Detailed information for compound 1560136

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 354.426 | Formula: C18H18N4O2S
  • H donors: 0 H acceptors: 4 LogP: 2.15 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCC(CC1)c1onc(n1)c1cccs1)Cc1ccccn1
  • InChi: 1S/C18H18N4O2S/c23-16(12-14-4-1-2-8-19-14)22-9-6-13(7-10-22)18-20-17(21-24-18)15-5-3-11-25-15/h1-5,8,11,13H,6-7,9-10,12H2
  • InChiKey: IAZGAFMCILNGDG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis geminin 0.0534 0.4997 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0256 0.0243
Brugia malayi Carboxylesterase family protein 0.0076 0.0566 0.1138
Loa Loa (eye worm) hypothetical protein 0.0076 0.0566 0.1141
Loa Loa (eye worm) hypothetical protein 0.053 0.4962 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0227
Echinococcus multilocularis para nitrobenzyl esterase 0.0076 0.0566 0.111
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0114 0.2041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0113 0.0225
Brugia malayi carbohydrate phosphorylase 0.0112 0.0914 0.184
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0113 0.02
Echinococcus multilocularis carboxylesterase 5A 0.0448 0.4166 0.8332
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0046 0.0066
Onchocerca volvulus 0.053 0.4962 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0227
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.017 0.0157
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0227
Brugia malayi RNase H family protein 0.0023 0.0061 0.012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0113 0.0225
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0256 0.0247
Echinococcus granulosus zinc finger protein 0.0019 0.0018 0.001
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0146 0.0292
Echinococcus multilocularis thymidylate kinase 0.007 0.051 0.0997
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0001 0.0003
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0126 0.2275
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0113 0.02
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0172 0.0319
Entamoeba histolytica glycogen phosphorylase, putative 0.0048 0.0301 0.0289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0256 0.0243
Entamoeba histolytica Thymidylate kinase, putative 0.007 0.051 0.0497
Onchocerca volvulus 0.023 0.2058 0.4074
Echinococcus multilocularis Glycosyl transferase, family 35 0.0112 0.0914 0.1808
Schistosoma mansoni phosphoglucomutase 0.0023 0.0061 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0113 0.0225
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.0845 0.1701
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0113 0.02
Schistosoma mansoni thymidine kinase 0.0531 0.4969 0.9944
Trypanosoma brucei unspecified product 0.0025 0.008 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.017 0.0157
Schistosoma mansoni hypothetical protein 0.002 0.0028 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0062 0.0049
Trypanosoma brucei ingi protein (ORF1) 0.0025 0.008 0.0071
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0256 0.0488
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0568 0.1113
Trypanosoma cruzi thymidine kinase, putative 0.1051 1 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.1031 0.2042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.017 0.0157
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0227
Schistosoma mansoni survival motor neuron protein 0.0104 0.0845 0.167
Schistosoma mansoni neuroligin 3 (S09 family) 0.0076 0.0566 0.111
Schistosoma mansoni thyroid hormone receptor 0.0152 0.131 0.2601
Giardia lamblia Cytidine deaminase 0.0053 0.0344 0.0332
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.1788 0.3602
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0113 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0194 0.0182
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0568 0.1144
Toxoplasma gondii thymidylate kinase 0.007 0.051 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0256 0.0488
Loa Loa (eye worm) hypothetical protein 0.0076 0.0566 0.1141
Schistosoma mansoni phosphoglucomutase 0.0023 0.0061 0.0096
Loa Loa (eye worm) RNA binding protein 0.0076 0.0568 0.1144
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0076 0.0566 0.111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0084 0.0071
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0114 0.0203
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0146 0.0295
Echinococcus multilocularis neuroligin 0.0076 0.0566 0.111
Brugia malayi Pre-SET motif family protein 0.0029 0.0114 0.0228
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0256 0.0243
Trypanosoma cruzi thymidylate kinase, putative 0.007 0.051 0.0497
Onchocerca volvulus Putative thymidylate kinase 0.007 0.051 0.0916
Plasmodium vivax SET domain protein, putative 0.0029 0.0114 0.2041
Onchocerca volvulus 0.0076 0.0566 0.1031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0113 0.0227
Trichomonas vaginalis thymidine kinase, putative 0.1051 1 1
Leishmania major thymidylate kinase-like protein 0.007 0.051 0.0497
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0113 0.0106
