Detailed information for compound 1560159

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 345.479 | Formula: C20H31N3O2
  • H donors: 0 H acceptors: 2 LogP: 3.35 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCC(CC1)C1CCN(CC1)c1cccnc1)OC(C)(C)C
  • InChi: 1S/C20H31N3O2/c1-20(2,3)25-19(24)23-13-8-17(9-14-23)16-6-11-22(12-7-16)18-5-4-10-21-15-18/h4-5,10,15-17H,6-9,11-14H2,1-3H3
  • InChiKey: CRZGKAWVJIDZPZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens G protein-coupled receptor 119 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi follicle stimulating hormone receptor G protein-coupled receptor 119 335 aa 274 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0035 0.0607 0.0839
Schistosoma mansoni hypothetical protein 0.002 0.0186 0.0248
Trichomonas vaginalis malate dehydrogenase, putative 0.0035 0.0607 0.0839
Toxoplasma gondii aldose reductase, putative 0.0107 0.2602 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0544 0.1796
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0186 0.0454
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0031 0.0497 0.1608
Echinococcus multilocularis voltage gated potassium channel subunit 0.0031 0.0497 0.0497
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0951 0.2985
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0387 0.0563
Echinococcus multilocularis chromobox protein 1 0.007 0.1573 0.1573
Brugia malayi hypothetical protein 0.002 0.0186 0.0237
Trypanosoma cruzi malate dehydrogenase, putative 0.0035 0.0607 0.2048
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0107 0.2602 0.2602
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0186 0.0186
Trichomonas vaginalis aldo-keto reductase, putative 0.0107 0.2602 0.4098
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0171 0.0171
Echinococcus multilocularis expressed protein 0.0034 0.0566 0.0566
Entamoeba histolytica malate dehydrogenase, putative 0.0035 0.0607 0.1795
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0107 0.2602 0.2602
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.004 0.0064
Brugia malayi hypothetical protein 0.002 0.0186 0.0237
Schistosoma mansoni malate dehydrogenase 0.0035 0.0607 0.1376
Leishmania major malate dehydrogenase, putative 0.009 0.213 0.8119
Plasmodium falciparum NADP-specific glutamate dehydrogenase 0.0024 0.0307 0.1048
Plasmodium falciparum malate dehydrogenase 0.009 0.213 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0107 0.2602 0.2602
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0171 0.0207
Schistosoma mansoni rab6-interacting 0.002 0.0186 0.0248
Trichomonas vaginalis aldo-keto reductase, putative 0.0107 0.2602 0.4098
Echinococcus granulosus L lactate dehydrogenase 0.0055 0.1162 0.1162
Brugia malayi Pre-SET motif family protein 0.003 0.0467 0.0693
Echinococcus granulosus cytosolic malate dehydrogenase 0.0035 0.0607 0.0607
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0107 0.2602 0.2602
Loa Loa (eye worm) hypothetical protein 0.0019 0.0171 0.0275
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.2633 0.8837
Trypanosoma cruzi aldo/keto reductase, putative 0.0031 0.0497 0.1608
Plasmodium vivax glutathione reductase, putative 0.0048 0.0951 0.4212
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0497 0.0659
Onchocerca volvulus 0.0031 0.0489 0.0502
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0107 0.2602 0.2602
Echinococcus multilocularis aldehyde reductase 0.0076 0.1743 0.1743
Schistosoma mansoni chromobox protein 0.007 0.1573 0.3964
Trichomonas vaginalis malate dehydrogenase, putative 0.0035 0.0607 0.0839
Trichomonas vaginalis set domain proteins, putative 0.0238 0.6214 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.2633 0.8837
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.2967 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0035 0.0607 0.0839
Entamoeba histolytica aldose reductase, putative 0.0107 0.2602 1
Onchocerca volvulus 0.005 0.1012 0.137
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0171 0.0275
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0035 0.0607 0.2048
Schistosoma mansoni lamin 0.0027 0.0387 0.0787
Echinococcus granulosus RUN 0.002 0.0186 0.0186
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0075 0.1708 0.6437
Onchocerca volvulus Putative alcohol dehydrogenase 0.0075 0.1708 0.2525
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0171 0.0171
Echinococcus multilocularis malate dehydrogenase 0.0035 0.0607 0.0607
Schistosoma mansoni aldo-keto reductase 0.0107 0.2602 0.6722
Trypanosoma cruzi malate dehydrogenase, putative 0.0035 0.0607 0.2048
Schistosoma mansoni loxhd1 0.002 0.0186 0.0248
Echinococcus granulosus malate dehydrogenase 0.0035 0.0607 0.0607
Loa Loa (eye worm) hypothetical protein 0.0019 0.0171 0.0275
Loa Loa (eye worm) hypothetical protein 0.0027 0.0387 0.0623
