TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 322.401 | Formula: C20H22N2O2
H donors: 1 H acceptors: 1 LogP: 2.87 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CNC(=O)COC1CC(=Nc2c1c(CC)ccc2)c1ccccc1
InChi: 1S/C20H22N2O2/c1-3-14-10-7-11-16-20(14)18(24-13-19(23)21-2)12-17(22-16)15-8-5-4-6-9-15/h4-11,18H,3,12-13H2,1-2H3,(H,21,23)
InChiKey: GOALOTBDIQGQDQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	snurportin 1	0.0295	0.4756	0.4756
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0038	0.0443	0.1194
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.0381	0.0381
Onchocerca volvulus		0.0103	0.1528	0.3495
Plasmodium falciparum	JmjC domain-containing protein, putative	0.002	0.0138	0.0088
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.0381	0.2135
Echinococcus multilocularis	pyruvate kinase	0.003	0.0313	0.0313
Echinococcus granulosus	acetylcholinesterase	0.0607	1	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0128	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0448	0.0448
Toxoplasma gondii	PHD-finger domain-containing protein	0.0061	0.0836	0.5979
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0517	0.1006
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.009	0.1313	1
Echinococcus granulosus	jumonji domain containing protein	0.0085	0.124	0.124
Loa Loa (eye worm)	hypothetical protein	0.009	0.1313	0.1313
Loa Loa (eye worm)	pyruvate kinase-PB	0.0027	0.0254	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0128	0.0128
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0572	0.0572
Loa Loa (eye worm)	hypothetical protein	0.002	0.0138	0.0138
Echinococcus granulosus	pyruvate kinase	0.002	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1528	0.1528
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0042	0.0517	0.0895
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.002	0.0142	0.0123
Echinococcus multilocularis	pyruvate kinase	0.0038	0.0448	0.0448
Plasmodium vivax	JmjC domain containing protein	0.002	0.0138	0.0088
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.1325	0.282
Mycobacterium tuberculosis	Probable oxidoreductase	0.0188	0.2957	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0042	0.0517	0.0918
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0022	0.0181	0.0126
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.002	0.0147	0.016
Loa Loa (eye worm)	pyruvate kinase	0.0038	0.0448	0.0448
Trichomonas vaginalis	CAMK family protein kinase	0.0045	0.0557	0.1013
Schistosoma mansoni	phosphatidylserine receptor	0.002	0.0138	0.0138
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.002	0.0147	0.0146
Echinococcus multilocularis	para nitrobenzyl esterase	0.0103	0.1528	0.1528
Schistosoma mansoni	ran	0.002	0.0147	0.0146
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.1325	0.282
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0269	0.0269
Loa Loa (eye worm)	aspartyl protease 6	0.0019	0.0128	0.0128
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0028	0.0278	0.037
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0128	0.0128
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0034	0.0381	0.0381
Echinococcus multilocularis	jumonji domain containing protein	0.0085	0.124	0.124
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0042	0.0517	0.0918
Echinococcus granulosus	carboxylesterase 5A	0.0607	1	1
Plasmodium falciparum	pyruvate kinase	0.0038	0.0448	0.2706
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.009	0.1313	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0128	0.0128
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0103	0.1528	0.1528
Echinococcus granulosus	pyruvate kinase	0.002	0.0135	0.0135
Echinococcus granulosus	peregrin	0.0061	0.0836	0.0836
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0019	0.0128	0.0128
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0103	0.1528	0.3299
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.1325	0.282
Echinococcus granulosus	snurportin 1	0.0295	0.4756	0.4756
Echinococcus multilocularis	acetylcholinesterase	0.0607	1	1
Brugia malayi	Pepsin A precursor	0.0019	0.0128	0.0128
Echinococcus multilocularis	pyruvate kinase	0.002	0.0135	0.0135
Echinococcus granulosus	acetylcholinesterase	0.0607	1	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0074	0.1053	0.1053
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.1325	0.282
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0038	0.0448	0.0448
Brugia malayi	PHD-finger family protein	0.0061	0.0836	0.0836
Onchocerca volvulus	Pyruvate kinase homolog	0.0038	0.0448	0.1025
Trypanosoma brucei	polo-like protein kinase	0.0091	0.1325	0.3149
