TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 338.384 | Formula: C17H14N4O2S
H donors: 2 H acceptors: 4 LogP: 2.3 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OCc1ccc(o1)c1ccc2c(c1)c(ncn2)NCc1nccs1
InChi: 1S/C17H14N4O2S/c22-9-12-2-4-15(23-12)11-1-3-14-13(7-11)17(21-10-20-14)19-8-16-18-5-6-24-16/h1-7,10,22H,8-9H2,(H,19,20,21)
InChiKey: YBMDCQHRXRLIDE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	CDC-like kinase 4	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Theileria parva	serine/threonine protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus granulosus	hypothetical protein	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania major	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Candida albicans	Serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus multilocularis	dual specificity protein kinase clk2	Get druggable targets OG5_126990	All targets in OG5_126990
Cryptosporidium parvum	serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium vivax	serine/threonine kinase-1, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium falciparum	protein serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Giardia lamblia	Kinase, CMGC CLK	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	ko:K08823 CDC-like kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus granulosus	dual specificity protein kinase clk2	Get druggable targets OG5_126990	All targets in OG5_126990
Neospora caninum	hypothetical protein	Get druggable targets OG5_126990	All targets in OG5_126990
Babesia bovis	protein serine/threonine kinase 1	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma congolense	kinetoplastid kinetochore protein, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Candida albicans	Serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus multilocularis		Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Loa Loa (eye worm)	CMGC/CLK protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma congolense	kinetoplastid kinetochore protein 10, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium berghei	serine/threonine kinase-1, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania major	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma brucei	kinetoplastid kinetochore protein 19	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	Serine/threonine-protein kinase Doa, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma congolense	kinetoplastid kinetochore protein, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Cryptosporidium hominis	serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania mexicana		Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma brucei	kinetoplastid kinetochore protein 10	Get druggable targets OG5_126990	All targets in OG5_126990
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium knowlesi	serine/threonine kinase-1, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium yoelii	protein serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0032	0.0498	0.0498
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0591	0.0968
Entamoeba histolytica	heat shock protein 90, putative	0.0034	0.0536	0.8467
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0246	0.0246
Brugia malayi	Importin beta-1 subunit	0.003	0.0456	0.0636
Brugia malayi	isocitrate dehydrogenase	0.0032	0.0498	0.0696
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0073	0.1367	0.4982
Trypanosoma brucei	heat shock protein 90, putative	0.0034	0.0536	0.168
Loa Loa (eye worm)	heat shock protein 90	0.0034	0.0536	0.0749
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0027	0.0391	0.5
Brugia malayi	hypothetical protein	0.0037	0.0613	0.0856
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0456	0.0456
Trypanosoma cruzi	heat shock protein 90, putative	0.002	0.0243	0.0514
Leishmania major	DNA polymerase eta, putative	0.002	0.0246	0.0524
Giardia lamblia	Kinase, CMGC CLK	0.0073	0.1367	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0051	0.0901	0.3132
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0246	0.0524
Schistosoma mansoni	transcription factor btf3	0.0036	0.0591	0.0825
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0086	0.1644	0.2295
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0456	0.1359
Trypanosoma cruzi	transcription factor btf3, putative	0.0036	0.0591	0.1895
Plasmodium falciparum	importin beta, putative	0.003	0.0456	0.1359
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0101	0.1958	0.2733
Loa Loa (eye worm)	ICD-1 protein	0.0036	0.0591	0.0825
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.0246	0.0524
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0478	0.0667
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0246	0.0524
Plasmodium falciparum	heat shock protein 90	0.0034	0.0536	0.168
Schistosoma mansoni	eyes absent homolog	0.0087	0.1659	0.2316
Brugia malayi	hypothetical protein	0.0033	0.0518	0.0724
Echinococcus granulosus	dna polymerase eta	0.002	0.0246	0.0246
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0288	0.0402
Leishmania major	heat shock protein 83-1	0.0034	0.0536	0.168
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0023	0.0306	0.0306
Leishmania major	GTP-binding protein, putative	0.0022	0.0288	0.0692
Trichomonas vaginalis	heat shock protein, putative	0.0027	0.0391	0.0562
