Detailed information for compound 1560551

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 389.25 | Formula: C16H14Cl2O5S
  • H donors: 1 H acceptors: 4 LogP: 3.97 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCS(=O)(=O)c1ccc(c(c1)Cl)c1cc(Cl)ccc1OCC(=O)O
  • InChi: 1S/C16H14Cl2O5S/c1-2-24(21,22)11-4-5-12(14(18)8-11)13-7-10(17)3-6-15(13)23-9-16(19)20/h3-8H,2,9H2,1H3,(H,19,20)
  • InChiKey: CNMBRSATMDIDOG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prostaglandin D2 receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi glutaminase DH11.1 0.0313 0.169 0.3004
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.014 0.0252
Plasmodium vivax metacaspase 1, putative 0.002 0.0021 0.0056
Echinococcus multilocularis caspase 8 0.002 0.0021 0.0021
Brugia malayi nuclear receptor RXR 0.0019 0.0013 0.0014
Leishmania major p-glycoprotein 0.0024 0.0043 0.0065
Brugia malayi hypothetical protein 0.0047 0.0174 0.0302
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.002 0.0021 0.0028
Brugia malayi AMP-binding enzyme family protein 0.0027 0.006 0.0098
Brugia malayi CXXC zinc finger family protein 0.0065 0.0275 0.0482
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0043 0.0113
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.007 0.0215
Brugia malayi jmjC domain containing protein 0.0035 0.0107 0.0182
Loa Loa (eye worm) CXXC zinc finger family protein 0.0065 0.0275 0.0491
Brugia malayi AMP-binding enzyme family protein 0.0027 0.006 0.0098
Echinococcus granulosus caspase 8 0.002 0.0021 0.0024
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0295 0.1591 0.2828
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0319 0.0358
Brugia malayi Cathepsin L-like precursor 0.0019 0.0015 0.0017
Loa Loa (eye worm) hypothetical protein 0.0128 0.0633 0.1128
Loa Loa (eye worm) hypothetical protein 0.0038 0.012 0.0213
Loa Loa (eye worm) hypothetical protein 0.0024 0.0043 0.0077
Plasmodium vivax SET domain protein, putative 0.0036 0.0108 0.0852
Leishmania major NAD synthase, putative 0.0094 0.0442 0.0827
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0117 0.0574 0.0574
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0043 0.0113
Echinococcus multilocularis muscleblind protein 0.0337 0.1831 0.1831
Echinococcus granulosus microtubule associated protein 2 0.1558 0.88 1
Brugia malayi secreted modular calcium-binding protein 1 0.0087 0.0402 0.0708
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.014 0.0465
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0015 0.0036
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.0125
Brugia malayi hypothetical protein 0.0045 0.0163 0.0281
Toxoplasma gondii glutamine-dependent NAD(+) synthetase protein, putative 0.0094 0.0442 0.3885
Leishmania major cathepsin L-like protease 0.0019 0.0015 0.0011
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0015 0.0012
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0043 0.0113
Mycobacterium leprae PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]) 0.0094 0.0442 0.1509
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.047 0.2588 1
Leishmania major cathepsin L-like protease 0.0019 0.0015 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0015 0.0036
Schistosoma mansoni smdr2 0.0024 0.0043 0.0044
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0146 0.0395
Echinococcus granulosus cpg binding protein 0.0069 0.0297 0.0337
Echinococcus granulosus mitogen activated protein kinase 0.0115 0.0562 0.0639
Brugia malayi ecdysteroid receptor 0.004 0.0134 0.0229
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0043 0.0049
Toxoplasma gondii transporter, major facilitator family protein 0.0128 0.0633 0.5632
Schistosoma mansoni glutaminase 0.0313 0.169 0.1916
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0027 0.0031
Brugia malayi hypothetical protein 0.0029 0.007 0.0115
Echinococcus granulosus lysine specific demethylase 6a 0.0035 0.0107 0.0122
Echinococcus multilocularis agrin 0.0087 0.0402 0.0402
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.014 0.0379
Brugia malayi beta-NAC-like protein 0.004 0.0134 0.0229
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.066 0.3672 1
Trypanosoma brucei NAD+ synthase, putative 0.0094 0.0442 0.0827
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0015 0.0036
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0093 0.0106
Mycobacterium ulcerans lipase LipD 0.0041 0.014 0.0486
Schistosoma mansoni jumonji/arid domain-containing protein 0.0136 0.0684 0.0773
Brugia malayi hypothetical protein 0.0128 0.0633 0.112
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0023
Onchocerca volvulus 0.0019 0.0015 0.0003
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0013 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0015 0.0036
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0078 0.0351 0.0394
Schistosoma mansoni multidrug resistance protein 0.0024 0.0043 0.0044
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0078 0.0351 0.0394
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0322 0.1746 0.6667
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0133 0.0663 0.0663
Echinococcus multilocularis transcription factor btf3 0.004 0.0134 0.0134
Schistosoma mansoni cpg binding protein 0.0069 0.0297 0.0332
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0015 0.0036
Echinococcus multilocularis lysine specific demethylase 6a 0.0035 0.0107 0.0107
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.002 0.0021 0.0056
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0021 0.0053
Onchocerca volvulus 0.0024 0.0043 0.0054
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0117 0.0574 0.0648
Loa Loa (eye worm) hypothetical protein 0.0045 0.0163 0.029
Loa Loa (eye worm) hypothetical protein 0.0027 0.006 0.0107
Trypanosoma cruzi metacaspase, putative 0.002 0.0021 0.0023
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.006 0.019
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0043 0.0113
Schistosoma mansoni thyroid hormone receptor 0.004 0.0134 0.0147
Brugia malayi sodium-independent organic anion transporter family protein 0.0128 0.0633 0.112
Brugia malayi hypothetical protein 0.0128 0.0633 0.112
Loa Loa (eye worm) hypothetical protein 0.0078 0.0351 0.0626
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.014 0.0379
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.025
Echinococcus multilocularis lipoxygenase domain containing protein 0.0045 0.0163 0.0163
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.006 0.019
Echinococcus granulosus cathepsin l1 0.0019 0.0015 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0015 0.0036
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0004 0.0004
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0043 0.0113
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0146 0.0263
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0013 0.0014
