Detailed information for compound 1561620

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 516.61 | Formula: C32H24N2O3S
  • H donors: 1 H acceptors: 1 LogP: 6.52 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(OC)cc(c1)c1c(C#Cc2cscc2)c2c(n1C)ccc(c2)c1cccc2c1c(C=O)c[nH]2
  • InChi: 1S/C32H24N2O3S/c1-34-30-10-8-21(26-5-4-6-29-31(26)23(18-35)17-33-29)15-28(30)27(9-7-20-11-12-38-19-20)32(34)22-13-24(36-2)16-25(14-22)37-3/h4-6,8,10-19,33H,1-3H3
  • InChiKey: WUKOQGDAHWMCID-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2322 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.032 0.1355
Loa Loa (eye worm) hypothetical protein 0.0051 0.032 0.1355
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0209 0.0801
Plasmodium falciparum glutathione reductase 0.0037 0.0209 0.6813
Echinococcus granulosus heat shock protein 90 0.0026 0.0118 0.0223
Schistosoma mansoni coup transcription factor 0.0051 0.032 0.0608
Leishmania major heat shock protein 83-1 0.0032 0.0169 0.0632
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.032 0.1355
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0107 0.0141
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.1093 0.4509
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0346 0.1253
Onchocerca volvulus 0.0053 0.033 0.1395
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.1762 0.7455
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0136 0.0178
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0658 0.0909
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0107 0.0454
Onchocerca volvulus Bile acid receptor homolog 0.0051 0.032 0.1355
Schistosoma mansoni microtubule-associated protein tau 0.0682 0.5265 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0107 0.0454
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.002 0.0008
Trichomonas vaginalis MYB, putative 0.002 0.0071 0.0304
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.007 0.0215
Loa Loa (eye worm) hypothetical protein 0.0051 0.032 0.1355
Echinococcus granulosus neurogenic locus protein delta 0.0017 0.005 0.0096
Mycobacterium leprae Polyketide synthase Pks13 0.004 0.0233 0.0264
Loa Loa (eye worm) acyl carrier protein 0.0013 0.0021 0.0087
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0454
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0923 0.7157 1
Echinococcus multilocularis endoplasmin 0.0026 0.0118 0.0155
Echinococcus multilocularis thyroid hormone receptor alpha 0.0051 0.032 0.0422
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.032 0.1355
Loa Loa (eye worm) glutathione reductase 0.0037 0.0209 0.0885
Trypanosoma cruzi heat shock protein, putative 0.0013 0.002 0.0008
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0107 0.0454
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1395
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0215 0.0409
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0267 0.1041
Schistosoma mansoni hypothetical protein 0.0032 0.0167 0.0317
Giardia lamblia DINP protein human, muc B family 0.0019 0.0067 0.021
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0107 0.0141
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0107 0.0204
Schistosoma mansoni notch 0.0017 0.005 0.0096
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0454
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2322 1
Brugia malayi MH2 domain containing protein 0.0016 0.0043 0.0181
Schistosoma mansoni retinoic acid receptor RXR 0.0051 0.032 0.0608
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0307 0.1211
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0018 0.0035
Loa Loa (eye worm) hypothetical protein 0.0027 0.013 0.055
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0067 0.0088
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0021 0.0079 0.0099
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0307 0.1211
Leishmania major heat shock protein 83-1 0.0032 0.0169 0.0632
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0169 0.0632
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0433 0.0822
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.002 0.0038
Loa Loa (eye worm) DR-78 0.0024 0.0107 0.0454
Brugia malayi tailless protein 0.0024 0.0107 0.0454
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0258 0.049
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.032 0.0608
Brugia malayi hypothetical protein 0.0027 0.013 0.055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0067 0.0203
Onchocerca volvulus 0.003 0.0152 0.0645
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0021 0.008 0.0101
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.032 0.0608
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0923 0.7157 1
Mycobacterium ulcerans hypothetical protein 0.0167 0.1226 0.121
Onchocerca volvulus 0.0051 0.0316 0.1338
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0107 0.0204
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0203
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0071 0.0304
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0028 0.0136 0.0178
Schistosoma mansoni cell polarity protein 0.0017 0.005 0.0096
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0169 0.0632
Loa Loa (eye worm) notch protein 0.0017 0.005 0.0213
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.005 0.0213
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0092 0.0121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.035 0.0665
Treponema pallidum fructose-bisphosphate aldolase 0.0307 0.2322 0.2308
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Brugia malayi steroid hormone receptor 0.0051 0.032 0.1355
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0068 0.005
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1395
Brugia malayi Cytochrome P450 family protein 0.0019 0.0068 0.0289
Loa Loa (eye worm) hypothetical protein 0.0013 0.0022 0.0095
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0139 0.0587
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.032 0.0608
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0107 0.0141