Brugia malayi	MH2 domain containing protein	0.0124	0.2449	0.3419
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0498	0.0498
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0032	0.0498	0.1528
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0613	0.0613
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0456	0.1359
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0014	0.0114	0.0114
Echinococcus multilocularis	isocitrate dehydrogenase	0.0032	0.0498	0.0498
Echinococcus multilocularis	geminin	0.0176	0.3551	0.3551
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0027	0.0391	0.0391
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0901	0.3132
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0478	0.0667
Schistosoma mansoni	apoptosis regulator bax	0.0086	0.1644	0.2295
Leishmania major	heat shock protein 83-1	0.0034	0.0536	0.168
Leishmania major	DNA polymerase kappa, putative	0.002	0.0246	0.0524
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0288	0.0288
Echinococcus multilocularis	snurportin 1	0.032	0.6597	0.6597
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.0288	0.0692
Trypanosoma cruzi	heat shock protein 85, putative	0.0034	0.0536	0.168
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1659	0.2316
Leishmania major	heat shock protein 83-1	0.0034	0.0536	0.168
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0246	0.0524
Echinococcus multilocularis	heat shock protein 90	0.0027	0.0391	0.0391
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.0073	0.1367	0.4983
Entamoeba histolytica	hypothetical protein	0.0037	0.0613	1
Echinococcus granulosus	dual specificity protein kinase clk2	0.0073	0.1367	0.1367
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0246	0.0524
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0478	0.0667
Onchocerca volvulus		0.0246	0.5035	1
Loa Loa (eye worm)	dihydrofolate reductase	0.0347	0.7163	1
Leishmania major	heat shock protein 83-1	0.0034	0.0536	0.168
Schistosoma mansoni	hypothetical protein	0.0032	0.0497	0.0694
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0347	0.7163	1
Brugia malayi	hypothetical protein	0.0087	0.1659	0.2316
Schistosoma mansoni	hypothetical protein	0.0032	0.0497	0.0694
Echinococcus granulosus	heat shock protein	0.0034	0.0536	0.0536
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0034	0.0536	0.2593
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0073	0.1367	0.4982
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0023	0.0306	0.0306
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0032	0.0498	0.1528
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0246	0.0524
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0828	0.1156
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0347	0.7163	1
Toxoplasma gondii	heat shock protein HSP90	0.0034	0.0536	0.168
Brugia malayi	heat shock protein 90	0.0034	0.0536	0.0749
Brugia malayi	Hsp90 protein	0.0014	0.0114	0.0159
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0536	0.168
Trichomonas vaginalis	endoplasmin, putative	0.0021	0.026	0.0296
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0032	0.0498	0.1528
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.0246	0.0524
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0497	0.0694
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0246	0.0524
Trypanosoma cruzi	heat shock protein 90, putative	0.0027	0.0391	0.11
Schistosoma mansoni	importin beta-1	0.003	0.0456	0.0636
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0828	0.1156
Echinococcus multilocularis		0.0072	0.1355	0.1355
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0478	0.0478
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0086	0.1644	0.1644
Schistosoma mansoni	serine/threonine protein kinase	0.0073	0.1367	0.1908
Echinococcus multilocularis	dihydrofolate reductase	0.0347	0.7163	0.7163
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1644	0.2295
Entamoeba histolytica	Ran family GTPase	0.0022	0.0288	0.3488
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0288	0.0692
Schistosoma mansoni	heat shock protein	0.0034	0.0536	0.0749
Schistosoma mansoni	hypothetical protein	0.0069	0.1282	0.1789
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0246	0.0246
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0086	0.1644	0.1644
Brugia malayi	Protein kinase domain containing protein	0.0073	0.1367	0.1908
Plasmodium vivax	endoplasmin, putative	0.0034	0.0536	0.168
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0536	0.168
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0246	0.0524
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0478	0.0667
Entamoeba histolytica	hypothetical protein	0.0037	0.0613	1
Brugia malayi	beta-NAC-like protein	0.0036	0.0591	0.0825
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0497	0.0694
Entamoeba histolytica	hypothetical protein	0.0037	0.0613	1
Trichomonas vaginalis	ran, putative	0.0022	0.0288	0.0354
Plasmodium vivax	ataxin-2 like protein, putative	0.0051	0.0901	0.3132
Plasmodium falciparum	basic transcription factor 3b, putative	0.0036	0.0591	0.1895
Giardia lamblia	Grp94/Hsp90	0.0027	0.0391	0.1293
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0086	0.1644	0.1644
Schistosoma mansoni	serine/threonine protein kinase	0.0073	0.1367	0.1908
