Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 8B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0127 | 0.0707 | 0.0707 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0269 | 0.489 | 0.8846 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0289 | 0.5468 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0227 | 0.3654 | 0.6379 |
Onchocerca volvulus | 0.0234 | 0.3849 | 0.3849 | |
Schistosoma mansoni | camp-specific cyclic nucleotide phosphodiesterase | 0.0121 | 0.0548 | 0.1002 |
Onchocerca volvulus | 0.0162 | 0.1751 | 0.1751 | |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0103 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.2557 | 0.2557 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0236 | 0.3913 | 0.3913 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0289 | 0.5468 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0103 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0103 | 0 | 0.5 |
Onchocerca volvulus | 0.0239 | 0.401 | 0.401 | |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.014 | 0.1101 | 0.1282 |
Mycobacterium ulcerans | hypothetical protein | 0.0103 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.0548 | 0.0548 |
Echinococcus granulosus | protein kinase c iota type | 0.0227 | 0.3654 | 0.6379 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0282 | 0.0282 |
Onchocerca volvulus | 0.0276 | 0.5085 | 0.5085 | |
Mycobacterium tuberculosis | Conserved protein TB27.3 | 0.0103 | 0 | 0.5 |
Brugia malayi | C1-like domain containing protein | 0.0236 | 0.3913 | 0.3913 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.1751 | 0.1751 |
Mycobacterium tuberculosis | Conserved protein | 0.0103 | 0 | 0.5 |
Schistosoma mansoni | atypical protein kinase C | 0.0233 | 0.3832 | 0.7007 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0162 | 0.1747 | 0.1747 |
Schistosoma mansoni | protein kinase C mu | 0.0236 | 0.3913 | 0.7156 |
Toxoplasma gondii | glyoxalase I, putative | 0.0443 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.7183 | 0.7183 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.401 | 0.401 |
Brugia malayi | protein kinase C II. | 0.0289 | 0.5468 | 0.5468 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0289 | 0.5468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5085 | 0.5085 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0103 | 0 | 0.5 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.0121 | 0.0548 | 0.0548 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.1751 | 0.1751 |
Mycobacterium tuberculosis | Conserved protein | 0.0103 | 0 | 0.5 |
Plasmodium vivax | glyoxalase I, putative | 0.0443 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0282 | 0.0282 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0198 | 0.2792 | 0.4658 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0164 | 0.1815 | 0.1815 |
Loa Loa (eye worm) | calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase | 0.0121 | 0.0548 | 0.0548 |
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.0443 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0103 | 0 | 0.5 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0249 | 0.431 | 0.5 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0236 | 0.3913 | 0.3913 |
Mycobacterium ulcerans | hypothetical protein | 0.0103 | 0 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0211 | 0.3186 | 0.5445 |
Echinococcus granulosus | protein kinase C gamma type | 0.0198 | 0.2792 | 0.4658 |
Brugia malayi | protein kinase C3,putative | 0.0156 | 0.1569 | 0.1569 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0269 | 0.489 | 0.8943 |
Plasmodium falciparum | glyoxalase I | 0.0443 | 1 | 1 |
Mycobacterium ulcerans | biphenyl-2,3-diol 1,2-dioxygenase | 0.0103 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5085 | 0.5085 |
Mycobacterium ulcerans | hypothetical protein | 0.0103 | 0 | 0.5 |
Mycobacterium ulcerans | glyoxalase GloA | 0.0103 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5085 | 0.5085 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0269 | 0.489 | 0.8943 |
Mycobacterium leprae | conserved hypothetical protein | 0.0103 | 0 | 0.5 |
Mycobacterium tuberculosis | Cadmium inducible protein CadI | 0.0103 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0459 | 0.0459 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0146 | 0.1262 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0289 | 0.5468 | 0.5468 |
Mycobacterium ulcerans | glyoxalase GloA | 0.0103 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.3849 | 0.3849 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0282 | 0.0282 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.7234 | 0.7234 |
Leishmania major | glyoxalase I,trypanothione-dependent glyoxalase I | 0.0443 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 1 | 1 |
Onchocerca volvulus | Lactoylglutathione lyase homolog | 0.0443 | 1 | 1 |
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.0443 | 1 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0269 | 0.489 | 0.8846 |
Brugia malayi | Protein kinase c protein 2 | 0.0198 | 0.2805 | 0.2805 |
Mycobacterium ulcerans | hypothetical protein | 0.0103 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.