TDR Targets

Basic information

Technical information

TDR Targets ID: 1561254
Name: 2-(7-methyl-4-oxo-2-phenylpyrazolo[1,5-d][1,2 ,4]triazin-5-yl)-N-[3-(4-methylpiperazin-1-yl )propyl]acetamide
MW: 423.511 | Formula: C22H29N7O2
H donors: 1 H acceptors: 3 LogP: 1.17 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)CCCNC(=O)Cn1nc(C)n2c(c1=O)cc(n2)c1ccccc1
InChi: 1S/C22H29N7O2/c1-17-24-28(16-21(30)23-9-6-10-27-13-11-26(2)12-14-27)22(31)20-15-19(25-29(17)20)18-7-4-3-5-8-18/h3-5,7-8,15H,6,9-14,16H2,1-2H3,(H,23,30)
InChiKey: OPRGYISEGLNNDB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(7-methyl-4-oxo-2-phenyl-pyrazolo[1,5-d][1,2,4]triazin-5-yl)-N-[3-(4-methylpiperazin-1-yl)propyl]acetamide
2-(7-methyl-4-oxo-2-phenyl-5-pyrazolo[1,5-d][1,2,4]triazinyl)-N-[3-(4-methyl-1-piperazinyl)propyl]acetamide
2-(4-keto-7-methyl-2-phenyl-pyrazolo[1,5-d][1,2,4]triazin-5-yl)-N-[3-(4-methylpiperazin-1-yl)propyl]acetamide
2-(7-methyl-4-oxo-2-phenyl-pyrazolo[1,5-d][1,2,4]triazin-5-yl)-N-[3-(4-methylpiperazin-1-yl)propyl]ethanamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0074	0.0203	0.0203
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	0.0209	0.0343
Loa Loa (eye worm)	peptidase family M1 containing protein	0.009	0.0299	0.0299
Brugia malayi	Cathepsin L-like precursor	0.0112	0.0433	0.0627
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0561	0.3157	0.4488
Trypanosoma cruzi	cysteine peptidase, putative	0.0112	0.0433	0.0484
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0075	0.0209	0.0302
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.009	0.013
Loa Loa (eye worm)	cysteine protease	0.0112	0.0433	0.0433
Leishmania major	cathepsin L-like protease	0.0112	0.0433	0.0203
Schistosoma mansoni	tyrosine kinase	0.0486	0.2704	0.2704
Loa Loa (eye worm)	ctsf protein	0.0112	0.0433	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0209	0.0209
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0074	0.0203	0.0203
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0433	0.0484
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0112	0.0433	0.1078
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0104	0.0924
Schistosoma mansoni	tyrosine kinase	0.03	0.1575	0.1575
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0074	0.0203	0.0203
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0281	0.1457	0.1457
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.009	0.009
Echinococcus multilocularis	cathepsin L cysteine protease	0.0112	0.0433	0.0433
Schistosoma mansoni	cathepsin F (C01 family)	0.0112	0.0433	0.0433
Onchocerca volvulus		0.0112	0.0433	0.0627
Schistosoma mansoni	tyrosine kinase	0.0499	0.2783	0.2783
Brugia malayi	ecdysteroid receptor	0.0074	0.0203	0.0294
Brugia malayi	Variant SH3 domain containing protein	0.0054	0.0085	0.0122
Entamoeba histolytica	hypothetical protein	0.0043	0.0018	0.0162
Echinococcus granulosus	epidermal growth factor receptor	0.0922	0.535	0.535
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0433	0.0484
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.009	0.0299	0.0638
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.009	0.0299	0.0299
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0067	0.0163	0.0163
Onchocerca volvulus		0.0074	0.0203	0.0294
Trypanosoma cruzi	cysteine peptidase, putative	0.0112	0.0433	0.0484
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0074	0.0203	0.0203
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0112	0.0433	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0203	0.0203
Brugia malayi	Papain family cysteine protease containing protein	0.0112	0.0433	0.0627
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0112	0.0433	0.1078
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.009	0.0299	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0203	0.0203
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.1689	1	1
Echinococcus multilocularis	cysteine protease	0.0112	0.0433	0.0433
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.009	0.0299	0.0299
Onchocerca volvulus		0.009	0.0299	0.0433
Brugia malayi	nuclear receptor NHR-88	0.0074	0.0203	0.0294
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.009	0.0299	0.0299
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0104	0.0924
Echinococcus multilocularis	NCK adaptor protein	0.0054	0.0085	0.0085
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.5696	0.5696
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0074	0.0203	0.0203
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.009	0.0299	0.0299
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.009	0.0299	0.0286
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0112	0.0433	0.1078
Brugia malayi	Furin-like cysteine rich region family protein	0.0922	0.535	0.7747
Schistosoma mansoni	growth factor receptor-bound protein	0.0054	0.0085	0.0085