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0122 0.0103
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0258 0.049
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Loa Loa (eye worm) pax transcription factor protein 2 0.0248 0.186 0.787
Echinococcus multilocularis protein jagged 1 0.0017 0.005 0.0066
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0118 0.0102
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.013 0.0247
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1395
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.032 0.0608
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0215 0.0284
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.007 0.0301
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0167 0.0605
Schistosoma mansoni notch 0.0017 0.005 0.0096
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1007 0.1914
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0031 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.032 0.1355
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0454
Onchocerca volvulus 0.0053 0.033 0.1395
Schistosoma mansoni hypothetical protein 0.0017 0.005 0.0096
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0026 0.0122 0.0514
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0433 0.1738
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0118 0.0223
Schistosoma mansoni thyroid hormone receptor 0.0051 0.032 0.0608
Schistosoma mansoni nuclear hormone receptor 0.0051 0.032 0.0608
Schistosoma mansoni notch 0.0017 0.005 0.0096
Brugia malayi heat shock protein 90 0.0032 0.0169 0.0715
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0167 0.0624
Echinococcus multilocularis fibropellin Ia 0.0017 0.005 0.0066
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2322 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0316 0.1338
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.2403 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Echinococcus multilocularis fat cadherin tumor suppressor 0.0017 0.005 0.0066
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0167 0.022
Mycobacterium ulcerans polyketide synthase Pks9 0.0016 0.0045 0.0027
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0167 0.022
Trichomonas vaginalis MYB72, putative 0.0019 0.007 0.0301
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0068 0.021
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0433 0.0569
Leishmania major DNA polymerase eta, putative 0.0019 0.0067 0.0203
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0213 0.028
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.032 0.0608
Onchocerca volvulus Huntingtin homolog 0.0121 0.0867 0.3665
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.013 0.0247
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0027 0.0128 0.054
Leishmania major heat shock protein 83-1 0.0032 0.0169 0.0632
Brugia malayi notch-like transmembrane receptor 0.0017 0.005 0.0213
Brugia malayi nuclear receptor NHR-67 0.0024 0.0107 0.0454
Schistosoma mansoni cpg binding protein 0.003 0.0152 0.0288
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0107 0.0454
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Echinococcus granulosus tumor protein p63 0.0348 0.2645 0.5024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.032 0.1355
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0203
Schistosoma mansoni hypothetical protein 0.0017 0.005 0.0096
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0122 0.0103
Schistosoma mansoni Smad4 0.0016 0.0043 0.0081
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0043 0.0056
Schistosoma mansoni hypothetical protein 0.004 0.0233 0.0442
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.032 0.0608
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0167 0.0317
Echinococcus multilocularis protein dispatched 1 0.0048 0.0291 0.0383
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.013 0.0247
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0203
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0018 0.0079
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0107 0.0204
Brugia malayi Blistered cuticle protein 3 0.0053 0.033 0.1395
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0077 0.0059
Giardia lamblia High cysteine protein 0.0017 0.005 0.0139
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0018 0.0596
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.002 0.0008
Echinococcus multilocularis notch 0.0017 0.005 0.0066
Toxoplasma gondii hypothetical protein 0.0051 0.0318 0.1152
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0018 0.0077
Echinococcus multilocularis protein patched 0.0042 0.0244 0.0322
Plasmodium vivax glutathione reductase, putative 0.0037 0.0209 0.6813
Echinococcus granulosus smad 0.0016 0.0043 0.0081
Brugia malayi EGF-like domain containing protein 0.0017 0.005 0.0213
Echinococcus multilocularis X box binding protein 1 0.0285 0.215 0.2829
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0118 0.0431
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.007 0.0215
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0209 0.0885
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0167 0.0317
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0396 0.0752
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2322 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Onchocerca volvulus Neurogenic locus notch homolog 0.0017 0.005 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0244 0.1053
Loa Loa (eye worm) hypothetical protein 0.0027 0.013 0.055
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.032 0.1355
Trichomonas vaginalis C-MYB, putative 0.0019 0.007 0.0301
Onchocerca volvulus 0.0053 0.033 0.1395
Echinococcus granulosus neural cadherin 0.0017 0.005 0.0096
Entamoeba histolytica hypothetical protein 0.0043 0.0258 0.1032
Brugia malayi hypothetical protein 0.0121 0.0867 0.3665
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0118 0.0507
Brugia malayi Endoplasmin precursor 0.0032 0.0169 0.0715
Echinococcus granulosus X box binding protein 1 0.0285 0.215 0.4083
