Detailed information for compound 1560406

Basic information

Technical information
  • TDR Targets ID: 1560406
  • Name: 5-fluoro-2-methoxy-N-naphthalen-2-ylbenzenesu lfonamide
  • MW: 331.361 | Formula: C17H14FNO3S
  • H donors: 1 H acceptors: 2 LogP: 3.77 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1S(=O)(=O)Nc1ccc2c(c1)cccc2)F
  • InChi: 1S/C17H14FNO3S/c1-22-16-9-7-14(18)11-17(16)23(20,21)19-15-8-6-12-4-2-3-5-13(12)10-15/h2-11,19H,1H3
  • InChiKey: MDPWTGXJJRZBGA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-fluoro-2-methoxy-N-(2-naphthyl)benzenesulfonamide
  • 5-fluoro-2-methoxy-N-naphthalen-2-yl-benzenesulfonamide
  • MLS-0202014.0001
  • ZINC00618652

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0484 0.1159
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.008 0.423 0.6114
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0012 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0484 0.1159
Entamoeba histolytica type A flavoprotein, putative 0.003 0.1266 0.6348
Toxoplasma gondii flavodoxin domain-containing protein 0.0039 0.1801 0.4257
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0213 0.0251
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.2405 0.2405
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0484 0.1159
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0079 0.4173 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.1111 0.131
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0634 0.1519
Onchocerca volvulus Matrix metalloproteinase homolog 0.0018 0.0553 0.4848
Onchocerca volvulus 0.0028 0.1141 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0484 0.1143
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0074
Trichomonas vaginalis NADPH cytochrome P450, putative 0.003 0.1266 0.2731
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.2405 0.5684
Plasmodium falciparum glutathione reductase 0.0049 0.2405 0.5684
Chlamydia trachomatis sulfite reductase 0.0049 0.2372 0.5607
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0484 0.1143
Echinococcus granulosus bloom syndrome protein 0.0022 0.0791 0.0791
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0015
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0791 0.0791
Mycobacterium ulcerans hypothetical protein 0.0021 0.0718 0.1697
Toxoplasma gondii endonuclease IV APN 0.008 0.423 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0484 0.1143
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0484 0.1143
Loa Loa (eye worm) hypothetical protein 0.0079 0.4173 0.4923
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0634 1
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0079 0.4173 1
Loa Loa (eye worm) RecQ helicase 0.0022 0.0791 0.0934
Trichomonas vaginalis NADPH cytochrome P450, putative 0.003 0.1266 0.2731
Echinococcus granulosus intermediate filament protein 0.0028 0.1141 0.1141
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0174 0.0416
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0351 0.083
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0012 0.0012
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0012 0.0012
Trichomonas vaginalis NADPH cytochrome P450, putative 0.003 0.1266 0.2731
Loa Loa (eye worm) hypothetical protein 0.0021 0.0718 0.0847
Brugia malayi intermediate filament protein 0.0028 0.1141 0.1347
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0791 0.1545
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.001 0.0063 0.009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0484 0.1159
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0079 0.4173 1
Loa Loa (eye worm) flavodoxin family protein 0.003 0.1266 0.1493
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0012 0.0029
Brugia malayi flavodoxin family protein 0.0079 0.4173 0.4923
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.6171 0.8909
Mycobacterium ulcerans hydrolase 0.001 0.0063 0.0148
Echinococcus multilocularis geminin 0.0177 1 1
Schistosoma mansoni lamin 0.0028 0.1141 0.1141
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0484 0.0699
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.1141 0.1347
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0012 0.0034
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.6919 1
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.008 0.423 0.4991
Loa Loa (eye worm) glutathione reductase 0.0049 0.2405 0.2837
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0484 0.1143
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0012 0.0015
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0634 0.0634
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.003 0.1266 0.3033
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0484 0.1329
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.008 0.423 0.6078
Mycobacterium ulcerans endonuclease IV 0.008 0.423 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0634 0.1499
Schistosoma mansoni hypothetical protein 0.0012 0.0161 0.0161
Plasmodium vivax flavodoxin domain containing protein 0.007 0.3638 0.8599
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0484 0.0484
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0363 0.0428
Schistosoma mansoni cytochrome P450 reductase 0.0079 0.4173 0.4173
Plasmodium falciparum glutathione reductase 0.0017 0.0484 0.1143
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0718 0.1038
Loa Loa (eye worm) acetyltransferase 0.0151 0.8476 1
Loa Loa (eye worm) FAD binding domain-containing protein 0.0049 0.2372 0.2798
Brugia malayi Hemopexin family protein 0.0012 0.0161 0.019
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.1894 0.5207
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0484 0.1143
