Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.1844 | 0.2827 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0035 | 0.1249 | 0.1742 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0866 | 0.2319 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.1473 | 0.4775 |
Brugia malayi | Bromodomain containing protein | 0.0035 | 0.1249 | 0.1249 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1249 | 0.1742 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 0.2764 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.2319 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.2357 | 0.2792 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.1473 | 0.4775 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0035 | 0.1249 | 0.1294 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.2357 | 0.2792 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0043 | 0.1844 | 0.2099 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0.1249 | 0.6309 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.1844 | 0.1844 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.0293 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.0293 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.1844 | 0.2827 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.2319 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0035 | 0.1249 | 0.0985 |
Onchocerca volvulus | Alhambra homolog | 0.0035 | 0.1249 | 0.5 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0035 | 0.1249 | 0.1294 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.1844 | 0.2099 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0054 | 0.2764 | 0.2764 |
Echinococcus granulosus | peregrin | 0.0035 | 0.1249 | 0.1294 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.0293 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.0866 | 0.0866 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.0293 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0293 | 0.5 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0.1249 | 0.6309 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 0.7682 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.426 | 0.4086 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3269 | 0.3066 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.5779 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 0.2764 | 0.4504 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.0293 | 0.5 |
Plasmodium falciparum | phd finger protein, putative | 0.0035 | 0.1249 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.1844 | 0.1598 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0293 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.1249 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0115 | 0.7682 | 0.7682 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0866 | 0.059 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 0.2764 | 0.3344 |
Brugia malayi | PHD-finger family protein | 0.0035 | 0.1249 | 0.1249 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0293 | 0.0293 |
Echinococcus multilocularis | peregrin | 0.0035 | 0.1249 | 0.1294 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.2319 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 0.2764 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 0.7682 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1249 | 0.0985 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2764 | 0.2545 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 0.2764 | 0.3344 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.1473 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 0.2764 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.0035 | 0.1249 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (binding) | 24.47 uM | PubChem BioAssay. VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.0212 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 26.6795 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 37.6858 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Potency (functional) | 58.4789 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.