Detailed information for compound 1563205

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 6180.67 | Formula: C182H226N75O133P19
  • H donors: 65 H acceptors: 98 LogP: -59.03 Rotable bonds: 112
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1OP(=O)(O)O)O)n1cnc2c1nc(N)[nH]c2=O)O)O)n1cnc2c1ncnc2N)O)O)n1cnc2c1nc(N)[nH]c2=O)O)O)n1ccc(nc1=O)N)O)O)n1cnc2c1ncnc2N)O)O)n1cnc2c1nc(N)[nH]c2=O)O)O)n1ccc(=O)[nH]c1=O)O)O)n1cnc2c1ncnc2N)O)O)n1cnc2c1ncnc2N)O)O)n1ccc(=O)[nH]c1=O)O)O)n1ccc(=O)[nH]c1=O)O)O)n1ccc(nc1=O)N)O)O)n1cnc2c1nc(N)[nH]c2=O)O)O)n1ccc(=O)[nH]c1=O)O)O)n1ccc(nc1=O)N)O)O)n1cnc2c1nc(N)[nH]c2=O)O)O)n1cnc2c1ncnc2N)O)O)n1cnc2c1nc(N)[nH]c2=O)O)O)n1ccc(nc1=O)N
  • InChi: 1S/C182H226N75O133P19/c183-71-1-9-239(175(288)219-71)150-90(263)109(52(17-258)353-150)373-392(299,300)336-31-66-123(104(277)164(367-66)253-47-214-85-139(253)228-170(193)234-145(85)283)388-407(329,330)347-30-65-122(103(276)162(366-65)251-45-212-83-132(191)202-40-207-137(83)251)385-406(327,328)352-35-70-125(106(279)166(371-70)255-49-216-87-141(255)230-172(195)236-147(87)285)387-404(323,324)342-21-56-112(93(266)152(356-56)241-11-3-73(185)221-177(241)290)375-395(305,306)338-23-58-116(97(270)156(358-58)245-15-7-77(261)225-181(245)294)379-399(313,314)350-33-67-124(105(278)165(368-67)254-48-215-86-140(254)229-171(194)235-146(86)284)386-403(321,322)341-20-55-111(92(265)151(355-55)240-10-2-72(184)220-176(240)289)374-394(303,304)337-22-57-114(95(268)154(357-57)243-13-5-75(259)223-179(243)292)377-396(307,308)339-24-59-115(96(269)155(359-59)244-14-6-76(260)224-180(244)293)378-397(309,310)344-26-61-121(102(275)161(362-61)250-44-211-82-131(190)201-39-206-136(82)250)384-405(325,326)345-27-63-119(100(273)159(364-63)248-42-209-80-129(188)199-37-204-134(80)248)383-402(319,320)343-25-60-117(98(271)157(360-60)246-16-8-78(262)226-182(246)295)380-400(315,316)351-34-69-127(108(281)168(370-69)257-51-218-89-143(257)232-174(197)238-149(89)287)390-409(333,334)348-29-64-120(101(274)160(365-64)249-43-210-81-130(189)200-38-205-135(81)249)382-401(317,318)340-19-54-113(94(267)153(354-54)242-12-4-74(186)222-178(242)291)376-398(311,312)349-32-68-126(107(280)167(369-68)256-50-217-88-142(256)231-173(196)237-148(88)286)389-408(331,332)346-28-62-118(99(272)158(363-62)247-41-208-79-128(187)198-36-203-133(79)247)381-393(301,302)335-18-53-110(372-391(296,297)298)91(264)163(361-53)252-46-213-84-138(252)227-169(192)233-144(84)282/h1-16,36-70,90-127,150-168,258,263-281H,17-35H2,(H,299,300)(H,301,302)(H,303,304)(H,305,306)(H,307,308)(H,309,310)(H,311,312)(H,313,314)(H,315,316)(H,317,318)(H,319,320)(H,321,322)(H,323,324)(H,325,326)(H,327,328)(H,329,330)(H,331,332)(H,333,334)(H2,183,219,288)(H2,184,220,289)(H2,185,221,290)(H2,186,222,291)(H2,187,198,203)(H2,188,199,204)(H2,189,200,205)(H2,190,201,206)(H2,191,202,207)(H,223,259,292)(H,224,260,293)(H,225,261,294)(H,226,262,295)(H2,296,297,298)(H3,192,227,233,282)(H3,193,228,234,283)(H3,194,229,235,284)(H3,195,230,236,285)(H3,196,231,237,286)(H3,197,232,238,287)/t52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-/m1/s1
  • InChiKey: VDOLMPWKZDPBBI-FEUYZKINSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ADAM-TS Spacer 1 family protein 0.0026 0.006 0.0131
Trypanosoma brucei aminopeptidase, putative 0.0102 0.046 0.9464
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0096 0.0429 0.0409
Schistosoma mansoni leucine aminopeptidase 0.0021 0.0036 0.0015
Echinococcus granulosus intermediate filament protein 0.0027 0.0066 0.0045
Echinococcus granulosus neuropeptide s receptor 0.0467 0.2375 0.2359
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.0788 0.0769
Echinococcus multilocularis leucine aminopeptidase protein 0.0106 0.0484 0.0464
Loa Loa (eye worm) hypothetical protein 0.0179 0.0862 0.0862
Mycobacterium ulcerans leucyl aminopeptidase 0.0106 0.0484 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0156 0.0156
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0102 0.046 0.044
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0108 0.0088
Echinococcus granulosus adam 0.0058 0.0228 0.0208
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0212 0.0192
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0089 0.0393 0.7452
Brugia malayi mbt repeat family protein 0.0048 0.0177 0.0389
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0212 0.0192
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0106 0.0484 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0102 0.046 1
Brugia malayi hypothetical protein 0.0102 0.046 0.1009
