Detailed information for compound 1561340

Basic information

Technical information
  • TDR Targets ID: 1561340
  • Name: 2-[(2-fluorobenzoyl)amino]-N,N-dimethyl-4,5,6 ,7-tetrahydro-1-benzothiophene-3-carboxamide
  • MW: 346.419 | Formula: C18H19FN2O2S
  • H donors: 1 H acceptors: 2 LogP: 4.11 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccccc1C(=O)Nc1sc2c(c1C(=O)N(C)C)CCCC2
  • InChi: 1S/C18H19FN2O2S/c1-21(2)18(23)15-12-8-4-6-10-14(12)24-17(15)20-16(22)11-7-3-5-9-13(11)19/h3,5,7,9H,4,6,8,10H2,1-2H3,(H,20,22)
  • InChiKey: YKPFZECYKCMBOB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(2-fluorobenzoyl)amino]-N,N-dimethyl-4,5,6,7-tetrahydrobenzothiophene-3-carboxamide
  • 2-[[(2-fluorophenyl)-oxomethyl]amino]-N,N-dimethyl-4,5,6,7-tetrahydrobenzothiophene-3-carboxamide
  • 2-[(2-fluorophenyl)carbonylamino]-N,N-dimethyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
  • Oprea1_040362
  • NCGC00099778-01
  • ZINC00076471

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Ankyrin 0.0016 0.0002 0.0001
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0084 0.0277 0.0276
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0071 0.0075
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.044 0.1943
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0102 0.0101
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0086 0.0302
Loa Loa (eye worm) TATA binding protein associated factor 0.0371 0.1457 0.1456
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0052 0.0033
Mycobacterium ulcerans hydrolase 0.0024 0.0033 0.005
Trypanosoma brucei aminopeptidase, putative 0.0371 0.1457 0.6655
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0107 0.0372 0.1415
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0084 0.0279 0.0398
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0037 0.0086 0.009
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0033 0.0031
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0547 0.2179 0.2178
Schistosoma mansoni inhibitor of apoptosis protein 0.0084 0.0279 0.0277
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0072 0.007
Onchocerca volvulus 0.0058 0.0174 0.0388
Giardia lamblia NADH oxidase lateral transfer candidate 0.0037 0.0086 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0547 0.2179 0.2178
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0084 0.0279 0.0277
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.044 0.1943
Trypanosoma cruzi trypanothione reductase, putative 0.0107 0.0372 0.1626
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0086 0.0302
Entamoeba histolytica hypothetical protein 0.0041 0.0102 0.0375
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0071 0.0233
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0176 0.0656 0.2945
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0072 0.0229 0.0228
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.044 0.1943
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0037 0.0086 0.0262
Toxoplasma gondii leucyl aminopeptidase LAP 0.0626 0.2501 0.2629
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0071 0.0233
Onchocerca volvulus Matrilysin homolog 0.0044 0.0114 0.0255
Brugia malayi POT family protein 0.0046 0.0124 0.0177
Trichomonas vaginalis hypothetical protein 0.0033 0.0071 0.0231
Plasmodium vivax M18 aspartyl aminopeptidase, putative 0.0071 0.0225 0.0236
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.044 0.1943
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.2453 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.0029 0.0052 0.0051
Brugia malayi Matrixin family protein 0.002 0.0016 0.0021
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0012 0.0011
Schistosoma mansoni ap endonuclease 0.0021 0.0021 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0086 0.0302
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0071 0.0225 0.0946
Echinococcus multilocularis leucine aminopeptidase protein 0.0626 0.2501 0.25
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0123 0.044 1
Brugia malayi hypothetical protein 0.0138 0.0501 0.0717
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0547 0.2179 0.2178
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.044 0.1943
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0001 0.0000000096266
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0037 0.0086 0.0069
Loa Loa (eye worm) intermediate filament protein 0.003 0.0058 0.0058
Echinococcus granulosus expressed conserved protein 0.0048 0.013 0.0128
Loa Loa (eye worm) hypothetical protein 0.0064 0.0196 0.0196
Echinococcus multilocularis Ankyrin 0.0016 0.0002 0.0001
Toxoplasma gondii hypothetical protein 0.0016 0.0001 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0086 0.0302
Mycobacterium tuberculosis Probable dehydrogenase 0.0243 0.0932 0.3674
Onchocerca volvulus 0.0266 0.1024 0.2295
Echinococcus granulosus 6 phosphofructokinase 0.0123 0.044 0.0439
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0033 0.0071 0.0231
