Detailed information for compound 1560554

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 266.291 | Formula: C17H14O3
  • H donors: 0 H acceptors: 1 LogP: 3.88 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cccc2c1oc(=O)c(c2)c1ccccc1
  • InChi: 1S/C17H14O3/c1-2-19-15-10-6-9-13-11-14(17(18)20-16(13)15)12-7-4-3-5-8-12/h3-11H,2H2,1H3
  • InChiKey: JWPFCIXQOFVAHQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus histone lysine n methyltransferase setb1 0.0037 0.002 0.0031
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.1055 0.5926 1
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0195 0.0938 0.5
Brugia malayi hypothetical protein 0.0065 0.0184 0.0195
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0686 0.3787 0.5984
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.004 0.0061
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.0422 0.0597
Echinococcus granulosus disco interacting protein 2 0.0442 0.2371 0.3621
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0105 0.0413 0.0631
Plasmodium vivax histone-lysine N-methyltransferase, putative 0.0093 0.0345 0.0548
Brugia malayi CXXC zinc finger family protein 0.0417 0.2222 0.2438
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0638 0.3507 0.5151
Echinococcus granulosus microtubule associated protein 2 0.0764 0.4237 0.647
Echinococcus granulosus histone h3 methyltransferase 0.1162 0.6548 1
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0148 0.066 0.0979
Brugia malayi GATA zinc finger family protein 0.0051 0.01 0.0103
Schistosoma mansoni cpg binding protein 0.0418 0.2232 0.3409
Schistosoma mansoni hepatoma derived growth factor 0.0106 0.0422 0.0644
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0195 0.0938 0.5
Echinococcus multilocularis PWWP domain containing protein 2A 0.0106 0.0422 0.0644
Mycobacterium tuberculosis Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) 0.086 0.4792 0.968
Schistosoma mansoni cpg binding protein 0.0417 0.2222 0.3393
Echinococcus multilocularis metastasis associated protein 1 (mta1) 0.0051 0.01 0.0153
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0148 0.066 0.0979
Brugia malayi NNMT/PNMT/TEMT family protein 0.0989 0.5544 0.6095
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0195 0.0938 0.0938
Loa Loa (eye worm) hypothetical protein 0.0442 0.2371 0.2592
Loa Loa (eye worm) hypothetical protein 0.0377 0.1992 0.2174
Echinococcus multilocularis hepatoma derived growth factor protein 0.0106 0.0422 0.0644
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0163 0.0753 0.1196
Trichomonas vaginalis conserved hypothetical protein 0.0195 0.0938 0.0938
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0195 0.0938 0.2268
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0558 0.3044 0.4648
Plasmodium vivax protein arginine N-methyltransferase 5, putative 0.0066 0.0186 0.0296
Toxoplasma gondii phosphorylase family protein 0.0195 0.0938 0.1722
Leishmania major hypothetical protein, conserved 0.0106 0.0422 0.067
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0638 0.3507 0.6443
Brugia malayi jmjC domain containing protein 0.0041 0.004 0.0036
Schistosoma mansoni methylthioadenosine phosphorylase 0.0195 0.0938 0.1432
Echinococcus granulosus purine nucleoside phosphorylase 0.0195 0.0938 0.1432
Schistosoma mansoni hypothetical protein 0.0106 0.0422 0.0644
Leishmania major nucleoside phosphorylase-like protein 0.0195 0.0938 0.1489
Schistosoma mansoni adenosylhomocysteinase 0.0395 0.2096 0.32
Plasmodium falciparum spermidine synthase 0.1119 0.6295 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0195 0.0938 0.1432
Brugia malayi SET domain containing protein 0.0151 0.0681 0.0742
Toxoplasma gondii phosphorylase family protein 0.0195 0.0938 0.1722
Brugia malayi Skb1 methyltransferase family protein 0.0066 0.0186 0.0198
Echinococcus multilocularis cpg binding protein 0.0418 0.2232 0.3409
