Detailed information for compound 1562128

Basic information

Technical information
  • TDR Targets ID: 1562128
  • Name: 3-amino-5H-phenanthridin-6-one
  • MW: 210.231 | Formula: C13H10N2O
  • H donors: 2 H acceptors: 2 LogP: 2.74 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc2c(c1)nc(c1c2cccc1)O
  • InChi: 1S/C13H10N2O/c14-8-5-6-10-9-3-1-2-4-11(9)13(16)15-12(10)7-8/h1-7H,14H2,(H,15,16)
  • InChiKey: DCUQUNJESLMZPF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 22860-48-6
  • STK291005
  • NSC109584

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.2178 0.4612
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.1651 0.1379
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0335 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0316 0.0174
Echinococcus multilocularis GPCR, family 2 0.0019 0.1651 0.1379
Brugia malayi Kringle domain containing protein 0.0014 0.1121 0.0832
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.2178 1
Onchocerca volvulus 0.0029 0.2735 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.1404 0.1932
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.6209 0.6085
Schistosoma mansoni hypothetical protein 0.0019 0.1651 0.1651
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.2178 0.4612
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0014 0.1121 0.0832
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0316 0.0174
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.4353 0.4353
Echinococcus multilocularis cpg binding protein 0.003 0.2917 0.2686
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.3145 0.2921
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.1651 0.1379
Brugia malayi AMP-binding enzyme family protein 0.0024 0.2178 0.1923
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0265 0.000000043526
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.4353 0.4169
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.2178 0.1923
Brugia malayi Latrophilin receptor protein 2 0.0019 0.1651 0.1379
Loa Loa (eye worm) hypothetical protein 0.0024 0.2178 0.1923
Entamoeba histolytica hypothetical protein 0.0043 0.4353 1
Schistosoma mansoni hypothetical protein 0.0019 0.1651 0.1651
Brugia malayi AMP-binding enzyme family protein 0.0024 0.2178 0.1923
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.2178 0.1923
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.2178 0.3182
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 1 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 1 1
Brugia malayi hypothetical protein 0.0043 0.4353 0.4169
Loa Loa (eye worm) hypothetical protein 0.0041 0.4099 0.3907
Toxoplasma gondii kringle domain-containing protein 0.0014 0.1121 0.0832
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0265 0.000000043526
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0265 0.000000043526
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.6397 0.6279
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.1651 0.1379
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 1 0.5
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0316 0.0174
Schistosoma mansoni tar DNA-binding protein 0.0064 0.6584 0.6584
Schistosoma mansoni tar DNA-binding protein 0.0064 0.6584 0.6584
Entamoeba histolytica hypothetical protein 0.0043 0.4353 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0014 0.1121 0.0832
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.0316 0.5
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0034 0.3254 0.3254
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0316 0.5
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0335 0.002
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.1512 0.2106
Schistosoma mansoni tar DNA-binding protein 0.0064 0.6584 0.6584
Schistosoma mansoni hypothetical protein 0.0014 0.1121 0.1121
Brugia malayi AMP-binding enzyme family protein 0.0024 0.2178 0.1923
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.2178 0.1923
Loa Loa (eye worm) hypothetical protein 0.0094 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.2178 0.1923
Loa Loa (eye worm) hypothetical protein 0.006 0.6209 0.6085
Echinococcus granulosus cpg binding protein 0.003 0.2917 0.2686
Loa Loa (eye worm) TAR-binding protein 0.0064 0.6584 0.6473
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 1 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.3145 0.2921
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0265 0.000000043526
Schistosoma mansoni hypothetical protein 0.0019 0.1651 0.1651
Schistosoma mansoni hypothetical protein 0.0041 0.4099 0.4099
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0265 0.000000043526
Schistosoma mansoni cpg binding protein 0.003 0.2917 0.2917
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 1 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0316 0.0174
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.1651 0.1651
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0316 0.0174
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.4353 0.4169
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0265 0.000000043526
Onchocerca volvulus 0.0024 0.2178 0.7697
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.2178 0.4612
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.1651 0.1379
Brugia malayi RNA binding protein 0.0064 0.6584 0.6473
Echinococcus granulosus tar DNA binding protein 0.0064 0.6584 0.6473
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.6397 0.6279
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0316 0.0174
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0517 0.0208
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.5591 0.5447
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.1121 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.1512 0.1235
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.1512 0.1235
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0316 0.0174
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.053 0.0221
Brugia malayi Protein kinase domain containing protein 0.0014 0.1121 0.0832
Entamoeba histolytica hypothetical protein 0.0043 0.4353 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.1512 0.1235
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.6209 0.6085
Brugia malayi TAR-binding protein 0.0064 0.6584 0.6473
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 1 1
Echinococcus multilocularis tissue type plasminogen activator 0.0014 0.1121 0.0832
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.1404 0.1932
Schistosoma mansoni tar DNA-binding protein 0.0064 0.6584 0.6584
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.1651 0.1379
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.2178 0.1923
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.2178 0.3182
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.6314 0.6314
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.1404 0.1932
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.1404 0.1932
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0265 0.000000043526
Loa Loa (eye worm) hypothetical protein 0.0018 0.1512 0.1235
Schistosoma mansoni cpg binding protein 0.0029 0.2735 0.2735
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.2178 0.1923
Brugia malayi CXXC zinc finger family protein 0.0029 0.2735 0.2498
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0316 0.0174
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0335 0.002
Loa Loa (eye worm) histone methyltransferase 0.0009 0.053 0.0221
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.2178 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.1512 0.1235
Loa Loa (eye worm) RNA binding protein 0.0064 0.6584 0.6473
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.6209 0.6085
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0335 0.0335
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 1 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.6397 1
Schistosoma mansoni hypothetical protein 0.0043 0.4353 0.4353
Loa Loa (eye worm) hypothetical protein 0.0014 0.1121 0.0832
Loa Loa (eye worm) TK/ROR protein kinase 0.0014 0.1121 0.0832
Echinococcus granulosus tissue type plasminogen activator 0.0014 0.1121 0.0832
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0265 0.000000043526
Leishmania major hypothetical protein, conserved 0.0014 0.1121 0.4326
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.6397 0.6279
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.2735 0.2498
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.2178 0.1923
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.2178 0.1923
Onchocerca volvulus 0.0014 0.1121 0.333
Schistosoma mansoni cpg binding protein 0.003 0.2917 0.2917
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.6584 0.6473
Entamoeba histolytica hypothetical protein 0.0043 0.4353 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.2178 0.1923
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.053 0.0221
Loa Loa (eye worm) hypothetical protein 0.0024 0.2178 0.1923
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0316 0.0174
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.1651 0.1379
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.1512 0.1235
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.3145 0.2921
Echinococcus multilocularis tar DNA binding protein 0.0064 0.6584 0.6473
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.1512 0.1235
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0335 0.002
Mycobacterium ulcerans hypothetical protein 0.0024 0.2178 0.1923
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.6584 0.6473
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0316 0.0174
Schistosoma mansoni tar DNA-binding protein 0.0064 0.6584 0.6584
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.4099 0.3907
Toxoplasma gondii hypothetical protein 0.0033 0.3145 0.2921
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.2178 0.1923
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.2178 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 1 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0316 0.0174
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 1 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0316 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.1651 0.1379
Loa Loa (eye worm) hypothetical protein 0.0018 0.1512 0.1235
Echinococcus granulosus GPCR family 2 0.0019 0.1651 0.1379
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.6397 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0316 1
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0316 0.0316

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2593 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 0.2818 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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