Detailed information for compound 1560133

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.464 | Formula: C20H21N3O3S
  • H donors: 0 H acceptors: 3 LogP: 3.16 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1CC(=O)N1CCC(CC1)c1onc(n1)c1cccs1
  • InChi: 1S/C20H21N3O3S/c1-25-16-6-3-2-5-15(16)13-18(24)23-10-8-14(9-11-23)20-21-19(22-26-20)17-7-4-12-27-17/h2-7,12,14H,8-11,13H2,1H3
  • InChiKey: PTOBLSJGSRSDOA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0069 0.0101
Mycobacterium ulcerans thymidylate kinase 0.0223 0.1705 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0296 0.1581
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0069 0.0101
Chlamydia trachomatis thymidylate kinase 0.0223 0.1705 1
Schistosoma mansoni protein kinase 0.0012 0.0019 0.0019
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0069 0.039
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0012 0.0019 0.01
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0035 0.0195
Brugia malayi RNase H family protein 0.0109 0.0794 0.4469
Echinococcus multilocularis ribonuclease H1 0.0109 0.0794 0.424
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0153 0.0245
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0069 0.039
Leishmania major hypothetical protein, conserved 0.0088 0.062 0.1044
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0012 0.0019 0.0019
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0019 0.0105
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.005 0.0101
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0012 0.0019 0.0014
Brugia malayi follicle stimulating hormone receptor 0.0232 0.1778 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.005 0.0267
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0779 0.4507
Plasmodium falciparum glutathione reductase 0.0047 0.0296 0.1487
Schistosoma mansoni thymidylate kinase 0.0223 0.1705 0.1705
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0153 0.0625
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.1778 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0012 0.0019 0.01
Trypanosoma brucei thymidine kinase 0.0742 0.5854 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0296 0.1645
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.005 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0019 0.0014
Echinococcus granulosus KRAB A domain containing protein 0.0012 0.0019 0.01
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0153 0.072
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0012 0.0019 0.01
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0069 0.0117
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0779 0.4507
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0153 0.0231
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0153 0.072
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0054 0.0054
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0109 0.0794 0.4496
Giardia lamblia Thymidine kinase 0.0742 0.5854 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0035 0.0195
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.005 0.0068
Echinococcus granulosus geminin 0.0169 0.127 0.6777
Echinococcus multilocularis thymidine kinase 0.0244 0.1874 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0069 0.0117
Trypanosoma cruzi ribonuclease H1, putative 0.0109 0.0794 0.1342
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.005 0.0068
Schistosoma mansoni intermediate filament proteins 0.0027 0.0134 0.0134
Trypanosoma brucei RNA helicase, putative 0.0548 0.43 0.7341
Schistosoma mansoni thymidylate kinase 0.0223 0.1705 0.1705
Plasmodium vivax thymidylate kinase, putative 0.0223 0.1705 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.013
Schistosoma mansoni lamin 0.0027 0.0134 0.0134
Trichomonas vaginalis reverse transcriptases, putative 0.0012 0.0019 0.0014
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0134 0.0756
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0134 0.0756
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0019 0.0105
Brugia malayi phosphofructokinase 0.0108 0.0786 0.4419
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0088 0.062 0.1044
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0786 0.0072
Loa Loa (eye worm) thymidylate kinase 0.0223 0.1705 0.9594
Brugia malayi Thioredoxin reductase 0.0047 0.0296 0.1667
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0153 0.0245
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0153 0.0245
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0019 0.0105
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0786 0.1327
Schistosoma mansoni phosphoglucomutase 0.0109 0.0794 0.0794
Brugia malayi 6-phosphofructokinase 0.0108 0.0786 0.4419
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0019 0.0105
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0786 0.1327
Brugia malayi Zinc knuckle family protein 0.0012 0.0019 0.0105
Echinococcus multilocularis thymidylate kinase 0.0223 0.1705 0.9102
Trypanosoma brucei trypanothione reductase 0.0047 0.0296 0.0489
Echinococcus granulosus thymidylate kinase 0.0223 0.1705 0.9102
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0019 0.0105
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.005 0.0068
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0088 0.062 0.1044
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0069 0.037
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0069 0.03
Schistosoma mansoni phosphoglucomutase 0.0109 0.0794 0.0794
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0153 0.0245
Leishmania major thymidine kinase, putative 0.0742 0.5854 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0069 0.0101
Brugia malayi 6-phosphofructokinase 0.0108 0.0786 0.4419
Echinococcus granulosus bloom syndrome protein 0.0021 0.0089 0.0478
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0069 0.0114
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0012 0.0019 0.0014
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0069 0.0117
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0069 0.0117
Entamoeba histolytica thymidine kinase, putative 0.0742 0.5854 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.005 0.0267