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.009	0.1313	1
Plasmodium vivax	SET domain protein, putative	0.0034	0.0381	0.2135
Echinococcus granulosus	PHD finger protein rhinoceros	0.0061	0.0836	0.0836
Leishmania major	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0028	0.0278	0.037
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0059	0.0794	0.0793
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0381	0.0381
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.002	0.0147	0.0023
Trypanosoma cruzi	hypothetical protein, conserved	0.0244	0.3906	1
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0038	0.0448	0.0637
Loa Loa (eye worm)	acetylcholinesterase 1	0.0607	1	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0091	0.1325	0.1324
Brugia malayi	Probable ClpP-like protease	0.009	0.1313	0.1313
Trypanosoma brucei	hypothetical protein, conserved	0.0244	0.3906	1
Loa Loa (eye worm)	hypothetical protein	0.0607	1	1
Trypanosoma brucei	pyruvate kinase 1, putative	0.0038	0.0448	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0381	0.0381
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0038	0.0448	0.0448
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0381	0.0381
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0572	0.0572
Echinococcus granulosus	pyruvate kinase	0.0038	0.0448	0.0448
Loa Loa (eye worm)	inositol-1	0.0042	0.0517	0.0517
Brugia malayi	PHD-finger family protein	0.002	0.0142	0.0142
Brugia malayi	hypothetical protein	0.0103	0.1528	0.1528
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0103	0.1528	0.1528
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0128	0.0128
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0103	0.1528	0.4667
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0572	0.0572
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0128	0.0128
Loa Loa (eye worm)	MH2 domain-containing protein	0.0137	0.2107	0.2107
Plasmodium vivax	pyruvate kinase, putative	0.0038	0.0448	0.2706
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0607	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0572	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0836	0.0836
Loa Loa (eye worm)	hypothetical protein	0.002	0.0138	0.0138
Giardia lamblia	PHD finger protein 15	0.0061	0.0836	0.5893
Trichomonas vaginalis	ran, putative	0.002	0.0147	0.0045
Loa Loa (eye worm)	jmjC domain-containing protein	0.0127	0.1934	0.1934
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0269	0.1193
Trichomonas vaginalis	CAMK family protein kinase	0.0045	0.0557	0.1013
Echinococcus multilocularis	pyruvate kinase	0.0038	0.0448	0.0448
Trichomonas vaginalis	pyruvate kinase, putative	0.0038	0.0448	0.0756
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1528	0.1528
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0042	0.0517	0.3147
Echinococcus multilocularis	acetylcholinesterase	0.0607	1	1
Brugia malayi	jmjC domain containing protein	0.002	0.0138	0.0138
Entamoeba histolytica	hypothetical protein	0.0022	0.0181	0.0295
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.002	0.0147	0.016
Schistosoma mansoni	pyruvate kinase	0.0038	0.0448	0.0448
Echinococcus granulosus	peptidase Clp S14 family	0.0059	0.0794	0.0793
Echinococcus multilocularis	jumonji domain containing 1A	0.002	0.0138	0.0138
Schistosoma mansoni	phd/f-box containing protein	0.002	0.0138	0.0138
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0103	0.1528	0.1528
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0128	0.0128
Trypanosoma cruzi	hypothetical protein, conserved	0.0244	0.3906	1
Loa Loa (eye worm)	PHD-finger family protein	0.0061	0.0836	0.0836
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.009	0.1313	0.1313
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0128	0.0128
Brugia malayi	Carboxylesterase family protein	0.0103	0.1528	0.1528
Toxoplasma gondii	PHD-finger domain-containing protein	0.0061	0.0836	0.5979
Schistosoma mansoni	gliotactin	0.0103	0.1528	0.1528
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.1325	0.282
Brugia malayi	Pre-SET motif family protein	0.0034	0.0381	0.0381
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0031	0.0325	0.1662
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0091	0.1325	1
Schistosoma mansoni	inositol monophosphatase	0.0042	0.0517	0.0517
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0022	0.0181	0.0115
Echinococcus multilocularis	neuroligin	0.0103	0.1528	0.1528
Leishmania major	pyruvate kinase	0.0038	0.0448	0.0823
Schistosoma mansoni	cathepsin D (A01 family)	0.0019	0.0128	0.0128
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.009	0.1313	1