Echinococcus granulosus lactate dehydrogenase a 0.009 0.213 0.213
Echinococcus multilocularis chromobox protein 1 0.007 0.1573 0.1573
Trichomonas vaginalis malate dehydrogenase, putative 0.0035 0.0607 0.0839
Trichomonas vaginalis glutamate dehydrogenase, putative 0.0024 0.0307 0.0349
Echinococcus multilocularis RUN 0.002 0.0186 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0406 0.0511
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0107 0.2602 0.2602
Brugia malayi intermediate filament protein 0.0027 0.0387 0.0563
Leishmania major prostaglandin f synthase, putative 0.0107 0.2602 1
Echinococcus granulosus glutamate dehydrogenase 0.0024 0.0307 0.0307
Plasmodium vivax SET domain protein, putative 0.003 0.0467 0.1836
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0107 0.2602 0.415
Echinococcus granulosus cytosolic malate dehydrogenase 0.0035 0.0607 0.0607
Echinococcus multilocularis musashi 0.0027 0.0387 0.0387
Schistosoma mansoni L-lactate dehydrogenase 0.009 0.213 0.5458
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0107 0.2602 0.2602
Mycobacterium ulcerans malate dehydrogenase 0.0035 0.0607 0.2048
Loa Loa (eye worm) doublecortin family protein 0.002 0.0186 0.0299
Schistosoma mansoni polycystin 1-related 0.002 0.0186 0.0248
Schistosoma mansoni malate dehydrogenase 0.009 0.213 0.5458
Loa Loa (eye worm) oxidoreductase 0.0107 0.2602 0.4187
Schistosoma mansoni L-lactate dehydrogenase 0.0035 0.0607 0.1376
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0171 0.0171
Echinococcus granulosus lactate dehydrogenase a 0.009 0.213 0.213
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0171 0.0207
Onchocerca volvulus Glutamate dehydrogenase, mitochondrial homolog 0.0024 0.0307 0.0201
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0497 0.0659
Echinococcus granulosus lamin dm0 0.0027 0.0387 0.0387
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.1171 0.1171
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0784 0.185
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0107 0.2602 0.8521
Leishmania major malate dehydrogenase 0.0035 0.0607 0.2048
Schistosoma mansoni glutamate dehydrogenase 0.0024 0.0307 0.0572
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.2633 0.8837
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0171 0.0171
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0035 0.0607 0.2048
Loa Loa (eye worm) hypothetical protein 0.002 0.0186 0.0299
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0107 0.2602 0.4098
Echinococcus multilocularis lamin 0.0027 0.0387 0.0387
Trichomonas vaginalis malate dehydrogenase, putative 0.0035 0.0607 0.0839
Trichomonas vaginalis malate dehydrogenase, putative 0.0035 0.0607 0.0839
Schistosoma mansoni chromobox protein 0.007 0.1573 0.3964
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0171 0.0207
Loa Loa (eye worm) oxidoreductase 0.0107 0.2602 0.4187
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0171 0.0171
Schistosoma mansoni aldo-keto reductase 0.0107 0.2602 0.6722
Trypanosoma brucei glycosomal malate dehydrogenase 0.0035 0.0607 0.2048
Entamoeba histolytica aldose reductase, putative 0.0107 0.2602 1
Echinococcus multilocularis tumor protein p63 0.0339 0.9018 0.9018
Trypanosoma cruzi aldo-keto reductase 0.0107 0.2602 1
Plasmodium falciparum lactate dehydrogenase, putative 0.0035 0.0607 0.2522
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0171 0.0171
Brugia malayi PXA domain containing protein 0.0019 0.0171 0.0212
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0171 0.0212
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0171 0.0207
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0094 0.0094
Echinococcus granulosus aldo keto reductase 0.0107 0.2602 0.2602
Toxoplasma gondii NADP-specific glutamate dehydrogenase 0.0024 0.0307 0.0851
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0107 0.2602 0.415
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0406 0.0511
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0437 0.0437
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0171 0.0171
Plasmodium vivax malate dehydrogenase, putative 0.009 0.213 1
Echinococcus multilocularis aldo keto reductase 0.0107 0.2602 0.2602
Toxoplasma gondii lactate dehydrogenase LDH2 0.009 0.213 0.8119
Loa Loa (eye worm) hypothetical protein 0.003 0.0467 0.0752
Trichomonas vaginalis malate dehydrogenase, putative 0.0035 0.0607 0.0839
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.2967 1
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0171 0.0207
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0075 0.1708 0.5619
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0171 0.0171
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0544 0.1796
Echinococcus multilocularis L lactate dehydrogenase 0.0055 0.1162 0.1162
Echinococcus granulosus voltage gated potassium channel subunit 0.0031 0.0497 0.0497