Schistosoma mansoni glycogen phosphorylase 0.0048 0.0301 0.0578
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0113 0.0106
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0113 0.02
Trichomonas vaginalis cytidine deaminase, putative 0.0053 0.0344 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.017 0.0157
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0061 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0148 0.0135
Onchocerca volvulus Glycogen phosphorylase homolog 0.0112 0.0914 0.1741
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.017 0.0157
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.0338 0.3101 0.6195
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0025 0.008 0.0071
Trypanosoma brucei ingi protein (ORF1) 0.0025 0.008 0.0071
Trichomonas vaginalis spcc417.12 protein, putative 0.0076 0.0566 0.0554
Loa Loa (eye worm) glycogen phosphorylase 0.0112 0.0914 0.1842
Echinococcus granulosus geminin 0.0534 0.4997 1
Echinococcus granulosus solute carrier family 28 0.0338 0.3101 0.6195
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0126 0.0117
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0126 0.2275
Echinococcus granulosus thymidine kinase 0.0531 0.4969 0.9944
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0395 0.0766
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0113 0.0227
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0448 0.4166 0.8332
Schistosoma mansoni zinc finger protein 0.0019 0.0018 0.001
Echinococcus granulosus glycogen phosphorylase 0.0112 0.0914 0.1808
Trypanosoma brucei thymidylate kinase, putative 0.007 0.051 0.0501
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0113 0.0225
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0284
Loa Loa (eye worm) hypothetical protein 0.0076 0.0566 0.1141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0086 0.0073
Schistosoma mansoni thyroid hormone receptor 0.0152 0.131 0.2601
Toxoplasma gondii ribonuclease HI protein 0.0023 0.0061 0.0962
Brugia malayi Bromodomain containing protein 0.0037 0.0194 0.0387
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0113 0.0225
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0113 0.02
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0256 0.0243
Trichomonas vaginalis thymidine kinase, putative 0.1051 1 1
Echinococcus granulosus thymidine kinase 0.0531 0.4969 0.9944
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0256 0.0243
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.0338 0.3101 0.6195
Schistosoma mansoni hypothetical protein 0.0534 0.4997 1
Trypanosoma brucei thymidylate kinase, putative 0.007 0.051 0.0501
Brugia malayi thymidylate kinase 0.007 0.051 0.1025
Brugia malayi Carboxylesterase family protein 0.0076 0.0566 0.1138
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.1031 0.2042
Brugia malayi hypothetical protein 0.003 0.0126 0.0251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0148 0.0135
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0126 0.2275
Schistosoma mansoni bromodomain containing protein 0.0061 0.0428 0.0833
Brugia malayi nuclear receptor NHR-88 0.0029 0.0113 0.0225
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0146 0.0295
Loa Loa (eye worm) carboxylesterase 0.0448 0.4166 0.8395
Entamoeba histolytica glycogen phosphorylase, putative 0.0048 0.0301 0.0289
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0027 0.0099 0.0086
Entamoeba histolytica glycogenphosphorylase, putative 0.0048 0.0301 0.0289
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0027 0.0099 0.0086
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0568 0.1144
Entamoeba histolytica hypothetical protein 0.0035 0.0172 0.0159
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0113 0.02
Loa Loa (eye worm) hypothetical protein 0.0045 0.0274 0.0553
Loa Loa (eye worm) hypothetical protein 0.0512 0.4792 0.9656
Loa Loa (eye worm) hypothetical protein 0.004 0.0217 0.0436
Schistosoma mansoni hypothetical protein 0.0163 0.141 0.2803
Leishmania major hypothetical protein, conserved 0.0027 0.0099 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0568 0.1113
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0013 0.0004
Echinococcus multilocularis musashi 0.0032 0.0146 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0113 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0113 0.0225
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.007 0.051 1
Onchocerca volvulus 0.0076 0.0566 0.1031
Echinococcus granulosus ribonuclease H1 0.0023 0.0061 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0113 0.0225
Echinococcus granulosus para nitrobenzyl esterase 0.0076 0.0566 0.111
Trichomonas vaginalis set domain proteins, putative 0.023 0.2058 0.2047
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.017 0.0161
Echinococcus multilocularis acetylcholinesterase 0.0448 0.4166 0.8332
Schistosoma mansoni hypothetical protein 0.0035 0.0172 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0113 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0084 0.0071
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0113 0.0225