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0001 0.0002
Plasmodium vivax multidomain scavenger receptor, putative 0.0045 0.0163 0.1348
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0024 0.0043 0.0086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0204 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0021 0.0053
Brugia malayi Melibiase family protein 0.0078 0.0351 0.0617
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0015 0.0036
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.016 0.082 0.155
Echinococcus granulosus lipoxygenase domain containing protein 0.0045 0.0163 0.0185
Trichomonas vaginalis abcb9, putative 0.0024 0.0043 0.0113
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0026 0.0024
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.047 0.2588 0.9527
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0134 0.0147
Echinococcus granulosus apoptotic protease activating factor 1 0.0047 0.0174 0.0198
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0043 0.0049
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0013 0.0015
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0009 0.0016
Schistosoma mansoni jumonji/arid domain-containing protein 0.0136 0.0684 0.0773
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0024 0.0043 0.0077
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0204 0.0232
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.006 0.019
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0134 0.0152
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0134 0.0147
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.0043 0.0113
Onchocerca volvulus Putative organic anion transporter 0.0128 0.0633 0.1108
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0134 0.0229
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0935 0.5241 1
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0146 0.0146
Schistosoma mansoni lozenge 0.0125 0.0621 0.0702
Brugia malayi RNA binding protein 0.0072 0.0319 0.0559
Schistosoma mansoni caspase-7 (C14 family) 0.0067 0.029 0.0324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0015 0.0036
Loa Loa (eye worm) DR-78 0.0019 0.0013 0.0023
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0087 0.0402 0.3529
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.014 0.0465
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0146 0.0395
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0121 0.0242
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.066 0.3672 1
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0078 0.0351 0.0953
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0015 0.0036
Leishmania major cathepsin L-like protease 0.0073 0.0322 0.0598
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0015 0.0003
Echinococcus granulosus Polycystic kidney disease protein 0.0045 0.0163 0.0185
Brugia malayi prostaglandin transporter 0.0128 0.0633 0.112
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0039 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0087 0.0402 0.0717
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.007 0.0215
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0115 0.0562 0.1058
Trypanosoma brucei Metacaspase-4 0.002 0.0021 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0134 0.0229
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0009 0.0016
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0015 0.0036
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0295 0.1591 0.2835
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0087 0.0402 0.0708
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0023
Mycobacterium ulcerans hypothetical protein 0.0027 0.006 0.019
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.025
Schistosoma mansoni coup transcription factor 0.004 0.0134 0.0147
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.004 0.0134 0.0238
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0015 0.0026
Echinococcus multilocularis phd:f box containing protein 0.0035 0.0107 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0134 0.0229
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.1591 0.4331
Loa Loa (eye worm) hypothetical protein 0.004 0.0134 0.0238
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0046
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0134 0.0134
Leishmania major cathepsin L-like protease 0.0073 0.0322 0.0598
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.014 0.025
Brugia malayi ABC transporter family protein 0.0024 0.0043 0.0068
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0004 0.0005
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0013 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.014 0.0379
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.006 0.0098
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0153 0.0777 0.0883
Schistosoma mansoni rab6-interacting 0.0045 0.0163 0.018
Brugia malayi Cathepsin L-like precursor 0.0019 0.0015 0.0017
Brugia malayi sodium-independent organic anion transporter family protein 0.0128 0.0633 0.112
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0043 0.0113
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.004 0.0134 0.0325
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0115 0.0562 0.1001
Brugia malayi hypothetical protein 0.0045 0.0163 0.0281
Loa Loa (eye worm) hypothetical protein 0.0128 0.0633 0.1128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0015 0.0036
Brugia malayi Inositol-1 0.0042 0.0146 0.0252
Brugia malayi sodium-independent organic anion transporter family protein 0.0128 0.0633 0.112
Echinococcus multilocularis Protein lozenge 0.0125 0.0621 0.0621
Schistosoma mansoni jumonji domain containing protein 0.0035 0.0107 0.0117
Brugia malayi beta-lactamase 0.0041 0.014 0.0241
Loa Loa (eye worm) hypothetical protein 0.1 0.5614 1
Echinococcus multilocularis geminin 0.0194 0.1012 0.1012
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0043 0.0049
Loa Loa (eye worm) hypothetical protein 0.004 0.0134 0.0238
Brugia malayi Doublecortin family protein 0.0045 0.0163 0.0281
Brugia malayi Cathepsin L-like precursor 0.0019 0.0015 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0108 0.0118
Echinococcus multilocularis caspase 2 0.0067 0.029 0.029
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0013 0.0013
Echinococcus multilocularis cpg binding protein 0.0069 0.0297 0.0297
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0013 0.0013
Echinococcus multilocularis muscleblind protein 1 0.0337 0.1831 0.1831
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0043 0.0113
Mycobacterium ulcerans hypothetical protein 0.0041 0.014 0.0486
Loa Loa (eye worm) hypothetical protein 0.0337 0.1831 0.3261
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0013 0.0023
Echinococcus multilocularis follistatin 0.0087 0.0402 0.0402