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0093 0.0317 0.0454
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0093 0.0317 0.1374
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0086 0.0302
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0093 0.0317 0.0317
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0371 0.1457 0.6655
Trypanosoma cruzi aspartyl aminopeptidase, putative 0.0071 0.0225 0.0946
Trypanosoma cruzi Aminopeptidase M1, putative 0.0547 0.2179 1
Echinococcus multilocularis aminopeptidase N 0.1103 0.4459 0.4458
Loa Loa (eye worm) TK/ROR protein kinase 0.0058 0.0174 0.0173
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0626 0.2501 0.2629
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0093 0.0317 0.1374
Toxoplasma gondii microneme protein MIC4 0.0016 0.0001 0.0001
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0021 0.002
Toxoplasma gondii aminopeptidase N, putative 0.2334 0.9512 1
Loa Loa (eye worm) hypothetical protein 0.0371 0.1457 0.1456
Echinococcus granulosus tissue type plasminogen activator 0.0058 0.0174 0.0172
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0071 0.0225 0.0946
Loa Loa (eye worm) glutathione reductase 0.0107 0.0372 0.0371
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0547 0.2179 1
Mycobacterium leprae PROBABLE AMINOPEPTIDASE PEPC 0.0071 0.0225 0.0777
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0071 0.0233
Loa Loa (eye worm) peptidase family M1 containing protein 0.0927 0.3737 0.3736
Loa Loa (eye worm) hypothetical protein 0.0071 0.0225 0.0224
Plasmodium vivax SET domain protein, putative 0.0033 0.0072 0.0075
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0021 0.002
Echinococcus multilocularis leucyl aminopeptidase 0.0093 0.0317 0.0316
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0086 0.0302
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0084 0.0279 0.0277
Echinococcus granulosus inhibitor of apoptosis protein 0.0084 0.0279 0.0277
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0021 0.0021
Echinococcus multilocularis aspartyl aminopeptidase 0.0071 0.0225 0.0224
Brugia malayi TATA binding protein associated factor 0.0371 0.1457 0.2087
Schistosoma mansoni hypothetical protein 0.0084 0.0279 0.0277
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0052 0.0054
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0093 0.0317 0.1374
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0071 0.0233
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0084 0.0279 0.0398
Echinococcus multilocularis 6 phosphofructokinase 0.0123 0.044 0.0439
Echinococcus multilocularis leukotriene A 4 hydrolase 0.2453 1 1
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.002 0.0016 0.0014
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0001 0.0001
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0243 0.0932 0.3674
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0371 0.1457 0.1531
Brugia malayi Flap endonuclease-1 0.003 0.0056 0.0079
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0037 0.0086 0.0302
Echinococcus multilocularis lamin 0.003 0.0058 0.0057
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0547 0.2179 1
Brugia malayi phosphofructokinase 0.0123 0.044 0.063
Entamoeba histolytica aminopeptidase, putative 0.0547 0.2179 1
Echinococcus granulosus caspase 2 0.0064 0.0196 0.0195
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.044 0.1943
Toxoplasma gondii hypothetical protein 0.0016 0.0001 0.0001
Loa Loa (eye worm) matrixin family protein 0.0048 0.0131 0.013
Echinococcus granulosus lamin dm0 0.003 0.0058 0.0057
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0547 0.2179 1
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0033 0.0071 0.0231
Brugia malayi 6-phosphofructokinase 0.0123 0.044 0.063
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.044 0.0439
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0123 0.044 0.169
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0086 0.0302
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0037 0.0086 0.0262
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0371 0.1457 0.6655
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0468 0.1856 0.8503
Schistosoma mansoni aminopeptidase A (M01 family) 0.0371 0.1457 0.1456
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0037 0.0086 0.0262
Onchocerca volvulus Matrilysin homolog 0.002 0.0016 0.0033
Trypanosoma brucei Aminopeptidase M1, putative 0.0547 0.2179 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0071 0.0231
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0056 0.0161
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0071 0.0233
Loa Loa (eye worm) phosphofructokinase 0.0123 0.044 0.0439
Schistosoma mansoni ap endonuclease 0.0021 0.0021 0.002
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0547 0.2179 1
Brugia malayi Uncoordinated protein 44 0.0016 0.0001 0.0001