Leishmania major heat shock protein, putative 0.0013 0.002 0.0008
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1007 0.1326
Brugia malayi nuclear receptor NHR-88 0.0051 0.032 0.1355
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.032 0.1355
Echinococcus granulosus dna polymerase eta 0.0019 0.0067 0.0127
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.2322 1
Brugia malayi hypothetical protein 0.0024 0.0107 0.0454
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0018 0.0596
Echinococcus granulosus protein jagged 1 0.0017 0.005 0.0096
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0167 0.022
Echinococcus multilocularis protein jagged 2 0.0017 0.005 0.0066
Brugia malayi Smad1 0.0016 0.0043 0.0181
Onchocerca volvulus 0.0017 0.005 0.0213
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0456 0.193
Echinococcus granulosus neurogenic locus notch protein 4 0.0017 0.005 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.032 0.1355
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1395
Trichomonas vaginalis pc-MYB2, putative 0.0019 0.007 0.0301
Echinococcus multilocularis expressed conserved protein 0.0091 0.0634 0.0834
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0077 0.0045
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0167 0.0317
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0067 0.0282
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0167 0.0624
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0169 0.0632
Brugia malayi EGF-like domain containing protein 0.0017 0.005 0.0213
Plasmodium vivax SET domain protein, putative 0.003 0.0152 0.4965
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0107 0.0204
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0152 0.029
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0433 0.183
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0139 0.0264
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Schistosoma mansoni slit 0.0017 0.005 0.0096
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0107 0.0204
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0068 0.0289
Loa Loa (eye worm) hypothetical protein 0.0051 0.032 0.1355
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0169 0.0632
Brugia malayi Animal haem peroxidase family protein 0.0053 0.033 0.1395
Trypanosoma brucei heat shock protein, putative 0.0032 0.0169 0.0632
Leishmania major heat shock protein 83-1 0.0032 0.0169 0.0632
Entamoeba histolytica hypothetical protein 0.0043 0.0258 0.1032
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0092 0.0175
Schistosoma mansoni hypothetical protein 0.0032 0.0167 0.0317
Brugia malayi MH1 domain containing protein 0.0016 0.0043 0.0181
Onchocerca volvulus Peroxidase homolog 0.0053 0.033 0.1395
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1395
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.1226 0.1704
Plasmodium vivax heat shock protein, putative 0.0013 0.002 0.066
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0066 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.032 0.1355
Echinococcus granulosus fibropellin Ia 0.0017 0.005 0.0096
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0016 0.0045 0.0052
Brugia malayi hypothetical protein 0.0053 0.033 0.1395
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.032 0.0422
Brugia malayi nuclear receptor RXR 0.0027 0.013 0.055
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0433 0.1738
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.032 0.0422
Brugia malayi ecdysteroid receptor 0.0051 0.032 0.1355
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0167 0.0219
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0107 0.0454
Loa Loa (eye worm) Smad1 0.0016 0.0043 0.0181
Trypanosoma brucei heat shock protein, putative 0.0032 0.0169 0.0632
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0067 0.0048
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.005 0.0066
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.032 0.1355
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.007 0.0215
Echinococcus multilocularis heat shock protein 90 0.0026 0.0118 0.0155
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0152 0.029
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0583 0.0757
Mycobacterium ulcerans polyketide synthase 0.0028 0.0136 0.0117
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0043 0.0181
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0067 0.0203
Onchocerca volvulus Slit protein homolog 0.0017 0.005 0.0213
Brugia malayi Animal haem peroxidase family protein 0.0053 0.033 0.1395
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0118 0.0153
Brugia malayi hypothetical protein 0.0043 0.0258 0.1091
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0067 0.0287
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.1092 0.1472
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0018 0.0596
Treponema pallidum heat shock protein 90 0.0026 0.0118 0.01
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1395
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0043 0.0081
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0067 0.0082
Brugia malayi EGF-like domain containing protein 0.0017 0.005 0.0213
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0107 0.0141
Brugia malayi MH2 domain containing protein 0.0016 0.0043 0.0181
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1395
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.005 0.0213
Loa Loa (eye worm) hypothetical protein 0.003 0.0152 0.0645
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.0118 0.01
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.032 0.0422
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0118 0.0417
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0203
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0152 0.029
Loa Loa (eye worm) Notch2 0.0017 0.005 0.0213
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0019 0.0063 0.0229
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0067 0.0203