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0171 0.0207
Echinococcus multilocularis malate dehydrogenase 0.0035 0.0607 0.0607
Trichomonas vaginalis glutamate dehydrogenase, putative 0.0024 0.0307 0.0349
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0387 0.0623
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0035 0.0607 0.0607
Echinococcus multilocularis Glutamate dehydrogenase, mitochondrial 0.0024 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0019 0.0171 0.0275
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0107 0.2602 0.415
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0171 0.0126
Loa Loa (eye worm) hypothetical protein 0.002 0.0186 0.0299
Loa Loa (eye worm) malate dehydrogenase 0.0035 0.0607 0.0977
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0467 0.1002
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0723 0.1028
Schistosoma mansoni lamin 0.0027 0.0387 0.0787
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0171 0.0207
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.1573 0.2531
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0031 0.0497 0.1981
Trichomonas vaginalis malate dehydrogenase, putative 0.0035 0.0607 0.0839
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.1171 0.1171
Mycobacterium tuberculosis Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0066 0.1456 0.4741
Trichomonas vaginalis glutamate dehydrogenase, putative 0.0024 0.0307 0.0349
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0107 0.2602 0.415
Schistosoma mansoni rab6-interacting 0.002 0.0186 0.0248
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.5416 0.8717
Onchocerca volvulus 0.0027 0.0387 0.0334
Trichomonas vaginalis malate dehydrogenase, putative 0.0035 0.0607 0.0839
Toxoplasma gondii aldo-keto reductase 0.0031 0.0497 0.1608
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0171 0.0207
Brugia malayi NADH-dependent xylose reductase 0.0031 0.0497 0.0741
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.2967 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0107 0.2602 0.2602
Loa Loa (eye worm) oxidoreductase 0.0107 0.2602 0.4187
Leishmania major glycosomal malate dehydrogenase 0.0035 0.0607 0.2048
Entamoeba histolytica aldose reductase, putative 0.0107 0.2602 1
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0171 0.0212
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0186 0.0186
Trichomonas vaginalis aldo-keto reductase, putative 0.0107 0.2602 0.4098
Trypanosoma brucei aldo-keto reductase, putative 0.0107 0.2602 1
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0035 0.0607 0.2522
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0171 0.0171
Echinococcus granulosus expressed protein 0.0034 0.0566 0.0566
Trichomonas vaginalis aldo-keto reductase, putative 0.0107 0.2602 0.4098
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0951 0.342
Trichomonas vaginalis malate dehydrogenase, putative 0.0017 0.0111 0.0028
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0107 0.2602 0.4098
Trypanosoma brucei prostaglandin f synthase 0.0107 0.2602 1
Schistosoma mansoni potassium channel beta 0.0031 0.0497 0.1081
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0171 0.0207
Mycobacterium leprae Conserved hypothetical protein 0.0076 0.1743 0.5047
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0566 0.0852
Trichomonas vaginalis malate dehydrogenase, putative 0.0017 0.0111 0.0028
Echinococcus multilocularis lactate dehydrogenase a 0.009 0.213 0.213
Loa Loa (eye worm) oxidoreductase 0.0107 0.2602 0.4187
Schistosoma mansoni lipoxygenase 0.002 0.0186 0.0248
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0031 0.0497 0.0497
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0094 0.0087
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0035 0.0607 0.0919
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0171 0.0126
Echinococcus multilocularis lactate dehydrogenase a 0.009 0.213 0.213
Loa Loa (eye worm) hypothetical protein 0.009 0.213 0.3428
Trichomonas vaginalis glutamate dehydrogenase, putative 0.0024 0.0307 0.0349
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0035 0.0607 0.2048
Mycobacterium tuberculosis Probable oxidoreductase 0.0107 0.2602 0.8729
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0075 0.1708 0.4903
Trichomonas vaginalis chromobox protein, putative 0.007 0.1573 0.2417
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0951 0.0951
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0031 0.0497 0.0659
Echinococcus multilocularis glutamate dehydrogenase 0.0024 0.0307 0.0307
Onchocerca volvulus 0.0107 0.2602 0.4007
Trichomonas vaginalis aldo/keto reductase, putative 0.0107 0.2602 0.4098
Plasmodium vivax lactate dehydrogenase 0.009 0.213 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0497 0.0659
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0094 0.0094