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0568 0.1113
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.007 0.051 1
Onchocerca volvulus 0.0053 0.0344 0.0579
Echinococcus granulosus acetylcholinesterase 0.0448 0.4166 0.8332
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0172 0.0319
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0114 0.0203
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0113 0.02
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0126 0.2275
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0076 0.0566 0.111
Trypanosoma cruzi thymidylate kinase, putative 0.007 0.051 0.0497
Echinococcus granulosus histone lysine methyltransferase setb 0.0045 0.0274 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0086 0.0073
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.017 0.0157
Schistosoma mansoni phosphoglucomutase 0.0023 0.0061 0.0096
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0113 0.02
Trichomonas vaginalis glycogen phosphorylase, putative 0.0112 0.0914 0.0902
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0256 0.0243
Brugia malayi TAR-binding protein 0.0076 0.0568 0.1141
Brugia malayi RNA binding protein 0.0076 0.0568 0.1141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0148 0.0135
Brugia malayi RNase H family protein 0.0023 0.0061 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0113 0.0227
Loa Loa (eye worm) carboxylesterase 0.0076 0.0566 0.1141
Entamoeba histolytica hypothetical protein 0.0035 0.0172 0.0159
Trichomonas vaginalis glycogen phosphorylase, putative 0.0112 0.0914 0.0902
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0113 0.0225
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0076 0.0566 0.111
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0227
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0113 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0108 0.0095
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0113 0.02
Schistosoma mansoni hypothetical protein 0.007 0.051 0.0997
Brugia malayi hypothetical protein 0.0019 0.0023 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0113 0.0227
Schistosoma mansoni intermediate filament proteins 0.0032 0.0146 0.0268
Trypanosoma brucei RNA helicase, putative 0.0088 0.0684 0.0675
Echinococcus multilocularis glycogen phosphorylase 0.0112 0.0914 0.1808
Giardia lamblia Deoxynucleoside kinase 0.0766 0.7243 0.724
Trypanosoma brucei cytidine deaminase 0.0053 0.0344 0.0335
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0256 0.0488
Trypanosoma brucei ribonuclease H1 0.0023 0.0061 0.0051
Schistosoma mansoni hypothetical protein 0.0124 0.1031 0.2042
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0126 0.0113
Echinococcus granulosus survival motor neuron protein 1 0.0512 0.4792 0.9587
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0104 0.0183
Echinococcus multilocularis Protein lozenge 0.0066 0.0477 0.0932
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0227
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0256 0.0243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0148 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0113 0.0227
Echinococcus granulosus BC026374 protein S09 family 0.0076 0.0566 0.111
Echinococcus multilocularis solute carrier family 28 0.0338 0.3101 0.6195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0086 0.0073
Brugia malayi Pre-SET motif family protein 0.0202 0.1788 0.3601
Loa Loa (eye worm) hypothetical protein 0.0037 0.0194 0.0392
Brugia malayi Bromodomain containing protein 0.0073 0.0538 0.1082
Loa Loa (eye worm) carboxylesterase 0.0076 0.0566 0.1141
Echinococcus multilocularis thymidine kinase 0.0531 0.4969 0.9944
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0053 0.0344 0.5991
Echinococcus granulosus intermediate filament protein 0.0032 0.0146 0.0268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0062 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0062 0.0049
Loa Loa (eye worm) thymidylate kinase 0.007 0.051 0.1027
Schistosoma mansoni acetylcholinesterase 0.0076 0.0566 0.111
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0113 0.02
Treponema pallidum ribonuclease H (rnhA) 0.0023 0.0061 0.0962
Loa Loa (eye worm) runx1 0.0066 0.0477 0.0962
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0256 0.0247
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0023 0.0061 0.0962
Brugia malayi hypothetical protein 0.053 0.4962 1
Leishmania major thymidine kinase, putative 0.1051 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0152 0.131 0.2601
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0126 0.0113
Schistosoma mansoni thymidylate kinase 0.007 0.051 0.0997
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0227
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.203 0.4092
Trichomonas vaginalis thymidylate kinase, putative 0.007 0.051 0.0497
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0256 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0117 0.0104
Echinococcus granulosus acetylcholinesterase 0.0448 0.4166 0.8332
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0171 0.0318
