Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus subtilis | 4'-phosphopantetheinyl transferase ffp | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | aminoadipate-semialdehyde dehydrogenase small subunit | 4'-phosphopantetheinyl transferase ffp | 224 aa | 183 aa | 27.3 % |
Onchocerca volvulus | 4'-phosphopantetheinyl transferase ffp | 224 aa | 186 aa | 26.3 % | |
Trichomonas vaginalis | conserved hypothetical protein | 4'-phosphopantetheinyl transferase ffp | 224 aa | 197 aa | 22.3 % |
Entamoeba histolytica | hypothetical protein | 4'-phosphopantetheinyl transferase ffp | 224 aa | 198 aa | 28.3 % |
Candida albicans | aminoadipate-semialdehyde dehydrogenase small subunit | 4'-phosphopantetheinyl transferase ffp | 224 aa | 183 aa | 27.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | 0.0096 | 0.0046 | 0.0097 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.01 | 0.0124 | 0.0262 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0302 | 0.3392 | 0.89 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.3028 | 0.6273 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0709 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.012 | 0.0249 |
Brugia malayi | Protein kinase c protein 2 | 0.0223 | 0.211 | 0.4474 |
Brugia malayi | protein kinase C II. | 0.0322 | 0.3716 | 0.788 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0209 | 0.1886 | 0.4948 |
Plasmodium vivax | topoisomerase I, putative | 0.0186 | 0.1518 | 0.5 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0302 | 0.3392 | 0.89 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0322 | 0.3716 | 0.975 |
Echinococcus multilocularis | unc 13 (munc13) | 0.01 | 0.012 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0124 | 0.0256 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0322 | 0.3716 | 0.975 |
Schistosoma mansoni | unc-13 (munc13) | 0.01 | 0.012 | 0.0255 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0096 | 0.0046 | 0.0097 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.01 | 0.0124 | 0.0262 |
Schistosoma mansoni | vav2 | 0.0102 | 0.0157 | 0.0334 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.012 | 0.0437 | 0.1147 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0186 | 0.1518 | 0.3983 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.467 | 0.9674 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.3028 | 0.6273 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0096 | 0.0046 | 0.0121 |
Brugia malayi | C1-like domain containing protein | 0.0383 | 0.4716 | 1 |
Onchocerca volvulus | 0.039 | 0.4827 | 1 | |
Schistosoma mansoni | protein kinase C mu | 0.0383 | 0.4716 | 1 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0383 | 0.4716 | 1 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0383 | 0.4716 | 0.9769 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0437 | 0.0905 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.01 | 0.0124 | 0.0324 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0221 | 0.2089 | 0.5482 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0322 | 0.3716 | 0.7698 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0302 | 0.3392 | 0.7193 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0152 | 0.0964 | 1 |
Plasmodium falciparum | topoisomerase I | 0.0186 | 0.1518 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0142 | 0.0807 | 0.2117 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.01 | 0.0124 | 0.0324 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.026 | 0.2711 | 0.5617 |
Loa Loa (eye worm) | hypothetical protein | 0.0361 | 0.4357 | 0.9026 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.3028 | 0.6273 |
Schistosoma mansoni | unc-13 (munc13) | 0.01 | 0.012 | 0.0255 |
Echinococcus multilocularis | protein kinase c iota type | 0.0328 | 0.3811 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.0209 | 0.1886 | 0.4948 |
Onchocerca volvulus | 0.0288 | 0.3163 | 0.6465 | |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0157 | 0.0326 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0096 | 0.0046 | 0.0097 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0139 | 0.0758 | 0.1608 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.012 | 0.0437 | 0.1147 |
Brugia malayi | protein kinase C3,putative | 0.0249 | 0.2529 | 0.5363 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0322 | 0.3716 | 0.788 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.3163 | 0.6553 |
Echinococcus granulosus | myotubularin protein 13 | 0.0102 | 0.0157 | 0.0413 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0302 | 0.3392 | 0.7193 |
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.01 | 0.012 | 0.0316 |
Echinococcus granulosus | unc 13 munc13 | 0.01 | 0.012 | 0.0316 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0186 | 0.1518 | 0.322 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0709 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.3163 | 0.6553 |
Onchocerca volvulus | 0.038 | 0.467 | 0.9666 | |
Onchocerca volvulus | 0.0279 | 0.3028 | 0.6178 | |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0186 | 0.1518 | 1 |
Brugia malayi | Pleckstrin Homology Domain | 0.0102 | 0.0157 | 0.0334 |
Brugia malayi | DNA topoisomerase I | 0.0186 | 0.1518 | 0.322 |
Echinococcus granulosus | protein kinase c iota type | 0.0328 | 0.3811 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0096 | 0.0046 | 0.0121 |
Onchocerca volvulus | 0.01 | 0.0124 | 0.0007 | |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.029 | 0.3209 | 0.6649 |
Schistosoma mansoni | atypical protein kinase C | 0.0339 | 0.3994 | 0.8469 |
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.01 | 0.012 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.4535 | 0.9394 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.012 | 0.0437 | 0.1147 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.1943 | 0.4026 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0186 | 0.1518 | 0.3983 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0102 | 0.0157 | 0.0413 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.013 | 0.0603 | 0.125 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0709 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 0.4827 | 1 |
Schistosoma mansoni | protein kinase C | 0.01 | 0.012 | 0.0255 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0186 | 0.1518 | 0.3145 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0139 | 0.0758 | 0.1608 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.962 uM | PUBCHEM_BIOASSAY: Inhibitos of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase): Dry Powder Follow up. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1490, AID1819, AID2701, AID2707] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.