Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0233 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0117 | 0.1964 | 0.0151 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0144 | 0.3805 | 0.2407 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0233 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0233 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0233 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0233 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0116 | 0.1841 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0233 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0233 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0233 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0207 | 0.8159 | 0.8159 |
Giardia lamblia | Hypothetical protein | 0.0207 | 0.8159 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0144 | 0.3805 | 0.3805 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0233 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0207 | 0.8159 | 0.8159 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0233 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0233 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0089 | 0 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0233 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0089 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0233 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0233 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0233 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0089 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0089 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0233 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0233 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0144 | 0.3805 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0144 | 0.3805 | 0.3805 |
Treponema pallidum | flavodoxin | 0.0089 | 0 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0233 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0233 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0089 | 0 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0233 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0116 | 0.1841 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0207 | 0.8159 | 0.8159 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0233 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0207 | 0.8159 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.