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0212 0.1113 0.4167
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.1012 0.2752
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0084 0.0386 0.0386
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0322 0.0598
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0134 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0134 0.0238
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0021 0.0053
Onchocerca volvulus 0.0128 0.0633 0.1108
Leishmania major hypothetical protein, conserved 0.0041 0.014 0.0252
Schistosoma mansoni caspase-7 (C14 family) 0.002 0.0021 0.0019
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0115 0.0562 0.1058
Echinococcus granulosus survival motor neuron protein 1 0.027 0.1449 0.1647
Trypanosoma brucei RNA helicase, putative 0.0111 0.0538 0.1012
Echinococcus granulosus mitogen activated protein kinase 3 0.0115 0.0562 0.0639
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0117 0.0574 0.0648
Onchocerca volvulus Cell death protein 3 homolog 0.0067 0.029 0.0494
Brugia malayi AMP-binding enzyme family protein 0.0027 0.006 0.0098
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0131 0.0656 0.1236
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0043 0.0113
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0128 0.0633 0.072
Brugia malayi Cathepsin L-like precursor 0.0019 0.0015 0.0017
Giardia lamblia Fructose-bisphosphate aldolase 0.066 0.3672 1
Schistosoma mansoni hypothetical protein 0.0047 0.0174 0.0193
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.014 0.0486
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0322 0.0598
Brugia malayi jmjC domain containing protein 0.0136 0.0684 0.1211
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.047 0.2588 1
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0128 0.0633 0.0633
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.047 0.2588 1
Mycobacterium ulcerans beta-lactamase 0.0041 0.014 0.0486
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0067 0.0286 0.0529
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0212 0.1113 1
Schistosoma mansoni inositol monophosphatase 0.0042 0.0146 0.0161
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0013 0.0015
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0319 0.0559
Loa Loa (eye worm) hypothetical protein 0.0128 0.0633 0.1128
Onchocerca volvulus 0.0019 0.0015 0.0003
Onchocerca volvulus 0.0045 0.0163 0.0267
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0015 0.0012
Schistosoma mansoni hypothetical protein 0.0194 0.1012 0.1145
Echinococcus multilocularis lysine specific demethylase 5A 0.0133 0.0663 0.0663
Schistosoma mansoni hypothetical protein 0.0055 0.022 0.0245
Toxoplasma gondii NAC domain-containing protein 0.004 0.0134 0.1082
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0024 0.0042 0.0047
Plasmodium falciparum basic transcription factor 3b, putative 0.004 0.0134 0.0462
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0001 0.0002
Mycobacterium tuberculosis Conserved protein 0.0041 0.014 0.0465
Echinococcus multilocularis RUN 0.0045 0.0163 0.0163
Loa Loa (eye worm) doublecortin family protein 0.0045 0.0163 0.029
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0024 0.0043 0.0258
Trichomonas vaginalis nh(3)-dependent NAD(+) synthetase, putative 0.0094 0.0442 0.1199
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0015 0.0017
Onchocerca volvulus Putative organic anion transporter 0.0128 0.0633 0.1108
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0023
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0087 0.0402 0.0708
Onchocerca volvulus 0.0041 0.014 0.0227
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0037
Onchocerca volvulus 0.0019 0.0015 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0134 0.0229
Schistosoma mansoni agrin 0.0087 0.0402 0.0453
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0043 0.0113
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.0043 0.0043
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.066 0.3672 1
Trypanosoma cruzi NAD+ synthase, putative 0.0094 0.0442 0.0827
Mycobacterium tuberculosis Conserved protein 0.0041 0.014 0.0465
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0013 0.0014
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0013 0.001
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.007 0.0117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0322 0.0598
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.0043 0.0043
Trypanosoma cruzi metacaspase, putative 0.002 0.0021 0.0023
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.066 0.3672 1
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0128 0.0633 0.0633
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0134 0.0215
Loa Loa (eye worm) jmjC domain-containing protein 0.0136 0.0684 0.1219
Brugia malayi hypothetical protein 0.0019 0.0012 0.0011
Plasmodium vivax basic transcription factor 3b, putative 0.004 0.0134 0.1082
Brugia malayi nuclear receptor NHR-67 0.0019 0.0013 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0134 0.0238
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0087 0.0402 0.3529
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0026
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0056 0.0227 0.0253
Echinococcus granulosus Solute carrier organic anion transporter family 0.0128 0.0633 0.072
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.007 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0021 0.0053
Plasmodium falciparum GMP synthase [glutamine-hydrolyzing] 0.0038 0.012 0.0408
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0021 0.0053
Schistosoma mansoni protein phosphatase 2C 0.0035 0.0107 0.0117
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.066 0.3672 1
Plasmodium falciparum glutamine-dependent NAD(+) synthetase, putative 0.0094 0.0442 0.1659
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0043 0.0043
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0027 0.0048
Trypanosoma brucei transcription factor BTF3, putative 0.004 0.0134 0.0239
Trichomonas vaginalis esterase, putative 0.0041 0.014 0.0379
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0134 0.0147
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0043 0.0258
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0134 0.0134
Schistosoma mansoni phosphatidylserine receptor 0.0035 0.0107 0.0117
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0021 0.0053
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0108 0.0852
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0013 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0026 0.0037
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0013 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.1591 0.4331
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0204 0.0232
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0319 0.0568