Onchocerca volvulus 0.0076 0.0566 0.1031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0113 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0062 0.0049
Treponema pallidum thymidylate kinase (tmk) 0.007 0.051 1
Echinococcus multilocularis acetylcholinesterase 0.0448 0.4166 0.8332
Schistosoma mansoni lamin 0.0032 0.0146 0.0268
Giardia lamblia GTOR 0.0044 0.0256 0.0243
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0148 0.2716
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0113 0.02
Loa Loa (eye worm) hypothetical protein 0.0076 0.0566 0.1141
Onchocerca volvulus 0.0076 0.0566 0.1031
Mycobacterium ulcerans thymidylate kinase 0.007 0.051 0.8982
Chlamydia trachomatis glycogen phosphorylase 0.0112 0.0914 1
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0061 0.0048
Giardia lamblia CDC8 0.007 0.051 0.0497
Leishmania major cytidine deaminase-like protein 0.0053 0.0344 0.0332
Onchocerca volvulus 0.0053 0.0344 0.0579
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0114 0.0203
Giardia lamblia Glycogen phosphorylase 0.0112 0.0914 0.0902
Onchocerca volvulus 0.0032 0.0146 0.0175
Giardia lamblia Ribonuclease H 0.0023 0.0061 0.0048
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0113 0.02
Loa Loa (eye worm) hypothetical protein 0.0069 0.0498 0.1004
Brugia malayi follicle stimulating hormone receptor 0.0227 0.203 0.409
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0113 0.02
Onchocerca volvulus 0.0029 0.0113 0.0106
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0013 0.0023
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0568 0.1141
Brugia malayi RNase H family protein 0.0023 0.0061 0.012
Brugia malayi Carboxylesterase family protein 0.0448 0.4166 0.8395
Schistosoma mansoni coup transcription factor 0.0029 0.0113 0.02
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.008 0.0071
Schistosoma mansoni lamin 0.0032 0.0146 0.0268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0062 0.0049
Echinococcus granulosus Na+ dependent nucleoside transporter 0.0338 0.3101 0.6195
Entamoeba histolytica glycogen phosphorylase, putative 0.0112 0.0914 0.0902
Mycobacterium tuberculosis Carboxylesterase LipT 0.0076 0.0566 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0146 0.0295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0148 0.0135
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0568 0.1113
Entamoeba histolytica hypothetical protein 0.0035 0.0172 0.0159
Brugia malayi steroid hormone receptor 0.0029 0.0113 0.0225
Trichomonas vaginalis ribonuclease H1, putative 0.0023 0.0061 0.0048
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0076 0.0566 0.111
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0473
Trypanosoma cruzi thymidine kinase, putative 0.1051 1 1
Echinococcus multilocularis cytidine deaminase 0.0053 0.0344 0.0665
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0034 0.0024
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0113 0.0106
Trypanosoma cruzi cytidine deaminase-like protein 0.0053 0.0344 0.0332
Schistosoma mansoni lozenge 0.0066 0.0477 0.0932
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0048 0.0301 0.5209
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0113 0.02
Trichomonas vaginalis thymidine kinase, putative 0.1051 1 1
Entamoeba histolytica cytidine deaminase, putative 0.0053 0.0344 0.0332
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0076 0.0566 1
Brugia malayi cytidine deaminase, identical 0.0053 0.0344 0.0691
Echinococcus granulosus glycogen phosphorylase 0.0112 0.0914 0.1808
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0062 0.0049
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0395 0.0766
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0568 0.1113
Echinococcus multilocularis zinc finger protein 0.0019 0.0018 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0113 0.0225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0113 0.0227
Brugia malayi nuclear hormone receptor 0.0029 0.0113 0.0225
Schistosoma mansoni hypothetical protein 0.0104 0.0845 0.167
Loa Loa (eye worm) hypothetical protein 0.0076 0.0566 0.1141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.017 0.0157
Entamoeba histolytica hypothetical protein 0.0035 0.0172 0.0159
Echinococcus granulosus carboxylesterase 5A 0.0448 0.4166 0.8332
Loa Loa (eye worm) acetylcholinesterase 1 0.0448 0.4166 0.8395
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0076 0.0566 1
Schistosoma mansoni gliotactin 0.0076 0.0566 0.111
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0076 0.0566 0.0554
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0113 0.0227
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0113 0.02
Loa Loa (eye worm) hypothetical protein 0.0448 0.4166 0.8395
Schistosoma mansoni glycogen phosphorylase 0.0112 0.0914 0.1808
Onchocerca volvulus 0.0104 0.0845 0.1601
Leishmania major hypothetical protein, conserved 0.003 0.0126 0.0113
Schistosoma mansoni hypothetical protein 0.0088 0.0684 0.1346
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0113 0.02
Brugia malayi hypothetical protein 0.0076 0.0566 0.1138
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0113 0.02
