Detailed information for compound 1561012

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 312.279 | Formula: C13H27Cl2N3O
  • H donors: 0 H acceptors: 1 LogP: 2.42 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(CCC[N+](C)(C)C)C(N(C1(C)C)Cl)(C)C.[Cl-]
  • InChi: 1S/C13H27ClN3O.ClH/c1-12(2)11(18)15(13(3,4)16(12)14)9-8-10-17(5,6)7;/h8-10H2,1-7H3;1H/q+1;/p-1
  • InChiKey: KJFQJPWHUGHMNQ-UHFFFAOYSA-M  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0105 0.0115
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0038 0.0205 0.0285
Toxoplasma gondii subtilisin SUB7 0.0031 0.0105 0.1471
Loa Loa (eye worm) CUTiclin family member 0.0043 0.027 0.0167
Loa Loa (eye worm) hypothetical protein 0.0043 0.027 0.0167
Mycobacterium leprae Possible secreted protease 0.0031 0.0105 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0107 0.012
Toxoplasma gondii subtilisin SUB1 0.0031 0.0105 0.1471
Giardia lamblia Furin precursor putative serine protease 0.0141 0.1662 0.4578
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0031 0.0105 0.5
Loa Loa (eye worm) hypothetical protein 0.0074 0.071 0.0612
Toxoplasma gondii subtilisin SUB4 0.0031 0.0105 0.1471
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0038 0.0205 0.0206
Toxoplasma gondii subtilisin SUB12 0.0031 0.0105 0.1471
Onchocerca volvulus 0.0072 0.0684 0.168
Onchocerca volvulus 0.0274 0.3557 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0043 0.027 0.0167
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0038 0.0205 0.0285
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0072 0.0684 0.0586
Echinococcus granulosus protein will die slowly 0.0274 0.3557 0.353
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0072 0.0684 0.0586
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0074 0.071 0.0612
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0172 0.2104 0.3499
Onchocerca volvulus 0.0043 0.027 0.048
Trichomonas vaginalis cyclin B, putative 0.005 0.0374 0.0571
Echinococcus granulosus voltage dependent calcium channel subunit 0.0043 0.027 0.023
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0172 0.2104 0.3499
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0031 0.0105 0.5
Schistosoma mansoni tyrosinase precursor 0.0072 0.0684 0.0586
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0089 0.0932 0.1119
Loa Loa (eye worm) hypothetical protein 0.0043 0.027 0.0167
Schistosoma mansoni smdr2 0.0038 0.0205 0.0101
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.005 0.0374 1
Echinococcus granulosus cyclins 0.0031 0.0107 0.0066
Brugia malayi neuroendocrine convertase 1 precursor 0.0457 0.6159 0.6118
Trypanosoma cruzi cyclin 6, putative 0.005 0.0374 1
Schistosoma mansoni cyclin B3 0.0031 0.0107 0.0003
Toxoplasma gondii subtilisin SUB11 0.0031 0.0105 0.1471
Brugia malayi celfurPC protein 0.0586 0.8 0.7979
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0038 0.0205 0.2884
Loa Loa (eye worm) hypothetical protein 0.0727 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0038 0.0205 0.0164
Trichomonas vaginalis ABC transporter, putative 0.0038 0.0205 0.0285
Echinococcus granulosus cyclins 0.0031 0.0107 0.0066
Onchocerca volvulus 0.0074 0.071 0.1755
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Brugia malayi von Willebrand factor type A domain containing protein 0.0043 0.027 0.0167
Plasmodium vivax hypothetical protein, conserved 0.0043 0.027 0.2734
Entamoeba histolytica P-glycoprotein-2, putative 0.0038 0.0205 0.3661
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0367 0.0265
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0038 0.0205 0.0285
Onchocerca volvulus 0.0074 0.071 0.1755
Brugia malayi Cyclin, N-terminal domain containing protein 0.005 0.0374 0.0272
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0027 0.0041 0.0008
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0043 0.027 0.0167
Brugia malayi von Willebrand factor type A domain containing protein 0.0043 0.027 0.0167
