Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dihydrofolate reductase | 0.0176 | 0.0711 | 0.0711 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0608 | 0.5706 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0432 | 0.3669 | 0.3669 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0608 | 0.5706 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0608 | 0.5706 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0432 | 0.3669 | 1 |
Onchocerca volvulus | 0.0432 | 0.3669 | 0.5 | |
Schistosoma mansoni | beta-hexosaminidase B | 0.0183 | 0.0796 | 0.0289 |
Schistosoma mansoni | beta-hexosaminidase B | 0.0183 | 0.0796 | 0.0289 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0432 | 0.3669 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 20 | 0.0183 | 0.0796 | 0.0289 |
Echinococcus granulosus | beta hexosaminidase subunit beta | 0.0183 | 0.0796 | 0.2171 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0183 | 0.0796 | 0.5 |
Echinococcus multilocularis | beta hexosaminidase subunit beta | 0.0183 | 0.0796 | 0.0796 |
Echinococcus granulosus | thymidylate synthase | 0.0432 | 0.3669 | 1 |
Brugia malayi | hypothetical protein | 0.0205 | 0.105 | 0.1148 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0608 | 0.5706 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, alpha subunit | 0.0183 | 0.0796 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0176 | 0.0711 | 0.1937 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, beta subunit | 0.0183 | 0.0796 | 0.5 |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.0183 | 0.0796 | 0.0289 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0608 | 0.5706 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0432 | 0.3669 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0608 | 0.5706 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0205 | 0.105 | 0.1148 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0432 | 0.3669 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0432 | 0.3669 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0205 | 0.105 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0432 | 0.3669 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0183 | 0.0796 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0176 | 0.0711 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 10.3183 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 141.2538 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.