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0113 0.02
Echinococcus granulosus tar DNA binding protein 0.0076 0.0568 0.1113
Echinococcus granulosus neuroligin 0.0076 0.0566 0.111
Schistosoma mansoni BC026374 protein (S09 family) 0.0076 0.0566 0.111
Plasmodium falciparum thymidylate kinase 0.007 0.051 1
Trichomonas vaginalis thymidylate kinase, putative 0.007 0.051 0.0497
Echinococcus granulosus lamin 0.0032 0.0146 0.0268
Brugia malayi hypothetical protein 0.0512 0.4792 0.9656
Schistosoma mansoni hypothetical protein 0.0534 0.4997 1
Plasmodium vivax thymidylate kinase, putative 0.007 0.051 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0045 0.0274 0.0525
Echinococcus granulosus Glycosyl transferase family 35 0.0112 0.0914 0.1808
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0028 0.0056
Loa Loa (eye worm) hypothetical protein 0.053 0.4962 1
Brugia malayi hypothetical protein 0.0035 0.0172 0.0344
Schistosoma mansoni thymidylate kinase 0.007 0.051 0.0997
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.022 0.1965 0.3916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0256 0.0243
Giardia lamblia Thymidine kinase 0.1051 1 1
Schistosoma mansoni glycogen phosphorylase 0.0112 0.0914 0.1808
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0171 0.0318
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0045 0.0274 0.0525
Echinococcus granulosus thymidylate kinase 0.007 0.051 0.0997
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0048 0.0301 0.5209
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0113 0.0225
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0046 0.0066
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0113 0.02
Echinococcus multilocularis thymidine kinase 0.0531 0.4969 0.9944
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0113 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0148 0.0135
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.007 0.051 0.8982
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0113 0.02
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0076 0.0566 0.111
Loa Loa (eye worm) hypothetical protein 0.0076 0.0566 0.1141
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0113 0.0225
Trichomonas vaginalis cytidine deaminase, putative 0.0053 0.0344 0.0332
Echinococcus multilocularis lamin 0.0032 0.0146 0.0268
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0113 0.02
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.0531 0.4969 0.9944
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0013 0.0026
Brugia malayi PHD-finger family protein 0.0024 0.0068 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0148 0.0135
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0113 0.02
Trypanosoma brucei thymidine kinase 0.1051 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0256 0.0243
Echinococcus multilocularis BC026374 protein (S09 family) 0.0076 0.0566 0.111
Onchocerca volvulus 0.0032 0.0146 0.0175
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0045 0.0274 0.0525
Echinococcus multilocularis transfer RNA-Ile 0.0531 0.4969 0.9944
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0046 0.0066
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0113 0.02
Loa Loa (eye worm) hypothetical protein 0.0448 0.4166 0.8395
Brugia malayi Carboxylesterase family protein 0.0076 0.0566 0.1138
Onchocerca volvulus 0.0076 0.0566 0.1031
Loa Loa (eye worm) hypothetical protein 0.0076 0.0566 0.1141
Onchocerca volvulus 0.0029 0.0114 0.0109
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0113 0.0225
Brugia malayi intermediate filament protein 0.0032 0.0146 0.0292
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0256 0.0513
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0053 0.0344 0.6671
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0113 0.0225
Echinococcus granulosus lamin dm0 0.0032 0.0146 0.0268
Mycobacterium ulcerans carboxylesterase, LipT 0.0076 0.0566 1
Echinococcus multilocularis ribonuclease H1 0.0023 0.0061 0.0096
Echinococcus multilocularis glycogen phosphorylase 0.0112 0.0914 0.1808
Brugia malayi ecdysteroid receptor 0.0029 0.0113 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0062 0.0049
Entamoeba histolytica glycogen phosphorylase, putative 0.0112 0.0914 0.0902
Brugia malayi Carboxylesterase family protein 0.0076 0.0566 0.1138
Echinococcus multilocularis lamin dm0 0.0032 0.0146 0.0268
Leishmania major ribonuclease H1, putative 0.0023 0.0061 0.0048
Echinococcus granulosus cytidine deaminase 0.0053 0.0344 0.0665
Echinococcus multilocularis survival motor neuron protein 1 0.0512 0.4792 0.9587
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0053 0.0344 0.0332
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0172 0.0319
Loa Loa (eye worm) hypothetical protein 0.003 0.0126 0.0254
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0113 0.02
Brugia malayi Carboxylesterase family protein 0.0448 0.4166 0.8395
Mycobacterium ulcerans cytidine deaminase 0.0053 0.0344 0.5991
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0568 0.1113

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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