Toxoplasma gondii histone lysine methyltransferase SET1 0.0075 0.0239 0.0439
Schistosoma mansoni adenosylhomocysteinase 0.0638 0.3507 0.5356
Loa Loa (eye worm) hypothetical protein 0.1162 0.6548 0.7196
Schistosoma mansoni methylthioadenosine phosphorylase 0.1055 0.5926 0.905
Echinococcus granulosus histone lysine n methyltransferase suv420h1 0.0151 0.0681 0.1039
Echinococcus granulosus purine nucleoside phosphorylase 0.0195 0.0938 0.1432
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0686 0.3787 0.5984
Loa Loa (eye worm) hypothetical protein 0.0065 0.0184 0.018
Echinococcus multilocularis purine nucleoside phosphorylase 0.0195 0.0938 0.1432
Echinococcus multilocularis disco interacting protein 2 0.0442 0.2371 0.3621
Brugia malayi hypothetical protein 0.0106 0.0422 0.0457
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0195 0.0938 0.0538
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0638 0.3507 0.5571
Schistosoma mansoni suppressor of variegation 4-20-related 0.0151 0.0681 0.1039
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0194 0.0928 0.1418
Trypanosoma cruzi spermidine synthase, putative 0.1119 0.6295 1
Toxoplasma gondii DNA methyltransferase 2, putative 0.0558 0.3044 0.5592
Plasmodium falciparum purine nucleoside phosphorylase 0.0195 0.0938 0.1489
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.1055 0.5926 0.9409
Plasmodium falciparum protein arginine N-methyltransferase 5, putative 0.0066 0.0186 0.0296
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.0148 0.066 0.0979
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0686 0.3787 0.5984
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0686 0.3787 0.5783
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0238 0.1182 0.1805
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0105 0.0413 0.0631
Loa Loa (eye worm) SET domain-containing protein 0.0151 0.0681 0.0728
Loa Loa (eye worm) SET domain-containing protein 0.0314 0.1625 0.1769
Echinococcus granulosus PWWP domain containing protein 2A 0.0106 0.0422 0.0644
Trichomonas vaginalis CDC6, putative 0.0051 0.01 0.01
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0195 0.0938 0.0938
Echinococcus granulosus purine nucleoside phosphorylase 0.0195 0.0938 0.1432
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0638 0.3507 0.3507
Echinococcus multilocularis metastasis associated protein MTA1 0.0051 0.01 0.0153
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0638 0.3507 0.5536
Echinococcus multilocularis arginine glutamic acid dipeptide (RE) repeats 0.0051 0.01 0.0153
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0082 0.0281 0.0429
Onchocerca volvulus 0.0141 0.0623 0.021
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0195 0.0938 0.0938
Echinococcus granulosus methylthioadenosine phosphorylase 0.1055 0.5926 0.905
Echinococcus multilocularis geminin 0.0186 0.0886 0.1352
Echinococcus granulosus PWWP domain containing protein 2A 0.0106 0.0422 0.0644
Onchocerca volvulus 0.0291 0.149 0.1115
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0195 0.0938 0.0938
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0989 0.5544 0.6089
Schistosoma mansoni hypothetical protein 0.0186 0.0886 0.1352
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0334 0.1744 0.277
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0051 0.01 0.0153
Loa Loa (eye worm) hypothetical protein 0.0053 0.0111 0.01
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0195 0.0938 0.5
Treponema pallidum pfs protein (pfs) 0.0195 0.0938 0.5
Toxoplasma gondii hypothetical protein 0.0106 0.0422 0.0775
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0051 0.01 0.0153
Trichomonas vaginalis set domain proteins, putative 0.1757 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0238 0.1182 0.1805
Echinococcus granulosus histone arginine methyltransferase CARMER 0.016 0.0733 0.1119
Brugia malayi PWWP domain containing protein 0.0106 0.0422 0.0457
