Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0107 | 0.2875 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0349 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0107 | 0.2875 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0107 | 0.2875 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0107 | 0.2875 | 0.5 |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.0009 | 0 | 0.5 |
Trypanosoma brucei | trans-sialidase, putative | 0.0027 | 0.0521 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0027 | 0.0521 | 1 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Leishmania major | tyrosine specific protein phosphatase, putative | 0.0009 | 0 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0107 | 0.2875 | 1 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, putative | 0.0027 | 0.0521 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0349 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0027 | 0.0521 | 1 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0027 | 0.0521 | 1 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, putative | 0.0027 | 0.0521 | 0.9998 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0027 | 0.0521 | 1 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0027 | 0.0521 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0027 | 0.0521 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0027 | 0.0521 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0009 | 0 | 0.5 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Onchocerca volvulus | 4.1 G protein, putative homolog | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0349 | 1 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0107 | 0.2875 | 0.5 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0349 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0027 | 0.0521 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0107 | 0.2875 | 0.5 |
Trypanosoma brucei | trans-sialidase | 0.0027 | 0.0521 | 1 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0027 | 0.0521 | 1 |
Leishmania major | protein-tyrosine phosphatase 1-like protein | 0.0009 | 0 | 0.5 |
Trypanosoma brucei | trans-sialidase, putative | 0.0027 | 0.0521 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0027 | 0.0521 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0107 | 0.2875 | 0.5 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0027 | 0.0521 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0027 | 0.0521 | 1 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0009 | 0 | 0.5 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0027 | 0.0521 | 0.9998 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0027 | 0.0521 | 1 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0027 | 0.0521 | 1 |
Giardia lamblia | Protein tyrosine phosphatase | 0.0009 | 0 | 0.5 |
Trypanosoma brucei | trans-sialidase, putative | 0.0027 | 0.0521 | 1 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Trypanosoma brucei | trans-sialidase, putative | 0.0027 | 0.0521 | 1 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Trypanosoma cruzi | trans-sialidase, putative | 0.0027 | 0.0521 | 0.9998 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0107 | 0.2875 | 0.5 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0027 | 0.0521 | 0.9998 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 45 % | Inhibition of human ICMT at 10 uM incubated with N-Acetyl-S-farnesyl-L-cysteine substrate for 5 mins followed by addition of [14C]-SAM measured after 30 mins by liquid scintillation counting | ChEMBL. | 21334890 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.