Plasmodium falciparum	phd finger protein, putative	0.0061	0.0836	0.5979
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.009	0.1313	0.1313
Trypanosoma cruzi	polo-like protein kinase, putative	0.0091	0.1325	0.3149
Echinococcus multilocularis	citrate lyase subunit beta protein	0.0028	0.0278	0.0277
Brugia malayi	aspartic protease BmAsp-2, identical	0.0019	0.0128	0.0128
Toxoplasma gondii	hypothetical protein	0.0031	0.0325	0.1662
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.002	0.0147	0.016
Brugia malayi	Pre-SET motif family protein	0.0239	0.3817	0.3817
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.002	0.0138	0.0138
Onchocerca volvulus		0.0103	0.1528	0.3495
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1528	0.1528
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0061	0.0836	0.0836
Echinococcus multilocularis	lysine specific demethylase 5A	0.0074	0.1053	0.1053
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0042	0.0517	0.3288
Brugia malayi	Carboxylesterase family protein	0.0103	0.1528	0.1528
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0239	0.3817	0.3817
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0517	0.1006
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.002	0.0138	0.0088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0572	0.0572
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0074	0.1053	0.1053
Toxoplasma gondii	pyruvate kinase PyK1	0.0038	0.0448	0.2706
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.1325	0.282
Schistosoma mansoni	hypothetical protein	0.0061	0.0836	0.0836
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.009	0.1313	0.3864
Trichomonas vaginalis	set domain proteins, putative	0.0272	0.4372	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.002	0.0138	0.0138
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0128	0.0128
Leishmania major	GTP-binding protein, putative	0.002	0.0147	0.0023
Echinococcus multilocularis	phd:f box containing protein	0.002	0.0138	0.0138
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0103	0.1528	0.1528
Schistosoma mansoni	BC026374 protein (S09 family)	0.0103	0.1528	0.1528
Giardia lamblia	Kinase, PLK	0.0091	0.1325	1
Echinococcus granulosus	BC026374 protein S09 family	0.0103	0.1528	0.1528
Schistosoma mansoni	jumonji domain containing protein	0.016	0.2488	0.2488
Schistosoma mansoni	serine/threonine protein kinase	0.0091	0.1325	0.1324
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1528	0.1528
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.002	0.0142	0.0123
Mycobacterium ulcerans	pyruvate kinase	0.0038	0.0448	0.0637
Schistosoma mansoni	jumonji domain containing protein	0.002	0.0138	0.0138
Brugia malayi	hypothetical protein	0.0019	0.0128	0.0128
Brugia malayi	Bromodomain containing protein	0.0061	0.0836	0.0836
Trichomonas vaginalis	spcc417.12 protein, putative	0.0103	0.1528	0.3299
Onchocerca volvulus		0.0272	0.4372	1
Onchocerca volvulus	Pyruvate kinase homolog	0.0038	0.0448	0.1025
Brugia malayi	Importin beta-1 subunit	0.0028	0.0269	0.0269
Schistosoma mansoni	cathepsin D (A01 family)	0.0019	0.0128	0.0128
Leishmania major	pyruvate kinase	0.0038	0.0448	0.0823
Loa Loa (eye worm)	jmjC domain-containing protein	0.002	0.0138	0.0138
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0061	0.0836	0.0836
Brugia malayi	Carboxylesterase family protein	0.0103	0.1528	0.1528
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0517	0.1006
Brugia malayi	MH2 domain containing protein	0.0137	0.2107	0.2107
Echinococcus granulosus	lysine specific demethylase 6a	0.002	0.0138	0.0138
Echinococcus granulosus	neuroligin	0.0103	0.1528	0.1528
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.002	0.0138	0.0138
Echinococcus granulosus	lysine specific demethylase 5A	0.0074	0.1053	0.1053
Schistosoma mansoni	importin beta-1	0.0028	0.0269	0.0269
Brugia malayi	RNA, U transporter 1	0.0079	0.1124	0.1124
Schistosoma mansoni	memapsin-2 (A01 family)	0.0478	0.7832	0.7832
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0103	0.1528	0.1528
Echinococcus multilocularis	pyruvate kinase	0.002	0.0135	0.0135
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0269	0.1193
Echinococcus granulosus	pyruvate kinase	0.002	0.0135	0.0135
Entamoeba histolytica	pyruvate kinase, putative	0.0027	0.0254	0.091
Brugia malayi	hypothetical protein	0.0019	0.0128	0.0128
Brugia malayi	follicle stimulating hormone receptor	0.0266	0.427	0.427
Plasmodium vivax	hypothetical protein, conserved	0.0061	0.0836	0.5979
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0128	0.0128
Schistosoma mansoni	pyruvate kinase	0.0038	0.0448	0.0448