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0172 0.2104 0.3499
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0367 0.0265
Echinococcus multilocularis cyclin B3 1 0.0031 0.0107 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.1662 0.2751
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0038 0.0205 0.0285
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.01 0.1078 0.0984
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0031 0.0107 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.1662 0.2751
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0367 0.0265
Trichomonas vaginalis abcb9, putative 0.0038 0.0205 0.0285
Loa Loa (eye worm) proprotein convertase 2 0.0172 0.2104 0.2021
Trichomonas vaginalis abcb9, putative 0.0038 0.0205 0.0285
Trichomonas vaginalis ABC transporter, putative 0.0038 0.0205 0.0285
Loa Loa (eye worm) hypothetical protein 0.0074 0.071 0.0612
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0038 0.0205 0.2884
Echinococcus multilocularis Furin 1 0.0172 0.2104 0.2592
Entamoeba histolytica P-glycoprotein 5, putative 0.0038 0.0205 0.3661
Echinococcus granulosus C type lectin domian containing protein 0.0074 0.071 0.0672
Onchocerca volvulus 0.005 0.0374 0.078
Trichomonas vaginalis cyclins, putative 0.005 0.0374 0.0571
Brugia malayi hypothetical protein 0.0074 0.071 0.0612
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0043 0.027 0.2734
Schistosoma mansoni multidrug resistance protein 0.0038 0.0205 0.0101
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0043 0.027 0.2734
Loa Loa (eye worm) hypothetical protein 0.0285 0.3717 0.3651
Toxoplasma gondii subtilisin SUB10 0.0031 0.0105 0.1471
Trichomonas vaginalis cyclin B, putative 0.005 0.0374 0.0571
Brugia malayi ABC transporter family protein 0.0038 0.0205 0.0101
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Brugia malayi Common central domain of tyrosinase family protein 0.0072 0.0684 0.0586
Brugia malayi von Willebrand factor type A domain containing protein 0.0043 0.027 0.0167
Plasmodium vivax thrombospondin-related anonymous protein 0.0043 0.027 0.2734
Loa Loa (eye worm) hypothetical protein 0.0043 0.027 0.0167
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0038 0.0205 0.0285
Trichomonas vaginalis cyclin B3, putative 0.0031 0.0107 0.012
Entamoeba histolytica P-glyco protein 6, putative 0.0038 0.0205 0.3661
Plasmodium falciparum SET domain protein, putative 0.0072 0.068 0.9499
Brugia malayi hypothetical protein 0.0074 0.071 0.0612
Loa Loa (eye worm) hypothetical protein 0.0043 0.027 0.0167
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0038 0.0205 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Entamoeba histolytica hypothetical protein, conserved 0.0043 0.027 0.6111
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0031 0.0107 0.0083
Onchocerca volvulus 0.0043 0.027 0.048
Entamoeba histolytica hypothetical protein, conserved 0.0043 0.027 0.6111
Loa Loa (eye worm) multidrug resistance protein 3 0.0038 0.0205 0.0101
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0031 0.0105 0.0064
Echinococcus granulosus multidrug resistance protein 1 0.0038 0.0205 0.0164
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0031 0.0105 0.008
Trichomonas vaginalis cyclin D, putative 0.0031 0.0107 0.012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Echinococcus granulosus collagen alpha 1VII chain 0.0043 0.027 0.023
Schistosoma mansoni tyrosinase precursor 0.0072 0.0684 0.0586
Echinococcus multilocularis cyclins 0.0031 0.0107 0.0083
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0144 0.004
Loa Loa (eye worm) hypothetical protein 0.0038 0.0205 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.1662 0.2751
Brugia malayi hypothetical protein 0.0074 0.071 0.0612
Brugia malayi hypothetical protein 0.0074 0.071 0.0612
Echinococcus multilocularis cyclins 0.0031 0.0107 0.0083
Loa Loa (eye worm) hypothetical protein 0.0043 0.027 0.0167
Onchocerca volvulus 0.0074 0.071 0.1755
Loa Loa (eye worm) hypothetical protein 0.005 0.0367 0.0265
