine/threonine kinase 0.0034 0.0119 0.0119
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0026 0.0019 0.0019
Trichomonas vaginalis adenylate cyclase, putative 0.0041 0.0202 0.0212
Echinococcus multilocularis transient receptor potential cation channel 0.0041 0.0193 0.0246
Echinococcus granulosus tm gpcr rhodopsin 0.0113 0.1033 0.1321
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0041 0.0202 0.0212
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0193 0.3845
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Schistosoma mansoni myosin xvIII 0.0113 0.1033 0.1033
Brugia malayi G-protein coupled receptor 0.0113 0.1033 0.1321
Loa Loa (eye worm) AGC/NDR protein kinase 0.0034 0.0119 0.0152
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0142 0.1364 0.1744
Brugia malayi Steroid receptor seven-up type 2 0.031 0.3305 0.4226
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0024
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Echinococcus granulosus potassium voltage gated channel protein 0.0041 0.0193 0.0246
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0246
Loa Loa (eye worm) AGC/PKG protein kinase 0.0061 0.0424 0.0543
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0113 0.1033 0.1033
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0246
Brugia malayi protein kinase C3,putative 0.0025 0.0012 0.0016
Echinococcus granulosus two pore calcium channel protein 2 0.0041 0.0193 0.0246
Echinococcus granulosus calcium activated potassium channel 0.0042 0.0205 0.0262
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.085 0.0861
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0041 0.0193 0.0246
Echinococcus multilocularis hyperpolarization activated cyclic 0.01 0.0883 0.1129
Onchocerca volvulus 0.0113 0.1033 0.3125
Schistosoma mansoni protein kinase C 0.0029 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.031 0.3305 0.4226
Loa Loa (eye worm) hypothetical protein 0.0034 0.0119 0.0152
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0034 0.0119 0.0152
Onchocerca volvulus 0.0113 0.1033 0.3125
Brugia malayi p70 ribosomal S6 kinase beta 0.0034 0.0119 0.0152
Trypanosoma brucei cAMP binding protein, putative 0.0065 0.047 0.0456
Schistosoma mansoni voltage-gated ion channel 0.0041 0.0193 0.0193
Echinococcus multilocularis rhodopsin orphan GPCR 0.0113 0.1033 0.1321
Brugia malayi hypothetical protein 0.0164 0.1615 0.2065
Leishmania major hypothetical protein, conserved 0.006 0.0412 0.0288
Trichomonas vaginalis adenylate cyclase, putative 0.0041 0.0202 0.0212
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0295 0.3139 0.4014
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0119 0.0027
Loa Loa (eye worm) G-protein coupled receptor 0.0113 0.1033 0.1321
Echinococcus multilocularis allatostatin A receptor 0.0113 0.1033 0.1321
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0025 0.0012 0.0016
Echinococcus granulosus potassium voltage gated channel protein 0.0041 0.0193 0.0246
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0041 0.0193 0.0246
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.006 0.0412 0.0412
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0113 0.1033 0.1321
Mycobacterium tuberculosis Conserved protein 0.006 0.0412 0.5
Loa Loa (eye worm) steroid hormone receptor 0.031 0.3305 0.4226
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.085 0.1651
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0113 0.1033 0.1033
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.07 0.7821 1
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0163 0.1607 0.2055
Loa Loa (eye worm) hypothetical protein 0.0157 0.1537 0.1965
Echinococcus granulosus rhodopsin orphan GPCR 0.0113 0.1033 0.1321
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.01 0.0883 0.0883
Echinococcus multilocularis voltage gated potassium channel 0.0041 0.0193 0.0246
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Echinococcus multilocularis somatostatin receptor 0.0113 0.1033 0.1321
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Brugia malayi nuclear hormone receptor family member nhr-6 0.0146 0.1412 0.1806
Onchocerca volvulus 0.0113 0.1033 0.3125
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0041 0.0193 0.0246
Trichomonas vaginalis adenylate cyclase type III, putative 0.0041 0.0202 0.0212
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0034 0.0119 0.0152
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0164 0.1615 0.1615
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0026 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.031 0.3305 0.4226
Onchocerca volvulus Bile acid receptor homolog 0.031 0.3305 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0026 0.0019 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-14 0.031 0.3305 0.4226
Echinococcus granulosus short transient receptor potential channel 6 0.0041 0.0193 0.0246
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.1342 0.1342
Echinococcus multilocularis neuropeptide receptor A26 0.0113 0.1033 0.1321
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0041 0.0193 0.0246
Echinococcus granulosus neuropeptides capa receptor 0.0113 0.1033 0.1321
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.1142 0.146
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0246
Echinococcus granulosus G protein coupled receptor 139 0.0113 0.1033 0.1321
Echinococcus multilocularis nervana 2 0.0026 0.0019 0.0024
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Loa Loa (eye worm) AGC/AKT protein kinase 0.0034 0.0119 0.0152
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.006 0.0412 0.0412
Echinococcus granulosus retinoic acid receptor rxr beta a 0.031 0.3305 0.4226
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0041 0.0202 0.0212
Schistosoma mansoni protein kinase C mu 0.0025 0.0012 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0146 0.1412 0.1806
Echinococcus granulosus transient receptor potential cation channel 0.0041 0.0193 0.0246
Loa Loa (eye worm) hypothetical protein 0.0146 0.1412 0.1806
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0146 0.1412 0.1806
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0119 0.0027
Brugia malayi cation channel family protein 0.0041 0.0193 0.0246
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0113 0.1033 0.3125
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0034 0.0119 0.0152
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0113 0.1033 0.1033
Loa Loa (eye worm) hypothetical protein 0.031 0.3305 0.4226
Echinococcus multilocularis two pore calcium channel protein 2 0.0041 0.0193 0.0246
Echinococcus granulosus Nuclear hormone receptor HR96 0.0146 0.1412 0.1806
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0113 0.1033 0.1033
Schistosoma mansoni serine/threonine protein kinase 0.022 0.227 0.227
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.031 0.3305 0.4226
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.031 0.3305 0.4226
