Detailed information for compound 1560363

Basic information

Technical information
  • TDR Targets ID: 1560363
  • Name: 2-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethy l]sulfanyl-8-methylpyrido[2,1-f][1,3,5]triazi n-4-one
  • MW: 366.437 | Formula: C19H18N4O2S
  • H donors: 0 H acceptors: 2 LogP: 2.51 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccn2c(c1)nc(nc2=O)SCC(=O)N1CCCc2c1cccc2
  • InChi: 1S/C19H18N4O2S/c1-13-8-10-23-16(11-13)20-18(21-19(23)25)26-12-17(24)22-9-4-6-14-5-2-3-7-15(14)22/h2-3,5,7-8,10-11H,4,6,9,12H2,1H3
  • InChiKey: BUKRDBGRYJHYTH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxo-ethyl]sulfanyl-8-methyl-pyrido[2,1-f][1,3,5]triazin-4-one
  • 2-[[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]thio]-8-methyl-4-pyrido[2,1-f][1,3,5]triazinone
  • 2-[[2-(3,4-dihydro-2H-quinolin-1-yl)-2-keto-ethyl]thio]-8-methyl-pyrido[2,1-f][1,3,5]triazin-4-one
  • ZINC04503769

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0398 0.0513
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.0398 0.0209
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0793 0.1153
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0605 0.0605
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0285 0.009
Trypanosoma brucei unspecified product 0.0032 0.0212 0.0212
Trypanosoma cruzi thymidine kinase, putative 0.0503 0.6257 1
Trypanosoma brucei unspecified product 0.0027 0.0144 0.0103
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0273 0.0311
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0605 0.246
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0212 0.0212
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0142 0.1625 1
Schistosoma mansoni lamin 0.0026 0.0138 0.0226
Echinococcus granulosus thymidine kinase 0.049 0.6094 1
Schistosoma mansoni hypothetical protein 0.0034 0.0234 0.0383
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0144 0.0103
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0273 0.1243
Trypanosoma brucei ingi protein (ORF1) 0.0027 0.0144 0.0103
Echinococcus granulosus dna polymerase eta 0.0077 0.0793 0.1301
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0509 0.3129
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0509 0.0834
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0793 0.488
Leishmania major DNA polymerase eta, putative 0.0045 0.038 0.0485
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.038 0.0485
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.038 0.1938
Schistosoma mansoni ap endonuclease 0.0038 0.0285 0.0467
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.0398 0.0653
Toxoplasma gondii thymidylate kinase 0.0142 0.1625 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.0398 0.0398
Echinococcus multilocularis ribonuclease H1 0.0022 0.0081 0.0081
Trypanosoma brucei thymidine kinase 0.0503 0.6257 1
Schistosoma mansoni hypothetical protein 0.0219 0.2618 0.4296
Trypanosoma cruzi thymidylate kinase, putative 0.0142 0.1625 0.2501
Echinococcus multilocularis thymidine kinase 0.049 0.6094 0.6094
Schistosoma mansoni thymidylate kinase 0.0142 0.1625 0.2667
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0398 0.0513
Echinococcus granulosus thymidylate kinase 0.0142 0.1625 0.2667
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0273 0.0311
Brugia malayi hypothetical protein 0.0025 0.0122 0.0751
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0509 0.0834
Echinococcus granulosus intermediate filament protein 0.0026 0.0138 0.0226
Brugia malayi Inositol-1 0.0037 0.0273 0.1677
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0285 0.0331
Loa Loa (eye worm) hypothetical protein 0.0026 0.0132 0.081
Trichomonas vaginalis thymidylate kinase, putative 0.0142 0.1625 0.2501
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.0398 0.0653
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0398 0.0925
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0398 0.0513
Loa Loa (eye worm) hypothetical protein 0.0034 0.0234 0.1438
Schistosoma mansoni lamin 0.0026 0.0138 0.0226
Echinococcus granulosus thymidine kinase 0.049 0.6094 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0285 0.0331
Echinococcus multilocularis thyroid hormone receptor alpha 0.014 0.1603 0.1603
Schistosoma mansoni hypothetical protein 0.013 0.1469 0.241
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0122 0.0067
Schistosoma mansoni hypothetical protein 0.0053 0.0485 0.0796
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0605 0.085
Trypanosoma cruzi thymidine kinase, putative 0.0503 0.6257 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0138 0.0849
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0285 0.0331
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0122 0.0067