Leishmania major heat shock protein 83-1 0.0032 0.0169 0.0632
Brugia malayi Pre-SET motif family protein 0.0206 0.1529 0.6469
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0122 0.0159
Plasmodium falciparum thioredoxin reductase 0.0013 0.0018 0.0596
Leishmania major heat shock protein 83-1 0.0032 0.0169 0.0632
Echinococcus multilocularis tumor protein p63 0.0348 0.2645 0.3482
Trichomonas vaginalis MYB3r3, putative 0.0019 0.007 0.0301
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0454
Brugia malayi MH2 domain containing protein 0.0235 0.1762 0.7455
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0028 0.0136 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.032 0.1355
Echinococcus multilocularis Smad4 0.0016 0.0043 0.0056
Mycobacterium tuberculosis Probable reductase 0.0085 0.0583 0.0805
Trypanosoma brucei heat shock protein, putative 0.0032 0.0169 0.0632
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0169 0.0715
Onchocerca volvulus 0.0234 0.1751 0.7408
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.032 0.1355
Plasmodium vivax endoplasmin, putative 0.0032 0.0169 0.5502
Brugia malayi hypothetical protein 0.005 0.0307 0.1299
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0362 0.276 0.276
Leishmania major heat shock protein 83-1 0.0032 0.0169 0.0632
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0658 0.0909
Echinococcus granulosus FTZ F1 alpha 0.0051 0.032 0.0608
Schistosoma mansoni peroxidasin 0.0053 0.033 0.0626
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0167 0.0605
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0017 0.005 0.0213
Onchocerca volvulus 0.0024 0.0107 0.0454
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.032 0.1355
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0107 0.0454
Echinococcus granulosus heat shock protein 90 0.0032 0.0169 0.0321
Schistosoma mansoni zinc finger protein 0.0024 0.0107 0.0204
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0209 0.6813
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Plasmodium falciparum endoplasmin, putative 0.002 0.0072 0.2331
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0028 0.0136 0.0178
Echinococcus multilocularis cpg binding protein 0.003 0.0152 0.0199
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0026 0.0122 0.0159
Onchocerca volvulus 0.0312 0.2364 1
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0017 0.005 0.0213
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.033 0.1395
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.032 0.1355
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2322 1
Brugia malayi conserved hypotetical protein 0.0024 0.0107 0.0454
Brugia malayi isocitrate dehydrogenase 0.0032 0.0167 0.0707
Schistosoma mansoni laminin gamma-3 chain 0.0017 0.005 0.0096
Schistosoma mansoni hypothetical protein 0.0017 0.005 0.0096
Brugia malayi Thioredoxin reductase 0.0037 0.0209 0.0885
Echinococcus granulosus geminin 0.0343 0.2606 0.495
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1395
Echinococcus multilocularis neurogenic locus notch protein 4 0.0017 0.005 0.0066
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0067 0.0203
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0169 0.0632
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.032 0.0422
Echinococcus multilocularis microtubule associated protein 2 0.0682 0.5265 0.693
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.002 0.066
Trypanosoma brucei unspecified product 0.0019 0.0067 0.0203
Loa Loa (eye worm) hypothetical protein 0.0051 0.032 0.1355
Onchocerca volvulus 0.0248 0.186 0.787
Loa Loa (eye worm) hypothetical protein 0.0027 0.013 0.055
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0244 0.0464
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0067 0.0203
Echinococcus granulosus notch 0.0017 0.005 0.0096
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.032 0.0422
Trichomonas vaginalis heat shock protein, putative 0.002 0.0072 0.0308
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0028 0.0136 0.0127
Schistosoma mansoni nuclear receptor 0.0024 0.0107 0.0204
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1395
Schistosoma mansoni septate junction protein 0.0017 0.005 0.0096
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0169 0.0632
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.032 0.1355
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.1762 0.7455
Onchocerca volvulus Chorion peroxidase homolog 0.0053 0.033 0.1395
Giardia lamblia Grp94/Hsp90 0.0026 0.0118 0.0431
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.032 0.0608
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0167 0.0624
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0107 0.0204
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.032 0.0422
Echinococcus multilocularis peroxidasin 0.0053 0.033 0.0434
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.1093 0.4509
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.032 0.1355
Mycobacterium ulcerans polyketide synthase 0.0026 0.0122 0.0103
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0169 0.0646
Onchocerca volvulus 0.0017 0.005 0.0213
Mycobacterium tuberculosis Probable thioesterase TesA 0.0024 0.0105 0.0135
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0583 0.0805
Leishmania major heat shock protein 83-1 0.0032 0.0169 0.0632
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0018 0.0018
Leishmania major heat shock protein 83-1 0.0032 0.0169 0.0632
Leishmania major heat shock protein 83-1 0.0032 0.0169 0.0632
Schistosoma mansoni hypothetical protein 0.0022 0.0092 0.0175
Loa Loa (eye worm) endoplasmin 0.0032 0.0169 0.0715
Onchocerca volvulus Putative cubilin 0.0017 0.005 0.0213
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.068 0.1292
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.007 0.0301
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0018 0.0035
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0067 0.0203
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.1093 0.4509
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0203