Echinococcus multilocularis sterol regulatory element binding protein 0.0288 0.3056 0.3908
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0295 0.3139 0.4014
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.031 0.3305 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Schistosoma mansoni histamine h1 receptor 0.0113 0.1033 0.1033
Schistosoma mansoni amine GPCR 0.0113 0.1033 0.1033
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0113 0.1033 0.1321
Echinococcus granulosus nervana 2 0.0026 0.0019 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0113 0.1033 0.1033
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Loa Loa (eye worm) AGC/PKN protein kinase 0.0034 0.0119 0.0152
Toxoplasma gondii hypothetical protein 0.0041 0.0193 0.3845
Echinococcus granulosus nuclear receptor 2DBD gamma 0.031 0.3305 0.4226
Echinococcus granulosus Protein kinase C brain isozyme 0.022 0.227 0.2903
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0288 0.3056 0.3056
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.006 0.0412 0.0527
Echinococcus multilocularis expressed conserved protein 0.0061 0.0424 0.0543
Brugia malayi Nuclear hormone receptor family member nhr-25 0.031 0.3305 0.4226
Schistosoma mansoni voltage-gated cation channel 0.0295 0.3139 0.3139
Echinococcus multilocularis short transient receptor potential channel 6 0.0041 0.0193 0.0246
Echinococcus granulosus rhodopsin orphan GPCR 0.0113 0.1033 0.1321
Schistosoma mansoni biogenic amine (5HT) receptor 0.0113 0.1033 0.1033
Treponema pallidum cyclic nucleotide binding protein 0.006 0.0412 0.5
Brugia malayi Hr1 repeat family protein 0.0034 0.0119 0.0152
Onchocerca volvulus 0.0113 0.1033 0.3125
Echinococcus granulosus biogenic amine 5HT receptor 0.0113 0.1033 0.1321
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0164 0.1615 0.2065
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0041 0.0193 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0202 0.0212
Echinococcus granulosus short transient receptor potential channel 6 0.0041 0.0193 0.0246
Trichomonas vaginalis adenylate cyclase, putative 0.0041 0.0202 0.0212
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.1297 0.1658
Trichomonas vaginalis adenylate cyclase, putative 0.0041 0.0202 0.0212
Echinococcus granulosus single minded 2 0.0041 0.0202 0.0258
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0041 0.0193 0.0246
Onchocerca volvulus 0.0113 0.1033 0.3125
Echinococcus multilocularis G-protein coupled receptor, putative 0.0113 0.1033 0.1321
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0041 0.0193 0.0246
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0146 0.1412 0.4272
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0328 0.3521 0.7588
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.006 0.0412 0.0679
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.006 0.0412 0.5
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.006 0.0412 0.0412
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0198 0.0254
Echinococcus granulosus g protein coupled receptor 0.0113 0.1033 0.1321
Echinococcus multilocularis serotonin receptor 0.0113 0.1033 0.1321
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.1342 0.1717
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0246
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0164 0.1615 0.1615
Echinococcus granulosus serine:threonine protein kinase N2 0.0034 0.0119 0.0152
Toxoplasma gondii transporter, cation channel family protein 0.0041 0.0193 0.3845
Loa Loa (eye worm) nuclear receptor NHR-67 0.0146 0.1412 0.1806
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0295 0.3139 0.4014
Schistosoma mansoni neuropeptide f receptor 76f 0.0113 0.1033 0.1033
Schistosoma mansoni serine/threonine protein kinase 0.022 0.227 0.227
Onchocerca volvulus 0.0113 0.1033 0.3125
Trichomonas vaginalis adenylate cyclase type III, putative 0.0041 0.0202 0.0212
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0041 0.0202 0.0212
Loa Loa (eye worm) neuropeptide F receptor 0.0113 0.1033 0.1321
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0041 0.0193 0.0193
Echinococcus granulosus 7tm_1 domain containing protein 0.0113 0.1033 0.1321
Loa Loa (eye worm) hypothetical protein 0.0067 0.0501 0.0641
Brugia malayi Transient-receptor-potential like protein 0.0041 0.0193 0.0246
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0113 0.1033 0.1321
Schistosoma mansoni hypothetical protein 0.0041 0.0202 0.0202
Echinococcus granulosus nervana 2 0.0026 0.0019 0.0024
Loa Loa (eye worm) hypothetical protein 0.0403 0.4387 0.5609
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0246
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.085 0.085
Echinococcus multilocularis potassium voltage gated channel protein 0.0041 0.0193 0.0246
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0102 0.0899 0.1149
Echinococcus granulosus acetylcholinesterase 0.0068 0.0511 0.0654
Echinococcus multilocularis Protein kinase C, brain isozyme 0.022 0.227 0.2903
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0527
Schistosoma mansoni opsin-like receptor 0.0113 0.1033 0.1033
Brugia malayi GnHR receptor homolog 0.0113 0.1033 0.1321
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0113 0.1033 0.1321
Brugia malayi hypothetical protein 0.0113 0.1033 0.1321
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.006 0.0412 0.1247
Loa Loa (eye worm) hypothetical protein 0.0027 0.003 0.0039
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.006 0.0412 0.0527
Brugia malayi hypothetical protein 0.0146 0.1412 0.1806
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0386 0.4195 0.4195
Echinococcus granulosus potassium large conductance calcium activated 0.0041 0.0193 0.0246
Schistosoma mansoni voltage-gated potassium channel 0.0142 0.1364 0.1364
Echinococcus multilocularis ryanodine receptor 44f 0.0041 0.0193 0.0246
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0113 0.1033 0.1321
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Echinococcus multilocularis transfer RNA-Gly 0.0041 0.0193 0.0246
Echinococcus granulosus hypothetical protein 0.0113 0.1033 0.1321
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0202 0.0212
Brugia malayi larval opioid receptor 0.0113 0.1033 0.1321
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0029 0.0058 0.0074
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0113 0.1033 0.1321
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0198 0.0204
Brugia malayi nuclear hormone receptor 0.0146 0.1412 0.1806
Brugia malayi Cyclic-nucleotide gated cation channel 0.01 0.0883 0.1129
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0113 0.1033 0.1321
Echinococcus granulosus hyperpolarization activated cyclic 0.01 0.0883 0.1129
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0202 0.0212
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0041 0.0193 0.0193
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.085 0.1651
Echinococcus granulosus orexin receptor type 2 0.0113 0.1033 0.1321
