Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0148 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1057 | 0.1009 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.7483 | 0.7483 |
Schistosoma mansoni | ets-related | 0.0265 | 1 | 1 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0087 | 0.2638 | 0.3526 |
Echinococcus granulosus | geminin | 0.0205 | 0.7483 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0053 | 0.0053 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.7483 | 0.7483 |
Schistosoma mansoni | gabp alpha | 0.0087 | 0.2638 | 0.2638 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.2767 | 0.2569 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0281 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2554 | 0.2514 |
Brugia malayi | Ets-domain containing protein | 0.0087 | 0.2638 | 0.2437 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0281 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.2114 | 0.2072 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0281 | 0.5 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0087 | 0.2638 | 0.2599 |
Echinococcus multilocularis | geminin | 0.0205 | 0.7483 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0281 | 0.5 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0087 | 0.2638 | 0.3526 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2003 | 0.2677 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0281 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0938 | 0.089 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2003 | 0.2677 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0148 | 0.0148 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1152 | 0.1105 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0281 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0281 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0148 | 0.0198 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.0935 | 0.0687 |
Loa Loa (eye worm) | fli-1 protein | 0.0265 | 1 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.2182 | 0.2182 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0817 | 0.1091 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0281 | 0.5 |
Brugia malayi | Ets-domain containing protein | 0.0087 | 0.2638 | 0.2437 |
Brugia malayi | hypothetical protein | 0.003 | 0.0281 | 0.0015 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0281 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0817 | 0.1091 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.1032 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.122 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.