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.004 0.0233 0.0314
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.005 0.0066
Toxoplasma gondii type I fatty acid synthase, putative 0.0028 0.0136 0.0491
Schistosoma mansoni smad 0.0016 0.0043 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.002 0.0008
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0244 0.0322
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0267 0.1041
Onchocerca volvulus Huntingtin homolog 0.0121 0.0867 0.3665
Brugia malayi hypothetical protein 0.0032 0.0169 0.0714
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.032 0.0608
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0118 0.01
Trichomonas vaginalis pc-MYB2, putative 0.0019 0.007 0.0301
Loa Loa (eye worm) hypothetical protein 0.0312 0.2364 1
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0169 0.0646
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0107 0.0204
Echinococcus granulosus microtubule associated protein 2 0.0682 0.5265 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2322 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.035 0.0665
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.032 0.0608
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0317 0.2403 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.1092 0.1076
Schistosoma mansoni hypothetical protein 0.0017 0.005 0.0096
Giardia lamblia Myb 1-like protein 0.002 0.0071 0.0227
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0122 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0043 0.0181
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.068 0.2877
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0454
Brugia malayi Cytochrome P450 family protein 0.0019 0.0068 0.0289
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0454
Echinococcus granulosus cpg binding protein 0.003 0.0152 0.0288
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0107 0.0204
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Brugia malayi glutathione reductase 0.0037 0.0209 0.0885
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0167 0.0707
Brugia malayi Animal haem peroxidase family protein 0.0053 0.033 0.1395
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Leishmania major heat shock protein 83-1 0.0032 0.0169 0.0632
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0167 0.0705
Onchocerca volvulus Dual oxidase homolog 0.0053 0.033 0.1395
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0017 0.005 0.0096
Schistosoma mansoni hypothetical protein 0.0017 0.005 0.0096
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.068 0.2866
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1285 1 1
Brugia malayi Pre-SET motif family protein 0.003 0.0152 0.0645
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0433 0.1738
Schistosoma mansoni patched 1 0.0042 0.0244 0.0464
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.035 0.0665
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0307 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0071 0.0304
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0028 0.0136 0.0178
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0028 0.0136 0.0178
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0433 0.1791
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0203
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.002 0.0073
Echinococcus granulosus peroxidasin 0.0053 0.033 0.0626
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0307 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0454
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1285 1 1
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.033 0.1395
Trypanosoma brucei heat shock protein, putative 0.0032 0.0169 0.0632
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0077 0.0059
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.005 0.0066
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0658 0.0861
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0043 0.0081
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0706 0.2986
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0068 0.021
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.005 0.0213
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.032 0.1355
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1395
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0028 0.0136 0.0117
Loa Loa (eye worm) hypothetical protein 0.0101 0.0706 0.2986
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0043 0.0056
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.032 0.0422
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0343 0.1362
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0067 0.0203
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.033 0.1395
Loa Loa (eye worm) hypothetical protein 0.0121 0.0867 0.3665
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.032 0.1355
Loa Loa (eye worm) hypothetical protein 0.0032 0.0167 0.0705
Loa Loa (eye worm) hypothetical protein 0.0051 0.032 0.1355
Giardia lamblia Fructose-bisphosphate aldolase 0.0307 0.2322 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.013 0.055
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0016 0.0045 0.0027
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0706 0.2986
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.007 0.0301
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.013 0.055
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0067 0.0082
Onchocerca volvulus 0.0051 0.032 0.1355
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0267 0.1041
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.032 0.1355
Toxoplasma gondii EGF family domain-containing protein 0.0017 0.005 0.0183
Loa Loa (eye worm) hypothetical protein 0.0019 0.0067 0.0282
Plasmodium falciparum heat shock protein 90 0.0032 0.0169 0.5502
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0043 0.0081
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0107 0.0454
Onchocerca volvulus 0.005 0.0309 0.1308