Onchocerca volvulus 0.031 0.3305 1
Schistosoma mansoni transmemberane protein 0.0026 0.0019 0.0019
Toxoplasma gondii hypothetical protein 0.0041 0.0193 0.3845
Echinococcus granulosus protein kinase c iota type 0.0058 0.0397 0.0508
Echinococcus granulosus cyclic nucleotide gated cation channel 0.01 0.0883 0.1129
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0025 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0034 0.0119 0.0152
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0113 0.1033 0.1033
Echinococcus granulosus Nuclear hormone receptor HR96 0.0146 0.1412 0.1806
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0025 0.0012 0.0016
Schistosoma mansoni transient receptor potential channel 0.0041 0.0193 0.0193
Echinococcus multilocularis two pore calcium channel protein 1 0.0041 0.0193 0.0246
Brugia malayi cation channel family protein 0.0041 0.0193 0.0246
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0113 0.1033 0.1321
Brugia malayi putative neuropeptide receptor NPR1 0.0113 0.1033 0.1321
Schistosoma mansoni amidase 0.0102 0.0899 0.0899
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.031 0.3305 0.4226
Onchocerca volvulus 0.0113 0.1033 0.3125
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0246
Echinococcus multilocularis transient receptor potential cation channel 0.0041 0.0193 0.0246
Loa Loa (eye worm) hypothetical protein 0.07 0.7821 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.01 0.0883 0.1129
Echinococcus multilocularis sodium channel protein 0.0098 0.0861 0.1101
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0146 0.1412 0.1806
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Echinococcus multilocularis orexin receptor type 2 0.0113 0.1033 0.1321
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0119 0.0119
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0284 0.0395
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.031 0.3305 0.4226
Schistosoma mansoni similar to Protein C20orf152 homolog 0.006 0.0412 0.0412
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0041 0.0193 0.0193
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0113 0.1033 0.1033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0113 0.1033 0.1321
Leishmania major protein kinase, putative 0.0061 0.0424 0.0304
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0041 0.0202 0.0212
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0246
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0041 0.0193 0.0246
Echinococcus granulosus potassium voltage gated channel protein 0.0041 0.0193 0.0246
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0041 0.0193 0.0246
Brugia malayi Nuclear hormone receptor-like 1 0.0164 0.1615 0.2065
Echinococcus granulosus sex peptide receptor 0.0113 0.1033 0.1321
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0113 0.1033 0.1033
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.006 0.0412 0.0527
Onchocerca volvulus 0.0146 0.1412 0.4272
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0198 0.3957
Schistosoma mansoni kinase 0.005 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0246
Mycobacterium tuberculosis Conserved hypothetical protein 0.006 0.0412 0.5
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.006 0.0412 0.8223
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0455 0.0455
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0119 0.0027
Trichomonas vaginalis adenylate cyclase type, putative 0.0041 0.0202 0.0212
Brugia malayi sulfakinin receptor protein 0.0113 0.1033 0.1321
Loa Loa (eye worm) hypothetical protein 0.0146 0.1412 0.1806
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.085 0.1086
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.01 0.0883 0.1129
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0113 0.1033 0.1033
Brugia malayi Nuclear hormone receptor family member nhr-31 0.031 0.3305 0.4226
Echinococcus multilocularis carboxylesterase 5A 0.0068 0.0511 0.0654
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.01 0.0883 0.0883
Echinococcus multilocularis dro:myosuppressin receptor 0.0113 0.1033 0.1321
Echinococcus granulosus geminin 0.0352 0.3797 0.4855
Onchocerca volvulus 0.0113 0.1033 0.3125
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0202 0.0212
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0119 0.0027
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.085 0.0861
Echinococcus multilocularis g-protein coupled receptor 0.0113 0.1033 0.1321
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0119 0.0152
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Loa Loa (eye worm) hypothetical protein 0.0164 0.1615 0.2065
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.031 0.3305 0.4226
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0113 0.1033 0.1321
Schistosoma mansoni coup transcription factor 0.031 0.3305 0.3305
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0159 0.1867
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Trypanosoma cruzi Flagellar Member 6 0.006 0.0412 0.0288
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.01 0.0883 0.1726
Echinococcus granulosus voltage dependent calcium channel 0.0295 0.3139 0.4014
Trichomonas vaginalis adenylate cyclase, putative 0.0041 0.0202 0.0212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0113 0.1033 0.1033
Echinococcus multilocularis sodium leak channel non selective protein 0.0041 0.0193 0.0246
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Onchocerca volvulus 0.0113 0.1033 0.3125
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0146 0.1412 0.1806
Loa Loa (eye worm) hypothetical protein 0.0164 0.1615 0.2065
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.006 0.0412 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.01 0.0883 0.1726
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0202 0.0212
Loa Loa (eye worm) ion channel NompC 0.0041 0.0193 0.0246
Trypanosoma cruzi protein kinase A regulatory subunit 0.006 0.0412 0.0288
Mycobacterium tuberculosis Conserved hypothetical protein 0.006 0.0412 0.5
Loa Loa (eye worm) hypothetical protein 0.0146 0.1412 0.1806
Echinococcus multilocularis neuropeptides capa receptor 0.0113 0.1033 0.1321
Onchocerca volvulus 0.0113 0.1033 0.3125
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Trichomonas vaginalis adenylate cyclase type, putative 0.0041 0.0202 0.0212
Schistosoma mansoni amine GPCR 0.0113 0.1033 0.1033
Echinococcus multilocularis neuropeptide Y receptor 0.0113 0.1033 0.1321
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0041 0.0193 0.0096
Brugia malayi nuclear receptor NHR-88 0.0146 0.1412 0.1806
Echinococcus multilocularis rhodopsin orphan GPCR 0.0113 0.1033 0.1321
Echinococcus multilocularis shaker cognate 0.0041 0.0193 0.0246
Brugia malayi nuclear hormone receptor 0.031 0.3305 0.4226
Schistosoma mansoni transient receptor potential channel 0.0041 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Echinococcus multilocularis fmrfamide receptor 0.0113 0.1033 0.1321
