Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0184 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0184 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0184 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0184 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0184 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0184 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0811 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0184 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0184 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0184 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0811 | 0.0811 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.7404 | 0.7404 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0184 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.7404 | 0.7404 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0811 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0811 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0811 | 0.0811 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0811 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0811 | 0.0811 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0811 | 0.0811 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.7404 | 0.7404 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0811 | 0.0811 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0031 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0031 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0031 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0891 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 5.8048 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.