Detailed information for compound 155951

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 967.148 | Formula: C44H66N14O9S
  • H donors: 11 H acceptors: 10 LogP: -1.45 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 3
  • SMILES: CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H]2N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)Cc1nc[nH]c1)Cc1ccccc1)CCCN=C(N)N)CCSC2)C(=O)N)NC(=O)C
  • InChi: 1S/C44H66N14O9S/c1-3-4-13-30(52-26(2)59)38(62)57-34-22-36(60)49-16-9-8-14-29(37(45)61)53-42(66)35-24-68-19-18-58(35)43(67)31(15-10-17-50-44(46)47)54-39(63)32(20-27-11-6-5-7-12-27)55-40(64)33(56-41(34)65)21-28-23-48-25-51-28/h5-7,11-12,23,25,29-35H,3-4,8-10,13-22,24H2,1-2H3,(H2,45,61)(H,48,51)(H,49,60)(H,52,59)(H,53,66)(H,54,63)(H,55,64)(H,56,65)(H,57,62)(H4,46,47,50)/t29-,30+,31+,32+,33+,34+,35-/m1/s1
  • InChiKey: WOHSQSMMWMHNJU-FIXOXVDHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi N-terminal motif family protein 0.0393 0.2123 0.2123
Loa Loa (eye worm) hypothetical protein 0.0046 0.0074 0.0074
Echinococcus multilocularis carboxylesterase 5A 0.0269 0.1395 0.1395
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0046 0.0074 0.0074
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0587 0.0587
Brugia malayi latrophilin 2 splice variant baaae 0.0209 0.1041 0.1041
Loa Loa (eye worm) hypothetical protein 0.0077 0.0261 0.0261
Loa Loa (eye worm) RNA binding protein 0.0132 0.0587 0.0587
Brugia malayi hypothetical protein 0.0077 0.0261 0.0261
Loa Loa (eye worm) transcription factor SMAD2 0.0484 0.2659 0.2659
Brugia malayi Latrophilin receptor protein 2 0.0097 0.0378 0.0378
Brugia malayi MH2 domain containing protein 0.0484 0.2659 0.2659
Mycobacterium ulcerans thymidylate synthase 0.0825 0.4675 0.4635
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0306 0.1613 0.1613
Schistosoma mansoni dihydrofolate reductase 0.1728 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0393 0.2122 1
Echinococcus granulosus carboxylesterase 5A 0.0269 0.1395 0.1395
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1652 0.9556 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0046 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0097 0.0378 0.0378
Schistosoma mansoni hypothetical protein 0.0097 0.0378 0.0378
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0097 0.0378 0.0378
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.1728 1 1
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.1728 1 1
Loa Loa (eye worm) carboxylesterase 0.0269 0.1395 0.1395
Loa Loa (eye worm) TAR-binding protein 0.0132 0.0587 0.0587
Brugia malayi Carboxylesterase family protein 0.0046 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0097 0.0378 0.0378
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0074 0.0074
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0587 0.0587
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1652 0.9556 1
Brugia malayi thymidylate synthase 0.0825 0.4675 0.4675
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0825 0.4675 0.4635
Schistosoma mansoni gliotactin 0.0046 0.0074 0.0074
Brugia malayi hypothetical protein 0.005 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0269 0.1395 0.1395
Echinococcus granulosus para nitrobenzyl esterase 0.0046 0.0074 0.0074
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0084 0.0084
Echinococcus multilocularis dihydrofolate reductase 0.1728 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0084 0.0084
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0269 0.1395 0.1395
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0097 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0209 0.1041 0.1041
Brugia malayi RNA binding protein 0.0132 0.0587 0.0587
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1652 0.9556 1
Brugia malayi Dihydrofolate reductase 0.1728 1 1
Echinococcus granulosus tar DNA binding protein 0.0132 0.0587 0.0587
Echinococcus granulosus thymidylate synthase 0.0825 0.4675 0.4675
Echinococcus multilocularis para nitrobenzyl esterase 0.0046 0.0074 0.0074
Echinococcus multilocularis GPCR, family 2 0.0097 0.0378 0.0378
Chlamydia trachomatis dihydrofolate reductase 0.1728 1 0.5
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0393 0.2123 0.4454
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1652 0.9556 1
Echinococcus multilocularis thymidylate synthase 0.0825 0.4675 0.4675
Brugia malayi RNA recognition motif domain containing protein 0.0132 0.0587 0.0587
Loa Loa (eye worm) MH2 domain-containing protein 0.0484 0.2659 0.2659
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0393 0.2123 0.2123
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0097 0.0378 0.0378
Onchocerca volvulus 0.0825 0.4675 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1652 0.9556 1