Schistosoma mansoni ryanodine receptor related 0.0041 0.0193 0.0193
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.031 0.3305 0.4226
Echinococcus multilocularis serine:threonine protein kinase 38 0.0034 0.0119 0.0152
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0412 0.0288
Onchocerca volvulus 0.0026 0.0019 0.0056
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.006 0.0412 0.8223
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0041 0.0193 0.0246
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.01 0.0883 0.0883
Echinococcus multilocularis hyperpolarization activated cyclic 0.01 0.0883 0.1129
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0527
Echinococcus multilocularis nervana 2 0.0026 0.0019 0.0024
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.006 0.0412 0.8223
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0041 0.0202 0.0258
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.07 0.7821 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.085 0.1651
Brugia malayi hypothetical protein 0.0113 0.1033 0.1321
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0246
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0113 0.1033 0.1321
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0063 0.0455 0.0582
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.031 0.3305 0.4226
Entamoeba histolytica protein kinase, putative 0.0034 0.0119 0.14
Leishmania major hypothetical protein, conserved 0.006 0.0412 0.0288
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0463 0.5077 0.6492
Loa Loa (eye worm) hypothetical protein 0.0146 0.1412 0.1806
Brugia malayi Protein kinase domain containing protein 0.0025 0.0012 0.0016
Echinococcus multilocularis transient receptor potential gamma protein 0.0041 0.0193 0.0246
Loa Loa (eye worm) voltage-gated calcium channel 0.0041 0.0193 0.0246
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.01 0.0883 0.0883
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.006 0.0412 0.0412
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0295 0.3139 0.4014
Echinococcus granulosus transient receptor potential cation channel 0.0041 0.0193 0.0246
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0025 0.0012 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0412 0.0679
Echinococcus multilocularis rhodopsin orphan GPCR 0.0113 0.1033 0.1321
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0157 0.1537 0.1965
Echinococcus granulosus g-protein coupled receptor 0.0113 0.1033 0.1321
Treponema pallidum cyclic nucleotide binding protein 0.006 0.0412 0.5
Trichomonas vaginalis adenylate cyclase, putative 0.0041 0.0202 0.0212
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0119 0.0027
Loa Loa (eye worm) hypothetical protein 0.031 0.3305 0.4226
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.085 0.1086
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0422 0.4606 1
Schistosoma mansoni voltage-gated potassium channel 0.0504 0.5558 0.5558
Brugia malayi nuclear receptor NHR-67 0.0146 0.1412 0.1806
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0026 0.0019 0.0024
Brugia malayi hypothetical protein 0.0113 0.1033 0.1321
Echinococcus multilocularis fmrfamide receptor 0.0113 0.1033 0.1321
Trichomonas vaginalis guanylate cyclase beta 2 subunit, putative 0.0041 0.0202 0.0212
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0026 0.0019 0.0019
Brugia malayi Protein kinase domain containing protein 0.0034 0.0119 0.0152
Schistosoma mansoni transient receptor potential channel 4 0.0041 0.0193 0.0193
Toxoplasma gondii hypothetical protein 0.0027 0.003 0.0605
Schistosoma mansoni amine GPCR 0.0113 0.1033 0.1033
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.006 0.0412 0.8223
Brugia malayi hypothetical protein 0.0164 0.1615 0.2065
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0113 0.1033 0.1321
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0193 0.0193
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0113 0.1033 0.1321
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0246
Loa Loa (eye worm) hypothetical protein 0.0068 0.0511 0.0654
Loa Loa (eye worm) voltage-dependent calcium channel 0.0067 0.0501 0.0641
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0113 0.1033 0.1321
Trypanosoma brucei polo-like protein kinase 0.0097 0.085 0.0949
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Loa Loa (eye worm) G-protein coupled receptor 0.0113 0.1033 0.1321
Loa Loa (eye worm) neuropeptide F receptor 0.0113 0.1033 0.1321
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0202 0.0212
Schistosoma mansoni atypical protein kinase C 0.0058 0.0397 0.0397
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0041 0.0193 0.0246
Brugia malayi neuropeptide F receptor 0.0113 0.1033 0.1321
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0041 0.0193 0.3845
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0041 0.0193 0.0246
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.006 0.0412 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.031 0.3305 0.4226
Echinococcus granulosus neuropeptide Y receptor 0.0113 0.1033 0.1321
Brugia malayi hypothetical protein 0.0113 0.1033 0.1321
Trichomonas vaginalis intestinal guanylate cyclase, putative 0.0041 0.0202 0.0212
Leishmania major cyclic nucleotide-binding protein-like protein 0.006 0.0412 0.0288
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0193 0.0193
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0068 0.0511 0.0511
Brugia malayi CHE-14 protein 0.0288 0.3056 0.3908
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0198 0.0204
Echinococcus granulosus unc 13 munc13 0.0029 0.0058 0.0074
Echinococcus granulosus neuropeptide receptor 0.0113 0.1033 0.1321
Brugia malayi hypothetical protein 0.0113 0.1033 0.1321
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0041 0.0193 0.0246
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Schistosoma mansoni fatty-acid amide hydrolase 0.0102 0.0899 0.0899
Schistosoma mansoni amine GPCR 0.0113 0.1033 0.1033
Echinococcus multilocularis neuropeptide Y receptor 0.0113 0.1033 0.1321
Schistosoma mansoni nuclear hormone receptor 0.031 0.3305 0.3305
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0125 0.117 0.1281
Echinococcus granulosus two pore calcium channel protein 1 0.0041 0.0193 0.0246
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0424 0.0424
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0202 0.0212
Echinococcus granulosus thyroid hormone receptor alpha 0.0146 0.1412 0.1806
Echinococcus multilocularis thyroid hormone receptor alpha 0.031 0.3305 0.4226
Echinococcus multilocularis transient receptor potential cation channel 0.0041 0.0193 0.0246
Echinococcus granulosus neuropeptide FF receptor 2 0.0113 0.1033 0.1321
Schistosoma mansoni biogenic amine receptor 0.0113 0.1033 0.1033
Loa Loa (eye worm) hypothetical protein 0.0102 0.0899 0.1149
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.006 0.0412 0.8223
