Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutamate receptor | 0.0019 | 0.1306 | 0.1306 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0041 | 0.5917 | 0.5872 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.7602 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.6626 | 0.864 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.3203 | 0.3869 |
Schistosoma mansoni | lamin | 0.0028 | 0.3203 | 0.1366 |
Loa Loa (eye worm) | glutamate receptor | 0.0049 | 0.7602 | 0.7602 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.9024 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.3203 | 0.3128 |
Onchocerca volvulus | 0.0028 | 0.3203 | 0.5 | |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0427 | 0.0427 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.3203 | 0.3203 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.3203 | 0.3128 |
Echinococcus multilocularis | lamin | 0.0028 | 0.3203 | 0.3128 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.3203 | 0.3128 |
Echinococcus granulosus | lamin | 0.0028 | 0.3203 | 0.3128 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.5917 | 0.5392 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0024 | 0.2282 | 0.2586 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.3203 | 0.3203 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0041 | 0.5917 | 0.5872 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0109 | 0.0109 |
Onchocerca volvulus | 0.0028 | 0.3203 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.3094 | 0.3094 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.3203 | 0.1366 |
Schistosoma mansoni | lamin | 0.0028 | 0.3203 | 0.1366 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.3203 | 0.3203 |
Echinococcus multilocularis | musashi | 0.0028 | 0.3203 | 0.3128 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.3203 | 0.3869 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2517 nM | Negative allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR assay | ChEMBL. | 21531137 |
Imax (binding) | = 61 % | Negative allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization at 10 uM by FLIPR assay relative to control | ChEMBL. | 21531137 |
Ki (binding) | = 5.68 uM | Displacement of [3H]-MPEP from human mGluR5 expressed in HEK293 cells after 2 hrs | ChEMBL. | 21531137 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.