Schistosoma mansoni multidrug resistance protein 0.0038 0.0205 0.0101
Schistosoma mansoni serine/threonine protein kinase 0.01 0.1078 0.0984
Toxoplasma gondii subtilisin SUB5 0.0031 0.0105 0.1471
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Schistosoma mansoni multidrug resistance protein 0.0038 0.0205 0.0101
Schistosoma mansoni histone-lysine n-methyltransferase seto7 0.0072 0.068 0.0582
Toxoplasma gondii rhoptry neck protein RON1 0.0074 0.071 1
Brugia malayi hypothetical protein 0.0074 0.071 0.0612
Echinococcus granulosus cyclin b3 0.0031 0.0107 0.0066
Trypanosoma cruzi CYC2-like cyclin, putative 0.005 0.0374 1
Trichomonas vaginalis ABC transporter, putative 0.0038 0.0205 0.0285
Trichomonas vaginalis hypothetical protein 0.0141 0.1662 0.2751
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0442 0.5945 0.5929
Schistosoma mansoni serine/threonine protein kinase 0.01 0.1078 0.0984
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0038 0.0205 0.0285
Trichomonas vaginalis cyclins, putative 0.005 0.0374 0.0571
Loa Loa (eye worm) WD40 repeat protein 0.0274 0.3557 0.3489
Onchocerca volvulus 0.0074 0.071 0.1755
Plasmodium vivax SET domain protein, putative 0.0072 0.068 0.9499
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0038 0.0205 0.5
Echinococcus multilocularis membrane bound transcription factor site 1 0.0031 0.0105 0.008
Loa Loa (eye worm) hypothetical protein 0.0074 0.071 0.0612
Onchocerca volvulus 0.0072 0.0684 0.168
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.1662 0.2751
Toxoplasma gondii microneme protein MIC2 0.0043 0.027 0.3803
Echinococcus multilocularis C type lectin domian containing protein 0.0074 0.071 0.0841
Echinococcus multilocularis cyclins 0.0031 0.0107 0.0083
Loa Loa (eye worm) hypothetical protein 0.0043 0.027 0.0167
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Brugia malayi Cyclin, N-terminal domain containing protein 0.005 0.0374 0.0272
Loa Loa (eye worm) hypothetical protein 0.0043 0.027 0.0167
Loa Loa (eye worm) hypothetical protein 0.0043 0.027 0.0167
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0038 0.0205 0.0285
Onchocerca volvulus 0.0043 0.027 0.048
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0172 0.2104 0.3499
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Loa Loa (eye worm) CUTiclin-Like family member 0.0043 0.027 0.0167
Toxoplasma gondii subtilisin SUB2 0.0031 0.0105 0.1471
Echinococcus multilocularis cyclin b3 0.0031 0.0107 0.0083
Echinococcus granulosus beta-adrenergic receptor kinase 0.01 0.1078 0.1041
Loa Loa (eye worm) hypothetical protein 0.005 0.0374 0.0272
Loa Loa (eye worm) hypothetical protein 0.0074 0.071 0.0612
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0072 0.0684 0.0586
Brugia malayi von Willebrand factor type A domain containing protein 0.0043 0.027 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0105 0.0115
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0038 0.0205 0.0285
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0442 0.5945 1
Toxoplasma gondii subtilisin SUB6 0.0031 0.0105 0.1471
Trypanosoma cruzi cyclin, putative 0.005 0.0374 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0172 0.2104 0.3499
Echinococcus granulosus cyclin B3 1 0.0031 0.0107 0.0066
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0043 0.027 0.0288
Onchocerca volvulus 0.0043 0.027 0.048
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0038 0.0205 0.0164
Brugia malayi von Willebrand Factor 0.0043 0.027 0.0167
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Loa Loa (eye worm) hypothetical protein 0.0043 0.027 0.0167
Entamoeba histolytica P-glycoprotein-2 0.0038 0.0205 0.3661
Brugia malayi Protein set-1 0.0072 0.068 0.0582
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0038 0.0205 0.0285
Echinococcus multilocularis 0.0586 0.8 1
Trichomonas vaginalis cyclins, putative 0.0031 0.0107 0.012
Brugia malayi pregnancy-associated plasma protein-A 0.0074 0.071 0.0612