Echinococcus multilocularis transient receptor potential cation channel 0.0041 0.0193 0.0246
Echinococcus granulosus hyperpolarization activated cyclic 0.01 0.0883 0.1129
Brugia malayi conserved hypotetical protein 0.0146 0.1412 0.1806
Echinococcus multilocularis voltage dependent calcium channel 0.0295 0.3139 0.4014
Loa Loa (eye worm) hypothetical protein 0.0164 0.1615 0.2065
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0041 0.0193 0.0193
Brugia malayi G protein-coupled receptor F59B2.13 0.0113 0.1033 0.1321
Echinococcus granulosus neuropeptides capa receptor 0.0113 0.1033 0.1321
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0113 0.1033 0.1033
Schistosoma mansoni vesicular amine transporter 0.0041 0.0193 0.0193
Echinococcus granulosus ryanodine receptor 44f 0.0041 0.0193 0.0246
Brugia malayi orphan nuclear receptor NR2E1 0.0146 0.1412 0.1806
Echinococcus granulosus protein kinase c epsilon type 0.0063 0.0455 0.0582
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.006 0.0412 0.0527
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.085 0.1086
Brugia malayi Nuclear hormone receptor family member nhr-1 0.031 0.3305 0.4226
Echinococcus granulosus NDR protein kinase 0.0034 0.0119 0.0152
Schistosoma mansoni growth hormone secretagogue receptor 0.0113 0.1033 0.1033
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.01 0.0883 0.0883
Schistosoma mansoni thyroid hormone receptor 0.031 0.3305 0.3305
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.031 0.3305 0.4226
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.01 0.0883 0.1129
Echinococcus granulosus serotonin receptor 0.0113 0.1033 0.1321
Echinococcus granulosus nervana 2 0.0026 0.0019 0.0024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0113 0.1033 0.1321
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0113 0.1033 0.1321
Brugia malayi voltage-dependent calcium channel 0.0041 0.0193 0.0246
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0119 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0284 0.0395
Echinococcus multilocularis geminin 0.0352 0.3797 0.4855
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0041 0.0193 0.0193
Echinococcus granulosus Protein patched homolog 1 0.0288 0.3056 0.3908
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0098 0.0861 0.1101
Loa Loa (eye worm) hypothetical protein 0.0027 0.003 0.0039
Loa Loa (eye worm) nuclear hormone receptor 0.0146 0.1412 0.1806
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0202 0.0212
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0041 0.0202 0.0212
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.031 0.3305 0.4226
Schistosoma mansoni unc-13 (munc13) 0.0029 0.0058 0.0058
Brugia malayi Tachykinin-like peptides receptor 99D 0.0113 0.1033 0.1321
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Brugia malayi Carboxylesterase family protein 0.0068 0.0511 0.0654
Echinococcus multilocularis transient receptor potential cation channel 0.0041 0.0193 0.0246
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0193 0.0193
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0041 0.0202 0.0212
Brugia malayi putative neuropeptide receptor 0.0113 0.1033 0.1321
Brugia malayi follicle stimulating hormone receptor 0.0113 0.1033 0.1321
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0193 0.0193
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0026 0.0019 0.0024
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Toxoplasma gondii transporter, cation channel family protein 0.0067 0.0501 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.01 0.0883 0.1129
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0041 0.0202 0.0212
Brugia malayi hypothetical protein 0.0113 0.1033 0.1321
Echinococcus granulosus voltage gated potassium channel 0.0041 0.0193 0.0246
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0125 0.117 0.1365
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.085 0.1651
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0041 0.0193 0.0246
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.006 0.0412 0.0288
Echinococcus multilocularis g protein coupled receptor 0.0113 0.1033 0.1321
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.006 0.0412 0.0527
Echinococcus granulosus peptide allatostatin:somatostatin 0.0113 0.1033 0.1321
Trichomonas vaginalis adenylate cyclase, putative 0.0041 0.0202 0.0212
Echinococcus granulosus voltage gated hydrogen channel 1 0.0041 0.0193 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-19 0.031 0.3305 0.4226
Loa Loa (eye worm) hypothetical protein 0.031 0.3305 0.4226
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0113 0.1033 0.1321
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0041 0.0202 0.0212
Trichomonas vaginalis adenylate cyclase, putative 0.0041 0.0202 0.0212
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0061 0.0424 0.0543
Leishmania major hypothetical protein, unknown function 0.006 0.0412 0.0288
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Toxoplasma gondii AGC kinase 0.0034 0.0119 0.2372
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0113 0.1033 0.1033
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0422 0.4606 1
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.006 0.0412 0.0381
Echinococcus multilocularis G protein coupled receptor 139 0.0113 0.1033 0.1321
Onchocerca volvulus Protein ultraspiracle homolog 0.031 0.3305 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0113 0.1033 0.1033
Schistosoma mansoni neuropeptide F-like receptor 0.0113 0.1033 0.1033
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.085 0.1651
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.085 0.0861
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.006 0.0412 0.0527
Brugia malayi Serotonin receptor 0.0113 0.1033 0.1321
Schistosoma mansoni hypothetical protein 0.0113 0.1033 0.1033
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0041 0.0193 0.0583
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0113 0.1033 0.1033
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.07 0.7821 1
Echinococcus granulosus ecdysone induced protein 78C 0.031 0.3305 0.4226
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0146 0.1412 0.1806
Schistosoma mansoni neuropeptide receptor 0.0113 0.1033 0.1033
Echinococcus granulosus potassium voltage gated channel protein 0.0041 0.0193 0.0246
Loa Loa (eye worm) hypothetical protein 0.01 0.0883 0.1129
Echinococcus granulosus Niemann Pick C1 protein 0.0288 0.3056 0.3908
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.031 0.3305 0.3305
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.01 0.0883 0.1129
Schistosoma mansoni adenoreceptor 0.0113 0.1033 0.1033
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0041 0.0193 0.0246
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0034 0.0119 0.0152
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0026 0.0019 0.0024
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.006 0.0412 0.5
Echinococcus multilocularis FTZ F1 alpha 0.031 0.3305 0.4226