Trypanosoma brucei Aminopeptidase M1, putative 0.0102 0.046 0.9464
Loa Loa (eye worm) hypothetical protein 0.0055 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0102 0.046 0.046
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.0788 0.1729
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.013 0.2104
Schistosoma mansoni patched 1 0.0041 0.0141 0.012
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0141 0.012
Leishmania major trypanothione reductase 0.0039 0.013 0.2104
Schistosoma mansoni aminopeptidase A (M01 family) 0.0102 0.046 0.044
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0116 0.1789
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1918 1 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0212 0.0192
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0133 0.0112
Onchocerca volvulus 0.0102 0.046 0.4944
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0173 0.0153
Trypanosoma brucei trypanothione reductase 0.0039 0.013 0.2104
Schistosoma mansoni hypothetical protein 0.004 0.0133 0.0113
Brugia malayi Peptidase family M1 containing protein 0.0102 0.046 0.1009
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0096 0.0429 0.0409
Loa Loa (eye worm) hypothetical protein 0.0102 0.046 0.046
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0106 0.0484 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.092 0.0902
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0428 0.0409
Echinococcus multilocularis protein patched 0.0041 0.0141 0.012
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0108 0.0088
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0102 0.046 0.9464
Chlamydia trachomatis cytosol aminopeptidase 0.0106 0.0484 0.5
Schistosoma mansoni hypothetical protein 0.0035 0.0108 0.0088
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0644 0.0625
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0173 0.038
Brugia malayi cytosol aminopeptidase 0.0021 0.0036 0.0078
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Brugia malayi angiogenesis inhibito 0.0026 0.006 0.0131
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0066 0.0144
Echinococcus multilocularis neuropeptide s receptor 0.0467 0.2375 0.2359
Brugia malayi TATA binding protein associated factor 0.0102 0.046 0.1009
Echinococcus granulosus leucyl aminopeptidase 0.0021 0.0036 0.0015
Toxoplasma gondii aminopeptidase N protein 0.0102 0.046 0.9347
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0177 0.0157
Schistosoma mansoni alpha glucosidase 0.0036 0.0116 0.0096
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0116 0.1789
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0173 0.0173
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.0862 1
Brugia malayi CHE-14 protein 0.0041 0.0141 0.0308
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0102 0.046 0.9464
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0096 0.0429 0.0409
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0102 0.046 0.9464
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0106 0.0484 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0116 0.0254
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0173 0.0153
Loa Loa (eye worm) hypothetical protein 0.0041 0.0141 0.0141
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0116 0.0212
Schistosoma mansoni alpha-glucosidase 0.0141 0.0667 0.0648
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0116 0.1789
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0212 0.0465
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0106 0.0484 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0173 0.0153
Loa Loa (eye worm) glutathione reductase 0.0039 0.013 0.013
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Mycobacterium tuberculosis Probable dehydrogenase 0.0089 0.0393 0.7452
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0021 0.0036 0.0078
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0428 0.094
Brugia malayi ADAMTS-like protease 0.0026 0.006 0.0131
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0428 0.0409
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0177 0.0157
Loa Loa (eye worm) MBCTL1 0.0055 0.0212 0.0212
Mycobacterium tuberculosis Probable reductase 0.0089 0.0393 0.7452
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0102 0.046 0.9321
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0096 0.0429 0.0409
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0116 0.0096
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0036 0.0015