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0498	0.0498
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0536	0.168
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0032	0.0498	0.1528
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0246	0.0524
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1282	0.1789
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0456	0.1359
Echinococcus granulosus	snurportin 1	0.032	0.6597	0.6597
Schistosoma mansoni	hypothetical protein	0.0032	0.0497	0.0694
Trypanosoma brucei	PAB1-binding protein , putative	0.0051	0.0901	0.3132
Echinococcus granulosus	neuropeptide receptor A26	0.0481	1	1
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0073	0.1367	0.4982
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0478	0.0478
Schistosoma mansoni	dihydrofolate reductase	0.0347	0.7163	1
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0032	0.0498	0.0498
Schistosoma mansoni	endoplasmin	0.0034	0.0536	0.0749
Schistosoma mansoni	hypothetical protein	0.0176	0.3551	0.4958
Echinococcus granulosus	transcription factor btf3	0.0036	0.0591	0.0591
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0246	0.0343
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0613	0.0856
Echinococcus granulosus	dna polymerase kappa	0.002	0.0246	0.0246
Loa Loa (eye worm)	hypothetical protein	0.002	0.0246	0.0343
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0101	0.1958	0.2733
Plasmodium falciparum	protein serine/threonine kinase-1	0.0073	0.1367	0.4982
Trypanosoma brucei	unspecified product	0.002	0.0246	0.0524
Plasmodium vivax	importin-beta 2, putative	0.003	0.0456	0.1359
Schistosoma mansoni	hypothetical protein	0.0176	0.3551	0.4958
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0497	0.0497
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0.0246	0.0268
Leishmania major	heat shock protein 83-1	0.0034	0.0536	0.168
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0288	0.0693
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0336	0.0881
Loa Loa (eye worm)	hypothetical protein	0.003	0.0456	0.0636
Leishmania major	heat shock protein 83-1	0.0034	0.0536	0.168
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0246	0.0524
Plasmodium vivax	basic transcription factor 3b, putative	0.0036	0.0591	0.1895
Echinococcus granulosus	endoplasmin	0.0027	0.0391	0.0391
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0246	0.0343
Plasmodium vivax	serine/threonine kinase-1, putative	0.0073	0.1367	0.4982
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.0073	0.1367	0.4983
Loa Loa (eye worm)	endoplasmin	0.0034	0.0536	0.0749
Toxoplasma gondii	heat shock protein 90, putative	0.0034	0.0536	0.168
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0133	0.2628	1
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0336	0.0881
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0497	0.0694
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0.0246	0.0268
Brugia malayi	Pre-SET motif family protein	0.0031	0.0478	0.0667
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0288	0.0402
Loa Loa (eye worm)	transcription factor SMAD2	0.0124	0.2449	0.3419
Trypanosoma cruzi	Heat shock protein 83, putative	0.0034	0.0536	0.168
Entamoeba histolytica	transcription factor BTF3, putative	0.0036	0.0591	0.9552
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0536	0.168
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0246	0.0524
Echinococcus multilocularis	endoplasmin	0.0027	0.0391	0.0391
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0613	0.0613
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0246	0.0524
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0032	0.0498	0.0696
Schistosoma mansoni	DNA polymerase eta	0.002	0.0246	0.0343
Schistosoma mansoni	heat shock protein	0.0034	0.0536	0.0749
Trichomonas vaginalis	set domain proteins, putative	0.0246	0.5035	1
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0027	0.0391	0.021
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0246	0.0246
Trypanosoma brucei	heat shock protein 84, putative	0.0014	0.0114	0.0001
Trichomonas vaginalis	heat shock protein, putative	0.0027	0.0391	0.0562
Toxoplasma gondii	isocitrate dehydrogenase	0.0032	0.0498	0.1528
Trypanosoma cruzi	transcription factor btf3, putative	0.0036	0.0591	0.1895
Mycobacterium ulcerans	heat shock protein 90	0.0027	0.0391	0.021
Echinococcus multilocularis	neuropeptide s receptor	0.0481	1	1
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0246	0.0343
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0032	0.0498	0.1528
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0216	0.4402	0.6146
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0591	0.0968
Entamoeba histolytica	hypothetical protein	0.0037	0.0613	1
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0133	0.2628	1
Echinococcus multilocularis	heat shock protein	0.0034	0.0536	0.0536
Trichomonas vaginalis	heat shock protein, putative	0.0021	0.026	0.0296
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0027	0.0391	0.11
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0032	0.0498	0.0365
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0246	0.0343
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0828	0.1156
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0828	0.0828