Loa Loa (eye worm) hypothetical protein 0.0146 0.1412 0.1806
Schistosoma mansoni patched 1 0.0288 0.3056 0.3056
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.006 0.0412 0.0754
Loa Loa (eye worm) hypothetical protein 0.0146 0.1412 0.1806
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0295 0.3139 0.4014
Leishmania major hypothetical protein, conserved 0.0065 0.047 0.0364
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0061 0.0424 0.8465
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0119 0.0027
Echinococcus granulosus voltage gated potassium channel 0.0142 0.1364 0.1744
Loa Loa (eye worm) ryanodine receptor 0.0041 0.0193 0.0246
Echinococcus multilocularis voltage dependent calcium channel 0.0295 0.3139 0.4014
Brugia malayi olfactory channel protein osm-9 0.0041 0.0193 0.0246
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0246
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Echinococcus multilocularis protein kinase c iota type 0.0058 0.0397 0.0508
Schistosoma mansoni biogenic amine (5HT) receptor 0.0113 0.1033 0.1033
Schistosoma mansoni steroid hormone receptor ad4bp 0.031 0.3305 0.3305
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0041 0.0193 0.0246
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.006 0.0412 0.5
Echinococcus multilocularis nuclear receptor nhr 48 0.0146 0.1412 0.1806
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0113 0.1033 0.1033
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0041 0.0193 0.0583
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.006 0.0412 0.0679
Schistosoma mansoni biogenic amine receptor 0.0113 0.1033 0.1033
Echinococcus granulosus g protein coupled receptor 0.0113 0.1033 0.1321
Echinococcus granulosus sodium channel protein 0.0041 0.0193 0.0246
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Brugia malayi ion channel NompC 0.0041 0.0193 0.0246
Echinococcus granulosus tachykinin peptides receptor 99D 0.0113 0.1033 0.1321
Loa Loa (eye worm) hypothetical protein 0.0146 0.1412 0.1806
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0034 0.0119 0.0152
Trypanosoma cruzi cAMP binding protein, putative 0.0065 0.047 0.0364
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0041 0.0202 0.0212
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.031 0.3305 0.4226
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0113 0.1033 0.1033
Echinococcus granulosus transient receptor potential gamma protein 0.0041 0.0193 0.0246
Brugia malayi neuropeptide F receptor 0.0113 0.1033 0.1321
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Echinococcus multilocularis potassium voltage gated channel protein 0.0041 0.0193 0.0246
Brugia malayi Dopamine receptor protein 1 0.0113 0.1033 0.1321
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0193 0.0193
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.07 0.7821 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0026 0.0019 0.0024
Echinococcus granulosus acetylcholinesterase 0.0068 0.0511 0.0654
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0119 0.0119
Brugia malayi nuclear receptor RXR 0.0146 0.1412 0.1806
Echinococcus granulosus neuropeptide Y receptor 0.0113 0.1033 0.1321
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.085 0.1651
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0026 0.0019 0.0024
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0113 0.1033 0.1321
Treponema pallidum catabolite gene activator (Crp) 0.006 0.0412 0.5
Brugia malayi Serotonin receptor 0.0113 0.1033 0.1321
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.031 0.3305 0.3305
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0113 0.1033 0.1033
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0193 0.0193
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0119 0.0152
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0113 0.1033 0.1321
Brugia malayi Nuclear hormone receptor E75 0.0146 0.1412 0.1806
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0113 0.1033 0.1321
Schistosoma mansoni hypothetical protein 0.0113 0.1033 0.1033
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.07 0.7821 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1412 0.1806
Loa Loa (eye worm) carboxylesterase 0.0068 0.0511 0.0654
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0142 0.1364 0.1744
Echinococcus multilocularis neuropeptide receptor 0.0113 0.1033 0.1321
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0041 0.0193 0.0246
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.006 0.0412 0.0679
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0034 0.0119 0.0152
Echinococcus multilocularis Niemann Pick C1 protein 0.0288 0.3056 0.3908
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0041 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.031 0.3305 0.4226
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0113 0.1033 0.1321
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.031 0.3305 0.4226
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0119 0.0027
Loa Loa (eye worm) hypothetical protein 0.031 0.3305 0.4226
Trichomonas vaginalis adenylyl cyclase type V, putative 0.0041 0.0202 0.0212
Trichomonas vaginalis adenylate cyclase, putative 0.0041 0.0202 0.0212
Echinococcus granulosus FTZ F1 alpha 0.031 0.3305 0.4226
Echinococcus multilocularis short transient receptor potential channel 6 0.0041 0.0193 0.0246
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.006 0.0412 0.0412
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0041 0.0193 0.0193
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0119 0.0027
Onchocerca volvulus 0.0113 0.1033 0.3125
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0041 0.0193 0.0246
Brugia malayi nuclear hormone receptor family member odr-7 0.0146 0.1412 0.1806
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Trypanosoma brucei cAMP response protein 1, putative 0.006 0.0412 0.0381
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0041 0.0193 0.0246
Brugia malayi amidase 0.0102 0.0899 0.1149
Schistosoma mansoni hypothetical protein 0.0352 0.3797 0.3797
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0146 0.1412 0.1806
Schistosoma mansoni biogenic amine receptor 0.0113 0.1033 0.1033
Loa Loa (eye worm) hypothetical protein 0.0146 0.1412 0.1806
Brugia malayi hypothetical protein 0.0041 0.0193 0.0246
Schistosoma mansoni Tr4/Tr2 (homologue) 0.031 0.3305 0.3305
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Onchocerca volvulus 0.0113 0.1033 0.3125
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0041 0.0193 0.0246
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0119 0.0119
Trichomonas vaginalis adenylate cyclase, putative 0.0041 0.0202 0.0212
Schistosoma mansoni voltage-gated potassium channel 0.0504 0.5558 0.5558
Echinococcus multilocularis conserved hypothetical protein 0.0041 0.0193 0.0246
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0463 0.5077 0.6492
Brugia malayi hypothetical protein 0.0146 0.1412 0.1806
