Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protoporphyrinogen oxidase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | thymidylate synthase | 0.5523 | 0.9557 | 1 |
Chlamydia trachomatis | thymidylate kinase | 0.0295 | 0.0229 | 0.375 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.5772 | 1 | 1 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0295 | 0.0229 | 0.0139 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.5523 | 0.9557 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5523 | 0.9557 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.5523 | 0.9557 | 1 |
Trypanosoma brucei | thymidine kinase | 0.0253 | 0.0155 | 0.0065 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0295 | 0.0229 | 0.0075 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0295 | 0.0229 | 0.0175 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5772 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.5772 | 1 | 1 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.0295 | 0.0229 | 0.0193 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0295 | 0.0229 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYX (TS) (TSase) | 0.1569 | 0.2502 | 0.2583 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0295 | 0.0229 | 0.0175 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.5772 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0467 | 0.0535 | 0.0515 |
Echinococcus multilocularis | thymidylate synthase | 0.5523 | 0.9557 | 1 |
Trypanosoma brucei | deoxyuridine triphosphatase, putative | 0.0369 | 0.0362 | 0.0273 |
Schistosoma mansoni | thymidylate kinase | 0.0295 | 0.0229 | 0.0193 |
Mycobacterium ulcerans | thymidylate kinase | 0.0295 | 0.0229 | 0.0193 |
Echinococcus granulosus | thymidylate kinase | 0.0295 | 0.0229 | 0.0239 |
Loa Loa (eye worm) | thymidylate synthase | 0.5523 | 0.9557 | 1 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.0295 | 0.0229 | 0.0239 |
Leishmania major | deoxyuridine triphosphatase, putative,dUTP diphosphatase | 0.0369 | 0.0362 | 0.021 |
Mycobacterium tuberculosis | Hypothetical protein | 0.2628 | 0.4391 | 0.4594 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0467 | 0.0535 | 0.0328 |
Onchocerca volvulus | 0.5523 | 0.9557 | 1 | |
Mycobacterium ulcerans | thymidylate synthase | 0.5523 | 0.9557 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5772 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.2628 | 0.4391 | 0.4303 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0467 | 0.0535 | 0.0515 |
Schistosoma mansoni | hypothetical protein | 0.0295 | 0.0229 | 0.0193 |
Leishmania major | thymidylate kinase-like protein | 0.0295 | 0.0229 | 0.0075 |
Echinococcus multilocularis | thymidylate kinase | 0.0295 | 0.0229 | 0.0193 |
Mycobacterium ulcerans | FAD-dependent thymidylate synthase | 0.1569 | 0.2502 | 0.2583 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0295 | 0.0229 | 0.0075 |
Brugia malayi | dihydrofolate reductase family protein | 0.0467 | 0.0535 | 0.0328 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyX (ts) (TSase) | 0.1569 | 0.2502 | 0.2618 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0369 | 0.0362 | 0.021 |
Giardia lamblia | CDC8 | 0.0295 | 0.0229 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0218 | 0.0091 | 0.0048 |
Brugia malayi | hypothetical protein | 0.2628 | 0.4391 | 0.4462 |
Schistosoma mansoni | dihydrofolate reductase | 0.0467 | 0.0535 | 0.0515 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2628 | 0.4391 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0467 | 0.0535 | 1 |
Schistosoma mansoni | thymidylate kinase | 0.0295 | 0.0229 | 0.0193 |
Echinococcus granulosus | dihydrofolate reductase | 0.0467 | 0.0535 | 0.056 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0295 | 0.0229 | 0.5 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0295 | 0.0229 | 0.0139 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0295 | 0.0229 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0467 | 0.0535 | 0.056 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0369 | 0.0362 | 0.021 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.5523 | 0.9557 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0467 | 0.0535 | 0.0515 |
Brugia malayi | Dihydrofolate reductase | 0.0467 | 0.0535 | 0.0328 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.82 uM | Inhibition of human PPO by capillary electrophoresis method | ChEMBL. | 22130420 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.