Echinococcus multilocularis c4b binding protein beta chain 0.0074 0.071 0.0841
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0038 0.0205 0.0164
Echinococcus multilocularis neuroendocrine convertase 2 0.0457 0.6159 0.7686
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0141 0.1662 0.2751
Brugia malayi multidrug resistance protein 3 0.0038 0.0205 0.0101
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0038 0.0205 0.0285
Toxoplasma gondii subtilisin SUB8 0.0031 0.0105 0.1471
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0172 0.2104 0.2021
Plasmodium falciparum cyclin 0.0031 0.0107 0.0045
Trichomonas vaginalis cyclins, putative 0.005 0.0374 0.0571
Entamoeba histolytica cyclin, putative 0.005 0.0374 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0105 0.0115
Brugia malayi von Willebrand factor type A domain containing protein 0.0043 0.027 0.0167
Echinococcus multilocularis cyclins 0.0031 0.0107 0.0083
Treponema pallidum 76K protein 0.0043 0.027 0.5
Plasmodium falciparum multidrug resistance protein 1 0.0038 0.0205 0.1656
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0038 0.0205 0.0285
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0038 0.0205 0.0285
Loa Loa (eye worm) hypothetical protein 0.0072 0.0684 0.0586
Treponema pallidum hypothetical protein 0.0043 0.027 0.5
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0038 0.0205 0.0101
Loa Loa (eye worm) tyrosinase 1 0.0072 0.0684 0.0586
Trichomonas vaginalis taga, putative 0.0038 0.0205 0.0285
Giardia lamblia High cysteine membrane protein Group 2 0.027 0.3504 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0038 0.0205 0.0285
Trypanosoma cruzi cyclin, putative 0.005 0.0374 1
Onchocerca volvulus 0.0072 0.0684 0.168
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0038 0.0205 0.0285
Leishmania major p-glycoprotein 0.0038 0.0205 0.3726
Trichomonas vaginalis cyclin A, putative 0.005 0.0374 0.0571
Echinococcus granulosus cyclin B 0.005 0.0374 0.0334
Plasmodium vivax multidrug resistance protein 1, putative 0.0038 0.0205 0.1656
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0031 0.0105 0.5
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0043 0.027 0.2734
Echinococcus granulosus furin 0.0727 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0038 0.0205 0.0164
Onchocerca volvulus 0.0043 0.027 0.048
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.1662 0.2751
Schistosoma mansoni cyclin B 0.005 0.0374 0.0272
Echinococcus multilocularis cyclin B 0.005 0.0374 0.0418
Brugia malayi von Willebrand factor type A domain containing protein 0.0043 0.027 0.0167
Entamoeba histolytica elongation factor-2 kinase, putative 0.0043 0.027 0.6111
Brugia malayi hypothetical protein 0.0074 0.071 0.0612
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.1662 0.2751
Brugia malayi Zona pellucida-like domain containing protein 0.0043 0.027 0.0167
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0043 0.027 0.0167
Echinococcus multilocularis histone lysine n methyltransferase setd8 0.0072 0.068 0.0803
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0043 0.027 0.3803
Trichomonas vaginalis cyclin D, putative 0.0031 0.0107 0.012
Entamoeba histolytica hypothetical protein 0.0043 0.027 0.6111
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0038 0.0205 0.0285
Schistosoma mansoni hypothetical protein 0.0141 0.1662 0.1574
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0038 0.0199 0.0158
Loa Loa (eye worm) hypothetical protein 0.0034 0.0144 0.004
Plasmodium falciparum thrombospondin-related anonymous protein 0.0043 0.027 0.2734
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0031 0.0105 0.5
Echinococcus granulosus cyclins 0.0031 0.0107 0.0066
Leishmania major cyclin 0.005 0.0374 1
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0141 0.1662 0.2751
Brugia malayi ShTK domain containing protein 0.0072 0.0684 0.0586
Trichomonas vaginalis WD repeat domain, putative 0.0274 0.3557 0.5957