Trypanosoma cruzi MIZ/SP-RING zinc finger, putative 0.0106 0.0422 0.0597
Echinococcus multilocularis histone lysine n methyltransferase setb1 0.0037 0.002 0.0031
Trypanosoma cruzi spermidine synthase, putative 0.1119 0.6295 1
Leishmania major arginine N-methyltransferase, type II, putative;with=GeneDB:Tb927.10.640 0.0042 0.0049 0.0078
Schistosoma mansoni hepatoma derived growth factor 0.0106 0.0422 0.0644
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0334 0.1744 0.277
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0238 0.1182 0.1805
Echinococcus granulosus purine nucleoside phosphorylase 0.0195 0.0938 0.1432
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.1055 0.5926 0.9409
Echinococcus granulosus metastasis associated protein 1 mta1 0.0051 0.01 0.0153
Loa Loa (eye worm) spermidine synthase 0.1119 0.6295 0.6917
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0163 0.0753 0.115
Trypanosoma brucei Histone methylation protein DOT1, putative 0.0148 0.066 0.0979
Trypanosoma cruzi transcription elongation factor s-II, putative 0.0106 0.0422 0.0597
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0065 0.0184 0.0216
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0314 0.1625 0.2482
Echinococcus granulosus cpg binding protein 0.0418 0.2232 0.3409
Schistosoma mansoni adenosylhomocysteinase 0.0395 0.2096 0.32
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.004 0.0022
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0065 0.0184 0.0216
Brugia malayi jmjC domain containing protein 0.0105 0.0413 0.0448
Echinococcus multilocularis purine nucleoside phosphorylase 0.0195 0.0938 0.1432
Echinococcus granulosus purine nucleoside phosphorylase 0.0195 0.0938 0.1432
Brugia malayi SET domain containing protein 0.0134 0.0582 0.0633
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.1055 0.5926 0.9409
Toxoplasma gondii Purine nucleoside phosphorylase 0.0195 0.0938 0.1722
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0558 0.3044 0.4648
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0163 0.0753 0.0807
Echinococcus multilocularis purine nucleoside phosphorylase 0.0195 0.0938 0.1432
Trypanosoma cruzi spermidine synthase, putative 0.1119 0.6295 1
Leishmania major methylthioadenosine phosphorylase, putative 0.1055 0.5926 0.9413
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0063 0.0096
Echinococcus granulosus spermidine synthase 0.1119 0.6295 0.9614
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0051 0.01 0.0153
Plasmodium vivax SET domain protein, putative 0.0172 0.0802 0.1274
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0163 0.0753 0.1127
Treponema pallidum uridine phosphorylase (udp) 0.0195 0.0938 0.5
Schistosoma mansoni histone J3 methyltransferase 0.1162 0.6548 1
Echinococcus granulosus peregrin 0.0139 0.0608 0.0929
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0558 0.3044 0.5592
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.016 0.0733 0.1119
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0686 0.3787 0.5984
Schistosoma mansoni hypothetical protein 0.0186 0.0886 0.1352
Echinococcus multilocularis purine nucleoside phosphorylase 0.0195 0.0938 0.1432
Schistosoma mansoni purine nucleoside phosphorylase 0.0195 0.0938 0.1432
Loa Loa (eye worm) hypothetical protein 0.0055 0.0123 0.0113
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0195 0.0938 0.1422
Loa Loa (eye worm) CXXC zinc finger family protein 0.0417 0.2222 0.2427
Schistosoma mansoni uridine phosphorylase 0.0195 0.0938 0.1432
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0638 0.3507 0.5536
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0195 0.0938 0.0938
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0195 0.0938 0.1422
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1601 0.9092 1
Schistosoma mansoni purine nucleoside phosphorylase 0.0195 0.0938 0.1432
