Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0029 | 0.0405 | 0.0491 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.0459 | 0.0624 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0129 | 0.3328 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0442 | 0.0442 |
Echinococcus multilocularis | thymidylate synthase | 0.0092 | 0.224 | 0.305 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0092 | 0.224 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0092 | 0.224 | 0.3874 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0755 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0755 | 0.1028 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0042 | 0.0791 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.7345 | 0.7345 |
Onchocerca volvulus | 0.0054 | 0.1158 | 0.3923 | |
Onchocerca volvulus | 0.0092 | 0.224 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0459 | 0.0459 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0042 | 0.0791 | 0.1019 |
Mycobacterium ulcerans | thymidylate synthase | 0.0092 | 0.224 | 1 |
Echinococcus multilocularis | musashi | 0.003 | 0.0459 | 0.0624 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0267 | 0.7345 | 1 |
Echinococcus multilocularis | geminin | 0.0191 | 0.5142 | 0.7001 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.5142 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0264 | 0.7263 | 0.9888 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.5142 | 1 |
Brugia malayi | hypothetical protein | 0.0044 | 0.0841 | 0.1088 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0037 | 0.066 | 0.0899 |
Brugia malayi | hypothetical protein | 0.0137 | 0.3573 | 0.4832 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.0459 | 0.0624 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.0459 | 0.0112 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0037 | 0.066 | 0.066 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0092 | 0.224 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0405 | 0.0405 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0459 | 0.0564 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0054 | 0.1158 | 0.1522 |
Brugia malayi | thymidylate synthase | 0.0092 | 0.224 | 0.3005 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0459 | 0.0564 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0042 | 0.0791 | 0.1019 |
Echinococcus granulosus | dihydrofolate reductase | 0.0037 | 0.066 | 0.0899 |
Schistosoma mansoni | survival motor neuron protein | 0.0054 | 0.1158 | 0.1588 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0755 | 0.5 |
Schistosoma mansoni | lamin | 0.003 | 0.0459 | 0.0112 |
Echinococcus granulosus | lamin | 0.003 | 0.0459 | 0.0624 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0129 | 0.3328 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0841 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0791 | 0.0791 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0129 | 0.3328 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0755 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0037 | 0.066 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0092 | 0.224 | 0.224 |
Brugia malayi | Dihydrofolate reductase | 0.0037 | 0.066 | 0.084 |
Brugia malayi | dihydrofolate reductase family protein | 0.0037 | 0.066 | 0.084 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0755 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0459 | 0.0459 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0264 | 0.7263 | 0.7263 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0267 | 0.7345 | 1 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0755 | 0.097 |
Schistosoma mansoni | lamin | 0.003 | 0.0459 | 0.0112 |
Schistosoma mansoni | dihydrofolate reductase | 0.0037 | 0.066 | 0.0538 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0755 | 0.1028 |
Echinococcus multilocularis | lamin | 0.003 | 0.0459 | 0.0624 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0129 | 0.3328 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0129 | 0.3328 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0092 | 0.224 | 0.305 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0459 | 0.0459 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0129 | 0.3328 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0755 | 0.0738 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0044 | 0.0841 | 0.1148 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.0459 | 0.0624 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0755 | 0.0738 |
Echinococcus granulosus | geminin | 0.0191 | 0.5142 | 0.7001 |
Brugia malayi | hypothetical protein | 0.0267 | 0.7345 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.1158 | 0.1588 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 50 ug ml-1 | Antiproliferative activity against human cisplatin-resistant A2780 cells after 72 hrs by MTT assay | ChEMBL. | 21396744 |
RFU (binding) | = 10.52 | Inhibition of human MDR1 expressed in mouse L5178Y cells assessed as rhodamine 123 accumulation at 20 ug/ml preincubated for 10 mins before rhodamine 123 challenge measured after 20 mins by flow cytometry relative to wild type | ChEMBL. | 21396744 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.