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0037 0.0086 0.009
Mycobacterium tuberculosis Probable reductase 0.0243 0.0932 0.3674
Trichomonas vaginalis glutathione reductase, putative 0.0037 0.0086 0.0302
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0547 0.2179 0.2178
Schistosoma mansoni hypothetical protein 0.0028 0.0049 0.0048
Brugia malayi hypothetical protein 0.0371 0.1457 0.2087
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0037 0.0086 0.0061
Trypanosoma cruzi aminopeptidase, putative 0.0371 0.1457 0.6655
Loa Loa (eye worm) hypothetical protein 0.0064 0.0196 0.0196
Plasmodium falciparum M1-family alanyl aminopeptidase 0.2334 0.9512 1
Toxoplasma gondii kringle domain-containing protein 0.0058 0.0174 0.0182
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0071
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.027 0.1043 0.4093
Onchocerca volvulus 0.0028 0.0049 0.0109
Toxoplasma gondii subtilisin SUB12 0.0016 0.0001 0.0001
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0001 0.0001
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0072 0.0075
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0243 0.0932 0.3674
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0547 0.2179 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0058 0.0174 0.0161
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0012
Plasmodium falciparum glutathione reductase 0.0107 0.0372 0.037
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0547 0.2179 0.2178
Entamoeba histolytica hypothetical protein 0.0041 0.0102 0.0375
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0052 0.0054
Loa Loa (eye worm) aspartyl aminopeptidase 0.0071 0.0225 0.0224
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0001 0.0000000096266
Schistosoma mansoni hypothetical protein 0.0041 0.0102 0.0101
Schistosoma mansoni leucine aminopeptidase 0.0093 0.0317 0.0316
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0071 0.0231
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0371 0.1457 0.6655
Brugia malayi Pre-SET motif family protein 0.0233 0.0891 0.1276
Brugia malayi glutathione reductase 0.0107 0.0372 0.0532
Loa Loa (eye worm) RecQ helicase 0.0024 0.0033 0.0032
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0371 0.1457 0.1456
Onchocerca volvulus 0.0084 0.0279 0.0623
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0072 0.007
Loa Loa (eye worm) hypothetical protein 0.0371 0.1457 0.1456
Onchocerca volvulus Deterin homolog 0.0084 0.0279 0.0623
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0093 0.0317 0.0454
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0033 0.0054
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0037 0.0086 0.0262
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0037 0.0086 0.009
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0243 0.0932 0.3674
Loa Loa (eye worm) hypothetical protein 0.0732 0.2936 0.2936
Echinococcus granulosus nuclear factor of activated T cells 5 0.0084 0.0277 0.0276
Plasmodium vivax glutathione reductase, putative 0.0107 0.0372 0.039
Brugia malayi hypothetical protein 0.0029 0.0052 0.0073
Echinococcus granulosus thioredoxin glutathione reductase 0.0107 0.0372 0.037
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0047 0.0127 0.0126
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0052 0.0143
Brugia malayi Matrixin family protein 0.002 0.0016 0.0021
Mycobacterium tuberculosis Probable oxidoreductase 0.027 0.1043 0.4123
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0001 0.0001
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0037 0.0086 0.0302
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0021 0.0029
Onchocerca volvulus 0.0064 0.0196 0.0439
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0093 0.0317 0.0454
Echinococcus granulosus leucine aminopeptidase protein 0.0626 0.2501 0.25
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0016 0.0001 0.0001
Toxoplasma gondii aminopeptidase n, putative 0.2334 0.9512 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0033
Plasmodium falciparum thioredoxin reductase 0.0037 0.0086 0.0069
Trypanosoma cruzi Cysteine peptidase, Clan CF, family C15 0.0487 0.1933 0.8862
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0547 0.2179 0.2178
Echinococcus granulosus leucyl aminopeptidase 0.0093 0.0317 0.0316
Brugia malayi cytosol aminopeptidase 0.0093 0.0317 0.0454
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0037 0.0086 0.0085
Echinococcus multilocularis musashi 0.003 0.0058 0.0057
Plasmodium falciparum M18 aspartyl aminopeptidase 0.0071 0.0225 0.0215
Onchocerca volvulus 0.002 0.0016 0.0033
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0093 0.0317 0.0316
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0371 0.1457 0.6655
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0056 0.0161
Entamoeba histolytica hypothetical protein 0.0041 0.0102 0.0375
Echinococcus multilocularis inhibitor of apoptosis protein 0.0084 0.0279 0.0277