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0195 0.0938 0.0938
Loa Loa (eye worm) hypothetical protein 0.0989 0.5544 0.6089
Toxoplasma gondii hypothetical protein 0.0972 0.5443 1
Brugia malayi hypothetical protein 0.0106 0.0422 0.0457
Leishmania major hypothetical protein, conserved 0.0148 0.066 0.1049
Schistosoma mansoni enhancer of zeste ezh 0.0314 0.1625 0.2482
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0558 0.3044 0.4835
Echinococcus multilocularis protein arginine N methyltransferase 5 0.0066 0.0186 0.0285
Loa Loa (eye worm) Skb1 methyltransferase 0.0066 0.0186 0.0183
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0195 0.0938 0.2268
Leishmania major modification methylase-like protein 0.0558 0.3044 0.4835
Entamoeba histolytica adenosylhomocysteinase, putative 0.0638 0.3507 1
Brugia malayi SET domain containing protein 0.0068 0.02 0.0213
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0558 0.3044 0.4795
Echinococcus multilocularis methylthioadenosine phosphorylase 0.1055 0.5926 0.905
Echinococcus multilocularis bromo adjacent y domain containing 1 0.0051 0.01 0.0153
Brugia malayi Pre-SET motif family protein 0.0209 0.1018 0.1113
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0195 0.0938 0.5
Echinococcus multilocularis histone h3 methyltransferase 0.1162 0.6548 1
Onchocerca volvulus 0.0417 0.2222 0.1879
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0195 0.0938 0.1025
Schistosoma mansoni uridine phosphorylase 0.0195 0.0938 0.1432
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.016 0.0733 0.1346
Schistosoma mansoni hypothetical protein 0.0051 0.01 0.0153
Echinococcus multilocularis polybromo 1 0.0051 0.01 0.0153
Brugia malayi uridine phosphorylase family protein 0.0195 0.0938 0.1025
Schistosoma mansoni bromo adjacent homology domain containing 0.0051 0.01 0.0153
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0172 0.0802 0.1224
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0065 0.0184 0.0216
Echinococcus granulosus uridine phosphorylase 1 0.0195 0.0938 0.1432
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0558 0.3044 0.8606
Schistosoma mansoni adenosylhomocysteinase 0.0395 0.2096 0.32
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0686 0.3787 0.5783
Echinococcus multilocularis peregrin 0.0139 0.0608 0.0929
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0638 0.3507 0.3507
Echinococcus multilocularis PWWP domain containing protein 2A 0.0106 0.0422 0.0644
Schistosoma mansoni SET domain protein 0.0124 0.0522 0.0797
Echinococcus granulosus SET and MYND domain containing protein 3 0.0078 0.0255 0.039
Toxoplasma gondii histone arginine methyltransferase PRMT5 0.0066 0.0186 0.0343
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0686 0.3787 0.4161
Trypanosoma cruzi spermidine synthase, putative 0.1119 0.6295 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0195 0.0938 0.0938
Schistosoma mansoni hypothetical protein 0.0057 0.0136 0.0208
Echinococcus granulosus DNA methyltransferase 2, putative 0.0558 0.3044 0.4648
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0686 0.3787 0.5984
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0195 0.0938 0.0938
Plasmodium falciparum adenosylhomocysteinase 0.0638 0.3507 0.5571
Trichomonas vaginalis adenosylhomocysteinase, putative 0.02 0.0966 0.0966
Loa Loa (eye worm) hypothetical protein 0.0377 0.1992 0.2174
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0148 0.066 0.0979
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0195 0.0938 0.2268
Leishmania major hypothetical protein, conserved 0.0148 0.066 0.1049
Loa Loa (eye worm) hypothetical protein 0.0377 0.1992 0.2174
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.004 0.0061
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0314 0.1625 0.2482
Entamoeba histolytica hypothetical protein 0.0106 0.0422 0.0716
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0188 0.0185