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0134 0.0238
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0013 0.0023
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0037
Onchocerca volvulus 0.0047 0.0174 0.0288
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0107 0.0191
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0115 0.0562 0.1058
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0134 0.0229
Brugia malayi Cathepsin L-like precursor 0.0019 0.0015 0.0017
Echinococcus granulosus GMP synthase glutamine hydrolyzing 0.0038 0.012 0.0136
Schistosoma mansoni rab6-interacting 0.0045 0.0163 0.018
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0115 0.0562 0.1058
Loa Loa (eye worm) hypothetical protein 0.004 0.0134 0.0238
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0134 0.0229
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.1591 0.4331
Onchocerca volvulus 0.1 0.5614 1
Trypanosoma cruzi metacaspase 5, putative 0.002 0.0021 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0322 0.0598
Leishmania major metacaspase, putative 0.002 0.0021 0.0023
Trypanosoma brucei metacaspase 0.002 0.0021 0.0023
Trypanosoma brucei GMP synthase [glutamine-hydrolysing] 0.0038 0.012 0.0212
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.014 0.0154
Plasmodium falciparum metacaspase 1 0.002 0.0021 0.0024
Mycobacterium tuberculosis Conserved protein 0.0041 0.014 0.0465
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0043 0.0049
Trichomonas vaginalis glutaminase, putative 0.0313 0.169 0.46
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0021 0.0053
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0009 0.0016
Brugia malayi beta-lactamase family protein 0.0041 0.014 0.0241
Loa Loa (eye worm) hypothetical protein 0.0027 0.006 0.0107
Toxoplasma gondii melibiase subfamily protein 0.0117 0.0574 0.5091
Loa Loa (eye worm) hypothetical protein 0.0035 0.0107 0.0191
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0107 0.0189
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0026 0.0037
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.014 0.014
Echinococcus granulosus caspase 2 0.0067 0.029 0.0329
Giardia lamblia Kinase, CMGC MAPK 0.0115 0.0562 0.0373
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.014 0.0159
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.006 0.0168
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0108 0.0118
Plasmodium vivax JmjC domain containing protein 0.0035 0.0107 0.0845
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0322 0.0598
Brugia malayi hypothetical protein 0.0041 0.014 0.0241
Leishmania major cathepsin L-like protease 0.0019 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0128 0.0633 0.1128
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0004 0.0005
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0043 0.0113
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0026 0.0024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0015 0.0036
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0043 0.0113
Brugia malayi multidrug resistance protein 3 0.0024 0.0043 0.0068
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0115 0.0562 0.4982
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0015 0.0003
Schistosoma mansoni inositol monophosphatase 0.0042 0.0146 0.0161
Brugia malayi Pre-SET motif family protein 0.0036 0.0108 0.0184
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0134 0.0238
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.007 0.0503
Loa Loa (eye worm) glutaminase 2 0.0313 0.169 0.301
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0134 0.0152
Echinococcus granulosus phd:f box containing protein 0.0035 0.0107 0.0122
Plasmodium vivax hypothetical protein, conserved 0.0041 0.014 0.1144
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0134 0.0152
Brugia malayi Cytochrome P450 family protein 0.0018 0.0009 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.066 0.3672 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0046
Schistosoma mansoni retinoic acid receptor RXR 0.0153 0.0777 0.0879
Leishmania major GMP synthase, putative,glutamine amidotransferase, putative 0.0038 0.012 0.0212
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0146 0.12
Brugia malayi nuclear receptor NHR-88 0.004 0.0134 0.0229
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0134 0.0152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0322 0.0598
Brugia malayi conserved hypotetical protein 0.0019 0.0013 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0134 0.0229
Brugia malayi ecdysone receptor 0.0019 0.0013 0.0014
Mycobacterium leprae conserved hypothetical protein 0.0041 0.014 0.0318
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0442 0.243 0.4629
Trypanosoma cruzi MFS transporter, putative 0.0128 0.0633 0.1194
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0322 0.0598
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.047 0.2588 0.6643
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0013 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0319 0.0358
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0027 0.0027
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0117 0.0574 0.0574
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0046
Schistosoma mansoni hypothetical protein 0.0041 0.014 0.0154
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0115 0.0562 0.1058
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0134 0.0215
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0134 0.0238
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0562 0.1527
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0037
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0121 0.0394
Loa Loa (eye worm) multidrug resistance protein 3 0.0024 0.0043 0.0077
Onchocerca volvulus Putative organic anion transporter 0.0128 0.0633 0.1108
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0043 0.0043
Brugia malayi hypothetical protein 0.0021 0.0026 0.0037
Echinococcus multilocularis JmjC domain containing protein 4 0.0035 0.0107 0.0107
Mycobacterium tuberculosis Conserved hypothetical protein 0.0492 0.2716 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.014 0.0155
Schistosoma mansoni zinc finger protein 0.0019 0.0013 0.001
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0322 0.1746 0.6408
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0134 0.0147
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0021 0.0023
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.002 0.0021 0.0021
Onchocerca volvulus 0.0055 0.022 0.037
Echinococcus granulosus caspase 0.002 0.0021 0.0024
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0043 0.0113
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.014 0.0379
Loa Loa (eye worm) hypothetical protein 0.0035 0.0107 0.0191
Echinococcus multilocularis microtubule associated protein 2 0.1558 0.88 0.88