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Loa Loa (eye worm) hypothetical protein 0.0043 0.027 0.0167
Loa Loa (eye worm) hypothetical protein 0.0072 0.0684 0.0586
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0043 0.027 0.2734
Onchocerca volvulus 0.0074 0.071 0.1755
Schistosoma mansoni hypothetical protein 0.0274 0.3557 0.3489
Echinococcus granulosus neuroendocrine convertase 2 0.0457 0.6159 0.6143
Plasmodium falciparum apical sushi protein 0.0074 0.071 1
Brugia malayi Sushi domain 0.0074 0.071 0.0612
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0043 0.027 0.0288
Loa Loa (eye worm) hypothetical protein 0.0074 0.071 0.0612
Trichomonas vaginalis cyclin B, putative 0.005 0.0374 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.1662 0.2751
Schistosoma mansoni c4b-binding protein beta chain 0.0074 0.071 0.0612
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0038 0.0205 0.0285
Trichomonas vaginalis cyclin B, putative 0.005 0.0374 0.0571
Echinococcus multilocularis cyclins 0.0031 0.0107 0.0083
Onchocerca volvulus 0.0074 0.071 0.1755
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0043 0.027 0.0395
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0038 0.0205 0.0206
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0038 0.0205 0.0206
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.027 0.0167
Brugia malayi von Willebrand factor type A domain containing protein 0.0043 0.027 0.0167
Loa Loa (eye worm) hypothetical protein 0.0038 0.0199 0.0095
Loa Loa (eye worm) hypothetical protein 0.0043 0.027 0.0167
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Brugia malayi Will die slowly protein 0.0274 0.3557 0.3489
Plasmodium vivax apical sushi protein, putative 0.0074 0.071 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0038 0.0205 0.0285
Loa Loa (eye worm) hypothetical protein 0.0043 0.027 0.0167
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0043 0.027 0.0167
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0031 0.0105 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.027 0.0167
Loa Loa (eye worm) ShTK domain-containing protein 0.0072 0.0684 0.0586
Echinococcus multilocularis multidrug resistance protein 1 0.0038 0.0205 0.0206
Onchocerca volvulus 0.0072 0.0684 0.168
Toxoplasma gondii histone lysine methyltransferase SET8 0.0072 0.068 0.9572
Trypanosoma brucei mitotic cyclin 6 0.005 0.0374 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Trichomonas vaginalis cyclin B, putative 0.0031 0.0107 0.012
Loa Loa (eye worm) hypothetical protein 0.0074 0.071 0.0612
Schistosoma mansoni hypothetical protein 0.0034 0.0144 0.004
Onchocerca volvulus 0.0043 0.027 0.048
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Echinococcus granulosus G protein coupled receptor kinase 1 0.0089 0.0932 0.0894
Echinococcus multilocularis beta adrenergic receptor kinase 0.01 0.1078 0.1303
Brugia malayi hypothetical protein 0.0043 0.027 0.0167
Echinococcus granulosus cyclins 0.0031 0.0107 0.0066
Entamoeba histolytica P-glycoprotein-1 0.0038 0.0205 0.3661
Echinococcus multilocularis protein will die slowly 0.0274 0.3557 0.4417
Loa Loa (eye worm) ShTK domain-containing protein 0.0072 0.0684 0.0586
Loa Loa (eye worm) hypothetical protein 0.0072 0.068 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.1662 0.2751
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0038 0.0205 0.0206
Echinococcus granulosus histone lysine n methyltransferase setd8 0.0072 0.068 0.0642
Trichomonas vaginalis cyclins, putative 0.005 0.0374 0.0571
Echinococcus multilocularis cyclins 0.0031 0.0107 0.0083
Schistosoma mansoni furin-1 (S08 family) 0.0316 0.4159 0.4097
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0038 0.0205 0.0164
Brugia malayi GCC2 and GCC3 family protein 0.0074 0.071 0.0612
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Echinococcus granulosus cyclins 0.0031 0.0107 0.0066
Brugia malayi proprotein convertase 2 0.0457 0.6159 0.6118
Trichomonas vaginalis ABC transporter, putative 0.0038 0.0205 0.0285