Mycobacterium ulcerans aminopeptidase N PepN 0.0371 0.1457 0.579
Brugia malayi hypothetical protein 0.1717 0.6978 1
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0468 0.1856 0.8503
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0033 0.0054
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0002 0.0001
Onchocerca volvulus Cell death protein 3 homolog 0.0064 0.0196 0.0439
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0086 0.0302
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0555 0.2212 0.2211
Onchocerca volvulus 0.003 0.0058 0.0129
Brugia malayi intermediate filament protein 0.003 0.0058 0.0083
Echinococcus multilocularis leucyl aminopeptidase 0.0093 0.0317 0.0316
Trichomonas vaginalis mercuric reductase, putative 0.0037 0.0086 0.0302
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0056 0.0161
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.044 0.1943
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0547 0.2179 0.2178
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0071 0.0225 0.0946
Echinococcus multilocularis caspase 2 0.0064 0.0196 0.0195
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0547 0.2179 0.2178
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0056 0.0055
Echinococcus granulosus aspartyl aminopeptidase 0.0071 0.0225 0.0224
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.044 0.1943
Brugia malayi Thioredoxin reductase 0.0107 0.0372 0.0532
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0071 0.7708
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0055
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0058 0.0174 0.0182
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0027 0.0046 0.0065
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0071 0.0225 0.0946
Plasmodium falciparum M17 leucyl aminopeptidase 0.0468 0.1856 0.1934
Toxoplasma gondii thioredoxin reductase 0.0107 0.0372 0.0391
Schistosoma mansoni flap endonuclease-1 0.0027 0.0044 0.0043
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Leishmania major trypanothione reductase 0.0107 0.0372 0.1626
Loa Loa (eye worm) POT family protein 0.0046 0.0124 0.0124
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0243 0.0932 0.3674
Leishmania major hypothetical protein, conserved 0.0058 0.0174 0.0707
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0086 0.0302
Schistosoma mansoni lamin 0.003 0.0058 0.0057
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0371 0.1457 0.6655
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0071 0.0233
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.027 0.1043 0.4123
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0071 0.0233
Echinococcus granulosus flap endonuclease 1 0.003 0.0056 0.0054
Echinococcus multilocularis lamin dm0 0.003 0.0058 0.0057
Toxoplasma gondii PAN/Apple domain-containing protein 0.0016 0.0001 0.0001
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0067 0.0065
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.044 0.0439
Echinococcus granulosus bloom syndrome protein 0.0024 0.0033 0.0031
Onchocerca volvulus 0.0547 0.2179 0.4886
Brugia malayi Kringle domain containing protein 0.0058 0.0174 0.0248
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.044 0.1943
Schistosoma mansoni hypothetical protein 0.0058 0.0174 0.0172
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0058 0.0083
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0056 0.0058
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0547 0.2179 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0123 0.044 0.1649
Onchocerca volvulus 0.0033 0.0072 0.0159
Echinococcus multilocularis tissue type plasminogen activator 0.0058 0.0174 0.0172
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0033 0.0071 0.1197
Echinococcus multilocularis leucyl aminopeptidase 0.0093 0.0317 0.0316
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0547 0.2179 0.2178
Loa Loa (eye worm) hypothetical protein 0.0084 0.0279 0.0278
Plasmodium falciparum glutathione reductase 0.0037 0.0086 0.0069
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0071 0.0074
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0093 0.0317 0.1374
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0037 0.0086 0.0262
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0037 0.0086 0.0085
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.003 0.0058 0.0058
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0547 0.2179 0.2178
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0071 0.0225 0.0224
Entamoeba histolytica Flap nuclease, putative 0.003 0.0056 0.0161
Trypanosoma cruzi metallo-peptidase, Clan MH, Family M20 0.0071 0.0225 0.0946
Echinococcus multilocularis expressed conserved protein 0.0048 0.013 0.0128
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0176 0.0656 0.0655
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0033 0.0071 0.0231
Onchocerca volvulus 0.003 0.0058 0.0129
Brugia malayi Aspartyl aminopeptidase 0.0071 0.0225 0.0322