Toxoplasma gondii	NAC domain-containing protein	0.0036	0.0591	0.1895
Entamoeba histolytica	deoxycytidyl transferase, putative	0.002	0.0246	0.2639
Trypanosoma brucei	heat shock protein 90, putative	0.0034	0.0536	0.168
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0536	0.168
Entamoeba histolytica	hypothetical protein	0.0024	0.0336	0.4441
Leishmania major	heat shock protein 83-1	0.0034	0.0536	0.168
Echinococcus granulosus	hypothetical protein	0.0072	0.1355	0.1355
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0497	0.0497
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0133	0.2628	1
Brugia malayi	dihydrofolate reductase family protein	0.0347	0.7163	1
Leishmania major	heat shock protein 83-1	0.0034	0.0536	0.168
Echinococcus granulosus	geminin	0.0176	0.3551	0.3551
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0478	0.1448
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0347	0.7163	1
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0073	0.1367	0.1908
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0478	0.0478
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0536	0.168
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0497	0.0497
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0086	0.1644	0.1644
Toxoplasma gondii	isocitrate dehydrogenase	0.0032	0.0498	0.1528
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0246	0.0524
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.032	0.6597	0.921
Echinococcus granulosus	GPCR family 2	0.0032	0.0497	0.0497
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0246	0.0524
Leishmania major	heat shock protein 83-1	0.0034	0.0536	0.168
Leishmania major	heat shock protein 83-1	0.0034	0.0536	0.168
Echinococcus multilocularis	dna polymerase eta	0.002	0.0246	0.0246
Leishmania major	heat shock protein 83-1	0.0034	0.0536	0.168
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0497	0.0497
Leishmania major	protein kinase, putative	0.0073	0.1367	0.4982
Leishmania major	heat shock protein 83-1	0.0034	0.0536	0.168
Plasmodium vivax	heat shock protein 86, putative	0.0034	0.0536	0.168
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0014	0.0114	0.0114
Leishmania major	heat shock protein 83-1	0.0034	0.0536	0.168
Trichomonas vaginalis	heat shock protein, putative	0.0034	0.0536	0.0858
Echinococcus multilocularis	neuropeptide receptor A26	0.0481	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0828	0.0828
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.1282	0.1789
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0288	0.0288
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0101	0.1958	0.2733
Loa Loa (eye worm)	MH2 domain-containing protein	0.0124	0.2449	0.3419
Trypanosoma brucei	transcription factor BTF3, putative	0.0036	0.0591	0.1896
Leishmania major	basic transcription factor 3a, putative	0.0036	0.0591	0.1895
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0478	0.0667
Echinococcus granulosus	importin subunit beta 1	0.003	0.0456	0.0456
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0133	0.2628	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0246	0.0524
Echinococcus multilocularis	heat shock protein 90	0.0034	0.0536	0.0536
Entamoeba histolytica	hypothetical protein	0.0036	0.0591	0.9552
Leishmania major	heat shock protein 83-1	0.0034	0.0536	0.168
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.0288	0.0692
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0288	0.0692
Leishmania major	protein kinase, putative	0.0073	0.1367	0.4982
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0901	0.3132
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0901	0.3132
Plasmodium falciparum	endoplasmin, putative	0.0021	0.026	0.058
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0086	0.1644	0.2295
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0246	0.0524
Loa Loa (eye worm)	heat shock protein 75	0.0014	0.0114	0.0159
Echinococcus multilocularis	transcription factor btf3	0.0036	0.0591	0.0591
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0133	0.2628	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0336	0.045
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0828	0.0828
Schistosoma mansoni	hypothetical protein	0.0023	0.0306	0.0427
Schistosoma mansoni	hypothetical protein	0.0086	0.1644	0.2295
Trichomonas vaginalis	CMGC family protein kinase	0.0073	0.1367	0.2545
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0336	0.045
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0901	0.1259
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0497	0.0497
Echinococcus granulosus	dihydrofolate reductase	0.0347	0.7163	0.7163
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0454	0.0454
Brugia malayi	hypothetical protein	0.0051	0.0901	0.1259
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0246	0.0343
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0246	0.0524
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0828	0.1156
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1958	0.2733
Plasmodium vivax	SET domain protein, putative	0.0031	0.0478	0.1448
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1659	0.2316
Echinococcus granulosus	heat shock protein 90	0.0027	0.0391	0.0391
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0536	0.168
