Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0683 | 0.5781 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0339 | 0.2022 | 0.3206 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0683 | 0.5781 | 1 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0683 | 0.5781 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0731 | 0.6307 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0731 | 0.6307 | 0.6307 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0683 | 0.5781 | 0.9165 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.0132 | 0.0229 |
Echinococcus multilocularis | GPCR, family 2 | 0.0339 | 0.2022 | 0.3498 |
Echinococcus granulosus | proteasome prosome macropain | 0.0683 | 0.5781 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0307 | 0.1681 | 0.2909 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0132 | 0.0132 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0307 | 0.1681 | 0.2909 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0683 | 0.5781 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0683 | 0.5781 | 0.5 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0683 | 0.5781 | 0.5 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.0132 | 0.0229 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.107 | 1 | 1 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0683 | 0.5781 | 0.5781 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0307 | 0.1681 | 0.2909 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0307 | 0.1681 | 0.2909 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0339 | 0.2022 | 0.2022 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0339 | 0.2022 | 0.3498 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0683 | 0.5781 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0731 | 0.6307 | 0.6307 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0307 | 0.1681 | 0.2909 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0307 | 0.1681 | 0.2909 |
Schistosoma mansoni | hypothetical protein | 0.0339 | 0.2022 | 0.3206 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0307 | 0.1681 | 0.2666 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.107 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0307 | 0.1681 | 0.2666 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0307 | 0.1681 | 0.2909 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 0.0132 | 0.021 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0683 | 0.5781 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0683 | 0.5781 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0683 | 0.5781 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0339 | 0.2022 | 0.2022 |
Mycobacterium ulcerans | proteasome PrcB | 0.0683 | 0.5781 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0339 | 0.2022 | 0.3498 |
Loa Loa (eye worm) | hypothetical protein | 0.107 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0307 | 0.1681 | 0.2909 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0307 | 0.1681 | 0.2909 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.0132 | 0.0229 |
Schistosoma mansoni | hypothetical protein | 0.0339 | 0.2022 | 0.3206 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.0132 | 0.0229 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0339 | 0.2022 | 0.3498 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0307 | 0.1681 | 0.2909 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0339 | 0.2022 | 0.2022 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.0132 | 0.0229 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0683 | 0.5781 | 1 |
Brugia malayi | proteasome subunit beta type 2 | 0.0307 | 0.1681 | 0.1681 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0339 | 0.2022 | 0.2022 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0683 | 0.5781 | 0.5781 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.0132 | 0.0229 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0165 | 0.0132 | 0.0132 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0307 | 0.1681 | 0.1681 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0339 | 0.2022 | 0.3498 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0307 | 0.1681 | 0.2909 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0307 | 0.1681 | 0.2909 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0339 | 0.2022 | 0.3498 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0683 | 0.5781 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0339 | 0.2022 | 0.3206 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0307 | 0.1681 | 0.2909 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0683 | 0.5781 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.