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0035 0.0607 0.0839
Echinococcus multilocularis lamin dm0 0.0027 0.0387 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0171 0.0126
Echinococcus granulosus lamin 0.0027 0.0387 0.0387
Mycobacterium tuberculosis Probable reductase 0.0108 0.2633 0.8837
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0107 0.2602 0.2602
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0035 0.0607 0.0839
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0238 0.6213 1
Leishmania major malate dehydrogenase, putative 0.0035 0.0607 0.2048
Echinococcus granulosus hypothetical protein 0.0107 0.2602 0.2602
Trichomonas vaginalis malate dehydrogenase, putative 0.0035 0.0607 0.0839
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0075 0.1708 0.6437
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0171 0.0171
Leishmania major mitochondrial malate dehydrogenase 0.0035 0.0607 0.2048
Loa Loa (eye worm) hypothetical protein 0.005 0.1012 0.1628
Giardia lamblia Aldose reductase 0.0107 0.2602 1
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0171 0.0207
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0107 0.2602 0.2602
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.2967 1
Schistosoma mansoni cellular tumor antigen P53 0.005 0.1012 0.246
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0107 0.2602 1
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0035 0.0607 0.1795
Trichomonas vaginalis aldo-keto reductase, putative 0.0107 0.2602 0.4098
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0171 0.0171
Leishmania major glutamate dehydrogenase, putative 0.0024 0.0307 0.0851
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0075 0.1708 0.6437
Brugia malayi glutathione reductase 0.0048 0.0951 0.1477
Echinococcus granulosus tumor protein p63 0.0339 0.9018 0.9018
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0805 0.1027
Trichomonas vaginalis aldo-keto reductase, putative 0.0107 0.2602 0.4098
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0951 0.0951
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0171 0.0171
Trichomonas vaginalis malate dehydrogenase, putative 0.0035 0.0607 0.0839
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0805 0.1163
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0171 0.0126
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0467 0.0467
Brugia malayi Thioredoxin reductase 0.0048 0.0951 0.1477
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0805 0.1163
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0107 0.2602 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0107 0.2602 0.2602
Entamoeba histolytica alcohol dehydrogenase, putative 0.0031 0.0497 0.1342
Leishmania major aldo-keto reductase-like protein 0.0107 0.2602 1
Echinococcus granulosus aldehyde reductase 0.0076 0.1743 0.1743
Plasmodium vivax aldehyde reductase, putative 0.0031 0.0497 0.1981
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0075 0.1708 0.6437
Echinococcus multilocularis L lactate dehydrogenase B chain 0.009 0.213 0.213
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0027 0.0374 0.0601
Trichomonas vaginalis aldo-keto reductase, putative 0.0107 0.2602 0.4098
Trypanosoma brucei cytosolic malate dehydrogenase 0.0035 0.0607 0.2048
Entamoeba histolytica malate dehydrogenase, putative 0.009 0.213 0.8059
Schistosoma mansoni malate dehydrogenase 0.0035 0.0607 0.1376
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0171 0.0171
Trichomonas vaginalis aldo-keto reductase, putative 0.0107 0.2602 0.4098
Echinococcus granulosus aldo keto reductase 0.0107 0.2602 0.2602
Plasmodium falciparum L-lactate dehydrogenase 0.009 0.213 1
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0031 0.0497 0.0741
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0186 0.0454
Onchocerca volvulus 0.0107 0.2602 0.4007
Trypanosoma cruzi glutamate dehydrogenase, putative 0.0024 0.0307 0.0851
Brugia malayi Alcohol dehydrogenase class III 0.0075 0.1708 0.2702
Loa Loa (eye worm) hypothetical protein 0.0019 0.0171 0.0275
Loa Loa (eye worm) hypothetical protein 0.0107 0.2602 0.4187
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0467 0.1002
Schistosoma mansoni pol-related 0.0107 0.2602 0.6722
Brugia malayi hypothetical protein 0.0019 0.0171 0.0212
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0544 0.1535
Brugia malayi lactate dehydrogenase. 0.009 0.213 0.3386
Trypanosoma brucei trypanothione reductase 0.0048 0.0951 0.342
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0387 0.0623
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.009 0.213 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0107 0.2602 0.2602
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0951 0.4212
Leishmania major cytosolic malate dehydrogenase 0.0035 0.0607 0.2048