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0498	0.0498
Trypanosoma cruzi	heat shock protein 85, putative	0.0027	0.0391	0.11
Leishmania major	heat shock protein 83-1	0.0034	0.0536	0.168
Schistosoma mansoni	heat shock protein	0.0014	0.0114	0.0159
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0901	0.3132
Schistosoma mansoni	hypothetical protein	0.0037	0.0613	0.0856
Echinococcus granulosus	heat shock protein 90	0.0034	0.0536	0.0536
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1355	0.1892
Trypanosoma brucei	Heat shock protein 83, putative	0.0034	0.0536	0.168
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0246	0.0524
Echinococcus multilocularis	dual specificity protein kinase clk2	0.0073	0.1367	0.1367
Trypanosoma cruzi	heat shock protein 90, putative	0.0034	0.0536	0.168
Leishmania major	heat shock protein 83-1	0.0034	0.0536	0.168
Schistosoma mansoni	ran	0.0022	0.0288	0.0402
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0027	0.0391	0.1293
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0828	0.0828
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0032	0.0498	0.1528
Schistosoma mansoni	hypothetical protein	0.032	0.6597	0.921
Trypanosoma brucei	heat shock protein, putative	0.0034	0.0536	0.168
Schistosoma mansoni	endoplasmin	0.0034	0.0536	0.0749
Trichomonas vaginalis	heat shock protein, putative	0.0027	0.0391	0.0562
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0828	0.1156
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0288	0.0692
Trypanosoma cruzi	heat shock protein 85, putative	0.0034	0.0536	0.168
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0497	0.0694
Brugia malayi	Pre-SET motif family protein	0.0216	0.4402	0.6146
Brugia malayi	Dihydrofolate reductase	0.0347	0.7163	1
Schistosoma mansoni	ran	0.0022	0.0288	0.0402
Brugia malayi	RNA, U transporter 1	0.0085	0.1626	0.227
Schistosoma mansoni	hypothetical protein	0.0086	0.1644	0.2295
Entamoeba histolytica	heat shock protein 90, putative	0.0034	0.0536	0.8467
Trypanosoma cruzi	heat shock protein 85, putative	0.0034	0.0536	0.168
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0246	0.0524
Schistosoma mansoni	hypothetical protein	0.0032	0.0497	0.0694
Leishmania major	heat shock protein 83-1	0.0034	0.0536	0.168
Leishmania major	hypothetical protein, conserved	0.0051	0.0901	0.3132
Treponema pallidum	heat shock protein 90	0.0027	0.0391	0.5
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0032	0.0498	0.1528
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.0073	0.1367	0.4982
Chlamydia trachomatis	dihydrofolate reductase	0.0347	0.7163	0.5
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0073	0.1367	0.4982
Brugia malayi	Isocitrate dehydrogenase	0.0032	0.0498	0.0696
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0133	0.2628	1
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.0288	0.0378
Brugia malayi	Endoplasmin precursor	0.0034	0.0536	0.0749
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0336	0.045
Schistosoma mansoni	hypothetical protein	0.0086	0.1644	0.2295
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0591	0.0968
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0032	0.0498	0.0696
Loa Loa (eye worm)	apoptosis regulator protein	0.0086	0.1644	0.2295
Onchocerca volvulus		0.0031	0.0478	0.074

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.8419 uM	PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of CDC-like Kinase 4 (Kinase-Glo Assay): SAR round 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1379, AID1770, AID1983, AID1997, AID2710, AID488872, AID488883, AID488887, AID504421, AID504424, AID504427, AID504428, AID504429, AID504430]	ChEMBL.	No reference
Potency (functional)	23.1882 uM	PUBCHEM_BIOASSAY: Assay for Inhibitors of Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1A (Kinase-Glo assay): round 2 SAR. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1770, AID1970, AID2705, AID488872]	ChEMBL.	No reference
Potency_Clk2_uM (functional)	23.57 uM	PUBCHEM_BIOASSAY: Kinase Inhibition Study on Inhibitors of CDC-like Kinase 2 (Reaction Biology data). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1459, AID1487, AID1498, AID1770, AID1970, AID1997, AID488872, AID488883, AID488887, AID493204]	ChEMBL.	No reference
Potency_Clk4_uM (functional)	3.062 uM	PUBCHEM_BIOASSAY: Kinase Inhibition Study on Inhibitors of CDC-like Kinase 4 (Reaction Biology data): SAR round 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1459, AID1487, AID1498, AID1770, AID1970, AID1997, AID488872, AID488883, AID488887, AID493204]	ChEMBL.	No reference
Potency_Dyrk1a_uM (functional)	23.29 uM	PUBCHEM_BIOASSAY: Kinase Inhibition Study on Inhibitors of Dyrk1a (Reaction Biology data). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1459, AID1487, AID1498, AID1770, AID1970, AID1997, AID488872, AID488883, AID488887, AID493204]	ChEMBL.	No reference
Potency_Dyrk1b_uM (functional)	19.17 uM	PUBCHEM_BIOASSAY: Kinase Inhibition Study on Inhibitors of Dyrk1b (Reaction Biology data). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1459, AID1487, AID1498, AID1770, AID1970, AID1997, AID488872, AID488883, AID488887, AID493204]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1734029

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1561158