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.07 0.7821 1
Schistosoma mansoni thyroid hormone receptor 0.031 0.3305 0.3305
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0041 0.0202 0.0212
Schistosoma mansoni nuclear receptor 0.0146 0.1412 0.1412
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0041 0.0193 0.0246
Echinococcus multilocularis potassium voltage gated channel protein 0.0041 0.0193 0.0246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.031 0.3305 0.4226
Echinococcus granulosus somatostatin receptor 0.0113 0.1033 0.1321
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0041 0.0193 0.0246
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0146 0.1412 0.1806
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0041 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0164 0.1615 0.2065
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0193 0.0193
Echinococcus granulosus allatostatin A receptor 0.0113 0.1033 0.1321
Loa Loa (eye worm) acetylcholinesterase 1 0.0068 0.0511 0.0654
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Echinococcus granulosus sterol regulatory element binding protein 0.0288 0.3056 0.3908
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.07 0.7821 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1412 0.1806
Brugia malayi Melatonin receptor type 1A 0.0113 0.1033 0.1321
Echinococcus granulosus cGMP dependent protein kinase 0.0061 0.0424 0.0543
Echinococcus multilocularis potassium large conductance calcium activated 0.0041 0.0193 0.0246
Echinococcus granulosus neuropeptide receptor 0.0113 0.1033 0.1321
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0034 0.0119 0.0152
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Loa Loa (eye worm) hypothetical protein 0.0288 0.3056 0.3908
Schistosoma mansoni calcium-activated potassium channel 0.0041 0.0193 0.0193
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.006 0.0412 0.0412
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0295 0.3139 0.3139
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.031 0.3305 0.4226
Brugia malayi G-protein coupled receptor 0.0113 0.1033 0.1321
Onchocerca volvulus 0.0113 0.1033 0.3125
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Echinococcus granulosus tm gpcr rhodopsin 0.0113 0.1033 0.1321
Leishmania major protein kinase A regulatory subunit, putative 0.006 0.0412 0.0288
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0202 0.0212
Trypanosoma brucei Flagellar Member 6 0.006 0.0412 0.0381
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0034 0.0119 0.0152
Echinococcus multilocularis g protein coupled receptor 0.0113 0.1033 0.1321
Loa Loa (eye worm) voltage-gated potassium channel 0.0041 0.0193 0.0246
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0041 0.0202 0.0212
Echinococcus multilocularis g protein coupled receptor 0.0113 0.1033 0.1321
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0295 0.3139 0.4014
Echinococcus granulosus cGMP dependent protein kinase 1 0.0061 0.0424 0.0543
Schistosoma mansoni opsin-like receptor 0.0113 0.1033 0.1033
Echinococcus multilocularis nervana 2 0.0026 0.0019 0.0024
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0026 0.0019 0.0024
Echinococcus multilocularis serine threonine protein kinase 0.0196 0.1992 0.2547
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.006 0.0412 0.0288
Schistosoma mansoni neuropeptide receptor 0.0113 0.1033 0.1033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0113 0.1033 0.1321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.031 0.3305 0.4226
Loa Loa (eye worm) acetyltransferase 0.014 0.1342 0.1717
Echinococcus granulosus transient receptor potential cation channel 0.0041 0.0193 0.0246
Echinococcus granulosus rhodopsin orphan GPCR 0.0113 0.1033 0.1321
Schistosoma mansoni nuclear hormone receptor 0.0146 0.1412 0.1412
Echinococcus multilocularis serotonin receptor 0.0113 0.1033 0.1321
Schistosoma mansoni neuropeptide receptor 0.0113 0.1033 0.1033
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0113 0.1033 0.1321
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0113 0.1033 0.1321
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0328 0.3521 0.7588
Loa Loa (eye worm) calcium channel 0.0295 0.3139 0.4014
Trypanosoma cruzi cAMP response protein 1 0.006 0.0412 0.0288
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.085 0.1086
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0041 0.0193 0.0246
Echinococcus multilocularis neuropeptide receptor 0.0113 0.1033 0.1321
Brugia malayi photoreceptor-specific nuclear receptor 0.031 0.3305 0.4226
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0146 0.1412 0.1412
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0202 0.0212
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.031 0.3305 0.3305
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.006 0.0412 0.9543
Echinococcus multilocularis neuropeptides capa receptor 0.0113 0.1033 0.1321
Loa Loa (eye worm) hypothetical protein 0.0029 0.0058 0.0074
Echinococcus granulosus voltage dependent calcium channel 0.0067 0.0501 0.0641
Echinococcus granulosus potassium voltage gated channel protein 0.0041 0.0193 0.0246
Echinococcus multilocularis RNA directed DNA polymerase 0.0157 0.1537 0.1965
Echinococcus granulosus transient receptor potential cation channel 0.0041 0.0193 0.0246
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0113 0.1033 0.1321
Echinococcus multilocularis patatin phospholipase domain containing protein 0.006 0.0412 0.0527
Loa Loa (eye worm) hypothetical protein 0.0146 0.1412 0.1806
Schistosoma mansoni 60S ribosomal protein L21 0.0082 0.0673 0.0673
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0146 0.1412 0.1806
Schistosoma mansoni retinoic acid receptor RXR 0.031 0.3305 0.3305
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.085 0.1651
Schistosoma mansoni opsin-like receptor 0.0113 0.1033 0.1033
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0119 0.0027
Schistosoma mansoni transient receptor potential channel 0.0041 0.0193 0.0193
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0328 0.3521 1
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0041 0.0202 0.0212
Trypanosoma cruzi cAMP response protein 1, putative 0.006 0.0412 0.0288
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0246
Schistosoma mansoni voltage-dependent calcium channel 0.0041 0.0193 0.0193
Echinococcus multilocularis unc 13 (munc13) 0.0029 0.0058 0.0074
Echinococcus multilocularis voltage gated potassium channel 0.0142 0.1364 0.1744
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0061 0.0424 0.0543
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0034 0.0119 0.0152
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Entamoeba histolytica protein kinase, putative 0.0034 0.0119 0.14
Brugia malayi Nuclear hormone receptor family member nhr-40 0.031 0.3305 0.4226
Echinococcus multilocularis protein dispatched 1 0.0288 0.3056 0.3908
Trichomonas vaginalis adenylate cyclase, putative 0.0041 0.0202 0.0212