Onchocerca volvulus 0.0442 0.2371 0.2035
Echinococcus granulosus adenosylhomocysteinase 0.0638 0.3507 0.5356
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0686 0.3787 0.4152
Loa Loa (eye worm) Carm1-pending protein 0.016 0.0733 0.0785
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0195 0.0938 0.2268
Echinococcus granulosus geminin 0.0186 0.0886 0.1352
Trypanosoma cruzi transcription elongation factor-like protein, putative 0.0106 0.0422 0.0597
Brugia malayi Spermidine synthase 0.1119 0.6295 0.6922
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0051 0.01 0.0153
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0558 0.3044 0.4835
Echinococcus multilocularis adenosylhomocysteinase 0.0638 0.3507 0.5356
Brugia malayi Pre-SET motif family protein 0.1601 0.9092 1
Leishmania major histone-lysine N-methyltransferase, putative 0.0148 0.066 0.1049
Schistosoma mansoni protein arginine n-methyltransferase 0.016 0.0733 0.1119
Schistosoma mansoni cpg binding protein 0.0418 0.2232 0.3409
Echinococcus granulosus polybromo 1 0.0051 0.01 0.0153
Loa Loa (eye worm) hypothetical protein 0.0238 0.1182 0.1281
Brugia malayi MTAP 0.1055 0.5926 0.6515
Brugia malayi hypothetical protein 0.0377 0.1992 0.2186
Entamoeba histolytica hypothetical protein 0.0195 0.0938 0.2268
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0163 0.0753 0.1127
Trypanosoma brucei spermidine synthase 0.1119 0.6295 1
Mycobacterium tuberculosis Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) 0.0882 0.492 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.004 0.0061
Loa Loa (eye worm) adenosylhomocysteinase 0.0638 0.3507 0.3844
Echinococcus granulosus arginine glutamic acid dipeptide RE repeats 0.0051 0.01 0.0153
Echinococcus granulosus bromo adjacent y domain containing 1 0.0051 0.01 0.0153
Loa Loa (eye worm) hypothetical protein 0.0119 0.0492 0.052
Schistosoma mansoni methylthioadenosine phosphorylase 0.1055 0.5926 0.905
Loa Loa (eye worm) hypothetical protein 0.0125 0.0527 0.0558
Schistosoma mansoni shk1 kinase-binding protein 0.0066 0.0186 0.0285
Schistosoma mansoni hypothetical protein 0.0106 0.0422 0.0644
Loa Loa (eye worm) uridine phosphorylase 0.0195 0.0938 0.1011
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0148 0.066 0.0979
Schistosoma mansoni polybromo-1 0.0051 0.01 0.0153
Trichomonas vaginalis shk1 kinase-binding protein, putative 0.0042 0.0049 0.0049
Echinococcus granulosus hepatoma derived growth factor protein 0.0106 0.0422 0.0644
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0163 0.0753 0.1127
Echinococcus granulosus purine nucleoside phosphorylase 0.0195 0.0938 0.1432
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0291 0.149 0.2275
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0195 0.0938 0.2268
Schistosoma mansoni phd finger protein 0.0106 0.0422 0.0644
Echinococcus granulosus purine nucleoside phosphorylase 0.0195 0.0938 0.1432
Echinococcus multilocularis histone lysine n methyltransferase suv420h1 0.0151 0.0681 0.1039
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0638 0.3507 1
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0442 0.2371 0.3621
Loa Loa (eye worm) hypothetical protein 0.0051 0.01 0.0088
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0638 0.3507 0.5536
Loa Loa (eye worm) hypothetical protein 0.0106 0.0422 0.0443
Schistosoma mansoni adenosylhomocysteinase 0.0395 0.2096 0.32
Brugia malayi polybromodomain protein 0.0051 0.01 0.0103
Echinococcus granulosus metastasis associated protein MTA1 0.0051 0.01 0.0153
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0122 0.0511 0.0781
Leishmania major S-adenosylmethionine decarboxylase 0.0686 0.3787 0.6015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0238 0.1182 0.1805
Brugia malayi SET domain containing protein 0.0314 0.1625 0.1781
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0195 0.0938 0.2268