Loa Loa (eye worm) hypothetical protein 0.0031 0.0489 0.0786
Echinococcus granulosus intermediate filament protein 0.0027 0.0387 0.0387
Brugia malayi chromobox protein homolog 3 0.0039 0.0723 0.1106
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0171 0.0275
Giardia lamblia Aldose reductase 0.0107 0.2602 1
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0544 0.1796
Onchocerca volvulus 0.0041 0.0784 0.0992
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0171 0.0207
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0171 0.0171
Schistosoma mansoni malate dehydrogenase 0.0035 0.0607 0.1376
Trichomonas vaginalis glutamate dehydrogenase, putative 0.0024 0.0307 0.0349
Trichomonas vaginalis rotamase, putative 0.0033 0.0544 0.0736
Echinococcus multilocularis expressed protein 0.0375 1 1
Toxoplasma gondii lactate dehydrogenase LDH1 0.009 0.213 0.8119
Giardia lamblia Malate dehydrogenase 0.0035 0.0607 0.2048
Plasmodium falciparum NADP-specific glutamate dehydrogenase 0.0024 0.0307 0.1048
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0566 0.0772
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.2633 0.8837
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0075 0.1708 0.6437
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0467 0.0467
Schistosoma mansoni intermediate filament proteins 0.0027 0.0387 0.0787
Toxoplasma gondii malate dehydrogenase MDH 0.009 0.213 0.8119
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0723 0.1028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0467 0.1002
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0566 0.0911
Schistosoma mansoni alcohol dehydrogenase 0.0075 0.1708 0.4327
Chlamydia trachomatis malate dehydrogenase 0.0035 0.0607 1
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0035 0.0607 0.0919
Mycobacterium tuberculosis Conserved protein 0.0031 0.0497 0.1404
Trypanosoma cruzi glutamate dehydrogenase, putative 0.0024 0.0307 0.0851
Echinococcus multilocularis aldo keto reductase 0.0107 0.2602 0.2602
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0075 0.1708 0.6437
Echinococcus granulosus lactate dehydrogenase protein 0.009 0.213 0.213
Echinococcus multilocularis lactate dehydrogenase protein 0.009 0.213 0.213
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.2633 0.8647
Trichomonas vaginalis malate dehydrogenase, putative 0.0035 0.0607 0.0839
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0171 0.0126
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0171 0.0171
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0467 0.149
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0171 0.0126
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0035 0.0607 0.1787
Plasmodium falciparum thioredoxin reductase 0.0048 0.0951 0.4212
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0171 0.0171
Onchocerca volvulus 0.0107 0.2602 0.4007
Plasmodium falciparum aldehyde reductase, putative 0.0031 0.0497 0.1981
Loa Loa (eye worm) malate dehydrogenase 0.0035 0.0607 0.0977
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0171 0.0212
Brugia malayi Heterochromatin protein 1 0.007 0.1573 0.2483
Brugia malayi PXA domain containing protein 0.0019 0.0171 0.0212
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0075 0.1708 0.2749
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0723 0.089
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.2633 0.8837
Onchocerca volvulus 0.0107 0.2602 0.4007
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0035 0.0607 0.2048
Brugia malayi glutamate dehydrogenase, mitochondrial precursor, putative 0.0024 0.0307 0.0433
Loa Loa (eye worm) glutathione reductase 0.0048 0.0951 0.1531
Trypanosoma brucei aldo/keto reductase, putative 0.0031 0.0497 0.1608
Trichomonas vaginalis aldo/keto reductase, putative 0.0107 0.2602 0.4098
Echinococcus granulosus chromobox protein 1 0.007 0.1573 0.1573
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0107 0.2602 0.2602
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0031 0.0497 0.1608
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0171 0.0171
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0107 0.2602 0.2602
Brugia malayi follicle stimulating hormone receptor 0.0238 0.6213 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0171 0.0126
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0035 0.0607 0.0446
Echinococcus granulosus aldo keto reductase 0.0107 0.2602 0.2602
Loa Loa (eye worm) hypothetical protein 0.0019 0.0171 0.0275
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0107 0.2602 0.2602
Brugia malayi Pre-SET motif family protein 0.0209 0.5416 0.8709
Loa Loa (eye worm) hypothetical protein 0.0039 0.0723 0.1163
Giardia lamblia NADP-specific glutamate dehydrogenase 0.0024 0.0307 0.0851
Trichomonas vaginalis rotamase, putative 0.0034 0.0566 0.0772
Trichomonas vaginalis aldo-keto reductase, putative 0.0107 0.2602 0.4098