Loa Loa (eye worm) hypothetical protein 0.0024 0.0043 0.0077
Onchocerca volvulus 0.0036 0.0108 0.017
Schistosoma mansoni multidrug resistance protein 0.0024 0.0043 0.0044
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0134 0.0238
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0139 0.0698 0.0788
Trichomonas vaginalis taga, putative 0.0024 0.0043 0.0113
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0015 0.0026
Echinococcus multilocularis GMP synthase (glutamine hydrolyzing) 0.0038 0.012 0.012
Brugia malayi hypothetical protein 0.027 0.1449 0.2574
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0043 0.0113
Leishmania major cathepsin L-like protease 0.0073 0.0322 0.0598
Toxoplasma gondii histone lysine methyltransferase SET1 0.0124 0.0614 0.5452
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0442 0.243 0.4629
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0134 0.0229
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.006 0.0124
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.002 0.0021 0.0019
Trypanosoma brucei protein kinase, putative 0.0115 0.0562 0.1058
Schistosoma mansoni hypothetical protein 0.0923 0.5177 0.5881
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0043 0.0113
Trypanosoma cruzi metacaspase, putative 0.002 0.0021 0.0023
Onchocerca volvulus 0.0128 0.0633 0.1108
Entamoeba histolytica P-glycoprotein-2 0.0024 0.0043 0.0078
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0134 0.0147
Loa Loa (eye worm) hypothetical protein 0.0087 0.0402 0.0717
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0935 0.5241 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0035 0.0107 0.0361
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.066 0.3672 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0015 0.0036
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0134 0.0147
Onchocerca volvulus 0.0041 0.014 0.0227
Brugia malayi jmjC domain containing protein 0.0035 0.0107 0.0182
Entamoeba histolytica hypothetical protein 0.0041 0.014 0.0343
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.006 0.0168
Trypanosoma brucei metacaspase 5, putative 0.002 0.0021 0.0023
Brugia malayi TAR-binding protein 0.0072 0.0319 0.0559
Leishmania major hypothetical protein, conserved 0.0029 0.007 0.0117
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0319 0.0568
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.002 0.0021 0.0056
Echinococcus granulosus lipoxygenase domain containing protein 0.0045 0.0163 0.0185
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0021 0.0053
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0021 0.0053
Entamoeba histolytica hypothetical protein 0.0041 0.014 0.0343
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0043 0.0113
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0013 0.0013
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0198 0.1036 0.1036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0322 0.0598
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0043 0.0049
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0134 0.0152
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0013 0.0014
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0026 0.0029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0023
Loa Loa (eye worm) hypothetical protein 0.0045 0.0163 0.029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0322 0.0598
Schistosoma mansoni polycystin 1-related 0.0045 0.0163 0.018
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.047 0.2588 1
Mycobacterium ulcerans GMP synthase 0.0038 0.012 0.041
Mycobacterium leprae Probable lipase LipE 0.0041 0.014 0.0318
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.014 0.0465
Echinococcus multilocularis multidrug resistance protein 1 0.0017 0.0001 0.0001
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0132 0.0657 0.0657
Echinococcus multilocularis caspase 0.002 0.0021 0.0021
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.007 0.0503
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.014 0.0486
Schistosoma mansoni nuclear receptor 0.0019 0.0013 0.001
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0146 0.0263
Echinococcus multilocularis Polycystic kidney disease protein 0.0045 0.0163 0.0163
Onchocerca volvulus 0.0019 0.0015 0.0003
Brugia malayi nuclear hormone receptor 0.0019 0.0013 0.0014
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.0043 0.0113
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0134 0.0134
Brugia malayi GMP synthase 0.0038 0.012 0.0204
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0442 0.243 0.4629
Brugia malayi MAP kinase sur-1 0.0115 0.0562 0.0993
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.006 0.019
Echinococcus granulosus follistatin 0.0087 0.0402 0.0457
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0015 0.0017
Schistosoma mansoni transcription factor btf3 0.004 0.0134 0.0147
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.014 0.0241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0322 0.0598
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.1591 0.4331
Schistosoma mansoni phd/f-box containing protein 0.0035 0.0107 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0015 0.0036
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0026 0.0026
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.006 0.019
Toxoplasma gondii protease inhibitor PI2 0.0087 0.0402 0.3529
Loa Loa (eye worm) hypothetical protein 0.0036 0.0108 0.0193
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0128 0.0633 0.1128
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0013 0.0015
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.0665 0.1184
Mycobacterium ulcerans NAD synthetase 0.0094 0.0442 0.1599
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0134 0.0147
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.025
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0021 0.0053
Loa Loa (eye worm) hypothetical protein 0.0047 0.0174 0.031
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.1012 0.2752
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0263 0.1407 0.5155
Leishmania major hypothetical protein, conserved 0.0035 0.0107 0.0189
Loa Loa (eye worm) inositol-1 0.0042 0.0146 0.0261
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0108 0.0118
Echinococcus multilocularis survival motor neuron protein 1 0.027 0.1449 0.1449
Leishmania major basic transcription factor 3a, putative 0.004 0.0134 0.0239
Echinococcus multilocularis apoptotic protease activating factor 1 0.0047 0.0174 0.0174
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0107 0.0191
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0131 0.0656 0.1236
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0021 0.0053
Treponema pallidum fructose-bisphosphate aldolase 0.066 0.3672 1
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0026 0.0036