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0786 0.4547
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0019 0.0105
Trichomonas vaginalis reverse transcriptases, putative 0.0012 0.0019 0.0014
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0786 0.1327
Toxoplasma gondii ribonuclease HI protein 0.0109 0.0794 0.4552
Leishmania major thymidylate kinase-like protein 0.0223 0.1705 0.2901
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0786 0.4443
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0012 0.0019 0.0019
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0019 0.0105
Schistosoma mansoni hypothetical protein 0.0169 0.127 0.127
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0223 0.1705 1
Toxoplasma gondii thioredoxin reductase 0.0047 0.0296 0.1574
Treponema pallidum ribonuclease H (rnhA) 0.0109 0.0794 0.4496
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0069 0.037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0108
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0089 0.0136
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0012 0.0019 0.0014
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0153 0.0625
Onchocerca volvulus Ribonuclease H1 homolog 0.0109 0.0794 0.4658
Schistosoma mansoni ap endonuclease 0.0019 0.0069 0.0069
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0019 0.0105
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.005 0.0068
Onchocerca volvulus 0.0027 0.0134 0.0788
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0786 0.1327
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0786 0.1327
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0786 0.4193
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.005 0.0068
Treponema pallidum thymidylate kinase (tmk) 0.0223 0.1705 1
Onchocerca volvulus Putative thymidylate kinase 0.0223 0.1705 1
Onchocerca volvulus 0.0012 0.0019 0.011
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0153 0.072
Brugia malayi intermediate filament protein 0.0027 0.0134 0.0756
Schistosoma mansoni hypothetical protein 0.0169 0.127 0.127
Brugia malayi hypothetical protein 0.0012 0.0019 0.0105
Loa Loa (eye worm) hypothetical protein 0.0026 0.013 0.0734
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.005 0.0068
Trichomonas vaginalis thymidine kinase, putative 0.0742 0.5854 1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0229 0.1752 0.1752
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0019 0.0105
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0122 0.0894 0.1511
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0019 0.0105
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0786 0.4443
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.005 0.0068
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0089 0.0136
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0786 0.0786
Echinococcus granulosus thymidine kinase 0.0244 0.1874 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0069 0.0101
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0153 0.0245
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0134 0.0756
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0012 0.0019 0.011
Plasmodium falciparum thioredoxin reductase 0.0047 0.0296 0.1487
Trichomonas vaginalis thymidylate kinase, putative 0.0223 0.1705 0.2901
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0012 0.0019 0.0014
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.005 0.0068
Trypanosoma brucei unspecified product 0.0122 0.0894 0.1511
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.005 0.0068
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0019 0.0105
Plasmodium falciparum thymidylate kinase 0.0223 0.1705 1
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0089 0.0478
Toxoplasma gondii exonuclease III APE 0.0019 0.0069 0.0217
Trypanosoma cruzi thymidine kinase, putative 0.0742 0.5854 1
Trypanosoma brucei ribonuclease H1 0.0109 0.0794 0.1342
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0875 0.1035
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.005 0.0068
Echinococcus multilocularis lamin 0.0027 0.0134 0.0717
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0786 0.4419
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0012 0.0019 0.01
Brugia malayi reverse transcriptase 0.0012 0.0019 0.0105
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0786 0.4419
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0786 0.4193
Leishmania major ribonuclease H1, putative 0.0109 0.0794 0.1342
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.005 0.0068
Brugia malayi RNase H family protein 0.0109 0.0794 0.4469
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0012 0.0019 0.01
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0153 0.0245
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0153 0.0712
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.005 0.0068
Onchocerca volvulus 0.0027 0.0134 0.0788
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0296 0.1667
Brugia malayi hypothetical protein 0.0012 0.0019 0.0105
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0019 0.0105
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0023 0.0124
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0069 0.0209
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0223 0.1705 1
Echinococcus granulosus lamin 0.0027 0.0134 0.0717
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0012 0.0019 0.01
Schistosoma mansoni hypothetical protein 0.0223 0.1705 0.1705
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0296 0.0489
Loa Loa (eye worm) glutathione reductase 0.0047 0.0296 0.1667
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0012 0.0019 0.01
Echinococcus multilocularis geminin 0.0169 0.127 0.6777
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0296 0.1581
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0786 0.1327
Brugia malayi reverse transcriptase 0.0012 0.0019 0.0105
Trypanosoma brucei ingi protein (ORF1) 0.0122 0.0894 0.1511
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.005 0.0101
Echinococcus granulosus lamin dm0 0.0027 0.0134 0.0717
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0779 0.4507
