Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0671 | 1 | 1 | |
Brugia malayi | Hexokinase family protein | 0.0671 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.2365 | 0.1496 |
Echinococcus multilocularis | hexokinase type 2 | 0.0671 | 1 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0123 | 0.1021 | 0.1021 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.2002 | 0.2002 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1021 | 0.1021 |
Echinococcus multilocularis | hexokinase | 0.0671 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0421 | 0.5906 | 0.5906 |
Trypanosoma brucei | hexokinase | 0.0671 | 1 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.0671 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0182 | 0.2002 | 0.2002 |
Trypanosoma cruzi | hexokinase, putative | 0.0671 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0208 | 0.2414 | 0.2414 |
Echinococcus granulosus | hexokinase | 0.0671 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1021 | 0.1021 |
Schistosoma mansoni | hexokinase | 0.0671 | 1 | 1 |
Onchocerca volvulus | 0.0421 | 0.5906 | 0.5441 | |
Plasmodium falciparum | hexokinase | 0.0671 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0671 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0671 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0458 | 0.6507 | 0.6507 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1021 | 0.1021 |
Echinococcus granulosus | hexokinase type 2 | 0.0671 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0671 | 1 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.5695 | 0.5206 |
Leishmania major | hexokinase, putative | 0.0671 | 1 | 0.5 |
Brugia malayi | Cation transporter family protein | 0.0123 | 0.1021 | 0.1021 |
Loa Loa (eye worm) | hexokinase | 0.0208 | 0.2414 | 0.2414 |
Entamoeba histolytica | hexokinase 2 | 0.0671 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.2507 | 0.2507 |
Brugia malayi | Hexokinase family protein | 0.0421 | 0.5906 | 0.5906 |
Loa Loa (eye worm) | hexokinase type II | 0.0671 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0671 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0612 | 0.0612 |
Echinococcus granulosus | hexokinase | 0.0671 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0671 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0671 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0671 | 1 | 0.5 |
Onchocerca volvulus | 0.0671 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0671 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.2507 | 0.2507 |
Echinococcus granulosus | geminin | 0.0205 | 0.2365 | 0.1496 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0123 | 0.1021 | 0.1021 |
Trypanosoma cruzi | hexokinase, putative | 0.0671 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2365 | 0.1496 |
Onchocerca volvulus | 0.0671 | 1 | 1 | |
Trypanosoma brucei | hexokinase, putative | 0.0671 | 1 | 0.5 |
Onchocerca volvulus | Hexokinase homolog | 0.0421 | 0.5906 | 0.5441 |
Echinococcus multilocularis | hexokinase | 0.0671 | 1 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.5695 | 0.5206 |
Brugia malayi | hexokinase type II | 0.0213 | 0.2507 | 0.2507 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2365 | 0.1496 |
Loa Loa (eye worm) | hexokinase | 0.0671 | 1 | 1 |
Onchocerca volvulus | 0.0182 | 0.2002 | 0.1092 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 32 uM | PUBCHEM_BIOASSAY: SAR analysis of agonists of the Cannabinoid Receptor 1 using an Image-Based Assay - Set 4. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2013, AID2026] | ChEMBL. | No reference |
EC50 (functional) | > 32 uM | PUBCHEM_BIOASSAY: SAR analysis of Agonists of the GPR35 Receptor using an Image-Based Assay - Set 4. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2013, AID2026] | ChEMBL. | No reference |
EC50 (functional) | > 32 uM | PUBCHEM_BIOASSAY: SAR analysis of agonists of the Cannabinoid Receptor 2 using an Image-Based Assay - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2013, AID2026] | ChEMBL. | No reference |
IC50 (functional) | = 29 uM | PUBCHEM_BIOASSAY: SAR Analysis of Selective Antagonists of GPR55 using an Image-Based Assay - Set 4. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2013, AID2026] | ChEMBL. | No reference |
IC50 (functional) | > 32 uM | PUBCHEM_BIOASSAY: SAR analysis of Antagonists of the GPR35 Receptor using an Image-Based Assay - Set 6. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2013, AID2026] | ChEMBL. | No reference |
IC50 (functional) | > 32 uM | PUBCHEM_BIOASSAY: SAR analysis of antagonists of the Cannabinoid Receptor 1 using an Image-Based Assay - Set 4. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2013, AID2026] | ChEMBL. | No reference |
IC50 (functional) | > 32 uM | PUBCHEM_BIOASSAY: SAR analysis of antagonists of the Cannabinoid Receptor 2 using an Image-Based Assay - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2013, AID2026] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.