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0112	0.0433	0.0484
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0281	0.1457	0.1457
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0112	0.0433	0.1078
Mycobacterium ulcerans	thymidylate synthase	0.1179	0.6906	1
Brugia malayi	hypothetical protein	0.0561	0.3157	0.4571
Onchocerca volvulus		0.1179	0.6906	1
Schistosoma mansoni	coup transcription factor	0.0074	0.0203	0.0203
Echinococcus granulosus	NCK adaptor protein	0.0054	0.0085	0.0085
Schistosoma mansoni	thyroid hormone receptor	0.0074	0.0203	0.0203
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0433	0.0484
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0112	0.0433	0.1078
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0433	0.0484
Echinococcus granulosus	thymidylate synthase	0.1179	0.6906	0.6906
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.009	0.0299	0.0286
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0281	0.1457	0.1457
Onchocerca volvulus		0.009	0.0299	0.0433
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0373	0.2015	0.281
Loa Loa (eye worm)	fibroinase	0.0112	0.0433	0.0433
Brugia malayi	protein-tyrosine kinase	0.0254	0.1294	0.1873
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0241	0.1215	0.1215
Schistosoma mansoni	thyroid hormone receptor	0.0074	0.0203	0.0203
Echinococcus multilocularis	FTZ F1 alpha	0.0074	0.0203	0.0203
Brugia malayi	cathepsin L-like precursor	0.0075	0.0209	0.0302
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0112	0.0433	0.1078
Brugia malayi	Cathepsin L-like precursor	0.0112	0.0433	0.0627
Echinococcus granulosus	cathepsin l1	0.0112	0.0433	0.0433
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0499	0.2783	0.2783
Schistosoma mansoni	tyrosine kinase	0.0486	0.2704	0.2704
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0004	0.0004
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.009	0.0299	0.0299
Brugia malayi	TATA binding protein associated factor	0.009	0.0299	0.0433
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0112	0.0433	0.1078
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0281	0.1457	0.1457
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0074	0.0203	0.0294
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0067	0.0163	0.0163
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0074	0.0203	0.0294
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0074	0.0203	0.0203
Onchocerca volvulus		0.0112	0.0433	0.0627
Loa Loa (eye worm)	SRC-1	0.0281	0.1457	0.1457
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0281	0.1457	0.1457
Schistosoma mansoni	tyrosine kinase	0.03	0.1575	0.1575
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0203	0.0203
Schistosoma mansoni	tyrosine kinase	0.0499	0.2783	0.2783
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0074	0.0203	0.0203
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0067	0.0163	0.0163
Onchocerca volvulus		0.0112	0.0433	0.0627
Onchocerca volvulus		0.0112	0.0433	0.0627
Toxoplasma gondii	cathepsin CPL	0.0112	0.0433	0.0203
Leishmania major	cathepsin L-like protease	0.0112	0.0433	0.0203
Brugia malayi	Cathepsin L-like precursor	0.0112	0.0433	0.0627
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0074	0.0203	0.0203
Brugia malayi	Cathepsin L-like precursor	0.0112	0.0433	0.0627
Schistosoma mansoni	adapter molecule crk	0.0054	0.0085	0.0085
Brugia malayi	Variant SH3 domain containing protein	0.0054	0.0085	0.0122
Loa Loa (eye worm)	TK protein kinase	0.0254	0.1294	0.1294
Leishmania major	cathepsin L-like protease	0.0112	0.0433	0.0203
Entamoeba histolytica	cysteine proteinase 1, putative	0.0058	0.0104	0.0924
Schistosoma mansoni	tyrosine kinase	0.0281	0.1457	0.1457
Brugia malayi	Cathepsin L-like precursor	0.0112	0.0433	0.0627
Echinococcus multilocularis	cathepsin L cysteine protease	0.0112	0.0433	0.0433
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.1689	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0433	0.0484
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0074	0.0203	0.0294
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0281	0.1457	0.1457
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0209	0.0209
Brugia malayi	Cathepsin L-like precursor	0.0075	0.0209	0.0302
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0241	0.1215	0.1215
Echinococcus granulosus	insulin receptor	0.03	0.1575	0.1575
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0104	0.0924
Giardia lamblia	Kinase, CMGC MAPK	0.0373	0.2015	0.5
Entamoeba histolytica	hypothetical protein	0.0043	0.0018	0.0162
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.1179	0.6906	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.0299	0.0299
Echinococcus granulosus	tyrosine protein kinase Blk	0.0254	0.1294	0.1294
Schistosoma mansoni	RAR-like nuclear receptor	0.0074	0.0203	0.0203