Brugia malayi Cathepsin L-like precursor 0.0019 0.0015 0.0017
Trypanosoma cruzi NAD+ synthase, putative 0.0094 0.0442 0.0827
Loa Loa (eye worm) fibroinase 0.0019 0.0015 0.0026
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0026 0.0046
Loa Loa (eye worm) ICD-1 protein 0.004 0.0134 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0021 0.0053
Brugia malayi jmjC domain containing protein 0.0035 0.0107 0.0182
Loa Loa (eye worm) cysteine protease 0.0019 0.0015 0.0026
Echinococcus granulosus nuclear factor of activated T cells 5 0.0084 0.0386 0.0439
Loa Loa (eye worm) hypothetical protein 0.004 0.0134 0.0238
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0015 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0023
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0015 0.0011
Schistosoma mansoni loxhd1 0.0045 0.0163 0.018
Plasmodium vivax multidrug resistance protein 1, putative 0.0024 0.0043 0.0258
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0013 0.001
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0076 0.0136
Loa Loa (eye worm) hypothetical protein 0.0035 0.0107 0.0191
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.006 0.019
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.025
Brugia malayi hypothetical protein 0.0019 0.0013 0.0014
Brugia malayi Cytochrome P450 family protein 0.0018 0.0009 0.0006
Plasmodium vivax hypothetical protein, conserved 0.002 0.0021 0.0056
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.014 0.016
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0015 0.0015
Loa Loa (eye worm) beta-lactamase 0.0041 0.014 0.025
Echinococcus granulosus dnaJ subfamily B 0.0923 0.5177 0.5883
Echinococcus multilocularis cysteine protease 0.0019 0.0015 0.0015
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0212 0.1113 0.4081
Entamoeba histolytica P-glycoprotein-1 0.0024 0.0043 0.0078
Brugia malayi beta-lactamase family protein 0.0041 0.014 0.0241
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0015 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0023
Trichomonas vaginalis set domain proteins, putative 0.0272 0.146 0.3973
Toxoplasma gondii ABC1 family protein 0.0041 0.014 0.1144
Brugia malayi Muscleblind-like protein 0.0337 0.1831 0.3255
Entamoeba histolytica P-glyco protein 6, putative 0.0024 0.0043 0.0078
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.006 0.0098
Echinococcus multilocularis pol protein 0.1768 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0134 0.0152
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0087 0.0402 0.3529
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.1012 0.2752
Echinococcus granulosus JmjC domain containing protein 4 0.0035 0.0107 0.0122
Schistosoma mansoni multidrug resistance protein 0.0024 0.0043 0.0044
Onchocerca volvulus 0.0041 0.014 0.0227
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0107 0.0189
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0134 0.0215
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.014 0.0379
Loa Loa (eye worm) hypothetical protein 0.004 0.0134 0.0238
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0134 0.0238
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0115 0.0562 0.1058
Mycobacterium ulcerans glutaminase 0.0313 0.169 0.6211
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0043 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0134 0.0238
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.022 0.0383
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0108 0.0118
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0212 0.1113 0.3961
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0107 0.0191
Schistosoma mansoni organic anion transporter 0.0128 0.0633 0.0715
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0013 0.0014
Brugia malayi MH2 domain containing protein 0.0133 0.0665 0.1176
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0021 0.0053
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0021 0.0058
Schistosoma mansoni lipoxygenase 0.0198 0.1036 0.1173
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0046
Schistosoma mansoni cpg binding protein 0.0065 0.0275 0.0308
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0134 0.0134
Toxoplasma gondii hypothetical protein 0.0151 0.0766 0.6837
Loa Loa (eye worm) hypothetical protein 0.0027 0.006 0.0107
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0087 0.0402 0.3529
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0043 0.0113
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0131 0.0656 0.1236
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0087 0.0402 0.0708
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.006 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0204 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0134 0.0229
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0021 0.0053
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0046
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0094 0.0442 0.0497
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0233 0.0428
Trypanosoma cruzi metacaspase, putative 0.002 0.0021 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0015 0.0036
Entamoeba histolytica P-glycoprotein 5, putative 0.0024 0.0043 0.0078
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0134 0.0229
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0087 0.0402 0.0717
Schistosoma mansoni nuclear receptor 0.0019 0.0013 0.001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0134 0.0229
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0035 0.0107 0.0845
Brugia malayi hypothetical protein 0.1 0.5614 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.014 0.0465
Loa Loa (eye worm) hypothetical protein 0.027 0.1449 0.2581
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.006 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0023
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.014 0.0465
Brugia malayi hypothetical protein 0.0019 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0023
Echinococcus granulosus geminin 0.0194 0.1012 0.115
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.014 0.0252
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0043 0.0049
Echinococcus multilocularis pol protein 0.1768 1 1
Echinococcus multilocularis mitogen activated protein kinase 0.0115 0.0562 0.0562
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0146 0.0166
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0039 0.0129 0.0146
Echinococcus multilocularis mitogen activated protein kinase 3 0.0115 0.0562 0.0562
Loa Loa (eye worm) hypothetical protein 0.004 0.0134 0.0238
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0013 0.0014
Echinococcus granulosus transcription factor btf3 0.004 0.0134 0.0152
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.014 0.014
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0035 0.0107 0.0845