Plasmodium falciparum M17 leucyl aminopeptidase 0.0106 0.0484 1
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0021 0.0036 0.0015
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.0788 0.0769
Echinococcus multilocularis adam 0.0058 0.0228 0.0208
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1918 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0089 0.0393 0.7452
Schistosoma mansoni intermediate filament proteins 0.0027 0.0066 0.0045
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0116 0.0116
Echinococcus granulosus leucine aminopeptidase protein 0.0106 0.0484 0.0464
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0099 0.0446 0.8933
Brugia malayi glutathione reductase 0.0039 0.013 0.0285
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.002
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0021 0.0036 0.0036
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0102 0.046 0.9464
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0106 0.0484 1
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0133 0.0112
Echinococcus granulosus expressed conserved protein 0.009 0.0398 0.0378
Echinococcus multilocularis expressed conserved protein 0.009 0.0398 0.0378
Schistosoma mansoni hypothetical protein 0.004 0.0133 0.0113
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0177 0.0157
Brugia malayi hypothetical protein 0.0035 0.0108 0.0238
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0036 0.0015
Loa Loa (eye worm) reprolysin 0.0096 0.0429 0.0429
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0102 0.046 1
Loa Loa (eye worm) aminopeptidase N 0.0102 0.046 0.046
Echinococcus granulosus lamin 0.0027 0.0066 0.0045
Entamoeba histolytica aminopeptidase, putative 0.0102 0.046 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0212 0.0192
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0177 0.0157
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0212 0.0192
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0106 0.0484 0.5
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0106 0.0484 1
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0021 0.0036 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0141 0.0718
Echinococcus multilocularis lamin dm0 0.0027 0.0066 0.0045
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0066 0.0066
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0089 0.0393 0.7452
Onchocerca volvulus 0.0102 0.046 0.4944
Echinococcus multilocularis protein dispatched 1 0.0047 0.0171 0.0151
Loa Loa (eye worm) hypothetical protein 0.0026 0.006 0.006
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0102 0.046 0.044
Echinococcus granulosus leucyl aminopeptidase 0.0021 0.0036 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0173 0.0153
Brugia malayi N-terminal motif family protein 0.0179 0.0862 0.1892
Echinococcus multilocularis musashi 0.0027 0.0066 0.0045
Loa Loa (eye worm) hypothetical protein 0.005 0.0189 0.0189
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0428 0.9108
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0644 0.0625
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0102 0.046 0.9464
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0089 0.0393 0.7452
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0102 0.046 0.9464
Schistosoma mansoni hypothetical protein 0.0293 0.1461 0.1444
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0116 0.0096
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Loa Loa (eye worm) hypothetical protein 0.0027 0.0066 0.0066
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0102 0.046 0.044
Loa Loa (eye worm) hypothetical protein 0.0102 0.046 0.046
Schistosoma mansoni alpha-glucosidase 0.0141 0.0667 0.0648
Echinococcus multilocularis neuropeptide receptor A26 0.0467 0.2375 0.2359
Loa Loa (eye worm) TATA binding protein associated factor 0.0102 0.046 0.046
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0141 0.012
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Schistosoma mansoni lamin 0.0027 0.0066 0.0045
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0102 0.046 0.9464
Onchocerca volvulus 0.0048 0.0177 0.1398
Echinococcus granulosus lamin dm0 0.0027 0.0066 0.0045
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0021 0.0036 0.0036
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0102 0.046 1
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1918 1 1
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0177 0.0177