Loa Loa (eye worm) thymidylate kinase 0.0142 0.1625 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0273 0.0311
Echinococcus multilocularis geminin 0.0178 0.2085 0.2085
Chlamydia trachomatis thymidylate kinase 0.0142 0.1625 0.5
Echinococcus multilocularis transfer RNA-Ile 0.049 0.6094 0.6094
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0398 0.0513
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0273 0.0311
Leishmania major hypothetical protein, conserved 0.0056 0.0516 0.0704
Brugia malayi intermediate filament protein 0.0026 0.0138 0.0849
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0398 0.0513
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.0398 0.0653
Loa Loa (eye worm) hypothetical protein 0.0025 0.0122 0.0751
Trichomonas vaginalis thymidine kinase, putative 0.0503 0.6257 1
Treponema pallidum thymidylate kinase (tmk) 0.0142 0.1625 1
Trypanosoma brucei RNA helicase, putative 0.0219 0.2618 0.4108
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0398 0.0513
Schistosoma mansoni ap endonuclease 0.0038 0.0285 0.0467
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.0398 0.0513
Giardia lamblia CDC8 0.0142 0.1625 0.2501
Echinococcus granulosus lamin 0.0026 0.0138 0.0226
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0398 0.0925
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0285 0.002
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0285 0.0331
Mycobacterium ulcerans thymidylate kinase 0.0142 0.1625 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0273 0.0311
Echinococcus multilocularis musashi 0.0026 0.0138 0.0138
Trypanosoma brucei thymidylate kinase, putative 0.0142 0.1625 0.2501
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0398 0.0513
Echinococcus multilocularis dna polymerase kappa 0.0047 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0849
Schistosoma mansoni hypothetical protein 0.0178 0.2085 0.3421
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0285 0.1082
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0285 0.0331
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0285 0.1082
Echinococcus multilocularis dna polymerase eta 0.0077 0.0793 0.0793
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0605 0.0993
Echinococcus granulosus ribonuclease H1 0.0022 0.0081 0.0132
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0605 0.3398
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.0398 0.0513
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0212 0.0212
Trypanosoma brucei unspecified product 0.0047 0.0398 0.0513
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0285 0.1752
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0138 0.0849
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0398 0.0513
Trichomonas vaginalis thymidylate kinase, putative 0.0142 0.1625 0.2501
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0027 0.0144 0.0103
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0605 0.246
Loa Loa (eye worm) hypothetical protein 0.005 0.0435 0.2677
Echinococcus granulosus lamin dm0 0.0026 0.0138 0.0226
Brugia malayi thymidylate kinase 0.0142 0.1625 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0398 0.1246
Onchocerca volvulus 0.0026 0.0138 0.0371
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0605 0.2727
Brugia malayi RNase H family protein 0.0022 0.0081 0.0496
Onchocerca volvulus Putative thymidylate kinase 0.0142 0.1625 1
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.0793 0.1153
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0056 0.0516 0.0704
Leishmania major thymidine kinase, putative 0.0503 0.6257 1
Echinococcus multilocularis lamin dm0 0.0026 0.0138 0.0138
Giardia lamblia DINP protein human, muc B family 0.0047 0.0398 0.0513
Schistosoma mansoni hypothetical protein 0.0178 0.2085 0.3421
Leishmania major DNA polymerase kappa, putative 0.0047 0.0398 0.0513
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0509 0.0834
Schistosoma mansoni inositol monophosphatase 0.0037 0.0273 0.0447
Leishmania major hypothetical protein, conserved 0.0025 0.0122 0.0067
Schistosoma mansoni thymidine kinase 0.049 0.6094 1
Toxoplasma gondii exonuclease III APE 0.0038 0.0285 0.1322
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0273 0.0447
Schistosoma mansoni thyroid hormone receptor 0.014 0.1603 0.263
Schistosoma mansoni phosphoglucomutase 0.0022 0.0081 0.0132
Brugia malayi hypothetical protein 0.0016 0.0007 0.0046
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0142 0.1625 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0398 0.0513
Schistosoma mansoni inositol monophosphatase 0.0037 0.0273 0.0447
Schistosoma mansoni thymidylate kinase 0.0142 0.1625 0.2667
Trypanosoma cruzi thymidylate kinase, putative 0.0142 0.1625 0.2501
Giardia lamblia Deoxynucleoside kinase 0.0389 0.4792 0.7629