Echinococcus multilocularis RNA directed DNA polymerase 0.0012 0.0019 0.01
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.005 0.0068
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0223 0.1705 1
Trypanosoma cruzi thymidylate kinase, putative 0.0223 0.1705 0.2901
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.031
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0069 0.0101
Loa Loa (eye worm) RecQ helicase 0.0021 0.0089 0.0503
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0012 0.0019 0.01
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0012 0.0019 0.01
Schistosoma mansoni hypothetical protein 0.0012 0.0019 0.0019
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0153 0.0625
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0153 0.0245
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0875 0.5076
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0012 0.0019 0.01
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.005 0.0186
Entamoeba histolytica Thymidylate kinase, putative 0.0223 0.1705 0.2901
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.005 0.005
Schistosoma mansoni lamin 0.0027 0.0134 0.0134
Echinococcus granulosus thymidine kinase 0.0244 0.1874 1
Schistosoma mansoni thymidine kinase 0.0244 0.1874 0.1874
Trichomonas vaginalis thymidine kinase, putative 0.0742 0.5854 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.005 0.0093
Onchocerca volvulus 0.0012 0.0019 0.011
Echinococcus multilocularis lamin dm0 0.0027 0.0134 0.0717
Trichomonas vaginalis ribonuclease H1, putative 0.0109 0.0794 0.1342
Trypanosoma brucei hypothetical protein, conserved 0.0122 0.0894 0.1511
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0779 0.4507
Brugia malayi reverse transcriptase 0.0012 0.0019 0.0105
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0019 0.0105
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0089 0.0503
Echinococcus multilocularis transfer RNA-Ile 0.0244 0.1874 1
Giardia lamblia CDC8 0.0223 0.1705 0.2891
Trichomonas vaginalis thymidylate kinase, putative 0.0223 0.1705 0.2901
Schistosoma mansoni hypothetical protein 0.0548 0.43 0.43
Echinococcus granulosus RNA directed DNA polymerase 0.0012 0.0019 0.01
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0108
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0012 0.0019 0.01
Brugia malayi Zinc knuckle family protein 0.0012 0.0019 0.0105
Giardia lamblia Ribonuclease H 0.0109 0.0794 0.1329
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0786 0.4419
Schistosoma mansoni phosphoglucomutase 0.0109 0.0794 0.0794
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0023 0.0124
Trypanosoma brucei thymidylate kinase, putative 0.0223 0.1705 0.2901
Brugia malayi hypothetical protein 0.0012 0.0019 0.0105
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0069 0.0101
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0153 0.0625
Schistosoma mansoni ap endonuclease 0.0019 0.0069 0.0069
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.005 0.0068
Trichomonas vaginalis thymidine kinase, putative 0.0742 0.5854 1
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0027 0.0134 0.0756
Echinococcus granulosus intermediate filament protein 0.0027 0.0134 0.0717
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0015 0.0087
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0786 0.1327
Brugia malayi glutathione reductase 0.0047 0.0296 0.1667
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0015 0.0087
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0153 0.0625
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.005 0.0281
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0786 0.1327
Plasmodium vivax glutathione reductase, putative 0.0047 0.0296 0.1567
Mycobacterium tuberculosis Probable reductase 0.0107 0.0779 0.4507
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.005 0.0054
Trypanosoma brucei ingi protein (ORF1) 0.0122 0.0894 0.1511
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0069 0.0087
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0875 0.5076
Leishmania major trypanothione reductase 0.0047 0.0296 0.0489
Brugia malayi Pao retrotransposon peptidase family protein 0.0012 0.0019 0.0105
Trypanosoma cruzi ribonuclease H1, putative 0.0109 0.0794 0.1342
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.005 0.0068
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0786 0.1327
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0875 0.5076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.005 0.0068
Trypanosoma cruzi thymidine kinase, putative 0.0742 0.5854 1
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0786 0.1327
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0012 0.0019 0.01
Echinococcus multilocularis thymidine kinase 0.0244 0.1874 1
Echinococcus granulosus ribonuclease H1 0.0109 0.0794 0.424
Trypanosoma brucei thymidylate kinase, putative 0.0223 0.1705 0.2901
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.005 0.0093
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0153 0.0712
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0069 0.0101
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.005 0.0068
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0012 0.0019 0.01
Echinococcus multilocularis musashi 0.0027 0.0134 0.0717
Brugia malayi hypothetical protein 0.0012 0.0019 0.0105
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0012 0.0019 0.0014
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0012 0.0019 0.01
Trypanosoma cruzi thymidylate kinase, putative 0.0223 0.1705 0.2901
Toxoplasma gondii thymidylate kinase 0.0223 0.1705 1
Brugia malayi RNase H family protein 0.0109 0.0794 0.4469
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0153 0.0245
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.005 0.0068
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.0244 0.1874 1
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0296 0.1567
Brugia malayi thymidylate kinase 0.0223 0.1705 0.9594
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0779 0.4507

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

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