Echinococcus granulosus BC026374 protein S09 family 0.0046 0.0074 0.0074
Loa Loa (eye worm) acetylcholinesterase 1 0.0269 0.1395 0.1395
Brugia malayi hypothetical protein 0.0046 0.0074 0.0074
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0132 0.0587 0.0587
Loa Loa (eye worm) hypothetical protein 0.0046 0.0074 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0084 0.0084
Echinococcus multilocularis tar DNA binding protein 0.0132 0.0587 0.0587
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0046 0.0074 0.0074
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0097 0.0378 0.0378
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0825 0.4675 0.4675
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0046 0.0074 0.0074
Schistosoma mansoni BC026374 protein (S09 family) 0.0046 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0035 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0046 0.0074 0.0074
Mycobacterium tuberculosis Hypothetical protein 0.0393 0.2122 0.2063
Echinococcus granulosus acetylcholinesterase 0.0269 0.1395 0.1395
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0074 0.0074
Loa Loa (eye worm) thymidylate synthase 0.0825 0.4675 0.4675
Schistosoma mansoni hypothetical protein 0.0209 0.1041 0.1041
Brugia malayi Calcitonin receptor-like protein seb-1 0.0306 0.1613 0.1613
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0587 0.0587
Loa Loa (eye worm) hypothetical protein 0.0046 0.0074 0.0074
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.001 0.001
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.1728 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0084 0.0084
Echinococcus multilocularis neuroligin 0.0046 0.0074 0.0074
Loa Loa (eye worm) carboxylesterase 0.0046 0.0074 0.0074
Brugia malayi Carboxylesterase family protein 0.0046 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0306 0.1613 0.1613
Echinococcus multilocularis acetylcholinesterase 0.0269 0.1395 0.1395
Brugia malayi Carboxylesterase family protein 0.0269 0.1395 0.1395
Loa Loa (eye worm) carboxylesterase 0.0046 0.0074 0.0074
Brugia malayi Carboxylesterase family protein 0.0046 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0097 0.0378 0.0378
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1652 0.9556 1
Brugia malayi Carboxylesterase family protein 0.0269 0.1395 0.1395
Loa Loa (eye worm) dihydrofolate reductase 0.1728 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0306 0.1613 0.1613
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0046 0.0074 0.0074
Echinococcus granulosus neuroligin 0.0046 0.0074 0.0074
Schistosoma mansoni acetylcholinesterase 0.0046 0.0074 0.0074
Echinococcus granulosus acetylcholinesterase 0.0269 0.1395 0.1395
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0393 0.2122 0.2002
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0587 0.0587
Echinococcus multilocularis BC026374 protein (S09 family) 0.0046 0.0074 0.0074
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0084 0.0084
Loa Loa (eye worm) latrophilin receptor protein 2 0.0097 0.0378 0.0378
Schistosoma mansoni hypothetical protein 0.0097 0.0378 0.0378
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0097 0.0378 0.0378
Echinococcus multilocularis acetylcholinesterase 0.0269 0.1395 0.1395
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0084 0.0084
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0587 0.0587
Brugia malayi TAR-binding protein 0.0132 0.0587 0.0587
Echinococcus granulosus GPCR family 2 0.0097 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0046 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0269 0.1395 0.1395
Brugia malayi Carboxylesterase family protein 0.0046 0.0074 0.0074
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0074 0.0074
Echinococcus granulosus dihydrofolate reductase 0.1728 1 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.001 0.001
Brugia malayi hypothetical protein 0.0393 0.2122 0.2122

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1 nM Decrease in frog skin reflectivity (melanotropic activity). ChEMBL. 9276019
EC50 (functional) = 1 nM Decrease in frog skin reflectivity (melanotropic activity). ChEMBL. 9276019
EC50 (functional) = 11.1 nM Decrease in lizard skin reflectivity (melanotropic activity). ChEMBL. 9276019
Relative potency (functional) = 0.1 Relative potency compared to alpha MSH in a frog skin bioassay. ChEMBL. 9276019
Relative potency (functional) = 0.09 Relative potency compared to alpha MSH in a lizard skin bioassay. ChEMBL. 9276019
Relative potency (functional) = 0.1 Relative potency compared to alpha MSH in a frog skin bioassay. ChEMBL. 9276019

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.