Entamoeba histolytica	cysteine proteinase, putative	0.0058	0.0104	0.0924
Onchocerca volvulus		0.009	0.0299	0.0433
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0074	0.0203	0.0294
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0104	0.0924
Echinococcus granulosus	epidermal growth factor receptor	0.0499	0.2783	0.2783
Onchocerca volvulus	Cathepsin L homolog	0.0112	0.0433	0.0627
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0085	0.0085
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0054	0.0085	0.0085
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0074	0.0203	0.0203
Trichomonas vaginalis	CMGC family protein kinase	0.0373	0.2015	0.6261
Echinococcus granulosus	ecdysone induced protein 78C	0.0074	0.0203	0.0203
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0075	0.0209	0.0154
Plasmodium vivax	vivapain-2	0.0112	0.0433	0.0484
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0104	0.0924
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0112	0.0433	0.1078
Schistosoma mansoni	tyrosine kinase	0.0281	0.1457	0.1457
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0074	0.0203	0.0294
Leishmania major	cathepsin L-like protease	0.0112	0.0433	0.0203
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.009	0.009
Brugia malayi	Cathepsin L-like precursor	0.0075	0.0209	0.0302
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.03	0.1575	0.1575
Brugia malayi	steroid hormone receptor	0.0074	0.0203	0.0294
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0433	0.0484
Trichomonas vaginalis	CMGC family protein kinase	0.0373	0.2015	0.6261
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0112	0.0433	0.1078
Echinococcus granulosus	aminopeptidase N	0.009	0.0299	0.0299
Brugia malayi	Papain family cysteine protease containing protein	0.0058	0.0104	0.0151
Echinococcus granulosus	tyrosine kinase	0.0254	0.1294	0.1294
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0203	0.0203
Schistosoma mansoni	aminopeptidase A (M01 family)	0.009	0.0299	0.0299
Brugia malayi	hypothetical protein	0.0043	0.0018	0.0026
Schistosoma mansoni	tyrosine kinase	0.0486	0.2704	0.2704
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0004	0.0006
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0112	0.0433	0.1078
Schistosoma mansoni	hypothetical protein	0.0205	0.0996	0.0996
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0281	0.1457	0.1457
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0074	0.0203	0.0294
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.009	0.0299	0.0638
Plasmodium vivax	vivapain-2	0.0112	0.0433	0.0484
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0074	0.0203	0.0203
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0373	0.2015	0.281
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.1179	0.6906	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0922	0.535	0.535
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.009	0.009
Brugia malayi	photoreceptor-specific nuclear receptor	0.0074	0.0203	0.0294
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.009	0.0299	0.0286
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0112	0.0433	0.1078
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0373	0.2015	0.2598
Onchocerca volvulus	Bile acid receptor homolog	0.0074	0.0203	0.0294
Leishmania major	cathepsin L-like protease	0.0112	0.0433	0.0203
Entamoeba histolytica	cysteine proteinase, putative	0.0058	0.0104	0.0924
Entamoeba histolytica	cysteine proteinase, putative	0.0112	0.0433	0.3844
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0104	0.0924
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.009	0.0299	0.0286
Loa Loa (eye worm)	TK protein kinase	0.0226	0.1127	0.1127
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.1179	0.6906	1
Brugia malayi	Cathepsin L-like precursor	0.0112	0.0433	0.0627
Entamoeba histolytica	cysteine protease, putative	0.0112	0.0433	0.3844
Trypanosoma brucei	Aminopeptidase M1, putative	0.009	0.0299	0.0286
Leishmania major	cysteine peptidase A (CPA)	0.0112	0.0433	0.0203
Schistosoma mansoni	growth factor receptor-bound protein	0.0054	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0203	0.0203
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0254	0.1294	0.1294
Entamoeba histolytica	hypothetical protein	0.0043	0.0018	0.0162
Schistosoma mansoni	tyrosine kinase	0.0067	0.0163	0.0163
Leishmania major	cathepsin L-like protease	0.0112	0.0433	0.0203
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.012	0.0174
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0074	0.0203	0.0294
Trichomonas vaginalis	conserved hypothetical protein	0.0561	0.3157	1
Trichomonas vaginalis	CMGC family protein kinase	0.0373	0.2015	0.6261
Brugia malayi	Peptidase family M1 containing protein	0.009	0.0299	0.0433
Echinococcus granulosus	cathepsin L	0.0058	0.0104	0.0104