Schistosoma mansoni lipoxygenase 0.0055 0.1171 0.2888
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0171 0.0171
Brugia malayi Doublecortin family protein 0.002 0.0186 0.0237
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0107 0.2602 0.2602
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0035 0.0607 0.2048
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0035 0.0607 0.2048
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0497 0.0659
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0186 0.0186
Echinococcus granulosus L lactate dehydrogenase B chain 0.009 0.213 0.213
Loa Loa (eye worm) oxidoreductase 0.0107 0.2602 0.4187
Toxoplasma gondii thioredoxin reductase 0.0048 0.0951 0.342
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0186 0.0186
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0107 0.2602 0.2602
Entamoeba histolytica alcohol dehydrogenase, putative 0.0031 0.0497 0.1342
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0186 0.0186
Onchocerca volvulus 0.0031 0.0497 0.0516
Echinococcus multilocularis lactate dehydrogenase a 0.009 0.213 0.213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0171 0.0275
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0107 0.2602 0.2602
Plasmodium vivax glutamate dehydrogenase (NADP+), putative 0.0024 0.0307 0.1048
Brugia malayi hypothetical protein 0.0019 0.0171 0.0212
Brugia malayi glutamate dehydrogenase, mitochondrial precursor, putative 0.0024 0.0307 0.0433
Trichomonas vaginalis aldo-keto reductase, putative 0.0107 0.2602 0.4098
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0171 0.0207
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0031 0.0497 0.1608
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0171 0.0207
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0171 0.0275
Echinococcus granulosus malate dehydrogenase 0.0035 0.0607 0.0607
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0171 0.0212
Trichomonas vaginalis aldo-keto reductase, putative 0.0107 0.2602 0.4098
Onchocerca volvulus 0.0027 0.0387 0.0334
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0035 0.0607 0.0607
Onchocerca volvulus 0.0238 0.6214 1
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0031 0.0497 0.08
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0107 0.2602 0.4098
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0107 0.2602 0.2602
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0171 0.0212
Mycobacterium ulcerans oxidoreductase 0.0107 0.2602 1
Onchocerca volvulus 0.0107 0.2602 0.4007
Mycobacterium ulcerans hypothetical protein 0.0031 0.0497 0.1608
Echinococcus granulosus Glutamate dehydrogenase mitochondrial 0.0024 0.0307 0.0307
Trichomonas vaginalis aldo-keto reductase, putative 0.0107 0.2602 0.4098
Trypanosoma cruzi aldo/keto reductase, putative 0.0107 0.2602 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0171 0.0207
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 0.0066 0.1456 0.4741
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0035 0.0607 0.0839
Treponema pallidum NADH oxidase 0.0016 0.0094 0.5
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0544 0.1796
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0171 0.0212
Schistosoma mansoni rotamase 0.0034 0.0566 0.1266
Echinococcus multilocularis aldo keto reductase 0.0107 0.2602 0.2602
Trichomonas vaginalis chromobox protein, putative 0.007 0.1573 0.2417
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0107 0.2602 0.2602
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0171 0.0171
Trypanosoma brucei malate dehydrogenase-related 0.0035 0.0607 0.2048
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0467 0.0467
Trichomonas vaginalis aldo/keto reductase, putative 0.0107 0.2602 0.4098
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0544 0.1796
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0171 0.0275
Plasmodium falciparum glutathione reductase 0.0048 0.0951 0.4212
Plasmodium falciparum aldo-keto reductase, putative 0.0031 0.0497 0.1981
Leishmania major trypanothione reductase 0.0048 0.0951 0.342
Onchocerca volvulus Glutamate dehydrogenase, mitochondrial homolog 0.0024 0.0307 0.0201
Echinococcus multilocularis aldo keto reductase 0.0107 0.2602 0.2602
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0951 0.1531
Onchocerca volvulus 0.0107 0.2602 0.4007
Echinococcus granulosus chromobox protein 1 0.007 0.1573 0.1573
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0171 0.0275

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) < 10 % Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation at 10 uM after 60 mins by HTRF assay ChEMBL. 21273063
EC50 (functional) = 3600 nM Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins by HTRF assay ChEMBL. 21273063

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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