Echinococcus multilocularis heat shock protein 90 0.0032 0.0169 0.0222
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0167 0.0624
Echinococcus granulosus expressed conserved protein 0.0091 0.0634 0.1204
Schistosoma mansoni hypothetical protein 0.0069 0.0456 0.0867
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0067 0.0282
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0018 0.0014
Echinococcus multilocularis protein jagged 1 0.0017 0.005 0.0066
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1395
Schistosoma mansoni heat shock protein 0.0013 0.002 0.0038
Schistosoma mansoni smad1 5 8 and 0.0016 0.0043 0.0081
Onchocerca volvulus Fatty acid synthase homolog 0.0052 0.0323 0.1368
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.032 0.1355
Brugia malayi nuclear hormone receptor 0.0051 0.032 0.1355
Echinococcus granulosus endoplasmin 0.0026 0.0118 0.0223
Brugia malayi Cadherin domain containing protein 0.0017 0.005 0.0213
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0307 1
Brugia malayi Hsp90 protein 0.0013 0.002 0.0086
Leishmania major DNA polymerase kappa, putative 0.0019 0.0067 0.0203
Schistosoma mansoni hypothetical protein 0.0017 0.005 0.0096
Echinococcus granulosus protein jagged 2 0.0017 0.005 0.0096
Trypanosoma brucei unspecified product 0.0013 0.002 0.0008
Trypanosoma brucei heat shock protein, putative 0.0032 0.0169 0.0632
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1529 0.6469
Brugia malayi CHE-14 protein 0.0042 0.0244 0.1034
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.032 0.1355
Brugia malayi nuclear hormone receptor 0.0024 0.0107 0.0454
Onchocerca volvulus 0.0017 0.005 0.0213
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.2403 1
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0169 0.0632
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0018 0.0596
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0118 0.0417
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.032 0.0422
Onchocerca volvulus 0.0027 0.0128 0.054
Brugia malayi EGF-like domain containing protein 0.0017 0.005 0.0213
Brugia malayi hypothetical protein 0.0312 0.2364 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0118 0.0417
Brugia malayi CXXC zinc finger family protein 0.0028 0.0139 0.0587
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0122 0.0103
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.007 0.0301
Leishmania major heat shock protein 83-1 0.0032 0.0169 0.0632
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0152 0.0201
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.032 0.0608
Schistosoma mansoni hypothetical protein 0.0032 0.0167 0.0317
Brugia malayi hypothetical protein 0.0027 0.013 0.055
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0107 0.0204
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0167 0.0222
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.032 0.1355
Schistosoma mansoni peroxidasin 0.0053 0.033 0.0626
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.032 0.1355
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0122 0.0159
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0583 0.0805
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0203
Brugia malayi EGF-like domain containing protein 0.0017 0.005 0.0213
Loa Loa (eye worm) hypothetical protein 0.0121 0.0867 0.3665
Echinococcus granulosus dna polymerase kappa 0.0019 0.0067 0.0127
Leishmania major cytochrome p450-like protein 0.0019 0.0068 0.021
Brugia malayi Animal haem peroxidase family protein 0.0053 0.033 0.1395
Schistosoma mansoni nuclear receptor 0.0024 0.0107 0.0204
Schistosoma mansoni notch 0.0017 0.005 0.0096
Loa Loa (eye worm) hypothetical protein 0.005 0.0307 0.1299
Toxoplasma gondii type I fatty acid synthase, putative 0.002 0.0077 0.0281
Leishmania major heat shock protein 83-1 0.0032 0.0169 0.0632
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0118 0.0507
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0583 0.0805
Entamoeba histolytica hypothetical protein 0.0043 0.0258 0.1032
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.002 0.0071 0.0256
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.032 0.1355
Toxoplasma gondii thioredoxin reductase 0.0037 0.0209 0.0758
Brugia malayi Pax transcription factor protein 2 0.0248 0.186 0.787
Plasmodium vivax heat shock protein 90, putative 0.0013 0.002 0.066
Echinococcus granulosus heat shock protein 0.0032 0.0169 0.0321
Trypanosoma brucei heat shock protein 84, putative 0.0013 0.002 0.0008
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.002 0.066
Brugia malayi EGF-like domain containing protein 0.0017 0.005 0.0213
Onchocerca volvulus Peroxidase homolog 0.0053 0.033 0.1395
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0067 0.0201
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0107 0.0204
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0454
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.013 0.055
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0167 0.0317
Trichomonas vaginalis C-MYB, putative 0.0019 0.007 0.0301
Loa Loa (eye worm) blistered cuticle protein 3 0.0053 0.033 0.1395
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.1092 0.1516
Echinococcus multilocularis neural cadherin 0.0017 0.005 0.0066
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0107 0.0454
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0167 0.022
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.002 0.0073
Loa Loa (eye worm) hypothetical protein 0.0042 0.0244 0.1034
Echinococcus multilocularis dna polymerase eta 0.0019 0.0067 0.0088
Onchocerca volvulus Peroxidasin homolog 0.0053 0.033 0.1395
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0316 0.0601
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0067 0.0088
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1395
Trichomonas vaginalis heat shock protein, putative 0.0013 0.002 0.0087
Schistosoma mansoni thyroid hormone receptor 0.0051 0.032 0.0608
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0107 0.0454
Brugia malayi Delta serrate ligand family protein 0.0017 0.005 0.0213