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0112	0.0433	0.0433
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0373	0.2015	0.2015
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0067	0.0163	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0209	0.0209
Echinococcus multilocularis	aminopeptidase N	0.009	0.0299	0.0299
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0281	0.1457	0.1457
Loa Loa (eye worm)	aminopeptidase N	0.009	0.0299	0.0299
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0074	0.0203	0.0294
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0054	0.0085	0.0085
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0112	0.0433	0.0433
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.009	0.009
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.03	0.1575	0.1575
Schistosoma mansoni	hypothetical protein	0.0041	0.0004	0.0004
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.009	0.0299	0.0286
Trypanosoma cruzi	cruzipain precursor, putative	0.0112	0.0433	0.0484
Echinococcus multilocularis	thymidylate synthase	0.1179	0.6906	0.6906
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0281	0.1457	0.1457
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0074	0.0203	0.0203
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0254	0.1294	0.1294
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0281	0.1457	0.1457
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0074	0.0203	0.0203
Loa Loa (eye worm)	TATA binding protein associated factor	0.009	0.0299	0.0299
Echinococcus granulosus	tyrosine protein kinase HCK	0.0226	0.1127	0.1127
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0074	0.0203	0.0203
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0074	0.0203	0.0203
Echinococcus multilocularis	cathepsin L	0.0058	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0203	0.0203
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0074	0.0203	0.0203
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0104	0.0924
Brugia malayi	Peptidase family M1 containing protein	0.009	0.0299	0.0433
Entamoeba histolytica	cysteine proteinase 2	0.0058	0.0104	0.0924
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0112	0.0433	0.0484
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0112	0.0433	0.1078
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0112	0.0433	0.0433
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0104	0.0924
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.009	0.0299	0.0299
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0112	0.0433	0.1078
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0112	0.0433	0.1078
Brugia malayi	hypothetical protein	0.009	0.0299	0.0433
Echinococcus multilocularis	insulin receptor	0.03	0.1575	0.1575
Echinococcus granulosus	FTZ F1 alpha	0.0074	0.0203	0.0203
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.009	0.0299	0.0299
Echinococcus granulosus	mitogen activated protein kinase 3	0.0373	0.2015	0.2015
Trypanosoma cruzi	cysteine peptidase, putative	0.0112	0.0433	0.0484
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0112	0.0433	0.1078
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0203	0.0203
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0074	0.0203	0.0203
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.009	0.0299	0.0299
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0373	0.2015	0.2598
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0112	0.0433	0.0433
Schistosoma mansoni	hypothetical protein	0.0043	0.0018	0.0018
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0074	0.0203	0.0294
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0433	0.0433
Onchocerca volvulus		0.0112	0.0433	0.0627
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0074	0.0203	0.0294
Echinococcus multilocularis	c src tyrosine kinase	0.0067	0.0163	0.0163
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0104	0.0924
Trypanosoma brucei	Aminopeptidase M1, putative	0.009	0.0299	0.0286
Schistosoma mansoni	serine/threonine protein kinase	0.0373	0.2015	0.2015
Brugia malayi	hypothetical protein	0.0776	0.4465	0.6466
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0112	0.0433	0.0484
Brugia malayi	nuclear hormone receptor	0.0074	0.0203	0.0294
Echinococcus granulosus	geminin	0.0205	0.0996	0.0996
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.009	0.0299	0.0286
Echinococcus granulosus	cathepsin L cysteine protease	0.0058	0.0104	0.0104
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0112	0.0433	0.1078
Loa Loa (eye worm)	hypothetical protein	0.006	0.012	0.012
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0074	0.0203	0.0203
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0058	0.0104	0.0104
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0281	0.1457	0.1457
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0054	0.0085	0.0085