Brugia malayi RNase H family protein 0.0022 0.0081 0.0496
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0234 0.1438
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0509 0.0834
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.0398 0.1246
Schistosoma mansoni intermediate filament proteins 0.0026 0.0138 0.0226
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0285 0.0285
Schistosoma mansoni phosphoglucomutase 0.0022 0.0081 0.0132
Leishmania major thymidylate kinase-like protein 0.0142 0.1625 0.2501
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0285 0.0331
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0605 0.0993
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0285 0.1322
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0398 0.0513
Onchocerca volvulus 0.0026 0.0138 0.0371
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.049 0.6094 1
Schistosoma mansoni phosphoglucomutase 0.0022 0.0081 0.0132
Giardia lamblia Thymidine kinase 0.0503 0.6257 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0793 0.488
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0273 0.0311
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0435 0.2677
Brugia malayi RNase H family protein 0.0022 0.0081 0.0496
Schistosoma mansoni hypothetical protein 0.0142 0.1625 0.2667
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0285 0.1322
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.013 0.1469 0.1469
Echinococcus granulosus geminin 0.0178 0.2085 0.3421
Trichomonas vaginalis thymidine kinase, putative 0.0503 0.6257 1
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0398 0.0513
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0509 0.3129
Loa Loa (eye worm) inositol-1 0.0037 0.0273 0.1677
Schistosoma mansoni DNA polymerase eta 0.0077 0.0793 0.1301
Trypanosoma brucei unspecified product 0.0032 0.0212 0.0212
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0122 0.0269
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.013 0.1469 0.241
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0509 0.0509
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.0398 0.2447
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0285 0.0331
Trypanosoma brucei thymidylate kinase, putative 0.0142 0.1625 0.2501
Echinococcus multilocularis thymidylate kinase 0.0142 0.1625 0.1625
Echinococcus granulosus dna polymerase kappa 0.0047 0.0398 0.0653
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0273 0.0273
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0398 0.2447
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0435 0.2677
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0212 0.0212
Leishmania major DNA polymerase eta, putative 0.0077 0.0793 0.1153
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0398 0.0513
Trypanosoma brucei ingi protein (ORF1) 0.0027 0.0144 0.0103
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0398 0.0513
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0509 0.0834
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0398 0.0513
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0285 0.0467
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0285 0.1752
Echinococcus multilocularis lamin 0.0026 0.0138 0.0138
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0285 0.0441
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0138 0.0849
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0273 0.0311
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0273 0.1243
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.0398 0.0513
Plasmodium vivax thymidylate kinase, putative 0.0142 0.1625 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0398 0.0513
Trichomonas vaginalis thymidine kinase, putative 0.0503 0.6257 1
Schistosoma mansoni thyroid hormone receptor 0.014 0.1603 0.263
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0122 0.0067
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0435 0.2677
Echinococcus multilocularis thymidine kinase 0.049 0.6094 0.6094
Entamoeba histolytica Thymidylate kinase, putative 0.0142 0.1625 0.226
Entamoeba histolytica thymidine kinase, putative 0.0503 0.6257 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0605 0.246
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0142 0.1625 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0398 0.0513
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0056 0.0516 0.0704
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0509 0.0509
Plasmodium falciparum thymidylate kinase 0.0142 0.1625 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0605 0.0993
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0398 0.0513

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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