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.032 0.1355
Schistosoma mansoni hypothetical protein 0.0285 0.215 0.4083
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0454
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0267 0.1041
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0067 0.0127
Schistosoma mansoni smad1 5 8 and 0.0016 0.0043 0.0081
Loa Loa (eye worm) hypothetical protein 0.0051 0.0318 0.1346
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0051 0.032 0.0608
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.035 0.1482
Schistosoma mansoni hypothetical protein 0.0343 0.2606 0.495
Echinococcus multilocularis slit 2 protein 0.0017 0.005 0.0066
Echinococcus multilocularis heat shock protein 0.0032 0.0169 0.0222
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0067 0.0203
Schistosoma mansoni hypothetical protein 0.0017 0.005 0.0096
Schistosoma mansoni hypothetical protein 0.004 0.0233 0.0442
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0167 0.0707
Leishmania major hypothetical protein, conserved 0.005 0.0307 0.1211
Leishmania major trypanothione reductase 0.0037 0.0209 0.0801
Schistosoma mansoni hypothetical protein 0.0343 0.2606 0.495
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.032 0.0608
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0167 0.0705
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0362 0.276 0.2746
Brugia malayi Cadherin domain containing protein 0.0017 0.005 0.0213
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0067 0.0127
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0362 0.276 1
Brugia malayi EGF-like domain containing protein 0.0017 0.005 0.0213
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.007 0.0301
Onchocerca volvulus 0.0028 0.0139 0.0587
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.002 0.0086
Schistosoma mansoni hypothetical protein 0.0043 0.0258 0.049
Brugia malayi nuclear receptor NHR-88 0.0024 0.0107 0.0454
Echinococcus granulosus protein jagged 2 0.0017 0.005 0.0096
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0152 0.029
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0169 0.0612
Plasmodium falciparum thioredoxin reductase 0.0037 0.0209 0.6813
Leishmania major heat shock protein 83-1 0.0032 0.0169 0.0632
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0052 0.0323 0.1368
Schistosoma mansoni endoplasmin 0.0032 0.0169 0.0321
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2322 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.035 0.0461
Trypanosoma brucei heat shock protein, putative 0.0032 0.0169 0.0632
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0152 0.029
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0136 0.0117
Schistosoma mansoni smad1 5 8 and 0.0016 0.0043 0.0081
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0362 0.276 0.3816
Brugia malayi ecdysone receptor 0.0024 0.0107 0.0454
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.033 0.1395
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0149 0.063
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0169 0.5502
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0692 0.1314
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0118 0.0507
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.035 0.0461
Loa Loa (eye worm) hypothetical protein 0.0051 0.032 0.1355
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2322 1
Trypanosoma brucei unspecified product 0.0013 0.002 0.0008
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0152 0.0552
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0258 0.0339
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0018 0.0066
Loa Loa (eye worm) fatty acid synthase 0.0028 0.0139 0.059
Echinococcus granulosus Smad4 0.0016 0.0043 0.0081
Mycobacterium ulcerans thioesterase 0.0024 0.0105 0.0087
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0454
Schistosoma mansoni cpg binding protein 0.0028 0.0139 0.0264
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0307 0.1211
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0706 0.2986
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0433 0.1738
Schistosoma mansoni heat shock protein 0.0032 0.0169 0.0321
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0067 0.0048
Brugia malayi Peroxidasin 0.0053 0.033 0.1395
Loa Loa (eye worm) hypothetical protein 0.0046 0.0275 0.1162
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0454
Loa Loa (eye worm) hypothetical protein 0.0097 0.068 0.2877
Mycobacterium leprae Probable polyketide synthase Pks1 0.0028 0.0136 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0203
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0244 0.1034
Loa Loa (eye worm) heat shock protein 75 0.0013 0.002 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0203
Onchocerca volvulus 0.0017 0.005 0.0213
Schistosoma mansoni cpg binding protein 0.003 0.0152 0.0288
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0107 0.0141
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.7598 1
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.005 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0203
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.035 0.0665
Brugia malayi GCC2 and GCC3 family protein 0.0017 0.005 0.0213
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0067 0.0127
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.007 0.0215
Leishmania major heat shock protein 83-1 0.0032 0.0169 0.0632
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.013 0.055
Schistosoma mansoni heat shock protein 0.0032 0.0169 0.0321
Schistosoma mansoni notch 0.0017 0.005 0.0096
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1751 0.7541
Onchocerca volvulus 0.0017 0.005 0.0213
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0018 0.0066
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0026 0.0122 0.0107
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0167 0.0705
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0167 0.0624
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0152 0.0201