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0115 0.0562 0.1058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0204 0.0227
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0212 0.1113 0.4068
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.1591 0.4331
Brugia malayi Cell death protein 3 precursor 0.0067 0.029 0.0508
Trichomonas vaginalis hypothetical protein 0.0212 0.1113 0.3029
Loa Loa (eye worm) hypothetical protein 0.0128 0.0633 0.1128
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0021 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0015 0.0036
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0015 0.0011
Leishmania major cathepsin L-like protease 0.0019 0.0015 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0134 0.0134
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0087 0.0402 0.0708
Brugia malayi jmjC domain containing protein 0.0035 0.0107 0.0182
Plasmodium falciparum multidrug resistance protein 1 0.0024 0.0043 0.011
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0004 0.0004
Entamoeba histolytica P-glycoprotein-2 0.0024 0.0043 0.0078
Schistosoma mansoni lipoxygenase 0.0117 0.0572 0.0646
Schistosoma mansoni thyroid hormone receptor 0.004 0.0134 0.0147
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.002 0.0021 0.0056
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0043 0.0113
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0013 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.1012 0.2752
Brugia malayi tailless protein 0.0019 0.0013 0.0014
Trypanosoma brucei metacaspase MCA2 0.002 0.0021 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0134 0.0229
Schistosoma mansoni hypothetical protein 0.0111 0.0538 0.0607
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0021 0.0053
Leishmania major mitochondrial DNA polymerase beta 0.0935 0.5241 1
Loa Loa (eye worm) glutaminase 0.0313 0.169 0.301
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0013 0.001
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0013 0.001
Plasmodium vivax glutamine-dependent NAD(+) synthetase, putative 0.0094 0.0442 0.3885
Schistosoma mansoni microtubule-associated protein tau 0.1558 0.88 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.1272 0.2266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0015 0.0036
Echinococcus granulosus FTZ F1 alpha 0.004 0.0134 0.0152
Toxoplasma gondii bifunctional GMP synthase/glutamine amidotransferase protein 0.0038 0.012 0.0956
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.066 0.3672 1
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0117 0.0574 0.0652
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0015 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0134 0.0229
Brugia malayi nuclear receptor RXR 0.0021 0.0026 0.0037
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0935 0.5241 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0023
Plasmodium falciparum enoyl-acyl carrier reductase 0.0212 0.1113 0.427
Plasmodium falciparum metacaspase-like protein 0.002 0.0021 0.0024
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0117 0.0574 0.0648
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0134 0.0239
Schistosoma mansoni jumonji domain containing protein 0.0133 0.0663 0.0749
Echinococcus multilocularis pol protein 0.1768 1 1
Mycobacterium tuberculosis Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) 0.0094 0.0442 0.158
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0322 0.0598
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0146 0.0263
Brugia malayi Cytochrome P450 family protein 0.003 0.0076 0.0127
Echinococcus multilocularis cysteine protease 0.0019 0.0015 0.0015
Onchocerca volvulus 0.0045 0.0163 0.0267
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0322 0.0598
Onchocerca volvulus 0.0027 0.006 0.0084
Schistosoma mansoni caspase-3 (C14 family) 0.002 0.0021 0.0019
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0204 0.0363
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0562 0.0634
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0015 0.0015
Plasmodium falciparum LCCL domain-containing protein 0.0045 0.0163 0.0576
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0322 0.0598
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.002 0.0021 0.0024
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0204 0.0354
Loa Loa (eye worm) hypothetical protein 0.0128 0.0633 0.1128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0322 0.0598
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0043 0.0043
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0013 0.0023
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0146 0.0263
Brugia malayi nuclear receptor NHR-88 0.0019 0.0013 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0015 0.0036
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0134 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0134 0.0229
Mycobacterium ulcerans hypothetical protein 0.0492 0.2716 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0023
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0043 0.0113
Echinococcus granulosus lysine specific demethylase 5A 0.0136 0.0684 0.0778
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0131 0.0656 0.1236
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0043 0.0113
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0204 0.0227
Schistosoma mansoni organic anion transporter 0.0128 0.0633 0.0715
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0043 0.0113
Brugia malayi Pre-SET motif family protein 0.0239 0.1272 0.2259
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.025
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.014 0.0252
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0074
Brugia malayi jmjC domain containing protein 0.0133 0.0663 0.1174
Brugia malayi steroid hormone receptor 0.004 0.0134 0.0229
Onchocerca volvulus 0.0019 0.0015 0.0003
Trichomonas vaginalis abcb9, putative 0.0024 0.0043 0.0113
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0035 0.0107 0.0189
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.0665 0.1184
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0562 0.1527
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.047 0.2588 0.9528
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0134 0.0152
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0319 0.0358
Schistosoma mansoni follistatin 0.0087 0.0402 0.0453
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.014 0.0465
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0319 0.0358
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.066 0.3672 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0134 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0134 0.036
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0562 0.1527
Onchocerca volvulus 0.0087 0.0402 0.0695