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0381	0.0381
Trichomonas vaginalis	importin beta-1, putative	0.0022	0.0181	0.0126
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0059	0.0794	0.1926
Schistosoma mansoni	protein phosphatase 2C	0.002	0.0138	0.0138
Trypanosoma brucei	pyruvate kinase 1	0.0038	0.0448	0.0823
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0269	0.0348
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0517	0.1006
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0091	0.1325	0.3149
Loa Loa (eye worm)	hypothetical protein	0.0105	0.1573	0.1573
Plasmodium falciparum	pyruvate kinase 2	0.002	0.0135	0.0065
Echinococcus granulosus	GTP binding nuclear protein Ran	0.002	0.0147	0.0146
Onchocerca volvulus		0.0019	0.0128	0.0292
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0103	0.1528	0.1528
Schistosoma mansoni	hypothetical protein	0.002	0.0142	0.0142
Trichomonas vaginalis	Citrate lyase beta chain, putative	0.0028	0.0278	0.0353
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0019	0.0128	0.0128
Onchocerca volvulus	Alhambra homolog	0.0061	0.0836	0.1913
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.002	0.0147	0.0095
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.002	0.0147	0.0023
Brugia malayi	Carboxylesterase family protein	0.0607	1	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.002	0.0138	0.0138
Plasmodium vivax	hypothetical protein, conserved	0.002	0.0142	0.0123
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0074	0.1053	0.1053
Plasmodium falciparum	importin beta, putative	0.0028	0.0269	0.1193
Giardia lamblia	Pyruvate kinase	0.0038	0.0448	0.2632
Brugia malayi	Inositol-1	0.0042	0.0517	0.0517
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0269	0.0348
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0266	0.427	0.427
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0128	0.0128
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.009	0.1313	1
Trichomonas vaginalis	CAMK family protein kinase	0.0091	0.1325	0.282
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0572	0.0572
Brugia malayi	jmjC domain containing protein	0.002	0.0138	0.0138
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0103	0.1528	0.1528
Loa Loa (eye worm)	pyruvate kinase	0.0038	0.0448	0.0448
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0021	0.0164	0.0163
Brugia malayi	aspartic protease BmAsp-1, identical	0.0019	0.0128	0.0128
Brugia malayi	jmjC domain containing protein	0.0201	0.3182	0.3182
Schistosoma mansoni	pyruvate kinase	0.002	0.0135	0.0135
Schistosoma mansoni	acetylcholinesterase	0.0103	0.1528	0.1528
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0572	0.0572
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0038	0.0448	0.1252
Loa Loa (eye worm)	pyruvate kinase	0.0038	0.0448	0.0448
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.002	0.0138	0.0088
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.009	0.1313	1
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0019	0.0128	0.0128
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0269	0.0269
Schistosoma mansoni	inositol monophosphatase	0.0042	0.0517	0.0517
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.036	0.0359
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0103	0.1528	0.4667
Loa Loa (eye worm)	carboxylesterase	0.0103	0.1528	0.1528
Echinococcus multilocularis	lysine specific demethylase 6a	0.002	0.0138	0.0138
Leishmania major	importin beta-1 subunit, putative	0.0022	0.0181	0.0115
Echinococcus granulosus	jumonji domain containing 1A	0.002	0.0138	0.0138
Echinococcus granulosus	citrate lyase subunit beta protein	0.0028	0.0278	0.0277
Onchocerca volvulus		0.0103	0.1528	0.3495
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.002	0.0142	0.0011
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.009	0.1313	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0042	0.0517	0.0918
Leishmania major	hypothetical protein, conserved	0.0244	0.3906	1
Brugia malayi	Carboxylesterase family protein	0.0103	0.1528	0.1528
Trichomonas vaginalis	pyruvate kinase, putative	0.0038	0.0448	0.0756
Mycobacterium ulcerans	short chain dehydrogenase	0.0188	0.2957	1
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1528	0.1528
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0038	0.0448	0.0823
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0019	0.0128	0.0128
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0572	0.0572
Echinococcus granulosus	pyruvate kinase	0.0038	0.0448	0.0448
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0128	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0607	1	1