Loa Loa (eye worm) hypothetical protein 0.0556 0.2214 0.2214
Toxoplasma gondii microneme protein MIC17A 0.0016 0.0001 0.0001
Loa Loa (eye worm) matrix metalloproteinase 0.002 0.0016 0.0015
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0371 0.1457 0.1513
Brugia malayi hypothetical protein 0.0041 0.0102 0.0145
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0056 0.0058
Brugia malayi hypothetical protein 0.0064 0.0196 0.028
Trypanosoma brucei pyroglutamyl-peptidase I, putative 0.0487 0.1933 0.8862
Schistosoma mansoni intermediate filament proteins 0.003 0.0058 0.0057
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0093 0.0317 0.1374
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0071 0.0075
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0037 0.0086 0.0085
Mycobacterium ulcerans leucyl aminopeptidase 0.0626 0.2501 1
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0093 0.0317 0.0317
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0086 0.0302
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0015
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0547 0.2179 0.2178
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0093 0.0317 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0071 0.0231
Loa Loa (eye worm) matrixin family protein 0.0044 0.0114 0.0114
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0371 0.1457 0.6655
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0176 0.0656 0.0655
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0056 0.0161
Leishmania major pyroglutamyl-peptidase I (C15 family) 0.0487 0.1933 0.8862
Toxoplasma gondii microneme protein MIC17C 0.0016 0.0001 0.0001
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0071 0.0053
Echinococcus granulosus intermediate filament protein 0.003 0.0058 0.0057
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0024 0.0033 0.005
Brugia malayi Cell death protein 3 precursor 0.0064 0.0196 0.028
Toxoplasma gondii microneme protein MIC17B 0.0016 0.0001 0.0001
Chlamydia trachomatis cytosol aminopeptidase 0.0626 0.2501 1
Toxoplasma gondii aminopeptidase N protein 0.2334 0.9512 1
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0071 0.0225 0.0946
Loa Loa (eye worm) aminopeptidase N 0.0547 0.2179 0.2178
Trypanosoma brucei aminopeptidase, putative 0.0093 0.0317 0.1374
Echinococcus granulosus aminopeptidase N 0.1103 0.4459 0.4458
Leishmania major aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 0.0071 0.0225 0.0946
Leishmania major ATP-dependent phosphofructokinase 0.0123 0.044 0.1943
Loa Loa (eye worm) thioredoxin reductase 0.0107 0.0372 0.0371
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0468 0.1856 0.8503
Toxoplasma gondii NADPH-glutathione reductase 0.0037 0.0086 0.009
Entamoeba histolytica aspartyl aminopeptidase, putative 0.0071 0.0225 0.0946
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0071 0.0074
Trichomonas vaginalis set domain proteins, putative 0.0265 0.1023 0.4645
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.2334 0.9512 1
Echinococcus granulosus lamin 0.003 0.0058 0.0057
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0093 0.0317 0.1374
Echinococcus granulosus leucyl aminopeptidase 0.0093 0.0317 0.0316
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0072 0.007
Trypanosoma brucei trypanothione reductase 0.0107 0.0372 0.1626
Loa Loa (eye worm) hypothetical protein 0.0071 0.0225 0.0224
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0037 0.0086 0.0069
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0084 0.0279 0.0277
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0072 0.007
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0001 0.0000000096266
Brugia malayi Death domain containing protein 0.0016 0.0001 0.0001
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0086 0.0302
Onchocerca volvulus Matrix metalloproteinase homolog 0.0044 0.0114 0.0255
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0174 0.0707
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0024 0.0033 0.0047
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0243 0.0932 0.3642
Onchocerca volvulus 0.0371 0.1457 0.3267
Brugia malayi Peptidase family M1 containing protein 0.0371 0.1457 0.2087
Loa Loa (eye worm) hypothetical protein 0.0058 0.0174 0.0173
Brugia malayi hypothetical protein 0.0547 0.2179 0.3122
Giardia lamblia Flap structure-specific endonuclease 0.003 0.0056 0.5332
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0052 0.0143
Brugia malayi Peptidase family M1 containing protein 0.1103 0.4459 0.6389
Brugia malayi Peptidase family M1 containing protein 0.0547 0.2179 0.3122
Brugia malayi Matrixin family protein 0.002 0.0016 0.0021
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0037 0.0086 0.0262
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0037 0.0086 0.0302
Mycobacterium ulcerans 6-phosphofructokinase 0.0123 0.044 0.169