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0018 0.0024
Brugia malayi Cytochrome P450 family protein 0.003 0.0149 0.063
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0018 0.0079
Leishmania major mitochondrial DNA polymerase beta 0.0317 0.2403 1
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1285 1 1
Echinococcus granulosus GPCR family 2 0.0032 0.0167 0.0317
Brugia malayi nuclear receptor RXR 0.0024 0.0107 0.0454
Schistosoma mansoni hypothetical protein 0.004 0.0233 0.0442
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0583 0.0805
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.005 0.0096
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.002 0.0027
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0433 0.183
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0107 0.0454
Schistosoma mansoni notch 0.0017 0.005 0.0096
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0167 0.544
Brugia malayi hypothetical protein 0.0024 0.0107 0.0454
Echinococcus multilocularis smad 0.0016 0.0043 0.0056
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0244 0.0464
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.007 0.0301
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0169 0.0654
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0026 0.0122 0.0107
Brugia malayi MH1 domain containing protein 0.0016 0.0043 0.0181
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1395
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.068 0.0895
Loa Loa (eye worm) hypothetical protein 0.0051 0.032 0.1355
Schistosoma mansoni hypothetical protein 0.0032 0.0167 0.0317
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0307 0.1113
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.032 0.0608
Trypanosoma brucei heat shock protein, putative 0.0032 0.0169 0.0632
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.035 0.1482
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.1395
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.032 0.0608
Entamoeba histolytica hypothetical protein 0.0043 0.0258 0.1032
Plasmodium falciparum glutathione reductase 0.0013 0.0018 0.0596
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.032 0.0608
Onchocerca volvulus 0.0024 0.0107 0.0454
Brugia malayi Muscle positioning protein 4 0.0017 0.005 0.0213
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.013 0.0171
Schistosoma mansoni DNA polymerase eta 0.0019 0.0067 0.0127
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.2322 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.032 0.1355
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0128 0.054
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0107 0.0204
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0068 0.0289
Mycobacterium tuberculosis Polyketide synthase Pks13 0.004 0.0233 0.0314
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0169 0.0632
Echinococcus granulosus slit 2 protein 0.0017 0.005 0.0096
Echinococcus multilocularis GPCR, family 2 0.0032 0.0167 0.0219
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0067 0.0203
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0454
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0213 0.0405
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.032 0.0608
Schistosoma mansoni hypothetical protein 0.004 0.0233 0.0442
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0107 0.0141
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0167 0.0219
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0169 0.0612
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0068 0.021
Onchocerca volvulus Peroxidasin homolog 0.0053 0.033 0.1395
Mycobacterium ulcerans thioesterase TesA 0.0024 0.0105 0.0087
Schistosoma mansoni endoplasmin 0.0032 0.0169 0.0321
Loa Loa (eye worm) hypothetical protein 0.0069 0.0456 0.193
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.005 0.0066
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0583 0.0805
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0167 0.544
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0209 0.0281
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0067 0.0203
Echinococcus granulosus protein jagged 1 0.0017 0.005 0.0096
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0024 0.0105 0.0084
Echinococcus granulosus delta-like protein 1 0.0017 0.005 0.0096
Brugia malayi Animal haem peroxidase family protein 0.0053 0.033 0.1395
Echinococcus multilocularis geminin 0.0343 0.2606 0.343
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0454
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.035 0.0665
Trypanosoma brucei trypanothione reductase 0.0037 0.0209 0.0801
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0107 0.0454
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0433 0.0822
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0169 0.0727
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0019 0.007 0.0215
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0167 0.022
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0027 0.0128 0.0167
Leishmania major heat shock protein 83-1 0.0032 0.0169 0.0632
Leishmania major heat shock protein 83-1 0.0032 0.0169 0.0632
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0068 0.0289
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.032 0.1355
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0658 0.0909
Trypanosoma brucei heat shock protein, putative 0.0032 0.0169 0.0632
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0067 0.0287
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0213
Loa Loa (eye worm) hypothetical protein 0.0027 0.013 0.055
Mycobacterium ulcerans polyketide synthase Pks13 0.004 0.0233 0.0215
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0067 0.0282
Trichomonas vaginalis endoplasmin, putative 0.002 0.0072 0.0308

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.8356 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3048 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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