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1528	0.1528
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0295	0.4756	0.4756
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0031	0.0325	0.1662
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.002	0.0147	0.0023
Schistosoma mansoni	ran	0.002	0.0147	0.0146
Schistosoma mansoni	kinase	0.0046	0.0578	0.0577
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.002	0.0138	0.0138
Schistosoma mansoni	peptidase Clp (S14 family)	0.009	0.1313	0.1313
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1528	0.1528
Mycobacterium ulcerans	carboxylesterase, LipT	0.0103	0.1528	0.4667
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0038	0.0448	0.0823
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.009	0.1313	1
Onchocerca volvulus	Pyruvate kinase homolog	0.0038	0.0448	0.1025
Brugia malayi	AF-10 protein	0.002	0.0142	0.0142
Plasmodium vivax	pyruvate kinase 2, putative	0.002	0.0135	0.0065
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.009	0.1313	0.3864
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0201	0.3182	0.3182
Onchocerca volvulus		0.0103	0.1528	0.3495
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0572	0.0572
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0091	0.1325	0.1324
Echinococcus multilocularis	pyruvate kinase	0.002	0.0135	0.0135
Echinococcus granulosus	JmjC domain containing protein 4	0.002	0.0138	0.0138
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0091	0.1325	0.303
Echinococcus multilocularis	peregrin	0.0061	0.0836	0.0836
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0269	0.0269
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.0381	0.0381
Brugia malayi	jmjC domain containing protein	0.0074	0.1053	0.1053
Onchocerca volvulus		0.0103	0.1528	0.3495
Echinococcus multilocularis	JmjC domain containing protein 4	0.002	0.0138	0.0138
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0142
Loa Loa (eye worm)	carboxylesterase	0.0103	0.1528	0.1528
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0059	0.0794	0.4744
Brugia malayi	serine/threonine-protein kinase plk-2	0.0091	0.1325	0.1325
Echinococcus multilocularis	inositol monophosphatase 1	0.0042	0.0517	0.0517
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0022	0.0181	0.0126
Brugia malayi	jmjC domain containing protein	0.002	0.0138	0.0138
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.002	0.0142	0.0011
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.002	0.0147	0.0146
Toxoplasma gondii	PHD-finger domain-containing protein	0.002	0.0142	0.0123
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0059	0.0794	0.1926
Onchocerca volvulus		0.0034	0.0381	0.0871
Toxoplasma gondii	pyruvate kinase PyKII	0.002	0.0135	0.0065
Echinococcus multilocularis	carboxylesterase 5A	0.0607	1	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0103	0.1528	0.1528
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.009	0.1313	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0254	0.0254
Loa Loa (eye worm)	carboxylesterase	0.0607	1	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0091	0.1325	0.3149
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.0381	0.0381
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0201	0.3182	0.3182
Onchocerca volvulus		0.0019	0.0128	0.0292
Loa Loa (eye worm)	transcription factor SMAD2	0.0137	0.2107	0.2107
Schistosoma mansoni	hypothetical protein	0.0295	0.4756	0.4756
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0038	0.0443	0.0616
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0103	0.1528	0.4667
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.002	0.0147	0.0147
Echinococcus granulosus	phd:f box containing protein	0.002	0.0138	0.0138
Brugia malayi	F/Y-rich N-terminus family protein	0.0021	0.0164	0.0164
Brugia malayi	jmjC domain containing protein	0.002	0.0138	0.0138
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0019	0.0128	0.0128
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0091	0.1325	0.1324
Echinococcus granulosus	inositol monophosphatase 1	0.0042	0.0517	0.0517
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0028	0.0278	0.037

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 1.88 uM	In vitro inhibitory activity on platelet aggregation induced by arachidonic acid (AA)	ChEMBL.	11212091
IC50 (functional)	= 1.88 uM	In vitro inhibitory activity on platelet aggregation induced by arachidonic acid (AA)	ChEMBL.	11212091

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	11212091

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 156288