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0001 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0086 0.0302
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0371 0.1457 0.1456
Brugia malayi Protein kinase domain containing protein 0.0016 0.0001 0.0001
Trypanosoma brucei Aminopeptidase M1, putative 0.0547 0.2179 1
Trypanosoma cruzi pyroglutamyl-peptidase I, putative 0.0487 0.1933 0.8862
Loa Loa (eye worm) hypothetical protein 0.0084 0.0279 0.0278
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0001 0.0001
Plasmodium falciparum thioredoxin reductase 0.0107 0.0372 0.037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0072 0.007
Echinococcus multilocularis apoptotic protease activating factor 1 0.0064 0.0196 0.0195
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.0891 0.089
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.044 0.0439
Schistosoma mansoni hypothetical protein 0.0064 0.0196 0.0195
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0027 0.0046 0.0065
Loa Loa (eye worm) hypothetical protein 0.0176 0.0656 0.0656
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0037 0.0086 0.0302
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.036 0.141 0.141
Echinococcus multilocularis flap endonuclease 1 0.003 0.0056 0.0054
Brugia malayi 6-phosphofructokinase 0.0123 0.044 0.063
Entamoeba histolytica hypothetical protein 0.0041 0.0102 0.0375
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0001 0.0001
Mycobacterium ulcerans aminopeptidase N PepN 0.0547 0.2179 0.8701
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0015
Brugia malayi Hemopexin family protein 0.0028 0.0049 0.007
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0371 0.1457 0.6655
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0072 0.0229 0.0228
Echinococcus multilocularis thioredoxin glutathione reductase 0.0107 0.0372 0.037
Mycobacterium tuberculosis Probable aminopeptidase PepC 0.0071 0.0225 0.0823
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0072 0.007
Plasmodium falciparum flap endonuclease 1 0.003 0.0056 0.0037
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0371 0.1457 0.1456
Brugia malayi Matrixin family protein 0.0048 0.0131 0.0186
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0626 0.2501 1
Leishmania major hypothetical protein, conserved 0.0029 0.0052 0.0143
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0001 0.0001
Toxoplasma gondii PAN domain-containing protein 0.0016 0.0001 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0052 0.0033
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0021 0.002
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0052 0.0143
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.027 0.1043 0.4123
Entamoeba histolytica aminopeptidase, putative 0.0071 0.0225 0.0946
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0468 0.1856 0.8503
Loa Loa (eye worm) leukotriene A4 hydrolase 0.2453 1 1
Schistosoma mansoni caspase-7 (C14 family) 0.0064 0.0196 0.0195
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0071 0.0225 0.0224
Onchocerca volvulus 0.1103 0.4459 1
Plasmodium vivax thioredoxin reductase, putative 0.0107 0.0372 0.039
Toxoplasma gondii microneme protein, putative 0.0016 0.0001 0.0001
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0626 0.2501 1
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.044 0.0439
Treponema pallidum NADH oxidase 0.0037 0.0086 0.1553
Loa Loa (eye worm) hypothetical protein 0.0176 0.0656 0.0656
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0071 0.0053
Brugia malayi hypothetical protein 0.0018 0.001 0.0014
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0071 0.0233
Trypanosoma cruzi aminopeptidase, putative 0.0547 0.2179 1
Loa Loa (eye worm) hypothetical protein 0.0371 0.1457 0.1456
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0072 0.007
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0058 0.0058
Brugia malayi Protein kinase domain containing protein 0.0058 0.0174 0.0248
Toxoplasma gondii exonuclease III APE 0.0021 0.0021 0.0022
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0626 0.2501 1
Schistosoma mansoni lamin 0.003 0.0058 0.0057
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0033 0.0046
Echinococcus granulosus apoptotic protease activating factor 1 0.0064 0.0196 0.0195
Brugia malayi Pre-SET motif family protein 0.0033 0.0072 0.0102
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0037 0.0086 0.0122
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0093 0.0317 0.1374
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0086 0.0302
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0015
Schistosoma mansoni hypothetical protein 0.0058 0.0172 0.0171
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0071 0.0075
Brugia malayi Matrixin family protein 0.002 0.0016 0.0021

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 26.1216 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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