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0442 0.5945 0.7418
Loa Loa (eye worm) hypothetical protein 0.0043 0.027 0.0167
Brugia malayi Cyclin, N-terminal domain containing protein 0.0031 0.0107 0.0003
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0038 0.0205 0.0285
Entamoeba histolytica P-glycoprotein-2 0.0038 0.0205 0.3661
Onchocerca volvulus 0.0043 0.027 0.048
Echinococcus multilocularis cyclins 0.0031 0.0107 0.0083
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0038 0.0205 0.0285
Echinococcus granulosus c4b binding protein beta chain 0.0074 0.071 0.0672
Loa Loa (eye worm) hypothetical protein 0.0038 0.0205 0.0101
Trichomonas vaginalis abcb9, putative 0.0038 0.0205 0.0285
Loa Loa (eye worm) endoprotease bli-4 0.0727 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.1662 0.2751
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Brugia malayi Zona pellucida-like domain containing protein 0.0043 0.027 0.0167
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0043 0.027 0.2734
Loa Loa (eye worm) hypothetical protein 0.0074 0.071 0.0612
Loa Loa (eye worm) cyclin domain-containing protein 0.0031 0.0107 0.0003
Onchocerca volvulus 0.0074 0.071 0.1755
Schistosoma mansoni hypothetical protein 0.0043 0.027 0.0167
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Loa Loa (eye worm) hypothetical protein 0.0074 0.071 0.0612
Giardia lamblia G2/mitotic-specific cyclin B 0.005 0.0374 0.0785
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0072 0.0684 0.0586
Onchocerca volvulus 0.0074 0.071 0.1755
Brugia malayi hypothetical protein 0.0074 0.071 0.0612
Loa Loa (eye worm) hypothetical protein 0.005 0.0374 0.0272
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0105 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.1662 0.2751
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0442 0.5945 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0172 0.2104 0.3499
Toxoplasma gondii rhoptry neck protein RON9 0.0074 0.071 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0038 0.0205 0.0206
Toxoplasma gondii subtilisin SUB9 0.0031 0.0105 0.1471
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0038 0.0205 0.3726
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0038 0.0205 0.0285
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0141 0.1662 0.2751
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.1662 0.2751
Onchocerca volvulus 0.0038 0.0205 0.0291
Loa Loa (eye worm) hypothetical protein 0.0074 0.071 0.0612
Entamoeba histolytica P-glycoprotein-5 0.0038 0.0205 0.3661
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0038 0.0205 0.0285
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0043 0.027 0.0167
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0727 1 1
Echinococcus granulosus Furin 1 0.0172 0.2104 0.2071
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0031 0.0105 0.0115
Echinococcus granulosus membrane bound transcription factor site 1 0.0031 0.0105 0.0064
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0038 0.0205 0.0285
Onchocerca volvulus 0.0074 0.071 0.1755
Echinococcus multilocularis multidrug resistance protein 1 0.0038 0.0205 0.0206
Onchocerca volvulus 0.0074 0.071 0.1755
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0038 0.0205 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0105 0.0115
Schistosoma mansoni hypothetical protein 0.0043 0.027 0.0167
Echinococcus multilocularis ATP binding cassette sub family B 0.0038 0.0199 0.0198
Schistosoma mansoni cyclins 0.0031 0.0107 0.0003

Activities

Activity type Activity value Assay description Source Reference
MBC (functional) = 4 ug ml-1 Antibacterial activity against Escherichia coli ATCC 25922 after 1 hr by modified CLSI M26-A method ChEMBL. 21459574
MFC (functional) = 32 ug ml-1 Antifungal activity against Candida albicans ATCC 10231 after 1 hr by modified CLSI M26-A method ChEMBL. 21459574

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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