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.009	0.0299	0.0299
Trichomonas vaginalis	CMGC family protein kinase	0.0373	0.2015	0.6261
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.009	0.0299	0.0286
Schistosoma mansoni	cathepsin F (C01 family)	0.0075	0.0209	0.0209
Echinococcus granulosus	c src tyrosine kinase	0.0067	0.0163	0.0163
Leishmania major	cathepsin L-like protease	0.0112	0.0433	0.0203
Onchocerca volvulus		0.0075	0.0209	0.0302
Echinococcus granulosus	cathepsin l1	0.0075	0.0209	0.0209
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0058	0.0104	0.0104
Schistosoma mansoni	cathepsin F (C01 family)	0.0112	0.0433	0.0433
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0433	0.0484
Echinococcus multilocularis	epidermal growth factor receptor	0.0499	0.2783	0.2783
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0433	0.0484
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0373	0.2015	0.2015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0112	0.0433	0.1078
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.1179	0.6906	0.5
Brugia malayi	thymidylate synthase	0.1179	0.6906	1
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.1179	0.6906	1
Brugia malayi	hypothetical protein	0.009	0.0299	0.0433
Brugia malayi	Tyrosine-protein kinase abl-1	0.0067	0.0163	0.0236
Schistosoma mansoni	nuclear hormone receptor	0.0074	0.0203	0.0203
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.009	0.0299	0.0299
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.009	0.009
Loa Loa (eye worm)	TK/INSR protein kinase	0.03	0.1575	0.1575
Entamoeba histolytica	cysteine proteinase, putative	0.0075	0.0209	0.1853
Onchocerca volvulus		0.0112	0.0433	0.0627
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0112	0.0433	0.1078
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0054	0.0085	0.0085
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0373	0.2015	0.2598
Onchocerca volvulus	Protein ultraspiracle homolog	0.0074	0.0203	0.0294
Echinococcus multilocularis	ecdysone induced protein 78C	0.0074	0.0203	0.0203
Leishmania major	cathepsin L-like protease	0.0112	0.0433	0.0203
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.1179	0.6906	1
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0373	0.2015	0.281
Echinococcus granulosus	cysteine protease	0.0058	0.0104	0.0104
Schistosoma mansoni	hypothetical protein	0.0205	0.0996	0.0996
Trypanosoma cruzi	aminopeptidase, putative	0.009	0.0299	0.0286
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0074	0.0203	0.0203
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0112	0.0433	0.1078
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0281	0.1457	0.1457
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0281	0.1457	0.1457
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0226	0.1127	0.1127
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0104	0.0924
Brugia malayi	Papain family cysteine protease containing protein	0.0058	0.0104	0.0151
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.009	0.0299	0.0286
Echinococcus multilocularis		0.0283	0.1472	0.1472
Brugia malayi	MAP kinase sur-1	0.0373	0.2015	0.2918
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.009	0.0299	0.0299
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.009	0.009
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.009	0.0299	0.0299
Loa Loa (eye worm)	steroid hormone receptor	0.0074	0.0203	0.0203
Entamoeba histolytica	hypothetical protein	0.0043	0.0018	0.0162
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0074	0.0203	0.0203
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0373	0.2015	0.281
Loa Loa (eye worm)	thymidylate synthase	0.1179	0.6906	0.6906
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.1179	0.6906	0.6906
Schistosoma mansoni	tyrosine kinase	0.0067	0.0163	0.0163
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0254	0.1294	0.1294
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0074	0.0203	0.0294
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0112	0.0433	0.1078
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0112	0.0433	0.1078
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.009	0.0299	0.0638
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0074	0.0203	0.0203
Trypanosoma cruzi	cysteine peptidase, putative	0.0112	0.0433	0.0484
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0074	0.0203	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0203	0.0203
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0074	0.0203	0.0203
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0433	0.0484
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0112	0.0433	0.1078
Onchocerca volvulus	Cathepsin L homolog	0.0112	0.0433	0.0627
Echinococcus multilocularis	geminin	0.0205	0.0996	0.0996