Loa Loa (eye worm) hypothetical protein 0.0146 0.1412 0.1806
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0113 0.1033 0.1321
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0113 0.1033 0.1321
Brugia malayi hypothetical protein 0.0113 0.1033 0.1321
Brugia malayi ecdysteroid receptor 0.031 0.3305 0.4226
Onchocerca volvulus 0.0113 0.1033 0.3125
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0463 0.5077 0.6492
Leishmania major regulatory subunit of protein kinase a-like protein 0.006 0.0412 0.0288
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.006 0.0412 0.0527
Brugia malayi Nuclear hormone receptor-like 1 0.0164 0.1615 0.2065
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0029 0.0058 0.0074
Trichomonas vaginalis adenylate cyclase type VI, putative 0.0041 0.0202 0.0212
Echinococcus granulosus nuclear receptor nhr 48 0.0146 0.1412 0.1806
Brugia malayi RE15519p 0.0113 0.1033 0.1321
Brugia malayi Protein kinase domain containing protein 0.0034 0.0119 0.0152
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.031 0.3305 0.4226
Onchocerca volvulus 0.0026 0.0019 0.0056
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0113 0.1033 0.1033
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0113 0.1033 0.1033
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.006 0.0412 0.0527
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0246
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.006 0.0412 0.0412
Onchocerca volvulus 0.0113 0.1033 0.3125
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.07 0.7821 0.7821
Schistosoma mansoni zinc finger protein 0.0146 0.1412 0.1412
Echinococcus granulosus cyclic nucleotide gated cation channel 0.006 0.0412 0.0527
Brugia malayi steroid hormone receptor 0.031 0.3305 0.4226
Loa Loa (eye worm) hypothetical protein 0.0164 0.1615 0.2065
Schistosoma mansoni nuclear receptor nhr-48 0.0146 0.1412 0.1412
Echinococcus granulosus dro:myosuppressin receptor 0.0113 0.1033 0.1321
Schistosoma mansoni unc-13 (munc13) 0.0029 0.0058 0.0058
Echinococcus granulosus shaker cognate 0.0041 0.0193 0.0246
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.006 0.0412 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.031 0.3305 0.4226
Echinococcus granulosus tm gpcr rhodopsin 0.0113 0.1033 0.1321
Echinococcus granulosus fatty acid amide hydrolase 1 0.0102 0.0899 0.1149
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.01 0.0883 0.1129
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.1342 0.1717
Echinococcus granulosus TRP transient receptor potential channel 0.0041 0.0193 0.0246
Brugia malayi Dopamine receptor 0.0113 0.1033 0.1321
Brugia malayi nuclear receptor RXR 0.0164 0.1615 0.2065
Schistosoma mansoni retinoid-x-receptor (RXR) 0.031 0.3305 0.3305
Loa Loa (eye worm) DR-78 0.0146 0.1412 0.1806
Brugia malayi Dopamine receptor protein 2 0.0113 0.1033 0.1321
Schistosoma mansoni voltage-gated potassium channel 0.0082 0.0673 0.0673
Echinococcus granulosus patatin phospholipase domain containing protein 0.006 0.0412 0.0527
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.031 0.3305 0.4226
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0246
Echinococcus multilocularis nervana 2 0.0026 0.0019 0.0024
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Entamoeba histolytica protein kinase, putative 0.0034 0.0119 0.14
Echinococcus granulosus biogenic amine 5HT receptor 0.0113 0.1033 0.1321
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.031 0.3305 0.3305
Trichomonas vaginalis adenylate cyclase, putative 0.0041 0.0202 0.0212
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0883 0.0883
Echinococcus granulosus rhodopsin orphan GPCR 0.0113 0.1033 0.1321
Brugia malayi ORL1-like opioid receptor 0.0113 0.1033 0.1321
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.006 0.0412 1
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.006 0.0412 0.0527
Trichomonas vaginalis conserved hypothetical protein 0.0288 0.3056 0.6554
Brugia malayi AKH receptor 0.0113 0.1033 0.1321
Echinococcus granulosus nervana 2 0.0026 0.0019 0.0024
Echinococcus granulosus neuropeptide s receptor 0.0113 0.1033 0.1321
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.01 0.0883 0.1129
Onchocerca volvulus Neuropeptide F receptor homolog 0.0113 0.1033 0.3125
Brugia malayi Egg laying defective protein 4 0.0061 0.0424 0.0543
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Toxoplasma gondii transporter, cation channel family protein 0.0041 0.0193 0.3845
Echinococcus granulosus nuclear receptor 2DBD gamma 0.031 0.3305 0.4226
Echinococcus granulosus transient receptor potential cation channel 0.0041 0.0193 0.0246
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0193 0.0193
Schistosoma mansoni RAR-like nuclear receptor 0.031 0.3305 0.3305
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.0246
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Echinococcus multilocularis neuropeptide s receptor 0.0113 0.1033 0.1321
Brugia malayi Nuclear hormone receptor family member nhr-49 0.031 0.3305 0.4226
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0202 0.0212
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.031 0.3305 0.4226
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0113 0.1033 0.1321
Echinococcus multilocularis sex peptide receptor 0.0113 0.1033 0.1321
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0119 0.0027
Loa Loa (eye worm) hypothetical protein 0.0142 0.1364 0.1744
Schistosoma mansoni hypothetical protein 0.0041 0.0193 0.0193
Echinococcus multilocularis rhodopsin orphan GPCR 0.0113 0.1033 0.1321
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.006 0.0412 0.0527
Loa Loa (eye worm) hypothetical protein 0.0113 0.1033 0.1321
Loa Loa (eye worm) hypothetical protein 0.031 0.3305 0.4226

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 1.72 uM kg-1 Inhibition of pentagastrin-stimulated gastric acid secretion in the anesthetized rat after iv administration ChEMBL. 7629813
ED50 (functional) = 1.72 uM kg-1 Inhibition of pentagastrin-stimulated gastric acid secretion in the anesthetized rat after iv administration ChEMBL. 7629813
IC50 (binding) = 0.76 uM Inhibition of K+ -stimulated gastric ATPase activity was measured using lyophilized gastric vesicles at pH 7 ChEMBL. 7629813
IC50 (binding) = 0.76 uM Inhibition of K+ -stimulated gastric ATPase activity was measured using lyophilized gastric vesicles at pH 7 ChEMBL. 7629813
Inhibition (functional) = 82 % Mean percent peak inhibition of histamine-stimulated gastric acid secretion in the heidenhain pouch dog following a single dose of 1 umol/kg through iv administration. ChEMBL. 7629813
Inhibition (functional) = 82 % Mean percent peak inhibition of histamine-stimulated gastric acid secretion in the heidenhain pouch dog following a single dose of 4 umol/kg through oral administration. ChEMBL. 7629813

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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