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.014 0.0465
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0024 0.0043 0.0065
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0023
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0035 0.0107 0.0117
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0212 0.1113 1
Echinococcus multilocularis jumonji domain containing 1A 0.0035 0.0107 0.0107
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0562 0.1527
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0146 0.0395
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.1071 0.2914
Trichomonas vaginalis abcb9, putative 0.0024 0.0043 0.0113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0015 0.0036
Loa Loa (eye worm) runx1 0.0125 0.0621 0.1107
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.007 0.0117
Echinococcus multilocularis expressed protein 0.0087 0.0402 0.0402
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.006 0.019
Loa Loa (eye worm) hypothetical protein 0.004 0.0134 0.0238
Echinococcus granulosus agrin 0.0087 0.0402 0.0457
Loa Loa (eye worm) ctsf protein 0.0019 0.0015 0.0026
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0133 0.0663 0.0754
Echinococcus granulosus muscleblind protein 0.0337 0.1831 0.208
Echinococcus granulosus tar DNA binding protein 0.0072 0.0319 0.0362
Trypanosoma cruzi metacaspase 5, putative 0.002 0.0021 0.0023
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0146 0.0509
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0043 0.0113
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0021 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0015 0.0036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.066 0.3672 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0402 0.0717
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0023
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0134 0.0239
Loa Loa (eye worm) hypothetical protein 0.0067 0.029 0.0516
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0134 0.036
Schistosoma mansoni hypothetical protein 0.0194 0.1012 0.1145
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0134 0.0229
Entamoeba histolytica hypothetical protein 0.0041 0.014 0.0343
Onchocerca volvulus 0.0128 0.0633 0.1108
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0043 0.0043
Entamoeba histolytica P-glycoprotein-5 0.0024 0.0043 0.0078
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.1012 0.2752
Echinococcus multilocularis dnaJ subfamily B 0.0923 0.5177 0.5177
Schistosoma mansoni nuclear hormone receptor 0.004 0.0134 0.0147
Entamoeba histolytica P-glycoprotein-2, putative 0.0024 0.0043 0.0078
Loa Loa (eye worm) agrin synaptic family protein 0.0087 0.0402 0.0717
Schistosoma mansoni survival motor neuron protein 0.0055 0.022 0.0245
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0117 0.0574 0.0648
Onchocerca volvulus 0.0128 0.0633 0.1108
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0322 0.1746 0.6416
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0043 0.0043
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0043 0.0113
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0015 0.0017
Schistosoma mansoni cpg binding protein 0.0069 0.0297 0.0332
Onchocerca volvulus 0.004 0.0134 0.0215
Loa Loa (eye worm) hypothetical protein 0.1 0.5614 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0198 0.1036 0.1177
Onchocerca volvulus 0.0128 0.0633 0.1108
Entamoeba histolytica NAD synthetase, putative 0.0094 0.0442 0.1167
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0042 0.0042
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0134 0.0134
Brugia malayi SPARC precursor 0.0087 0.0402 0.0708
Onchocerca volvulus 0.0019 0.0015 0.0003
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0108 0.0123
Onchocerca volvulus Glucosylceramidase homolog 0.0194 0.1012 0.1783
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0204 0.0204
Plasmodium vivax GMP synthetase, putative 0.0038 0.012 0.0956
Onchocerca volvulus 0.0065 0.0275 0.0469
Schistosoma mansoni GMP synthetase 0.0038 0.012 0.0131
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.1591 0.4331
Echinococcus multilocularis lipoxygenase domain containing protein 0.0045 0.0163 0.0163
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0212 0.1113 0.4256
Brugia malayi hypothetical protein 0.0021 0.0026 0.0037
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.025
Echinococcus granulosus jumonji domain containing 1A 0.0035 0.0107 0.0122
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0319 0.0358
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.006 0.0124
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0134 0.0229
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0108 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0015 0.0036
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0043 0.0113
Loa Loa (eye worm) hypothetical protein 0.0128 0.0633 0.1128
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0024 0.0043 0.0105
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.014 0.0155
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0146 0.036
Echinococcus granulosus RUN 0.0045 0.0163 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0134 0.036
Brugia malayi nuclear hormone receptor 0.004 0.0134 0.0229
Entamoeba histolytica transcription factor BTF3, putative 0.004 0.0134 0.0325
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.1012 0.2752
Schistosoma mansoni hypothetical protein 0.0045 0.0163 0.018
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0043 0.0113
Trypanosoma cruzi cruzipain precursor, putative 0.0073 0.0322 0.0598
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0015 0.0003
Loa Loa (eye worm) hypothetical protein 0.0087 0.0402 0.0717
Trypanosoma brucei metacaspase MCA3 0.002 0.0021 0.0023
Onchocerca volvulus 0.0019 0.0015 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.1071 0.2914
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0015 0.0036
Loa Loa (eye worm) RNA binding protein 0.0072 0.0319 0.0568
Onchocerca volvulus 0.0272 0.1461 0.2585
Loa Loa (eye worm) hypothetical protein 0.0337 0.1831 0.3261
Leishmania major cathepsin L-like protease 0.0019 0.0015 0.0011
Entamoeba histolytica hypothetical protein 0.0041 0.014 0.0343
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0319 0.0319
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.1012 0.2752

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.5 nM Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assay ChEMBL. 21592791
Intrinsic activity (binding) <= 0.1 Intrinsic activity at human CRTh2 receptor in human eosinophils assessed as stimulation of DK-PGD2-induced up-regulation of CD11b expression after 15 mins by flow cytometry relative to DK-PGD2 ChEMBL. 21592791

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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