Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.005 | 0.0994 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0994 | 0.0994 |
Schistosoma mansoni | acetylcholinesterase | 0.005 | 0.0994 | 0.0994 |
Brugia malayi | Carboxylesterase family protein | 0.005 | 0.0994 | 0.0994 |
Brugia malayi | Carboxylesterase family protein | 0.0294 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.005 | 0.0994 | 0.0994 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.005 | 0.0994 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.005 | 0.0994 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.005 | 0.0994 | 0.0994 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0994 | 0.0994 |
Echinococcus multilocularis | acetylcholinesterase | 0.0294 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.005 | 0.0994 | 0.0994 |
Brugia malayi | hypothetical protein | 0.005 | 0.0994 | 0.0994 |
Echinococcus granulosus | neuroligin | 0.005 | 0.0994 | 0.0994 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.005 | 0.0994 | 0.0994 |
Onchocerca volvulus | 0.005 | 0.0994 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0994 | 0.0994 |
Echinococcus multilocularis | neuroligin | 0.005 | 0.0994 | 0.0994 |
Onchocerca volvulus | 0.005 | 0.0994 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.005 | 0.0994 | 0.0994 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0994 | 0.0994 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.005 | 0.0994 | 0.0994 |
Onchocerca volvulus | 0.005 | 0.0994 | 0.5 | |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.005 | 0.0994 | 0.0994 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.005 | 0.0994 | 0.0994 |
Brugia malayi | Carboxylesterase family protein | 0.005 | 0.0994 | 0.0994 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0294 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.005 | 0.0994 | 0.0994 |
Echinococcus multilocularis | acetylcholinesterase | 0.0294 | 1 | 1 |
Onchocerca volvulus | 0.005 | 0.0994 | 0.5 | |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.005 | 0.0994 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.005 | 0.0994 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0294 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0294 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0294 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.005 | 0.0994 | 0.0994 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.005 | 0.0994 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.005 | 0.0994 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0294 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0994 | 0.0994 |
Loa Loa (eye worm) | carboxylesterase | 0.005 | 0.0994 | 0.0994 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0994 | 0.0994 |
Brugia malayi | Carboxylesterase family protein | 0.005 | 0.0994 | 0.0994 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.005 | 0.0994 | 0.0994 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0294 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.005 | 0.0994 | 0.0994 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0294 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.005 | 0.0994 | 0.0994 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0994 | 0.0994 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.005 | 0.0994 | 0.0994 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2512 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.