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.013 0.013
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.0788 0.0769
Mycobacterium tuberculosis Probable oxidoreductase 0.0099 0.0446 0.8933
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0116 0.0212
Echinococcus multilocularis lamin 0.0027 0.0066 0.0045
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0177 0.0157
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0102 0.046 0.9321
Echinococcus granulosus aminopeptidase N 0.0102 0.046 0.044
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0177 0.0157
Brugia malayi Peptidase family M1 containing protein 0.0102 0.046 0.1009
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0102 0.046 0.9321
Schistosoma mansoni lamin 0.0027 0.0066 0.0045
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0141 0.0141
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.0788 0.0788
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0102 0.046 0.9464
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0099 0.0446 0.8933
Loa Loa (eye worm) hypothetical protein 0.0026 0.006 0.006
Brugia malayi mbt repeat family protein 0.0048 0.0177 0.0389
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0177 0.1398
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0096 0.0428 0.0428
Brugia malayi Reprolysin 0.0078 0.0333 0.073
Brugia malayi Thioredoxin reductase 0.0039 0.013 0.0285
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0102 0.046 0.9321
Schistosoma mansoni hypothetical protein 0.004 0.0133 0.0113
Onchocerca volvulus 0.0102 0.046 0.4944
Onchocerca volvulus 0.0095 0.0424 0.4494
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0141 0.012
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0106 0.0484 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0021 0.0036 0.0078
Trypanosoma cruzi aminopeptidase, putative 0.0102 0.046 0.9464
Trypanosoma brucei Aminopeptidase M1, putative 0.0102 0.046 0.9464
Loa Loa (eye worm) hypothetical protein 0.0048 0.0177 0.0177
Brugia malayi hypothetical protein 0.0058 0.0228 0.05
Echinococcus multilocularis aminopeptidase N 0.0102 0.046 0.044
Loa Loa (eye worm) peptidase family M1 containing protein 0.0102 0.046 0.046
Schistosoma mansoni hypothetical protein 0.004 0.0133 0.0113
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0108 0.0088
Toxoplasma gondii aminopeptidase N, putative 0.0102 0.046 0.9347
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0436 0.0416
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0102 0.046 0.9464
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0173 0.0153
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0036 0.0015
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0102 0.046 0.044
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Trypanosoma cruzi aminopeptidase, putative 0.0102 0.046 0.9464
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0021 0.0036 0.0015
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0099 0.0446 0.5811
Brugia malayi hypothetical protein 0.0102 0.046 0.1009
Brugia malayi Peptidase family M1 containing protein 0.0102 0.046 0.1009
Brugia malayi Disintegrin family protein 0.0018 0.002 0.0045
Trypanosoma cruzi Aminopeptidase M1, putative 0.0102 0.046 0.9464
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0063
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.092 0.0902
Toxoplasma gondii aminopeptidase n, putative 0.0102 0.046 0.9347
Brugia malayi hypothetical protein 0.0882 0.4557 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0102 0.046 0.044
Brugia malayi intermediate filament protein 0.0027 0.0066 0.0144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0173 0.0153
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0173 0.0153
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0058 0.0228 0.0208
Toxoplasma gondii leucyl aminopeptidase LAP 0.0106 0.0484 1
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0102 0.046 0.9464
Echinococcus granulosus neuropeptide receptor A26 0.0467 0.2375 0.2359
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0177 0.0157
Trypanosoma brucei glucosidase, putative 0.0036 0.0116 0.1789
Toxoplasma gondii thioredoxin reductase 0.0039 0.013 0.0383

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0.3 uM Induction of mitotic arrest in human U2OS cells assessed as appearance of monopolar spindles after 72 hrs by Zeiss microscopy ChEMBL. 20397705

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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