Loa Loa (eye worm) hypothetical protein 0.0051 0.01 0.0088
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0122 0.0511 0.0781
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0972 0.5443 0.8647
Trichomonas vaginalis shk1 kinase-binding protein, putative 0.0042 0.0049 0.0049
Schistosoma mansoni protein arginine n-methyltransferase 0.0132 0.0569 0.0869
Chlamydia trachomatis AMP nucleosidase 0.0195 0.0938 0.5
Mycobacterium ulcerans spermidine synthase 0.0882 0.492 0.7983
Echinococcus multilocularis purine nucleoside phosphorylase 0.0195 0.0938 0.1432
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0063 0.0096
Loa Loa (eye worm) hypothetical protein 0.0076 0.0243 0.0246
Loa Loa (eye worm) PWWP domain-containing protein 0.0106 0.0422 0.0443
Echinococcus multilocularis uridine phosphorylase 1 0.0195 0.0938 0.1432
Echinococcus multilocularis SET and MYND domain containing protein 3 0.0078 0.0255 0.039
Plasmodium falciparum histone-lysine N-methyltransferase, putative 0.0093 0.0345 0.0548
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0172 0.0802 0.1224
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0172 0.0802 0.1473
Loa Loa (eye worm) hypothetical protein 0.0989 0.5544 0.6089
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.1055 0.5926 0.651
Echinococcus granulosus protein arginine N methyltransferase 7 0.0163 0.0753 0.115
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0029 0.0045
Brugia malayi hypothetical protein 0.0377 0.1992 0.2186
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.0422 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0195 0.0938 0.0938
Loa Loa (eye worm) hypothetical protein 0.0051 0.01 0.0088
Trypanosoma brucei transcription elongation factor s-II, putative 0.0106 0.0422 0.0597
Brugia malayi Disco-interacting protein 2 homolog 0.0442 0.2371 0.2603
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0638 0.3507 0.6452
Toxoplasma gondii hypothetical protein 0.0148 0.066 0.1213
Echinococcus multilocularis microtubule associated protein 2 0.0764 0.4237 0.647
Echinococcus granulosus protein arginine N methyltransferase 5 0.0066 0.0186 0.0285
Trypanosoma brucei uridine phosphorylase 0.0195 0.0938 0.1422
Entamoeba histolytica Skb1 methyltransferase, putative 0.0066 0.0186 0.0008
Echinococcus multilocularis spermidine synthase 0.1119 0.6295 0.9614
Toxoplasma gondii adenosylhomocysteinase, putative 0.0638 0.3507 0.6443
Onchocerca volvulus 0.0377 0.1992 0.164
Schistosoma mansoni hypothetical protein 0.0106 0.0422 0.0644
Brugia malayi ELM2 domain containing protein 0.0051 0.01 0.0103
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0195 0.0938 0.1489
Leishmania major S-adenosylhomocysteine hydrolase 0.0638 0.3507 0.5571
Leishmania major spermidine synthase 0.1119 0.6295 1
Schistosoma mansoni microtubule-associated protein tau 0.0764 0.4237 0.647
Echinococcus multilocularis purine nucleoside phosphorylase 0.0195 0.0938 0.1432
Brugia malayi Protein arginine N-methyltransferase 0.0163 0.0753 0.0821
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.1162 0.6548 0.72
Plasmodium vivax spermidine synthase, putative 0.1119 0.6295 1
Brugia malayi Carm1-pending protein 0.016 0.0733 0.0799
Trichomonas vaginalis origin recognition complex subunit, putative 0.0051 0.01 0.01
Trypanosoma brucei histone-lysine n-methyltransferase 0.0148 0.066 0.0979
Brugia malayi Adenosylhomocysteinase 0.0638 0.3507 0.3853
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0288 0.044
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0195 0.0938 0.1422
Giardia lamblia UPL-1 0.0195 0.0938 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.07 mM Inhibition of mushroom tyrosinase using L-3,4- dihydroxyphenylalanine as substrate measured for 5 mins by spectrophotometric analysis ChEMBL. 21514152

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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