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0634 0.1519
Mycobacterium tuberculosis Probable reductase 0.0113 0.6171 0.8918
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0634 0.1499
Trichomonas vaginalis NADPH cytochrome P450, putative 0.003 0.1266 0.2731
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.003 0.1266 0.3033
Entamoeba histolytica type A flavoprotein, putative 0.003 0.1266 0.6348
Brugia malayi FAD binding domain containing protein 0.0079 0.4173 0.4923
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0484 0.1159
Plasmodium falciparum thioredoxin reductase 0.0017 0.0484 0.1143
Schistosoma mansoni ap endonuclease 0.002 0.0634 0.0634
Loa Loa (eye worm) matrixin family protein 0.002 0.0652 0.0769
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0274 0.0274
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.2115 0.4999
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0484 0.1159
Schistosoma mansoni DNA helicase recq1 0.0009 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0013 0.0243 0.0287
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.003 0.1266 0.3033
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0079 0.4173 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.6919 1
Echinococcus multilocularis lamin dm0 0.0028 0.1141 0.1141
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0079 0.4173 0.4173
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0634 0.1499
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0484 0.1143
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0079 0.4173 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.8476 0.8476
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.6171 0.8918
Loa Loa (eye worm) intermediate filament protein 0.0028 0.1141 0.1347
Onchocerca volvulus 0.0028 0.1141 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0634 0.1743
Schistosoma mansoni lamin 0.0028 0.1141 0.1141
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0079 0.4173 0.9865
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.2115 0.4999
Brugia malayi glutathione reductase 0.0049 0.2405 0.2837
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.2115 0.4854
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.2405 0.3475
Echinococcus granulosus lamin 0.0028 0.1141 0.1141
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0484 0.1159
Schistosoma mansoni ap endonuclease 0.002 0.0634 0.0634
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.6171 0.8918
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0634 0.5009
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0484 0.1143
Leishmania major p450 reductase, putative 0.0079 0.4173 1
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0484 0.1159
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0791 0.1545
Schistosoma mansoni hypothetical protein 0.0177 1 1
Onchocerca volvulus Matrilysin homolog 0.0018 0.0553 0.4848
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0049 0.2372 0.2372
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0012 0.0012
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0512 0.0512
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0484 0.0484
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0634 0.1519
Leishmania major trypanothione reductase 0.0049 0.2405 0.5762
Leishmania major cytochrome P450 reductase, putative 0.007 0.3638 0.8717
Plasmodium vivax hypothetical protein, conserved 0.003 0.1266 0.2992
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.003 0.1266 0.2992
Brugia malayi FAD binding domain containing protein 0.0049 0.2372 0.2798
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0174 0.0416
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0079 0.4173 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0012 0.0029
Entamoeba histolytica type A flavoprotein, putative 0.003 0.1266 0.6348
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0174 0.0416
Plasmodium falciparum thioredoxin reductase 0.0049 0.2405 0.5684
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0079 0.4173 0.4173
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.1894 1
Trypanosoma brucei trypanothione reductase 0.0049 0.2405 0.5762
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.003 0.1266 0.2992
Toxoplasma gondii flavodoxin domain-containing protein 0.0039 0.1801 0.4257
Schistosoma mansoni DNA helicase recq5 0.0009 0.0012 0.0012
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0079 0.4173 0.4173
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.8476 0.8476
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.6919 1
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0363 0.0428
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0079 0.4173 0.4173
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0484 0.1143
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0079 0.4173 0.9865
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0634 0.0634
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0634 0.0748
Schistosoma mansoni intermediate filament proteins 0.0028 0.1141 0.1141
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.8223 0.8223
Entamoeba histolytica type A flavoprotein, putative 0.003 0.1266 0.6348
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0484 0.1159
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0718 0.0847
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0484 0.1159
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.003 0.1249 0.1249
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0274 0.0274
Plasmodium vivax glutathione reductase, putative 0.0049 0.2405 0.5684
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0718 0.1697