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0104	0.0924
Trypanosoma cruzi	Aminopeptidase M1, putative	0.009	0.0299	0.0286
Entamoeba histolytica	cysteine proteinase, putative	0.0112	0.0433	0.3844
Entamoeba histolytica	protein kinase, putative	0.0226	0.1127	1
Brugia malayi	Peptidase family M1 containing protein	0.009	0.0299	0.0433
Brugia malayi	Nuclear hormone receptor-like 1	0.0074	0.0203	0.0294
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0112	0.0433	0.0433
Trypanosoma cruzi	aminopeptidase, putative	0.009	0.0299	0.0286
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0074	0.0203	0.0203
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0058	0.0104	0.0104
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0281	0.1457	0.1457
Onchocerca volvulus		0.0112	0.0433	0.0627
Brugia malayi	SRC-1	0.0281	0.1457	0.2109
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0074	0.0203	0.0203
Trypanosoma brucei	protein kinase, putative	0.0373	0.2015	0.281
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0433	0.0484
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0373	0.2015	0.281
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0104	0.0924
Echinococcus granulosus	growth factor receptor bound protein 2	0.0054	0.0085	0.0085
Entamoeba histolytica	cysteine protease, putative	0.0058	0.0104	0.0924
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.1689	1	1
Brugia malayi	Protein kinase domain containing protein	0.03	0.1575	0.228
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.009	0.0299	0.0286
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0254	0.1294	0.1294
Entamoeba histolytica	aminopeptidase, putative	0.009	0.0299	0.2653
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0284	0.1477	0.1477
Entamoeba histolytica	cysteine proteinase, putative	0.0058	0.0104	0.0924
Echinococcus granulosus	mitogen activated protein kinase	0.0373	0.2015	0.2015
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0018	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0112	0.0433	0.1078
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.009	0.0299	0.0299
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0433	0.0484
Trypanosoma brucei	aminopeptidase, putative	0.009	0.0299	0.0286
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.1179	0.6906	1
Entamoeba histolytica	cysteine proteinase, putative	0.0058	0.0104	0.0924
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0074	0.0203	0.0203
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0281	0.1457	0.1457
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.012	0.012
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.009	0.009
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0074	0.0203	0.0294
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.009	0.0299	0.0299
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.012	0.0174
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0922	0.535	0.535
Schistosoma mansoni	nck2/grb4	0.0054	0.0085	0.0085
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.009	0.0299	0.0299
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0074	0.0203	0.0294
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0112	0.0433	0.1078
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	0.0209	0.0343
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0018	0.0018
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0074	0.0203	0.0203
Brugia malayi	Sex muscle abnormal protein 5	0.0054	0.0085	0.0122
Loa Loa (eye worm)	hypothetical protein	0.009	0.0299	0.0299
Brugia malayi	Steroid receptor seven-up type 2	0.0074	0.0203	0.0294
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0074	0.0203	0.0203
Onchocerca volvulus	Cathepsin F homolog	0.0112	0.0433	0.0627
Schistosoma mansoni	tyrosine kinase	0.0922	0.535	0.535
Echinococcus multilocularis	cysteine protease	0.0112	0.0433	0.0433
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0112	0.0433	0.1078
Loa Loa (eye worm)	hypothetical protein	0.009	0.0299	0.0299
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.1179	0.6906	1
Echinococcus multilocularis	mitogen activated protein kinase	0.0373	0.2015	0.2015
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0074	0.0203	0.0203
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0281	0.1457	0.1457
Schistosoma mansoni	retinoic acid receptor RXR	0.0074	0.0203	0.0203
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0018	0.0018
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0074	0.0203	0.0203

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.1889 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	9.2 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	16.5113 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	25.929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1733068

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1561254