Brugia malayi Matrixin family protein 0.002 0.0652 0.0769
Treponema pallidum flavodoxin 0.003 0.1266 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0362 0.0855
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0484 0.1159
Echinococcus multilocularis lamin 0.0028 0.1141 0.1141
Loa Loa (eye worm) hypothetical protein 0.0018 0.0523 0.0617
Schistosoma mansoni NADPH flavin oxidoreductase 0.004 0.1837 0.1837
Brugia malayi Thioredoxin reductase 0.0049 0.2405 0.2837
Echinococcus multilocularis musashi 0.0028 0.1141 0.1141
Toxoplasma gondii exonuclease III APE 0.002 0.0634 0.1499
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0213 0.0251
Trichomonas vaginalis sulfite reductase, putative 0.0079 0.4173 1
Entamoeba histolytica type A flavoprotein, putative 0.003 0.1266 0.6348
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.2115 0.4999
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0718 0.629
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.1141 0.1347
Loa Loa (eye worm) FAD binding domain-containing protein 0.0079 0.4173 0.4923
Loa Loa (eye worm) matrixin family protein 0.0018 0.0553 0.0653
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.2405 0.2405
Giardia lamblia Nitric oxide synthase, inducible 0.007 0.3638 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0484 0.0484
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.1894 0.4477
Brugia malayi flavodoxin family protein 0.003 0.1266 0.1493
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0634 0.0748
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.8476 1
Loa Loa (eye worm) hypothetical protein 0.008 0.423 0.4991
Giardia lamblia Hypothetical protein 0.007 0.3638 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.063 0.149
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0634 0.0916
Schistosoma mansoni diflavin oxidoreductase 0.0039 0.1801 0.1801
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0484 0.057
Plasmodium falciparum nitric oxide synthase, putative 0.0079 0.4173 0.9865
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0484 0.1159
Loa Loa (eye worm) hypothetical protein 0.0013 0.0243 0.0287
Toxoplasma gondii thioredoxin reductase 0.0049 0.2405 0.5684
Schistosoma mansoni hypothetical protein 0.0177 1 1
Mycobacterium ulcerans epimerase 0.0021 0.0718 0.1697
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.003 0.1249 0.1249
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0484 0.1159
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.6171 0.8918
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0012 0.0029
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0484 0.0775
Mycobacterium leprae conserved hypothetical protein 0.0021 0.0718 0.0956
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0484 0.1159
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0634 0.1151
Echinococcus multilocularis methionine synthase reductase 0.0049 0.2372 0.2372
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0079 0.4173 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.2115 0.2115
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.003 0.1266 0.3033
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0634 0.1519
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.6171 0.8918
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0484 0.1159
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0012 0.0015
Chlamydia trachomatis endonuclease IV 0.008 0.423 1
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.001 0.0063 0.0074
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.423 1
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.002 0.063 0.063
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0484 0.1143
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0079 0.4173 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.1141 0.1347
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0484 0.1159
Onchocerca volvulus 0.0012 0.0161 0.1408
Loa Loa (eye worm) hypothetical protein 0.0014 0.0274 0.0323
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.007 0.3638 0.8662
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0634 0.2677
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0634 0.1151
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0791 0.0934
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.6171 0.8918
Treponema pallidum NADH oxidase 0.0017 0.0484 0.382
Leishmania major hypothetical protein, conserved 0.003 0.1266 0.3033
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0012 0.0015
Echinococcus granulosus lamin dm0 0.0028 0.1141 0.1141
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.2115 0.4854
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.423 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.6919 1
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.2405 0.2837
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0484 0.1159
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0484 0.0775
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.2405 0.5762
Echinococcus granulosus methionine synthase reductase 0.0049 0.2372 0.2372
Trypanosoma cruzi p450 reductase, putative 0.0079 0.4173 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 100 uM PUBCHEM_BIOASSAY: Luminescent assay for HTS discovery of chemical inhibitors of placental alkaline phosphatase confirmation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1577, AID518, AID690] ChEMBL. No reference
IC50 (binding) > 100 uM PUBCHEM_BIOASSAY: SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1548, AID1574, AID1577, AID1659, AID518] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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